Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nicotinamide phosphoribosyltransferase (Mus musculus) | BDBM50236217 (CHEMBL4061448) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi del Piemonte Orientale"A. Avogadro" Curated by ChEMBL | Assay Description Inhibition of recombinant mouse NAMPT expressed in bacterial expression system using nicotinamide as substrate after 1 hr by fluorescence based NMNAT... | J Med Chem 60: 1768-1792 (2017) Article DOI: 10.1021/acs.jmedchem.6b01392 BindingDB Entry DOI: 10.7270/Q2TQ63TK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nicotinamide phosphoribosyltransferase (Mus musculus) | BDBM50236220 (CHEMBL4074848) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi del Piemonte Orientale"A. Avogadro" Curated by ChEMBL | Assay Description Inhibition of recombinant mouse NAMPT expressed in bacterial expression system using nicotinamide as substrate after 1 hr by fluorescence based NMNAT... | J Med Chem 60: 1768-1792 (2017) Article DOI: 10.1021/acs.jmedchem.6b01392 BindingDB Entry DOI: 10.7270/Q2TQ63TK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human)) | BDBM50236217 (CHEMBL4061448) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi del Piemonte Orientale"A. Avogadro" Curated by ChEMBL | Assay Description Inhibition of NAMPT in human Jurkat T cells assessed as reduction in NAD levels | J Med Chem 60: 1768-1792 (2017) Article DOI: 10.1021/acs.jmedchem.6b01392 BindingDB Entry DOI: 10.7270/Q2TQ63TK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nicotinamide phosphoribosyltransferase (Mus musculus) | BDBM81395 (APO-866) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents | MMDB PDB Article PubMed | n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi del Piemonte Orientale"A. Avogadro" Curated by ChEMBL | Assay Description Inhibition of recombinant mouse NAMPT expressed in bacterial expression system using nicotinamide as substrate after 1 hr by fluorescence based NMNAT... | J Med Chem 60: 1768-1792 (2017) Article DOI: 10.1021/acs.jmedchem.6b01392 BindingDB Entry DOI: 10.7270/Q2TQ63TK | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human)) | BDBM50236220 (CHEMBL4074848) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi del Piemonte Orientale"A. Avogadro" Curated by ChEMBL | Assay Description Inhibition of NAMPT in human Jurkat T cells assessed as reduction in NAD levels | J Med Chem 60: 1768-1792 (2017) Article DOI: 10.1021/acs.jmedchem.6b01392 BindingDB Entry DOI: 10.7270/Q2TQ63TK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human)) | BDBM50236219 (CHEMBL4066091) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi del Piemonte Orientale"A. Avogadro" Curated by ChEMBL | Assay Description Inhibition of NAMPT in human Jurkat T cells assessed as reduction in NAD levels | J Med Chem 60: 1768-1792 (2017) Article DOI: 10.1021/acs.jmedchem.6b01392 BindingDB Entry DOI: 10.7270/Q2TQ63TK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nicotinamide phosphoribosyltransferase (Mus musculus) | BDBM50236219 (CHEMBL4066091) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi del Piemonte Orientale"A. Avogadro" Curated by ChEMBL | Assay Description Inhibition of recombinant mouse NAMPT expressed in bacterial expression system using nicotinamide as substrate after 1 hr by fluorescence based NMNAT... | J Med Chem 60: 1768-1792 (2017) Article DOI: 10.1021/acs.jmedchem.6b01392 BindingDB Entry DOI: 10.7270/Q2TQ63TK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nicotinamide phosphoribosyltransferase (Mus musculus) | BDBM50236221 (CHEMBL4078882) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi del Piemonte Orientale"A. Avogadro" Curated by ChEMBL | Assay Description Inhibition of recombinant mouse NAMPT expressed in bacterial expression system using nicotinamide as substrate after 1 hr by fluorescence based NMNAT... | J Med Chem 60: 1768-1792 (2017) Article DOI: 10.1021/acs.jmedchem.6b01392 BindingDB Entry DOI: 10.7270/Q2TQ63TK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nicotinamide phosphoribosyltransferase (Mus musculus) | BDBM50236223 (CHEMBL4083606) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi del Piemonte Orientale"A. Avogadro" Curated by ChEMBL | Assay Description Inhibition of recombinant mouse NAMPT expressed in bacterial expression system using nicotinamide as substrate after 1 hr by fluorescence based NMNAT... | J Med Chem 60: 1768-1792 (2017) Article DOI: 10.1021/acs.jmedchem.6b01392 BindingDB Entry DOI: 10.7270/Q2TQ63TK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nicotinamide phosphoribosyltransferase (Mus musculus) | BDBM50236222 (CHEMBL4101611) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi del Piemonte Orientale"A. Avogadro" Curated by ChEMBL | Assay Description Inhibition of recombinant mouse NAMPT expressed in bacterial expression system using nicotinamide as substrate after 1 hr by fluorescence based NMNAT... | J Med Chem 60: 1768-1792 (2017) Article DOI: 10.1021/acs.jmedchem.6b01392 BindingDB Entry DOI: 10.7270/Q2TQ63TK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nicotinamide phosphoribosyltransferase (Mus musculus) | BDBM50236224 (CHEMBL4088492) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi del Piemonte Orientale"A. Avogadro" Curated by ChEMBL | Assay Description Inhibition of recombinant mouse NAMPT expressed in bacterial expression system using nicotinamide as substrate after 1 hr by fluorescence based NMNAT... | J Med Chem 60: 1768-1792 (2017) Article DOI: 10.1021/acs.jmedchem.6b01392 BindingDB Entry DOI: 10.7270/Q2TQ63TK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nicotinamide phosphoribosyltransferase (Mus musculus) | BDBM50236216 (CHEMBL4064240) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi del Piemonte Orientale"A. Avogadro" Curated by ChEMBL | Assay Description Inhibition of recombinant mouse NAMPT expressed in bacterial expression system using nicotinamide as substrate after 1 hr by fluorescence based NMNAT... | J Med Chem 60: 1768-1792 (2017) Article DOI: 10.1021/acs.jmedchem.6b01392 BindingDB Entry DOI: 10.7270/Q2TQ63TK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nicotinamide phosphoribosyltransferase (Mus musculus) | BDBM50236218 (CHEMBL4094769) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi del Piemonte Orientale"A. Avogadro" Curated by ChEMBL | Assay Description Inhibition of recombinant mouse NAMPT expressed in bacterial expression system using nicotinamide as substrate after 1 hr by fluorescence based NMNAT... | J Med Chem 60: 1768-1792 (2017) Article DOI: 10.1021/acs.jmedchem.6b01392 BindingDB Entry DOI: 10.7270/Q2TQ63TK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium release-activated calcium channel protein/Stromal interaction molecule 1 (Homo sapiens (Human)) | BDBM50549365 (CHEMBL3403742) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 228 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01305 BindingDB Entry DOI: 10.7270/Q2HH6PPZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nicotinamide phosphoribosyltransferase (Mus musculus) | BDBM50236215 (CHEMBL4087071) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 269 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi del Piemonte Orientale"A. Avogadro" Curated by ChEMBL | Assay Description Inhibition of recombinant mouse NAMPT expressed in bacterial expression system using nicotinamide as substrate after 1 hr by fluorescence based NMNAT... | J Med Chem 60: 1768-1792 (2017) Article DOI: 10.1021/acs.jmedchem.6b01392 BindingDB Entry DOI: 10.7270/Q2TQ63TK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium release-activated calcium channel protein/Stromal interaction molecule 1 (Homo sapiens (Human)) | BDBM50549358 (CHEMBL4753023) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 361 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01305 BindingDB Entry DOI: 10.7270/Q2HH6PPZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium release-activated calcium channel protein/Stromal interaction molecule 1 (Homo sapiens (Human)) | BDBM50549357 (CHEMBL4794288) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 781 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01305 BindingDB Entry DOI: 10.7270/Q2HH6PPZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium release-activated calcium channel protein/Stromal interaction molecule 1 (Homo sapiens (Human)) | BDBM50549360 (CHEMBL4780000) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 802 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01305 BindingDB Entry DOI: 10.7270/Q2HH6PPZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium release-activated calcium channel protein/Stromal interaction molecule 1 (Homo sapiens (Human)) | BDBM50549363 (CHEMBL4751678) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 807 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01305 BindingDB Entry DOI: 10.7270/Q2HH6PPZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium release-activated calcium channel protein/Stromal interaction molecule 1 (Homo sapiens (Human)) | BDBM50549362 (CHEMBL4761656) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 851 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01305 BindingDB Entry DOI: 10.7270/Q2HH6PPZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium release-activated calcium channel protein/Stromal interaction molecule 1 (Homo sapiens (Human)) | BDBM50549356 (CHEMBL4799904) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 866 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01305 BindingDB Entry DOI: 10.7270/Q2HH6PPZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium release-activated calcium channel protein/Stromal interaction molecule 1 (Homo sapiens (Human)) | BDBM50549359 (CHEMBL4750981) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01305 BindingDB Entry DOI: 10.7270/Q2HH6PPZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium release-activated calcium channel protein/Stromal interaction molecule 1 (Homo sapiens (Human)) | BDBM50549361 (CHEMBL4742227) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.62E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01305 BindingDB Entry DOI: 10.7270/Q2HH6PPZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium release-activated calcium channel protein/Stromal interaction molecule 1 (Homo sapiens (Human)) | BDBM50549364 (CHEMBL4742960) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.79E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01305 BindingDB Entry DOI: 10.7270/Q2HH6PPZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium release-activated calcium channel protein/Stromal interaction molecule 1 (Homo sapiens (Human)) | BDBM50018011 (Aubagio | CHEBI:68540 | HMR-1726 | TERIFLUNOMIDE) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01305 BindingDB Entry DOI: 10.7270/Q2HH6PPZ | |||||||||||
More data for this Ligand-Target Pair |