| Reaction Details |
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 | Report a problem with these data |
| Target | Nicotinamide phosphoribosyltransferase |
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| Ligand | BDBM50236222 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1658849 (CHEMBL4008461) |
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| IC50 | 31±n/a nM |
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| Citation |  Travelli, C; Aprile, S; Rahimian, R; Grolla, AA; Rogati, F; Bertolotti, M; Malagnino, F; di Paola, R; Impellizzeri, D; Fusco, R; Mercalli, V; Massarotti, A; Stortini, G; Terrazzino, S; Del Grosso, E; Fakhfouri, G; Troiani, MP; Alisi, MA; Grosa, G; Sorba, G; Canonico, PL; Orsomando, G; Cuzzocrea, S; Genazzani, AA; Galli, U; Tron, GC Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity. J Med Chem60:1768-1792 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nicotinamide phosphoribosyltransferase |
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| Name: | Nicotinamide phosphoribosyltransferase |
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| Synonyms: | NAMPT_MOUSE | NAmPRTase | Nampt | Pbef1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 55450.71 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_108315 |
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| Residue: | 491 |
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| Sequence: | MNAAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKVRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKEVYREHFQDDVFNERGWNYILEKYDGHLPIEVKAVP
EGSVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGIALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTEAPLIIRPDSGNPLDTVLKVLDILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKKWSIENVSFGSGGALLQKLTRDLLNCSFKCSYVVTNGLGVNVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGHDLLHTVFKNGKVTKSYSFDEVRKNA
QLNIEQDVAPH
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| BDBM50236222 |
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| n/a |
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| Name | BDBM50236222 |
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| Synonyms: | CHEMBL4101611 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H28N4O |
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| Mol. Mass. | 412.5267 |
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| SMILES | C(CCCOc1ccccc1-c1ccccc1)CCCn1cc(nn1)-c1cccnc1 |
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| Structure | 
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