Found 9 hits with Last Name = 'gong' and Initial = 'as' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Thrombopoietin receptor
(Homo sapiens (Human)) | BDBM50327451
(1-(2-(1-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-...)Show SMILES CC(=NNC(=S)N1CCc2cc(ccc12)C(O)=O)c1c(C)[nH]n(-c2ccc(C)c(C)c2)c1=O |w:2.2| Show InChI InChI=1S/C24H25N5O3S/c1-13-5-7-19(11-14(13)2)29-22(30)21(16(4)27-29)15(3)25-26-24(33)28-10-9-17-12-18(23(31)32)6-8-20(17)28/h5-8,11-12,27H,9-10H2,1-4H3,(H,26,33)(H,31,32) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 6 | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceuticals Co, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human TPOR expressed in human BaF3 cells |
Bioorg Med Chem Lett 20: 5670-2 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.028
BindingDB Entry DOI: 10.7270/Q2DR2VRW |
More data for this
Ligand-Target Pair | |
Thrombopoietin receptor
(Homo sapiens (Human)) | BDBM50327452
(1-(2-(1-(1-(2,3-dihydro-1H-inden-5-yl)-3-methyl-5-...)Show SMILES CC(=NNC(=S)N1CCc2cc(ccc12)C(O)=O)c1c(C)[nH]n(-c2ccc3CCCc3c2)c1=O |w:2.2| Show InChI InChI=1S/C25H25N5O3S/c1-14(26-27-25(34)29-11-10-18-12-19(24(32)33)7-9-21(18)29)22-15(2)28-30(23(22)31)20-8-6-16-4-3-5-17(16)13-20/h6-9,12-13,28H,3-5,10-11H2,1-2H3,(H,27,34)(H,32,33) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceuticals Co, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human TPOR expressed in human BaF3 cells |
Bioorg Med Chem Lett 20: 5670-2 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.028
BindingDB Entry DOI: 10.7270/Q2DR2VRW |
More data for this
Ligand-Target Pair | |
Thrombopoietin receptor
(Homo sapiens (Human)) | BDBM50327453
(1-(2-(1-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-...)Show SMILES CC(=NNC(=S)N1CCCc2cc(ccc12)C(O)=O)c1c(C)[nH]n(-c2ccc(C)c(C)c2)c1=O |w:2.2| Show InChI InChI=1S/C25H27N5O3S/c1-14-7-9-20(12-15(14)2)30-23(31)22(17(4)28-30)16(3)26-27-25(34)29-11-5-6-18-13-19(24(32)33)8-10-21(18)29/h7-10,12-13,28H,5-6,11H2,1-4H3,(H,27,34)(H,32,33) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 64 | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceuticals Co, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human TPOR expressed in human BaF3 cells |
Bioorg Med Chem Lett 20: 5670-2 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.028
BindingDB Entry DOI: 10.7270/Q2DR2VRW |
More data for this
Ligand-Target Pair | |
Thrombopoietin receptor
(Homo sapiens (Human)) | BDBM50327454
(1-(2-(1-(1-(2,3-dihydro-1H-inden-5-yl)-3-methyl-5-...)Show SMILES CC(=NNC(=S)N1CCCc2cc(ccc12)C(O)=O)c1c(C)[nH]n(-c2ccc3CCCc3c2)c1=O |w:2.2| Show InChI InChI=1S/C26H27N5O3S/c1-15(23-16(2)29-31(24(23)32)21-10-8-17-5-3-6-18(17)14-21)27-28-26(35)30-12-4-7-19-13-20(25(33)34)9-11-22(19)30/h8-11,13-14,29H,3-7,12H2,1-2H3,(H,28,35)(H,33,34) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 35 | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceuticals Co, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human TPOR expressed in human BaF3 cells |
Bioorg Med Chem Lett 20: 5670-2 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.028
BindingDB Entry DOI: 10.7270/Q2DR2VRW |
More data for this
Ligand-Target Pair | |
Thrombopoietin receptor
(Homo sapiens (Human)) | BDBM50327459
(1-(2-(1-(1-(2,3-dihydro-1H-inden-5-yl)-3-methyl-5-...)Show SMILES CC(=NN=C(O)N1CCc2cc(ccc12)C(O)=O)c1c(C)[nH]n(-c2ccc3CCCc3c2)c1=O |w:1.0,3.2| Show InChI InChI=1S/C25H25N5O4/c1-14(26-27-25(34)29-11-10-18-12-19(24(32)33)7-9-21(18)29)22-15(2)28-30(23(22)31)20-8-6-16-4-3-5-17(16)13-20/h6-9,12-13,28H,3-5,10-11H2,1-2H3,(H,27,34)(H,32,33) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 46 | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceuticals Co, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human TPOR expressed in human BaF3 cells |
Bioorg Med Chem Lett 20: 5670-2 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.028
BindingDB Entry DOI: 10.7270/Q2DR2VRW |
More data for this
Ligand-Target Pair | |
Thrombopoietin receptor
(Homo sapiens (Human)) | BDBM50327456
(CHEMBL1257847 | N'-(1-(1-(3,4-dimethylphenyl)-3-me...)Show SMILES CC(=NNC(=S)N1CCc2cc(ccc12)C(=O)N1CCOCC1)c1c(C)[nH]n(-c2ccc(C)c(C)c2)c1=O |w:2.2| Show InChI InChI=1S/C28H32N6O3S/c1-17-5-7-23(15-18(17)2)34-27(36)25(20(4)31-34)19(3)29-30-28(38)33-10-9-21-16-22(6-8-24(21)33)26(35)32-11-13-37-14-12-32/h5-8,15-16,31H,9-14H2,1-4H3,(H,30,38) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 31 | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceuticals Co, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human TPOR expressed in human BaF3 cells |
Bioorg Med Chem Lett 20: 5670-2 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.028
BindingDB Entry DOI: 10.7270/Q2DR2VRW |
More data for this
Ligand-Target Pair | |
Thrombopoietin receptor
(Homo sapiens (Human)) | BDBM50327457
(1-(2-(1-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-...)Show SMILES CCNC(=O)c1ccc2N(CCc2c1)C(=S)NN=C(C)c1c(C)[nH]n(-c2ccc(C)c(C)c2)c1=O |w:17.18| Show InChI InChI=1S/C26H30N6O2S/c1-6-27-24(33)20-8-10-22-19(14-20)11-12-31(22)26(35)29-28-17(4)23-18(5)30-32(25(23)34)21-9-7-15(2)16(3)13-21/h7-10,13-14,30H,6,11-12H2,1-5H3,(H,27,33)(H,29,35) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 26 | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceuticals Co, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human TPOR expressed in human BaF3 cells |
Bioorg Med Chem Lett 20: 5670-2 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.028
BindingDB Entry DOI: 10.7270/Q2DR2VRW |
More data for this
Ligand-Target Pair | |
Thrombopoietin receptor
(Homo sapiens (Human)) | BDBM50327458
(1-(2-(1-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-...)Show SMILES CC(=NN=C(O)N1CCc2cc(ccc12)C(O)=O)c1c(C)[nH]n(-c2ccc(C)c(C)c2)c1=O |w:1.0,3.2| Show InChI InChI=1S/C24H25N5O4/c1-13-5-7-19(11-14(13)2)29-22(30)21(16(4)27-29)15(3)25-26-24(33)28-10-9-17-12-18(23(31)32)6-8-20(17)28/h5-8,11-12,27H,9-10H2,1-4H3,(H,26,33)(H,31,32) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 42 | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceuticals Co, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human TPOR expressed in human BaF3 cells |
Bioorg Med Chem Lett 20: 5670-2 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.028
BindingDB Entry DOI: 10.7270/Q2DR2VRW |
More data for this
Ligand-Target Pair | |
Thrombopoietin receptor
(Homo sapiens (Human)) | BDBM50327455
(1-(2-(1-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-...)Show SMILES CNC(=O)c1ccc2N(CCc2c1)C(=S)NN=C(C)c1c(C)[nH]n(-c2ccc(C)c(C)c2)c1=O |w:16.17| Show InChI InChI=1S/C25H28N6O2S/c1-14-6-8-20(12-15(14)2)31-24(33)22(17(4)29-31)16(3)27-28-25(34)30-11-10-18-13-19(23(32)26-5)7-9-21(18)30/h6-9,12-13,29H,10-11H2,1-5H3,(H,26,32)(H,28,34) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 22 | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceuticals Co, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human TPOR expressed in human BaF3 cells |
Bioorg Med Chem Lett 20: 5670-2 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.028
BindingDB Entry DOI: 10.7270/Q2DR2VRW |
More data for this
Ligand-Target Pair | |
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