Found 33 hits with Last Name = 'hanson' and Initial = 'sr' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Coagulation factor VII
(Homo sapiens (Human)) | BDBM14714
((2R)-N-[(3-aminobenzene)sulfonyl]-2-[(4-carbamimid...)Show SMILES CCOc1cc(OCC)c(F)c(c1)[C@@H](Nc1ccc(C(N)=N)c(O)c1)C(=O)NS(=O)(=O)c1cccc(N)c1 |r| Show InChI InChI=1S/C25H28FN5O6S/c1-3-36-16-12-19(22(26)21(13-16)37-4-2)23(30-15-8-9-18(24(28)29)20(32)11-15)25(33)31-38(34,35)17-7-5-6-14(27)10-17/h5-13,23,30,32H,3-4,27H2,1-2H3,(H3,28,29)(H,31,33)/t23-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| MMDB
PC cid
PC sid
PDB
UniChem
| MMDB
PDB
Article
PubMed
| 0.350 | -53.4 | n/a | n/a | n/a | n/a | n/a | 7.8 | 22 |
Genentech
| Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su... |
J Biol Chem 280: 9160-9 (2005)
Article DOI: 10.1074/jbc.M409068200
BindingDB Entry DOI: 10.7270/Q2JM27W3 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50180400
(2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6,2'-...)Show SMILES NC(=O)NCc1ccc(O)c(c1)-c1cc(cc(-c2nc3ccc(cc3[nH]2)C(N)=N)c1O)C(CC(O)=O)C(O)=O Show InChI InChI=1S/C26H24N6O7/c27-23(28)12-2-3-18-19(8-12)32-24(31-18)17-7-13(14(25(37)38)9-21(34)35)6-16(22(17)36)15-5-11(1-4-20(15)33)10-30-26(29)39/h1-8,14,33,36H,9-10H2,(H3,27,28)(H,31,32)(H,34,35)(H,37,38)(H3,29,30,39) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Genomics
Curated by ChEMBL
| Assay Description
Binding affinity to F7a/TF complex |
Bioorg Med Chem Lett 16: 2037-41 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.059
BindingDB Entry DOI: 10.7270/Q2639PBP |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM14898
(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-5-(...)Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1cc(cc(c1O)-c1cc(F)ccc1O)C(CC(O)=O)C(O)=O Show InChI InChI=1S/C24H19FN4O6/c25-12-2-4-19(30)14(8-12)15-5-11(13(24(34)35)9-20(31)32)6-16(21(15)33)23-28-17-3-1-10(22(26)27)7-18(17)29-23/h1-8,13,30,33H,9H2,(H3,26,27)(H,28,29)(H,31,32)(H,34,35) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Genomics
Curated by ChEMBL
| Assay Description
Binding affinity to F7a/TF complex |
Bioorg Med Chem Lett 16: 2037-41 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.059
BindingDB Entry DOI: 10.7270/Q2639PBP |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50180405
(2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5'-ca...)Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1cc(cc(c1O)-c1cc(CC(O)=O)ccc1O)C(CC(O)=O)C(O)=O Show InChI InChI=1S/C26H22N4O8/c27-24(28)12-2-3-18-19(9-12)30-25(29-18)17-8-13(14(26(37)38)10-22(34)35)7-16(23(17)36)15-5-11(6-21(32)33)1-4-20(15)31/h1-5,7-9,14,31,36H,6,10H2,(H3,27,28)(H,29,30)(H,32,33)(H,34,35)(H,37,38) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Genomics
Curated by ChEMBL
| Assay Description
Binding affinity to F7a/TF complex |
Bioorg Med Chem Lett 16: 2037-41 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.059
BindingDB Entry DOI: 10.7270/Q2639PBP |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50180403
(2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5'-ca...)Show SMILES NC(=O)Cc1ccc(O)c(c1)-c1cc(cc(-c2nc3ccc(cc3[nH]2)C(N)=N)c1O)C(CC(O)=O)C(O)=O Show InChI InChI=1S/C26H23N5O7/c27-21(33)6-11-1-4-20(32)15(5-11)16-7-13(14(26(37)38)10-22(34)35)8-17(23(16)36)25-30-18-3-2-12(24(28)29)9-19(18)31-25/h1-5,7-9,14,32,36H,6,10H2,(H2,27,33)(H3,28,29)(H,30,31)(H,34,35)(H,37,38) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Genomics
Curated by ChEMBL
| Assay Description
Binding affinity to F7a/TF complex |
Bioorg Med Chem Lett 16: 2037-41 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.059
BindingDB Entry DOI: 10.7270/Q2639PBP |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50180404
(2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5'-(2...)Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1cc(cc(c1O)-c1cc(CCC(O)=O)ccc1O)C(CC(O)=O)C(O)=O Show InChI InChI=1S/C27H24N4O8/c28-25(29)13-3-4-19-20(10-13)31-26(30-19)18-9-14(15(27(38)39)11-23(35)36)8-17(24(18)37)16-7-12(1-5-21(16)32)2-6-22(33)34/h1,3-5,7-10,15,32,37H,2,6,11H2,(H3,28,29)(H,30,31)(H,33,34)(H,35,36)(H,38,39) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Genomics
Curated by ChEMBL
| Assay Description
Binding affinity to F7a/TF complex |
Bioorg Med Chem Lett 16: 2037-41 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.059
BindingDB Entry DOI: 10.7270/Q2639PBP |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50180401
(2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5'-ca...)Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1cc(cc(c1O)-c1cc(ccc1O)C(N)=O)C(CC(O)=O)C(O)=O Show InChI InChI=1S/C25H21N5O7/c26-22(27)10-1-3-17-18(8-10)30-24(29-17)16-7-12(13(25(36)37)9-20(32)33)6-15(21(16)34)14-5-11(23(28)35)2-4-19(14)31/h1-8,13,31,34H,9H2,(H3,26,27)(H2,28,35)(H,29,30)(H,32,33)(H,36,37) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Genomics
Curated by ChEMBL
| Assay Description
Binding affinity to F7a/TF complex |
Bioorg Med Chem Lett 16: 2037-41 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.059
BindingDB Entry DOI: 10.7270/Q2639PBP |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50180406
(2-[5'-aminomethyl-5-(5-carbamimidoyl-1H-benzoimida...)Show SMILES NCc1ccc(O)c(c1)-c1cc(cc(-c2nc3ccc(cc3[nH]2)C(N)=N)c1O)C(CC(O)=O)C(O)=O Show InChI InChI=1S/C25H23N5O6/c26-10-11-1-4-20(31)15(5-11)16-6-13(14(25(35)36)9-21(32)33)7-17(22(16)34)24-29-18-3-2-12(23(27)28)8-19(18)30-24/h1-8,14,31,34H,9-10,26H2,(H3,27,28)(H,29,30)(H,32,33)(H,35,36) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 35 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Genomics
Curated by ChEMBL
| Assay Description
Binding affinity to F7a/TF complex |
Bioorg Med Chem Lett 16: 2037-41 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.059
BindingDB Entry DOI: 10.7270/Q2639PBP |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50180407
(2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5'-ca...)Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1cc(cc(c1O)-c1cc(ccc1O)C(O)=O)C(CC(O)=O)C(O)=O Show InChI InChI=1S/C25H20N4O8/c26-22(27)10-1-3-17-18(8-10)29-23(28-17)16-7-12(13(25(36)37)9-20(31)32)6-15(21(16)33)14-5-11(24(34)35)2-4-19(14)30/h1-8,13,30,33H,9H2,(H3,26,27)(H,28,29)(H,31,32)(H,34,35)(H,36,37) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 43 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Genomics
Curated by ChEMBL
| Assay Description
Binding affinity to F7a/TF complex |
Bioorg Med Chem Lett 16: 2037-41 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.059
BindingDB Entry DOI: 10.7270/Q2639PBP |
More data for this
Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50180402
(2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6,2'-...)Show SMILES NC(=O)Nc1ccc(O)c(c1)-c1cc(cc(-c2nc3ccc(cc3[nH]2)C(N)=N)c1O)C(CC(O)=O)C(O)=O Show InChI InChI=1S/C25H22N6O7/c26-22(27)10-1-3-17-18(7-10)31-23(30-17)16-6-11(13(24(36)37)9-20(33)34)5-15(21(16)35)14-8-12(29-25(28)38)2-4-19(14)32/h1-8,13,32,35H,9H2,(H3,26,27)(H,30,31)(H,33,34)(H,36,37)(H3,28,29,38) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 44 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Genomics
Curated by ChEMBL
| Assay Description
Binding affinity to F7a/TF complex |
Bioorg Med Chem Lett 16: 2037-41 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.059
BindingDB Entry DOI: 10.7270/Q2639PBP |
More data for this
Ligand-Target Pair | |
Vitamin K-dependent protein C
(Homo sapiens (Human)) | BDBM14714
((2R)-N-[(3-aminobenzene)sulfonyl]-2-[(4-carbamimid...)Show SMILES CCOc1cc(OCC)c(F)c(c1)[C@@H](Nc1ccc(C(N)=N)c(O)c1)C(=O)NS(=O)(=O)c1cccc(N)c1 |r| Show InChI InChI=1S/C25H28FN5O6S/c1-3-36-16-12-19(22(26)21(13-16)37-4-2)23(30-15-8-9-18(24(28)29)20(32)11-15)25(33)31-38(34,35)17-7-5-6-14(27)10-17/h5-13,23,30,32H,3-4,27H2,1-2H3,(H3,28,29)(H,31,33)/t23-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| MMDB
PC cid
PC sid
PDB
UniChem
| Article
PubMed
| 87 | -39.9 | n/a | n/a | n/a | n/a | n/a | 7.8 | 22 |
Genentech
| Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su... |
J Biol Chem 280: 9160-9 (2005)
Article DOI: 10.1074/jbc.M409068200
BindingDB Entry DOI: 10.7270/Q2JM27W3 |
More data for this
Ligand-Target Pair | |
Plasma kallikrein
(Homo sapiens (Human)) | BDBM14714
((2R)-N-[(3-aminobenzene)sulfonyl]-2-[(4-carbamimid...)Show SMILES CCOc1cc(OCC)c(F)c(c1)[C@@H](Nc1ccc(C(N)=N)c(O)c1)C(=O)NS(=O)(=O)c1cccc(N)c1 |r| Show InChI InChI=1S/C25H28FN5O6S/c1-3-36-16-12-19(22(26)21(13-16)37-4-2)23(30-15-8-9-18(24(28)29)20(32)11-15)25(33)31-38(34,35)17-7-5-6-14(27)10-17/h5-13,23,30,32H,3-4,27H2,1-2H3,(H3,28,29)(H,31,33)/t23-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| MMDB
PC cid
PC sid
PDB
UniChem
| Article
PubMed
| 114 | -39.2 | n/a | n/a | n/a | n/a | n/a | 7.8 | 22 |
Genentech
| Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su... |
J Biol Chem 280: 9160-9 (2005)
Article DOI: 10.1074/jbc.M409068200
BindingDB Entry DOI: 10.7270/Q2JM27W3 |
More data for this
Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM14714
((2R)-N-[(3-aminobenzene)sulfonyl]-2-[(4-carbamimid...)Show SMILES CCOc1cc(OCC)c(F)c(c1)[C@@H](Nc1ccc(C(N)=N)c(O)c1)C(=O)NS(=O)(=O)c1cccc(N)c1 |r| Show InChI InChI=1S/C25H28FN5O6S/c1-3-36-16-12-19(22(26)21(13-16)37-4-2)23(30-15-8-9-18(24(28)29)20(32)11-15)25(33)31-38(34,35)17-7-5-6-14(27)10-17/h5-13,23,30,32H,3-4,27H2,1-2H3,(H3,28,29)(H,31,33)/t23-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| MMDB
PC cid
PC sid
PDB
UniChem
| Article
PubMed
| 1.20E+3 | -33.5 | n/a | n/a | n/a | n/a | n/a | 7.8 | 22 |
Genentech
| Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su... |
J Biol Chem 280: 9160-9 (2005)
Article DOI: 10.1074/jbc.M409068200
BindingDB Entry DOI: 10.7270/Q2JM27W3 |
More data for this
Ligand-Target Pair | |
Urokinase-type plasminogen activator
(Homo sapiens (Human)) | BDBM14714
((2R)-N-[(3-aminobenzene)sulfonyl]-2-[(4-carbamimid...)Show SMILES CCOc1cc(OCC)c(F)c(c1)[C@@H](Nc1ccc(C(N)=N)c(O)c1)C(=O)NS(=O)(=O)c1cccc(N)c1 |r| Show InChI InChI=1S/C25H28FN5O6S/c1-3-36-16-12-19(22(26)21(13-16)37-4-2)23(30-15-8-9-18(24(28)29)20(32)11-15)25(33)31-38(34,35)17-7-5-6-14(27)10-17/h5-13,23,30,32H,3-4,27H2,1-2H3,(H3,28,29)(H,31,33)/t23-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| MMDB
PC cid
PC sid
PDB
UniChem
| Article
PubMed
| >3.40E+3 | >-30.9 | n/a | n/a | n/a | n/a | n/a | 7.8 | 22 |
Genentech
| Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su... |
J Biol Chem 280: 9160-9 (2005)
Article DOI: 10.1074/jbc.M409068200
BindingDB Entry DOI: 10.7270/Q2JM27W3 |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM14714
((2R)-N-[(3-aminobenzene)sulfonyl]-2-[(4-carbamimid...)Show SMILES CCOc1cc(OCC)c(F)c(c1)[C@@H](Nc1ccc(C(N)=N)c(O)c1)C(=O)NS(=O)(=O)c1cccc(N)c1 |r| Show InChI InChI=1S/C25H28FN5O6S/c1-3-36-16-12-19(22(26)21(13-16)37-4-2)23(30-15-8-9-18(24(28)29)20(32)11-15)25(33)31-38(34,35)17-7-5-6-14(27)10-17/h5-13,23,30,32H,3-4,27H2,1-2H3,(H3,28,29)(H,31,33)/t23-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| MMDB
PC cid
PC sid
PDB
UniChem
| Article
PubMed
| >3.50E+3 | >-30.8 | n/a | n/a | n/a | n/a | n/a | 7.8 | 22 |
Genentech
| Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su... |
J Biol Chem 280: 9160-9 (2005)
Article DOI: 10.1074/jbc.M409068200
BindingDB Entry DOI: 10.7270/Q2JM27W3 |
More data for this
Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM14714
((2R)-N-[(3-aminobenzene)sulfonyl]-2-[(4-carbamimid...)Show SMILES CCOc1cc(OCC)c(F)c(c1)[C@@H](Nc1ccc(C(N)=N)c(O)c1)C(=O)NS(=O)(=O)c1cccc(N)c1 |r| Show InChI InChI=1S/C25H28FN5O6S/c1-3-36-16-12-19(22(26)21(13-16)37-4-2)23(30-15-8-9-18(24(28)29)20(32)11-15)25(33)31-38(34,35)17-7-5-6-14(27)10-17/h5-13,23,30,32H,3-4,27H2,1-2H3,(H3,28,29)(H,31,33)/t23-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| MMDB
PC cid
PC sid
PDB
UniChem
| Article
PubMed
| 3.60E+3 | -30.8 | n/a | n/a | n/a | n/a | n/a | 7.8 | 22 |
Genentech
| Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su... |
J Biol Chem 280: 9160-9 (2005)
Article DOI: 10.1074/jbc.M409068200
BindingDB Entry DOI: 10.7270/Q2JM27W3 |
More data for this
Ligand-Target Pair | |
Tissue-type plasminogen activator
(Homo sapiens (Human)) | BDBM14714
((2R)-N-[(3-aminobenzene)sulfonyl]-2-[(4-carbamimid...)Show SMILES CCOc1cc(OCC)c(F)c(c1)[C@@H](Nc1ccc(C(N)=N)c(O)c1)C(=O)NS(=O)(=O)c1cccc(N)c1 |r| Show InChI InChI=1S/C25H28FN5O6S/c1-3-36-16-12-19(22(26)21(13-16)37-4-2)23(30-15-8-9-18(24(28)29)20(32)11-15)25(33)31-38(34,35)17-7-5-6-14(27)10-17/h5-13,23,30,32H,3-4,27H2,1-2H3,(H3,28,29)(H,31,33)/t23-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| MMDB
PC cid
PC sid
PDB
UniChem
| Article
PubMed
| >3.90E+3 | >-30.6 | n/a | n/a | n/a | n/a | n/a | 7.8 | 22 |
Genentech
| Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su... |
J Biol Chem 280: 9160-9 (2005)
Article DOI: 10.1074/jbc.M409068200
BindingDB Entry DOI: 10.7270/Q2JM27W3 |
More data for this
Ligand-Target Pair | |
Serine protease 1
(Bos taurus (bovine)) | BDBM14714
((2R)-N-[(3-aminobenzene)sulfonyl]-2-[(4-carbamimid...)Show SMILES CCOc1cc(OCC)c(F)c(c1)[C@@H](Nc1ccc(C(N)=N)c(O)c1)C(=O)NS(=O)(=O)c1cccc(N)c1 |r| Show InChI InChI=1S/C25H28FN5O6S/c1-3-36-16-12-19(22(26)21(13-16)37-4-2)23(30-15-8-9-18(24(28)29)20(32)11-15)25(33)31-38(34,35)17-7-5-6-14(27)10-17/h5-13,23,30,32H,3-4,27H2,1-2H3,(H3,28,29)(H,31,33)/t23-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| MMDB
PC cid
PC sid
PDB
UniChem
| Article
PubMed
| 4.00E+3 | -30.5 | n/a | n/a | n/a | n/a | n/a | 7.8 | 22 |
Genentech
| Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su... |
J Biol Chem 280: 9160-9 (2005)
Article DOI: 10.1074/jbc.M409068200
BindingDB Entry DOI: 10.7270/Q2JM27W3 |
More data for this
Ligand-Target Pair | |
Arylsulfatase
(Pseudomonas aeruginosa) | BDBM50400985
(CHEMBL2205724)Show InChI InChI=1S/C7H6F2O4S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4,7H,(H,10,11,12) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| 2.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bielefeld University
Curated by ChEMBL
| Assay Description
Inhibition of Pseudomonas aeruginosa aryl sulfatase after 20 mins by spectrophotometry |
Bioorg Med Chem 20: 622-7 (2012)
Article DOI: 10.1016/j.bmc.2011.04.044
BindingDB Entry DOI: 10.7270/Q2MP54FG |
More data for this
Ligand-Target Pair | |
Similar to alpha-tubulin isoform 1
(Bos taurus) | BDBM50473488
(CHEMBL141477)Show SMILES COc1ccc(CNc2nc(NCc3ccc(OC)cc3)c3ncn(C4CCCCC4)c3n2)cc1 Show InChI InChI=1S/C27H32N6O2/c1-34-22-12-8-19(9-13-22)16-28-25-24-26(33(18-30-24)21-6-4-3-5-7-21)32-27(31-25)29-17-20-10-14-23(35-2)15-11-20/h8-15,18,21H,3-7,16-17H2,1-2H3,(H2,28,29,31,32) | PDB
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
New York University
Curated by ChEMBL
| Assay Description
Inhibition of tubulin polymerization using bovine brain tubulin |
J Med Chem 44: 4497-500 (2001)
Article DOI: 10.1021/jm010451+
BindingDB Entry DOI: 10.7270/Q2XW4NJH |
More data for this
Ligand-Target Pair | |
Similar to alpha-tubulin isoform 1
(Bos taurus) | BDBM50473496
(CHEMBL136246)Show SMILES COc1ccc(CNc2nc(NCc3ccc(OC)cc3)c3ncn(C4CCCC4)c3n2)cc1 Show InChI InChI=1S/C26H30N6O2/c1-33-21-11-7-18(8-12-21)15-27-24-23-25(32(17-29-23)20-5-3-4-6-20)31-26(30-24)28-16-19-9-13-22(34-2)14-10-19/h7-14,17,20H,3-6,15-16H2,1-2H3,(H2,27,28,30,31) | PDB
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
New York University
Curated by ChEMBL
| Assay Description
Inhibition of tubulin polymerization using bovine brain tubulin |
J Med Chem 44: 4497-500 (2001)
Article DOI: 10.1021/jm010451+
BindingDB Entry DOI: 10.7270/Q2XW4NJH |
More data for this
Ligand-Target Pair | |
Similar to alpha-tubulin isoform 1
(Bos taurus) | BDBM50473487
(CHEMBL336919)Show SMILES COc1ccc(CNc2nc(NCc3ccc(OC)cc3)c3ncn(C4CCC(O)CC4)c3n2)cc1 |(-.37,-14,;-.37,-12.46,;.97,-11.69,;2.29,-12.46,;3.64,-11.69,;3.64,-10.15,;4.95,-9.37,;4.95,-7.83,;6.27,-7.04,;6.27,-5.52,;7.58,-4.73,;7.58,-3.19,;8.9,-2.42,;10.44,-2.42,;11.2,-1.07,;12.74,-1.07,;13.52,-2.41,;15.06,-2.38,;15.83,-3.72,;12.75,-3.73,;11.21,-3.73,;8.93,-5.5,;10.39,-5.02,;11.3,-6.26,;10.41,-7.51,;10.89,-8.96,;12.39,-9.25,;12.88,-10.73,;11.85,-11.88,;12.32,-13.35,;10.34,-11.56,;9.86,-10.11,;8.93,-7.04,;7.61,-7.81,;2.29,-9.38,;.97,-10.15,)| Show InChI InChI=1S/C27H32N6O3/c1-35-22-11-3-18(4-12-22)15-28-25-24-26(33(17-30-24)20-7-9-21(34)10-8-20)32-27(31-25)29-16-19-5-13-23(36-2)14-6-19/h3-6,11-14,17,20-21,34H,7-10,15-16H2,1-2H3,(H2,28,29,31,32) | PDB
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
New York University
Curated by ChEMBL
| Assay Description
Inhibition of tubulin polymerization using bovine brain tubulin |
J Med Chem 44: 4497-500 (2001)
Article DOI: 10.1021/jm010451+
BindingDB Entry DOI: 10.7270/Q2XW4NJH |
More data for this
Ligand-Target Pair | |
Similar to alpha-tubulin isoform 1
(Bos taurus) | BDBM50473495
(CHEMBL139282)Show SMILES COc1ccc(CNc2nc(NCc3ccc(OC)cc3)c3ncn(C4CCNCC4)c3n2)cc1 Show InChI InChI=1S/C26H31N7O2/c1-34-21-7-3-18(4-8-21)15-28-24-23-25(33(17-30-23)20-11-13-27-14-12-20)32-26(31-24)29-16-19-5-9-22(35-2)10-6-19/h3-10,17,20,27H,11-16H2,1-2H3,(H2,28,29,31,32) | PDB
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
New York University
Curated by ChEMBL
| Assay Description
Inhibition of tubulin polymerization using bovine brain tubulin |
J Med Chem 44: 4497-500 (2001)
Article DOI: 10.1021/jm010451+
BindingDB Entry DOI: 10.7270/Q2XW4NJH |
More data for this
Ligand-Target Pair | |
Similar to alpha-tubulin isoform 1
(Bos taurus) | BDBM50473493
(CHEMBL138292)Show SMILES COc1ccc(CNc2nc(NCc3ccc(OC)cc3)c3ncn(C4CCOC4)c3n2)cc1 Show InChI InChI=1S/C25H28N6O3/c1-32-20-7-3-17(4-8-20)13-26-23-22-24(31(16-28-22)19-11-12-34-15-19)30-25(29-23)27-14-18-5-9-21(33-2)10-6-18/h3-10,16,19H,11-15H2,1-2H3,(H2,26,27,29,30) | PDB
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
New York University
Curated by ChEMBL
| Assay Description
Inhibition of tubulin polymerization using bovine brain tubulin |
J Med Chem 44: 4497-500 (2001)
Article DOI: 10.1021/jm010451+
BindingDB Entry DOI: 10.7270/Q2XW4NJH |
More data for this
Ligand-Target Pair | |
Similar to alpha-tubulin isoform 1
(Bos taurus) | BDBM50473490
(CHEMBL139200)Show SMILES COc1ccc(CNc2nc(NCc3ccc(OC)cc3)c3ncn(C4CCC4)c3n2)cc1 Show InChI InChI=1S/C25H28N6O2/c1-32-20-10-6-17(7-11-20)14-26-23-22-24(31(16-28-22)19-4-3-5-19)30-25(29-23)27-15-18-8-12-21(33-2)13-9-18/h6-13,16,19H,3-5,14-15H2,1-2H3,(H2,26,27,29,30) | PDB
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
New York University
Curated by ChEMBL
| Assay Description
Inhibition of tubulin polymerization using bovine brain tubulin |
J Med Chem 44: 4497-500 (2001)
Article DOI: 10.1021/jm010451+
BindingDB Entry DOI: 10.7270/Q2XW4NJH |
More data for this
Ligand-Target Pair | |
Similar to alpha-tubulin isoform 1
(Bos taurus) | BDBM50473494
(Myoseverin)Show SMILES COc1ccc(CNc2nc(NCc3ccc(OC)cc3)c3ncn(C(C)C)c3n2)cc1 Show InChI InChI=1S/C24H28N6O2/c1-16(2)30-15-27-21-22(25-13-17-5-9-19(31-3)10-6-17)28-24(29-23(21)30)26-14-18-7-11-20(32-4)12-8-18/h5-12,15-16H,13-14H2,1-4H3,(H2,25,26,28,29) | PDB
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
New York University
Curated by ChEMBL
| Assay Description
Inhibition of tubulin polymerization using bovine brain tubulin |
J Med Chem 44: 4497-500 (2001)
Article DOI: 10.1021/jm010451+
BindingDB Entry DOI: 10.7270/Q2XW4NJH |
More data for this
Ligand-Target Pair | |
Similar to alpha-tubulin isoform 1
(Bos taurus) | BDBM50473489
(CHEMBL140649)Show SMILES COc1ccc(CNc2nc(NCc3ccc(OC)cc3)c3ncn(C)c3n2)cc1 Show InChI InChI=1S/C22H24N6O2/c1-28-14-25-19-20(23-12-15-4-8-17(29-2)9-5-15)26-22(27-21(19)28)24-13-16-6-10-18(30-3)11-7-16/h4-11,14H,12-13H2,1-3H3,(H2,23,24,26,27) | PDB
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
New York University
Curated by ChEMBL
| Assay Description
Inhibition of tubulin polymerization using bovine brain tubulin |
J Med Chem 44: 4497-500 (2001)
Article DOI: 10.1021/jm010451+
BindingDB Entry DOI: 10.7270/Q2XW4NJH |
More data for this
Ligand-Target Pair | |
Similar to alpha-tubulin isoform 1
(Bos taurus) | BDBM50473492
(CHEMBL140654)Show SMILES CCn1cnc2c(NCc3ccc(OC)cc3)nc(NCc3ccc(OC)cc3)nc12 Show InChI InChI=1S/C23H26N6O2/c1-4-29-15-26-20-21(24-13-16-5-9-18(30-2)10-6-16)27-23(28-22(20)29)25-14-17-7-11-19(31-3)12-8-17/h5-12,15H,4,13-14H2,1-3H3,(H2,24,25,27,28) | PDB
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
New York University
Curated by ChEMBL
| Assay Description
Inhibition of tubulin polymerization using bovine brain tubulin |
J Med Chem 44: 4497-500 (2001)
Article DOI: 10.1021/jm010451+
BindingDB Entry DOI: 10.7270/Q2XW4NJH |
More data for this
Ligand-Target Pair | |
Similar to alpha-tubulin isoform 1
(Bos taurus) | BDBM50473491
(CHEMBL343349)Show SMILES COc1ccc(CNc2nc(NCc3ccc(OC)cc3)c3[nH]cnc3n2)cc1 Show InChI InChI=1S/C21H22N6O2/c1-28-16-7-3-14(4-8-16)11-22-19-18-20(25-13-24-18)27-21(26-19)23-12-15-5-9-17(29-2)10-6-15/h3-10,13H,11-12H2,1-2H3,(H3,22,23,24,25,26,27) | PDB
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
New York University
Curated by ChEMBL
| Assay Description
Inhibition of tubulin polymerization using bovine brain tubulin |
J Med Chem 44: 4497-500 (2001)
Article DOI: 10.1021/jm010451+
BindingDB Entry DOI: 10.7270/Q2XW4NJH |
More data for this
Ligand-Target Pair | |
Arylsulfatase
(Klebsiella pneumoniae) | BDBM50400983
(CHEMBL2205726)Show SMILES [NH3+]CCOCCOCCNC(=O)C(F)c1ccc(OS([O-])(=O)=O)cc1 Show InChI InChI=1S/C14H21FN2O7S/c15-13(11-1-3-12(4-2-11)24-25(19,20)21)14(18)17-6-8-23-10-9-22-7-5-16/h1-4,13H,5-10,16H2,(H,17,18)(H,19,20,21) | UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bielefeld University
Curated by ChEMBL
| Assay Description
Inhibition of Klebsiella pneumoniae aryl sulfatase after 0.5 hrs by para-nitrocatechol sulfate-based colorimetric assay |
Bioorg Med Chem 20: 622-7 (2012)
Article DOI: 10.1016/j.bmc.2011.04.044
BindingDB Entry DOI: 10.7270/Q2MP54FG |
More data for this
Ligand-Target Pair | |
Arylsulfatase
(Pseudomonas aeruginosa) | BDBM50400983
(CHEMBL2205726)Show SMILES [NH3+]CCOCCOCCNC(=O)C(F)c1ccc(OS([O-])(=O)=O)cc1 Show InChI InChI=1S/C14H21FN2O7S/c15-13(11-1-3-12(4-2-11)24-25(19,20)21)14(18)17-6-8-23-10-9-22-7-5-16/h1-4,13H,5-10,16H2,(H,17,18)(H,19,20,21) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Bielefeld University
Curated by ChEMBL
| Assay Description
Inhibition of Pseudomonas aeruginosa aryl sulfatase after 0.5 hrs by para-nitrocatechol sulfate-based colorimetric assay |
Bioorg Med Chem 20: 622-7 (2012)
Article DOI: 10.1016/j.bmc.2011.04.044
BindingDB Entry DOI: 10.7270/Q2MP54FG |
More data for this
Ligand-Target Pair | |
Arylsulfatase
(Klebsiella pneumoniae) | BDBM50400984
(CHEMBL2205725)Show InChI InChI=1S/C7H6F2O4S/c8-7(9)5-3-1-2-4-6(5)13-14(10,11)12/h1-4,7H,(H,10,11,12) | UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.00E+7 | n/a | n/a | n/a | n/a | n/a | n/a |
Bielefeld University
Curated by ChEMBL
| Assay Description
Inhibition of Klebsiella pneumoniae aryl sulfatase after 20 mins by spectrophotometry |
Bioorg Med Chem 20: 622-7 (2012)
Article DOI: 10.1016/j.bmc.2011.04.044
BindingDB Entry DOI: 10.7270/Q2MP54FG |
More data for this
Ligand-Target Pair | |
Steryl-sulfatase
(Homo sapiens (Human)) | BDBM50400983
(CHEMBL2205726)Show SMILES [NH3+]CCOCCOCCNC(=O)C(F)c1ccc(OS([O-])(=O)=O)cc1 Show InChI InChI=1S/C14H21FN2O7S/c15-13(11-1-3-12(4-2-11)24-25(19,20)21)14(18)17-6-8-23-10-9-22-7-5-16/h1-4,13H,5-10,16H2,(H,17,18)(H,19,20,21) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.50E+7 | n/a | n/a | n/a | n/a | n/a | n/a |
Bielefeld University
Curated by ChEMBL
| Assay Description
Displacement of 3H-DHEAS from human steroid sulfatase after 1 hr by liquid scintillation counting analysis |
Bioorg Med Chem 20: 622-7 (2012)
Article DOI: 10.1016/j.bmc.2011.04.044
BindingDB Entry DOI: 10.7270/Q2MP54FG |
More data for this
Ligand-Target Pair | |
Search and Browse
