Reaction Details |
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Target | 5-hydroxytryptamine receptor 6 |
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Ligand | BDBM50305272 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_603319 (CHEMBL1038009) |
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IC50 | 276±n/a nM |
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Citation | Ivachtchenko, AV; Frolov, EB; Mitkin, OD; Tkachenko, SE; Okun, IM; Khvat, AV Synthesis and biological activity of 5-styryl and 5-phenethyl-substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles. Bioorg Med Chem Lett20:78-82 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 6 |
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Name: | 5-hydroxytryptamine receptor 6 |
Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46968.43 |
Organism: | Homo sapiens (Human) |
Description: | P50406 |
Residue: | 440 |
Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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BDBM50305272 |
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n/a |
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Name | BDBM50305272 |
Synonyms: | 2,8-Dimethyl-5-(2-p-tolylethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole | CHEMBL605081 |
Type | Small organic molecule |
Emp. Form. | C22H26N2 |
Mol. Mass. | 318.4552 |
SMILES | CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)cc1 |
Structure |
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