| Reaction Details |
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 | Report a problem with these data |
| Target | Thrombopoietin receptor |
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| Ligand | BDBM50327452 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_664584 (CHEMBL1260125) |
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| EC50 | 3±n/a nM |
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| Citation |  Tang, PC; Lu, HJ; Chen, YQ; Zheng, H; Song, P; Wang, L; Qin, Q; Gong, AS Novel indoline-1- or 3,4-dihydroquinoline-1(2H)-substituted carbothiohydrazides as TPO receptor agonists. Bioorg Med Chem Lett20:5670-2 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thrombopoietin receptor |
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| Name: | Thrombopoietin receptor |
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| Synonyms: | C-mpl | CD_antigen=CD110 | MPL | Myeloproliferative leukemia protein | TPO-R | TPOR | TPOR_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 71243.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_535587 |
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| Residue: | 635 |
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| Sequence: | MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPS
GTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTR
TQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNST
GPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGS
CLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVT
CQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDS
IIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQE
TCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDP
TRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLG
QYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLG
TMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
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| BDBM50327452 |
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| n/a |
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| Name | BDBM50327452 |
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| Synonyms: | 1-(2-(1-(1-(2,3-dihydro-1H-inden-5-yl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)ethyl)hydrazinecarbonothioyl)indoline-5-carboxylic acid | CHEMBL1257604 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H25N5O3S |
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| Mol. Mass. | 475.563 |
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| SMILES | CC(=NNC(=S)N1CCc2cc(ccc12)C(O)=O)c1c(C)[nH]n(-c2ccc3CCCc3c2)c1=O |w:2.2| |
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| Structure | 
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