Compile Data Set for Download or QSAR

Found 110 hits with Last Name = 'frolov' and Initial = 'eb'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H1 receptor (Homo sapiens (Human))	BDBM50305271 (5-[2-(4-Fluorophenyl)ethyl]-2,8-dimethyl-2,3,4,5-t...) Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(F)cc1 Show InChI InChI=1S/C21H23FN2/c1-15-3-8-20-18(13-15)19-14-23(2)11-10-21(19)24(20)12-9-16-4-6-17(22)7-5-16/h3-8,13H,9-12,14H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...				Bioorg Med Chem Lett 20: 78-82 (2010) Article DOI: 10.1016/j.bmcl.2009.11.037 BindingDB Entry DOI: 10.7270/Q25Q4W6C
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50305268 (8-Fluoro-2-methyl-5-(2-p-tolylethyl)-2,3,4,5-tetra...) Show SMILES CN1CCc2c(C1)c1cc(F)ccc1n2CCc1ccc(C)cc1 Show InChI InChI=1S/C21H23FN2/c1-15-3-5-16(6-4-15)9-12-24-20-8-7-17(22)13-18(20)19-14-23(2)11-10-21(19)24/h3-8,13H,9-12,14H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...				Bioorg Med Chem Lett 20: 78-82 (2010) Article DOI: 10.1016/j.bmcl.2009.11.037 BindingDB Entry DOI: 10.7270/Q25Q4W6C
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50305266 (8-Fluoro-5-[2-(4-methoxyphenyl)ethyl]-2-methyl-2,3...) Show SMILES COc1ccc(CCn2c3CCN(C)Cc3c3cc(F)ccc23)cc1 Show InChI InChI=1S/C21H23FN2O/c1-23-11-10-21-19(14-23)18-13-16(22)5-8-20(18)24(21)12-9-15-3-6-17(25-2)7-4-15/h3-8,13H,9-12,14H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...				Bioorg Med Chem Lett 20: 78-82 (2010) Article DOI: 10.1016/j.bmcl.2009.11.037 BindingDB Entry DOI: 10.7270/Q25Q4W6C
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50305260 (2-Methyl-5-((Z)-styryl)-2,3,4,5-tetrahydro-1H-pyri...) Show SMILES CN1CCc2c(C1)c1ccccc1n2\C=C/c1ccccc1 Show InChI InChI=1S/C20H20N2/c1-21-13-12-20-18(15-21)17-9-5-6-10-19(17)22(20)14-11-16-7-3-2-4-8-16/h2-11,14H,12-13,15H2,1H3/b14-11-	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...				Bioorg Med Chem Lett 20: 78-82 (2010) Article DOI: 10.1016/j.bmcl.2009.11.037 BindingDB Entry DOI: 10.7270/Q25Q4W6C
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50305267 (8-Fluoro-2-methyl-5-[2-(4-trifluoromethylphenyl)et...) Show SMILES CN1CCc2c(C1)c1cc(F)ccc1n2CCc1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C21H20F4N2/c1-26-10-9-20-18(13-26)17-12-16(22)6-7-19(17)27(20)11-8-14-2-4-15(5-3-14)21(23,24)25/h2-7,12H,8-11,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...				Bioorg Med Chem Lett 20: 78-82 (2010) Article DOI: 10.1016/j.bmcl.2009.11.037 BindingDB Entry DOI: 10.7270/Q25Q4W6C
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50305262 (8-Fluoro-2-methyl-5-phenethyl-2,3,4,5-tetrahydro-1...) Show SMILES CN1CCc2c(C1)c1cc(F)ccc1n2CCc1ccccc1 Show InChI InChI=1S/C20H21FN2/c1-22-11-10-20-18(14-22)17-13-16(21)7-8-19(17)23(20)12-9-15-5-3-2-4-6-15/h2-8,13H,9-12,14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...				Bioorg Med Chem Lett 20: 78-82 (2010) Article DOI: 10.1016/j.bmcl.2009.11.037 BindingDB Entry DOI: 10.7270/Q25Q4W6C
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50305263 (2,8-Dimethyl-5-phenethyl-2,3,4,5-tetrahydro-1H-pyr...) Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccccc1 Show InChI InChI=1S/C21H24N2/c1-16-8-9-20-18(14-16)19-15-22(2)12-11-21(19)23(20)13-10-17-6-4-3-5-7-17/h3-9,14H,10-13,15H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...				Bioorg Med Chem Lett 20: 78-82 (2010) Article DOI: 10.1016/j.bmcl.2009.11.037 BindingDB Entry DOI: 10.7270/Q25Q4W6C
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50305269 (5-[2-(4-Methoxyphenyl)ethyl]-2,8-dimethyl-2,3,4,5-...) Show SMILES COc1ccc(CCn2c3CCN(C)Cc3c3cc(C)ccc23)cc1 Show InChI InChI=1S/C22H26N2O/c1-16-4-9-21-19(14-16)20-15-23(2)12-11-22(20)24(21)13-10-17-5-7-18(25-3)8-6-17/h4-9,14H,10-13,15H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...				Bioorg Med Chem Lett 20: 78-82 (2010) Article DOI: 10.1016/j.bmcl.2009.11.037 BindingDB Entry DOI: 10.7270/Q25Q4W6C
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50305265 (2-Methyl-5-phenethyl-8-trifluoromethyl-2,3,4,5-tet...) Show SMILES CN1CCc2c(C1)c1cc(ccc1n2CCc1ccccc1)C(F)(F)F Show InChI InChI=1S/C21H21F3N2/c1-25-11-10-20-18(14-25)17-13-16(21(22,23)24)7-8-19(17)26(20)12-9-15-5-3-2-4-6-15/h2-8,13H,9-12,14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...				Bioorg Med Chem Lett 20: 78-82 (2010) Article DOI: 10.1016/j.bmcl.2009.11.037 BindingDB Entry DOI: 10.7270/Q25Q4W6C
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50305258 (2,8-Dimethyl-5-((Z)-styryl)-2,3,4,5-tetrahydro-1H-...) Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2\C=C/c1ccccc1 Show InChI InChI=1S/C21H22N2/c1-16-8-9-20-18(14-16)19-15-22(2)12-11-21(19)23(20)13-10-17-6-4-3-5-7-17/h3-10,13-14H,11-12,15H2,1-2H3/b13-10-	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...				Bioorg Med Chem Lett 20: 78-82 (2010) Article DOI: 10.1016/j.bmcl.2009.11.037 BindingDB Entry DOI: 10.7270/Q25Q4W6C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50305258 (2,8-Dimethyl-5-((Z)-styryl)-2,3,4,5-tetrahydro-1H-...) Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2\C=C/c1ccccc1 Show InChI InChI=1S/C21H22N2/c1-16-8-9-20-18(14-16)19-15-22(2)12-11-21(19)23(20)13-10-17-6-4-3-5-7-17/h3-10,13-14H,11-12,15H2,1-2H3/b13-10-	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	87	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...				Bioorg Med Chem Lett 20: 78-82 (2010) Article DOI: 10.1016/j.bmcl.2009.11.037 BindingDB Entry DOI: 10.7270/Q25Q4W6C
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50305270 (2,8-Dimethyl-5-[2-(4-trifluoromethylphenyl)ethyl]-...) Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C22H23F3N2/c1-15-3-8-20-18(13-15)19-14-26(2)11-10-21(19)27(20)12-9-16-4-6-17(7-5-16)22(23,24)25/h3-8,13H,9-12,14H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	98	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...				Bioorg Med Chem Lett 20: 78-82 (2010) Article DOI: 10.1016/j.bmcl.2009.11.037 BindingDB Entry DOI: 10.7270/Q25Q4W6C
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50346044 (2-methyl-5-(2-(pyridin-3-yl)ethyl)-2,3,4,5-tetrahy...) Show SMILES CN1CCc2c(C1)c1ccccc1n2CCc1cccnc1 Show InChI InChI=1S/C19H21N3/c1-21-11-9-19-17(14-21)16-6-2-3-7-18(16)22(19)12-8-15-5-4-10-20-13-15/h2-7,10,13H,8-9,11-12,14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1...				Bioorg Med Chem Lett 19: 3183-7 (2009) Article DOI: 10.1016/j.bmcl.2009.04.128 BindingDB Entry DOI: 10.7270/Q2FJ2H4X
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50305264 (8-Methoxy-2-methyl-5-phenethyl-2,3,4,5-tetrahydro-...) Show SMILES COc1ccc2n(CCc3ccccc3)c3CCN(C)Cc3c2c1 Show InChI InChI=1S/C21H24N2O/c1-22-12-11-21-19(15-22)18-14-17(24-2)8-9-20(18)23(21)13-10-16-6-4-3-5-7-16/h3-9,14H,10-13,15H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	104	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...				Bioorg Med Chem Lett 20: 78-82 (2010) Article DOI: 10.1016/j.bmcl.2009.11.037 BindingDB Entry DOI: 10.7270/Q25Q4W6C
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50346052 (8-fluoro-2-methyl-5-(2-(6-methylpyridin-3-yl)ethyl...) Show SMILES CN1CCc2c(C1)c1cc(F)ccc1n2CCc1ccc(C)nc1 Show InChI InChI=1S/C20H22FN3/c1-14-3-4-15(12-22-14)7-10-24-19-6-5-16(21)11-17(19)18-13-23(2)9-8-20(18)24/h3-6,11-12H,7-10,13H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1...				Bioorg Med Chem Lett 19: 3183-7 (2009) Article DOI: 10.1016/j.bmcl.2009.04.128 BindingDB Entry DOI: 10.7270/Q2FJ2H4X
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50305272 (2,8-Dimethyl-5-(2-p-tolylethyl)-2,3,4,5-tetrahydro...) Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)cc1 Show InChI InChI=1S/C22H26N2/c1-16-4-7-18(8-5-16)10-13-24-21-9-6-17(2)14-19(21)20-15-23(3)12-11-22(20)24/h4-9,14H,10-13,15H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	112	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...				Bioorg Med Chem Lett 20: 78-82 (2010) Article DOI: 10.1016/j.bmcl.2009.11.037 BindingDB Entry DOI: 10.7270/Q25Q4W6C
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50346050 (2-methyl-5-(2-(pyridin-4-yl)ethyl)-2,3,4,5-tetrahy...) Show SMILES CN1CCc2c(C1)c1ccccc1n2CCc1ccncc1 Show InChI InChI=1S/C19H21N3/c1-21-12-9-19-17(14-21)16-4-2-3-5-18(16)22(19)13-8-15-6-10-20-11-7-15/h2-7,10-11H,8-9,12-14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1...				Bioorg Med Chem Lett 19: 3183-7 (2009) Article DOI: 10.1016/j.bmcl.2009.04.128 BindingDB Entry DOI: 10.7270/Q2FJ2H4X
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50346058 (8-fluoro-2-methyl-5-(2-(pyridin-4-yl)ethyl)-2,3,4,...) Show SMILES CN1CCc2c(C1)c1cc(F)ccc1n2CCc1ccncc1 Show InChI InChI=1S/C19H20FN3/c1-22-10-7-19-17(13-22)16-12-15(20)2-3-18(16)23(19)11-6-14-4-8-21-9-5-14/h2-5,8-9,12H,6-7,10-11,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1...				Bioorg Med Chem Lett 19: 3183-7 (2009) Article DOI: 10.1016/j.bmcl.2009.04.128 BindingDB Entry DOI: 10.7270/Q2FJ2H4X
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50346057 (8-bromo-2-methyl-5-(2-(pyridin-2-yl)ethyl)-2,3,4,5...) Show SMILES CN1CCc2c(C1)c1cc(Br)ccc1n2CCc1ccccn1 Show InChI InChI=1S/C19H20BrN3/c1-22-10-8-19-17(13-22)16-12-14(20)5-6-18(16)23(19)11-7-15-4-2-3-9-21-15/h2-6,9,12H,7-8,10-11,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1...				Bioorg Med Chem Lett 19: 3183-7 (2009) Article DOI: 10.1016/j.bmcl.2009.04.128 BindingDB Entry DOI: 10.7270/Q2FJ2H4X
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50305262 (8-Fluoro-2-methyl-5-phenethyl-2,3,4,5-tetrahydro-1...) Show SMILES CN1CCc2c(C1)c1cc(F)ccc1n2CCc1ccccc1 Show InChI InChI=1S/C20H21FN2/c1-22-11-10-20-18(14-22)17-13-16(21)7-8-19(17)23(20)12-9-15-5-3-2-4-6-15/h2-8,13H,9-12,14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	131	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2...				Bioorg Med Chem Lett 20: 78-82 (2010) Article DOI: 10.1016/j.bmcl.2009.11.037 BindingDB Entry DOI: 10.7270/Q25Q4W6C
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50305263 (2,8-Dimethyl-5-phenethyl-2,3,4,5-tetrahydro-1H-pyr...) Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccccc1 Show InChI InChI=1S/C21H24N2/c1-16-8-9-20-18(14-16)19-15-22(2)12-11-21(19)23(20)13-10-17-6-4-3-5-7-17/h3-9,14H,10-13,15H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	146	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2...				Bioorg Med Chem Lett 20: 78-82 (2010) Article DOI: 10.1016/j.bmcl.2009.11.037 BindingDB Entry DOI: 10.7270/Q25Q4W6C
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50305258 (2,8-Dimethyl-5-((Z)-styryl)-2,3,4,5-tetrahydro-1H-...) Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2\C=C/c1ccccc1 Show InChI InChI=1S/C21H22N2/c1-16-8-9-20-18(14-16)19-15-22(2)12-11-21(19)23(20)13-10-17-6-4-3-5-7-17/h3-10,13-14H,11-12,15H2,1-2H3/b13-10-	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	154	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2...				Bioorg Med Chem Lett 20: 78-82 (2010) Article DOI: 10.1016/j.bmcl.2009.11.037 BindingDB Entry DOI: 10.7270/Q25Q4W6C
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50305261 (CHEMBL589390 | Dimebolin) Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)nc1 Show InChI InChI=1S/C21H25N3/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17/h4-7,12-13H,8-11,14H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	158	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...				Bioorg Med Chem Lett 20: 78-82 (2010) Article DOI: 10.1016/j.bmcl.2009.11.037 BindingDB Entry DOI: 10.7270/Q25Q4W6C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50305263 (2,8-Dimethyl-5-phenethyl-2,3,4,5-tetrahydro-1H-pyr...) Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccccc1 Show InChI InChI=1S/C21H24N2/c1-16-8-9-20-18(14-16)19-15-22(2)12-11-21(19)23(20)13-10-17-6-4-3-5-7-17/h3-9,14H,10-13,15H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	158	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...				Bioorg Med Chem Lett 20: 78-82 (2010) Article DOI: 10.1016/j.bmcl.2009.11.037 BindingDB Entry DOI: 10.7270/Q25Q4W6C
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50305261 (CHEMBL589390 | Dimebolin) Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)nc1 Show InChI InChI=1S/C21H25N3/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17/h4-7,12-13H,8-11,14H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1...				Bioorg Med Chem Lett 19: 3183-7 (2009) Article DOI: 10.1016/j.bmcl.2009.04.128 BindingDB Entry DOI: 10.7270/Q2FJ2H4X
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50346059 (2,8-dimethyl-5-(2-(pyridin-4-yl)ethyl)-2,3,4,5-tet...) Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccncc1 Show InChI InChI=1S/C20H23N3/c1-15-3-4-19-17(13-15)18-14-22(2)11-8-20(18)23(19)12-7-16-5-9-21-10-6-16/h3-6,9-10,13H,7-8,11-12,14H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1...				Bioorg Med Chem Lett 19: 3183-7 (2009) Article DOI: 10.1016/j.bmcl.2009.04.128 BindingDB Entry DOI: 10.7270/Q2FJ2H4X
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50305255 (25-[(Z)-2-(4-Fluorophenyl)vinyl]-2,8-dimethyl-2,3,...) Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2\C=C/c1ccc(F)cc1 Show InChI InChI=1S/C21H21FN2/c1-15-3-8-20-18(13-15)19-14-23(2)11-10-21(19)24(20)12-9-16-4-6-17(22)7-5-16/h3-9,12-13H,10-11,14H2,1-2H3/b12-9-	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...				Bioorg Med Chem Lett 20: 78-82 (2010) Article DOI: 10.1016/j.bmcl.2009.11.037 BindingDB Entry DOI: 10.7270/Q25Q4W6C
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50305260 (2-Methyl-5-((Z)-styryl)-2,3,4,5-tetrahydro-1H-pyri...) Show SMILES CN1CCc2c(C1)c1ccccc1n2\C=C/c1ccccc1 Show InChI InChI=1S/C20H20N2/c1-21-13-12-20-18(15-21)17-9-5-6-10-19(17)22(20)14-11-16-7-3-2-4-8-16/h2-11,14H,12-13,15H2,1H3/b14-11-	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	181	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2...				Bioorg Med Chem Lett 20: 78-82 (2010) Article DOI: 10.1016/j.bmcl.2009.11.037 BindingDB Entry DOI: 10.7270/Q25Q4W6C
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50346045 (2-methyl-5-(2-(pyridin-4-yl)ethyl)-8-(trifluoromet...) Show SMILES CN1CCc2c(C1)c1cc(ccc1n2CCc1ccncc1)C(F)(F)F Show InChI InChI=1S/C20H20F3N3/c1-25-10-7-19-17(13-25)16-12-15(20(21,22)23)2-3-18(16)26(19)11-6-14-4-8-24-9-5-14/h2-5,8-9,12H,6-7,10-11,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1...				Bioorg Med Chem Lett 19: 3183-7 (2009) Article DOI: 10.1016/j.bmcl.2009.04.128 BindingDB Entry DOI: 10.7270/Q2FJ2H4X
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50305272 (2,8-Dimethyl-5-(2-p-tolylethyl)-2,3,4,5-tetrahydro...) Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)cc1 Show InChI InChI=1S/C22H26N2/c1-16-4-7-18(8-5-16)10-13-24-21-9-6-17(2)14-19(21)20-15-23(3)12-11-22(20)24/h4-9,14H,10-13,15H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	276	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...				Bioorg Med Chem Lett 20: 78-82 (2010) Article DOI: 10.1016/j.bmcl.2009.11.037 BindingDB Entry DOI: 10.7270/Q25Q4W6C
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50346049 (2,8-dimethyl-5-(2-pyrazine-2-ylethyl)-gamma-carbol...) Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1cnccn1 Show InChI InChI=1S/C19H22N4/c1-14-3-4-18-16(11-14)17-13-22(2)9-6-19(17)23(18)10-5-15-12-20-7-8-21-15/h3-4,7-8,11-12H,5-6,9-10,13H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1...				Bioorg Med Chem Lett 19: 3183-7 (2009) Article DOI: 10.1016/j.bmcl.2009.04.128 BindingDB Entry DOI: 10.7270/Q2FJ2H4X
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50305259 (2-Methyl-5-((E)-styryl)-2,3,4,5-tetrahydro-1H-pyri...) Show SMILES CN1CCC2C(C1)c1ccccc1N2\C=C\c1ccccc1 Show InChI InChI=1S/C20H22N2/c1-21-13-12-20-18(15-21)17-9-5-6-10-19(17)22(20)14-11-16-7-3-2-4-8-16/h2-11,14,18,20H,12-13,15H2,1H3/b14-11+	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	345	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...				Bioorg Med Chem Lett 20: 78-82 (2010) Article DOI: 10.1016/j.bmcl.2009.11.037 BindingDB Entry DOI: 10.7270/Q25Q4W6C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50346059 (2,8-dimethyl-5-(2-(pyridin-4-yl)ethyl)-2,3,4,5-tet...) Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccncc1 Show InChI InChI=1S/C20H23N3/c1-15-3-4-19-17(13-15)18-14-22(2)11-8-20(18)23(19)12-7-16-5-9-21-10-6-16/h3-6,9-10,13H,7-8,11-12,14H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human recombinant 5-HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced intracellular cAMP accu...				Bioorg Med Chem Lett 19: 3183-7 (2009) Article DOI: 10.1016/j.bmcl.2009.04.128 BindingDB Entry DOI: 10.7270/Q2FJ2H4X
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50346060 (8-methoxy-2-methyl-5-(2-(pyridin-4-yl)ethyl)-2,3,4...) Show SMILES COc1ccc2n(CCc3ccncc3)c3CCN(C)Cc3c2c1 Show InChI InChI=1S/C20H23N3O/c1-22-11-8-20-18(14-22)17-13-16(24-2)3-4-19(17)23(20)12-7-15-5-9-21-10-6-15/h3-6,9-10,13H,7-8,11-12,14H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1...				Bioorg Med Chem Lett 19: 3183-7 (2009) Article DOI: 10.1016/j.bmcl.2009.04.128 BindingDB Entry DOI: 10.7270/Q2FJ2H4X
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50346044 (2-methyl-5-(2-(pyridin-3-yl)ethyl)-2,3,4,5-tetrahy...) Show SMILES CN1CCc2c(C1)c1ccccc1n2CCc1cccnc1 Show InChI InChI=1S/C19H21N3/c1-21-11-9-19-17(14-21)16-6-2-3-7-18(16)22(19)12-8-15-5-4-10-20-13-15/h2-7,10,13H,8-9,11-12,14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound...				Bioorg Med Chem Lett 19: 3183-7 (2009) Article DOI: 10.1016/j.bmcl.2009.04.128 BindingDB Entry DOI: 10.7270/Q2FJ2H4X
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50346061 (2,8-dimethyl-5-(2-(pyridin-3-yl)ethyl)-2,3,4,5-tet...) Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1cccnc1 Show InChI InChI=1S/C20H23N3/c1-15-5-6-19-17(12-15)18-14-22(2)10-8-20(18)23(19)11-7-16-4-3-9-21-13-16/h3-6,9,12-13H,7-8,10-11,14H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	440	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human recombinant 5-HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced intracellular cAMP accu...				Bioorg Med Chem Lett 19: 3183-7 (2009) Article DOI: 10.1016/j.bmcl.2009.04.128 BindingDB Entry DOI: 10.7270/Q2FJ2H4X
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50346058 (8-fluoro-2-methyl-5-(2-(pyridin-4-yl)ethyl)-2,3,4,...) Show SMILES CN1CCc2c(C1)c1cc(F)ccc1n2CCc1ccncc1 Show InChI InChI=1S/C19H20FN3/c1-22-10-7-19-17(13-22)16-12-15(20)2-3-18(16)23(19)11-6-14-4-8-21-9-5-14/h2-5,8-9,12H,6-7,10-11,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	470	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound...				Bioorg Med Chem Lett 19: 3183-7 (2009) Article DOI: 10.1016/j.bmcl.2009.04.128 BindingDB Entry DOI: 10.7270/Q2FJ2H4X
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50346061 (2,8-dimethyl-5-(2-(pyridin-3-yl)ethyl)-2,3,4,5-tet...) Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1cccnc1 Show InChI InChI=1S/C20H23N3/c1-15-5-6-19-17(12-15)18-14-22(2)10-8-20(18)23(19)11-7-16-4-3-9-21-13-16/h3-6,9,12-13H,7-8,10-11,14H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1...				Bioorg Med Chem Lett 19: 3183-7 (2009) Article DOI: 10.1016/j.bmcl.2009.04.128 BindingDB Entry DOI: 10.7270/Q2FJ2H4X
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50346050 (2-methyl-5-(2-(pyridin-4-yl)ethyl)-2,3,4,5-tetrahy...) Show SMILES CN1CCc2c(C1)c1ccccc1n2CCc1ccncc1 Show InChI InChI=1S/C19H21N3/c1-21-12-9-19-17(14-21)16-4-2-3-5-18(16)22(19)13-8-15-6-10-20-11-7-15/h2-7,10-11H,8-9,12-14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound...				Bioorg Med Chem Lett 19: 3183-7 (2009) Article DOI: 10.1016/j.bmcl.2009.04.128 BindingDB Entry DOI: 10.7270/Q2FJ2H4X
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50346051 (2,8-dimethyl-5-(2-(pyridin-2-yl)ethyl)-2,3,4,5-tet...) Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccccn1 Show InChI InChI=1S/C20H23N3/c1-15-6-7-19-17(13-15)18-14-22(2)11-9-20(18)23(19)12-8-16-5-3-4-10-21-16/h3-7,10,13H,8-9,11-12,14H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1...				Bioorg Med Chem Lett 19: 3183-7 (2009) Article DOI: 10.1016/j.bmcl.2009.04.128 BindingDB Entry DOI: 10.7270/Q2FJ2H4X
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50305253 (5-[(Z)-2-(4-Methoxyphenyl)vinyl]-2,8-dimethyl-2,3,...) Show SMILES COc1ccc(\C=C/n2c3CCN(C)Cc3c3cc(C)ccc23)cc1 Show InChI InChI=1S/C22H24N2O/c1-16-4-9-21-19(14-16)20-15-23(2)12-11-22(20)24(21)13-10-17-5-7-18(25-3)8-6-17/h4-10,13-14H,11-12,15H2,1-3H3/b13-10-	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...				Bioorg Med Chem Lett 20: 78-82 (2010) Article DOI: 10.1016/j.bmcl.2009.11.037 BindingDB Entry DOI: 10.7270/Q25Q4W6C
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50346062 (2-methyl-5-(2-(pyridin-2-yl)ethyl)-8-(trifluoromet...) Show SMILES CN1CCc2c(C1)c1cc(ccc1n2CCc1ccccn1)C(F)(F)F Show InChI InChI=1S/C20H20F3N3/c1-25-10-8-19-17(13-25)16-12-14(20(21,22)23)5-6-18(16)26(19)11-7-15-4-2-3-9-24-15/h2-6,9,12H,7-8,10-11,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	560	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1...				Bioorg Med Chem Lett 19: 3183-7 (2009) Article DOI: 10.1016/j.bmcl.2009.04.128 BindingDB Entry DOI: 10.7270/Q2FJ2H4X
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50346063 (8-fluoro-2-methyl-5-(2-(pyridin-2-yl)ethyl)-2,3,4,...) Show SMILES CN1CCc2c(C1)c1cc(F)ccc1n2CCc1ccccn1 Show InChI InChI=1S/C19H20FN3/c1-22-10-8-19-17(13-22)16-12-14(20)5-6-18(16)23(19)11-7-15-4-2-3-9-21-15/h2-6,9,12H,7-8,10-11,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	610	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound...				Bioorg Med Chem Lett 19: 3183-7 (2009) Article DOI: 10.1016/j.bmcl.2009.04.128 BindingDB Entry DOI: 10.7270/Q2FJ2H4X
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50346056 (8-fluoro-2-methyl-5-(2-(pyridin-3-yl)ethyl)-2,3,4,...) Show SMILES CN1CCc2c(C1)c1cc(F)ccc1n2CCc1cccnc1 Show InChI InChI=1S/C19H20FN3/c1-22-9-7-19-17(13-22)16-11-15(20)4-5-18(16)23(19)10-6-14-3-2-8-21-12-14/h2-5,8,11-12H,6-7,9-10,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	650	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium level increase during phase-1...				Bioorg Med Chem Lett 19: 3183-7 (2009) Article DOI: 10.1016/j.bmcl.2009.04.128 BindingDB Entry DOI: 10.7270/Q2FJ2H4X
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50305269 (5-[2-(4-Methoxyphenyl)ethyl]-2,8-dimethyl-2,3,4,5-...) Show SMILES COc1ccc(CCn2c3CCN(C)Cc3c3cc(C)ccc23)cc1 Show InChI InChI=1S/C22H26N2O/c1-16-4-9-21-19(14-16)20-15-23(2)12-11-22(20)24(21)13-10-17-5-7-18(25-3)8-6-17/h4-9,14H,10-13,15H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	666	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...				Bioorg Med Chem Lett 20: 78-82 (2010) Article DOI: 10.1016/j.bmcl.2009.11.037 BindingDB Entry DOI: 10.7270/Q25Q4W6C
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50305262 (8-Fluoro-2-methyl-5-phenethyl-2,3,4,5-tetrahydro-1...) Show SMILES CN1CCc2c(C1)c1cc(F)ccc1n2CCc1ccccc1 Show InChI InChI=1S/C20H21FN2/c1-22-11-10-20-18(14-22)17-13-16(21)7-8-19(17)23(20)12-9-15-5-3-2-4-6-15/h2-8,13H,9-12,14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	692	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...				Bioorg Med Chem Lett 20: 78-82 (2010) Article DOI: 10.1016/j.bmcl.2009.11.037 BindingDB Entry DOI: 10.7270/Q25Q4W6C
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50346052 (8-fluoro-2-methyl-5-(2-(6-methylpyridin-3-yl)ethyl...) Show SMILES CN1CCc2c(C1)c1cc(F)ccc1n2CCc1ccc(C)nc1 Show InChI InChI=1S/C20H22FN3/c1-14-3-4-15(12-22-14)7-10-24-19-6-5-16(21)11-17(19)18-13-23(2)9-8-20(18)24/h3-6,11-12H,7-10,13H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	730	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human histamine H1 receptor in SK-N-SH cells assessed as inhibition of histamine-induced calcium flow during phase-II compound...				Bioorg Med Chem Lett 19: 3183-7 (2009) Article DOI: 10.1016/j.bmcl.2009.04.128 BindingDB Entry DOI: 10.7270/Q2FJ2H4X
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50346051 (2,8-dimethyl-5-(2-(pyridin-2-yl)ethyl)-2,3,4,5-tet...) Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccccn1 Show InChI InChI=1S/C20H23N3/c1-15-6-7-19-17(13-15)18-14-22(2)11-9-20(18)23(19)12-8-16-5-3-4-10-21-16/h3-7,10,13H,8-9,11-12,14H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	860	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human recombinant 5-HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced intracellular cAMP accu...				Bioorg Med Chem Lett 19: 3183-7 (2009) Article DOI: 10.1016/j.bmcl.2009.04.128 BindingDB Entry DOI: 10.7270/Q2FJ2H4X
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50305261 (CHEMBL589390 | Dimebolin) Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)nc1 Show InChI InChI=1S/C21H25N3/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17/h4-7,12-13H,8-11,14H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	890	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human recombinant 5-HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced intracellular cAMP accu...				Bioorg Med Chem Lett 19: 3183-7 (2009) Article DOI: 10.1016/j.bmcl.2009.04.128 BindingDB Entry DOI: 10.7270/Q2FJ2H4X
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50305256 (2,8-Dimethyl-5-((Z)-2-p-tolylvinyl)-2,3,4,5-tetrah...) Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2\C=C/c1ccc(C)cc1 Show InChI InChI=1S/C22H24N2/c1-16-4-7-18(8-5-16)10-13-24-21-9-6-17(2)14-19(21)20-15-23(3)12-11-22(20)24/h4-10,13-14H,11-12,15H2,1-3H3/b13-10-	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	910	n/a	n/a	n/a	n/a	n/a	n/a
Chemical Diversity Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...				Bioorg Med Chem Lett 20: 78-82 (2010) Article DOI: 10.1016/j.bmcl.2009.11.037 BindingDB Entry DOI: 10.7270/Q25Q4W6C
					More data for this Ligand-Target Pair

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