| Reaction Details |
|---|
 | Report a problem with these data |
| Target | RNA-directed RNA polymerase |
|---|
| Ligand | BDBM50495955 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1293306 (CHEMBL3123718) |
|---|
| IC50 | >100000±n/a nM |
|---|
| Citation |  Du, J; Chun, BK; Mosley, RT; Bansal, S; Bao, H; Espiritu, C; Lam, AM; Murakami, E; Niu, C; Micolochick Steuer, HM; Furman, PA; Sofia, MJ Use of 2'-spirocyclic ethers in HCV nucleoside design. J Med Chem57:1826-35 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| RNA-directed RNA polymerase |
|---|
| Name: | RNA-directed RNA polymerase |
|---|
| Synonyms: | 2.7.7.48 | NS5b | RNA-directed RNA polymerase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 65779.30 |
|---|
| Organism: | Hepacivirus C |
|---|
| Description: | ChEMBL_118447 |
|---|
| Residue: | 591 |
|---|
| Sequence: | SMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRSASLRQKKVTFDRLQVL
DDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSAKSKFGYGAKDVRNLSSKAVNHIR
SVWKDLLEDTETPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVS
TLPQAVMGSSYGFQYSPGQRVEFLVNTWKSKKCPMGFSYDTRCFDSTVTENDIRVEESIY
QCCDLAPEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKAS
AACRAAKLQDCTMLVCGDDLVVICESAGTQEDAASLRAFTEAMTRYSAPPGDPPQPEYDL
ELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLW
ARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIQRLHGLSAFSLHSYSPG
EINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVRTKLKLTPIP
AASQLDLSSWFVAGYSGGDIYHSLSRARPRWFMWCLLLLSVGVGIYLLPNR
|
|
|
|---|
| BDBM50495955 |
|---|
| n/a |
|---|
| Name | BDBM50495955 |
|---|
| Synonyms: | CHEMBL3121493 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C12H20N3O14P3 |
|---|
| Mol. Mass. | 523.2202 |
|---|
| SMILES | Nc1ccn([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@]22CCCO2)c(=O)n1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
