Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
RNA-directed RNA polymerase (Hepacivirus C) | BDBM50480722 (CHEMBL373691) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | 310 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmasset, Inc. Curated by ChEMBL | Assay Description Inhibition of HCV NS5B polymerase S282T mutant assessed as incorporation of [alpha32P]UTP into newly synthesized RNA by liquid scintillation counting | Antimicrob Agents Chemother 52: 458-64 (2008) Article DOI: 10.1128/aac.01184-07 BindingDB Entry DOI: 10.7270/Q21N83Z9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RNA-directed RNA polymerase (Hepacivirus C) | BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars | Article PubMed | 2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmasset, Inc. Curated by ChEMBL | Assay Description Inhibition of HCV NS5B polymerase S282T mutant assessed as incorporation of [alpha32P]UTP into newly synthesized RNA by liquid scintillation counting | Antimicrob Agents Chemother 52: 458-64 (2008) Article DOI: 10.1128/aac.01184-07 BindingDB Entry DOI: 10.7270/Q21N83Z9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RNA-directed RNA polymerase (Hepacivirus C) | BDBM50495953 (CHEMBL3121385) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmasset, Inc. Curated by ChEMBL | Assay Description Inhibition of HCV genotype 1b recombinant NS5B RNA dependent RNA polymerase S282T mutant using IRES RNA as substrate after 30 mins by radioactive ass... | J Med Chem 57: 1826-35 (2014) Article DOI: 10.1021/jm401224y BindingDB Entry DOI: 10.7270/Q2JQ140V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NS5B (Hepatitis C virus) | BDBM50332459 (((2R,3R,4R,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 5.94E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmasset, Inc. Curated by ChEMBL | Assay Description Inhibition of HCV NS5B polymerase | Bioorg Med Chem Lett 20: 7376-80 (2010) Article DOI: 10.1016/j.bmcl.2010.10.035 BindingDB Entry DOI: 10.7270/Q2222V1G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RNA-directed RNA polymerase (Hepacivirus C) | BDBM50495954 (CHEMBL3121384) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.04E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmasset, Inc. Curated by ChEMBL | Assay Description Inhibition of HCV genotype 1b recombinant NS5B RNA dependent RNA polymerase S282T mutant using IRES RNA as substrate after 30 mins by radioactive ass... | J Med Chem 57: 1826-35 (2014) Article DOI: 10.1021/jm401224y BindingDB Entry DOI: 10.7270/Q2JQ140V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase alpha catalytic subunit (Homo sapiens (Human)) | BDBM50090910 (3alpha,16,17,18-tetrahydroxyaphidicolone | 6,13-di...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
303A College Road East Curated by ChEMBL | Assay Description Inhibition of human DNA polymerase alpha assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin... | Antimicrob Agents Chemother 54: 3187-96 (2010) Article DOI: 10.1128/AAC.00399-10 BindingDB Entry DOI: 10.7270/Q2G1614S | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
RNA-directed RNA polymerase (Hepacivirus C) | BDBM50495956 (CHEMBL223482 | PS-6130) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.67E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmasset, Inc. Curated by ChEMBL | Assay Description Inhibition of HCV genotype 1b recombinant NS5B RNA dependent RNA polymerase S282T mutant using IRES RNA as substrate after 30 mins by radioactive ass... | J Med Chem 57: 1826-35 (2014) Article DOI: 10.1021/jm401224y BindingDB Entry DOI: 10.7270/Q2JQ140V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase subunit gamma-1 (Homo sapiens (Human)) | BDBM50333127 ((beta-D-2',3'-dideoxy-5'-F-cytidine-5'-triphosphat...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
303A College Road East Curated by ChEMBL | Assay Description Inhibition of human DNA polymerase gamma assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin... | Antimicrob Agents Chemother 54: 3187-96 (2010) Article DOI: 10.1128/AAC.00399-10 BindingDB Entry DOI: 10.7270/Q2G1614S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RNA-directed RNA polymerase (Hepacivirus C) | BDBM50495952 (CHEMBL3121489) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmasset, Inc. Curated by ChEMBL | Assay Description Inhibition of HCV genotype 1b recombinant NS5B RNA dependent RNA polymerase S282T mutant using IRES RNA as substrate after 30 mins by radioactive ass... | J Med Chem 57: 1826-35 (2014) Article DOI: 10.1021/jm401224y BindingDB Entry DOI: 10.7270/Q2JQ140V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RNA-directed RNA polymerase (Hepacivirus C) | BDBM50495957 (CHEMBL3121492) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmasset, Inc. Curated by ChEMBL | Assay Description Inhibition of HCV genotype 1b recombinant NS5B RNA dependent RNA polymerase S282T mutant using IRES RNA as substrate after 30 mins by radioactive ass... | J Med Chem 57: 1826-35 (2014) Article DOI: 10.1021/jm401224y BindingDB Entry DOI: 10.7270/Q2JQ140V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RNA-directed RNA polymerase (Hepacivirus C) | BDBM50495955 (CHEMBL3121493) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmasset, Inc. Curated by ChEMBL | Assay Description Inhibition of HCV genotype 1b recombinant NS5B RNA dependent RNA polymerase S282T mutant using IRES RNA as substrate after 30 mins by radioactive ass... | J Med Chem 57: 1826-35 (2014) Article DOI: 10.1021/jm401224y BindingDB Entry DOI: 10.7270/Q2JQ140V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase beta (Homo sapiens (Human)) | BDBM50090910 (3alpha,16,17,18-tetrahydroxyaphidicolone | 6,13-di...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
303A College Road East Curated by ChEMBL | Assay Description Inhibition of human DNA polymerase beta assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper binding... | Antimicrob Agents Chemother 54: 3187-96 (2010) Article DOI: 10.1128/AAC.00399-10 BindingDB Entry DOI: 10.7270/Q2G1614S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase subunit gamma-1 (Homo sapiens (Human)) | BDBM50090910 (3alpha,16,17,18-tetrahydroxyaphidicolone | 6,13-di...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
303A College Road East Curated by ChEMBL | Assay Description Inhibition of human DNA polymerase gamma assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin... | Antimicrob Agents Chemother 54: 3187-96 (2010) Article DOI: 10.1128/AAC.00399-10 BindingDB Entry DOI: 10.7270/Q2G1614S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-directed RNA polymerase II subunit RPB1 (Homo sapiens (Human)) | BDBM50333128 (((2S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
303A College Road East Curated by ChEMBL | Assay Description Inhibition of human RNA polymerase 2 | Antimicrob Agents Chemother 54: 3187-96 (2010) Article DOI: 10.1128/AAC.00399-10 BindingDB Entry DOI: 10.7270/Q2G1614S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA-directed RNA polymerase II subunit RPB1 (Homo sapiens (Human)) | BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
303A College Road East Curated by ChEMBL | Assay Description Inhibition of human RNA polymerase 2 | Antimicrob Agents Chemother 54: 3187-96 (2010) Article DOI: 10.1128/AAC.00399-10 BindingDB Entry DOI: 10.7270/Q2G1614S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase alpha catalytic subunit (Homo sapiens (Human)) | BDBM50333127 ((beta-D-2',3'-dideoxy-5'-F-cytidine-5'-triphosphat...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
303A College Road East Curated by ChEMBL | Assay Description Inhibition of human DNA polymerase alpha assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin... | Antimicrob Agents Chemother 54: 3187-96 (2010) Article DOI: 10.1128/AAC.00399-10 BindingDB Entry DOI: 10.7270/Q2G1614S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase alpha catalytic subunit (Homo sapiens (Human)) | BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
303A College Road East Curated by ChEMBL | Assay Description Inhibition of human DNA polymerase alpha assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin... | Antimicrob Agents Chemother 54: 3187-96 (2010) Article DOI: 10.1128/AAC.00399-10 BindingDB Entry DOI: 10.7270/Q2G1614S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase subunit gamma-1 (Homo sapiens (Human)) | BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
303A College Road East Curated by ChEMBL | Assay Description Inhibition of human DNA polymerase gamma assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin... | Antimicrob Agents Chemother 54: 3187-96 (2010) Article DOI: 10.1128/AAC.00399-10 BindingDB Entry DOI: 10.7270/Q2G1614S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase beta (Homo sapiens (Human)) | BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
303A College Road East Curated by ChEMBL | Assay Description Inhibition of human DNA polymerase beta assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper binding... | Antimicrob Agents Chemother 54: 3187-96 (2010) Article DOI: 10.1128/AAC.00399-10 BindingDB Entry DOI: 10.7270/Q2G1614S | |||||||||||
More data for this Ligand-Target Pair |