Compile Data Set for Download or QSAR

Found 505 hits with Last Name = 'hitoshi' and Initial = 'y'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM327994 (N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- met...) Show SMILES COc1ccc(CC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1 Show InChI InChI=1S/C33H37N5O3/c1-41-30-9-6-24(7-10-30)20-25-12-18-38(19-13-25)33(40)28-8-11-31(35-22-28)32(39)36-29-14-16-37(17-15-29)23-27-4-2-26(21-34)3-5-27/h2-11,22,25,29H,12-20,23H2,1H3,(H,36,39)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmc.2022.116951 BindingDB Entry DOI: 10.7270/Q2HX1HM7
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM327998 (N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- cya...) Show SMILES O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCC(CC1)Oc1ccc(cc1)C#N Show InChI InChI=1S/C32H32N6O3/c33-19-23-1-3-25(4-2-23)22-37-15-11-27(12-16-37)36-31(39)30-10-7-26(21-35-30)32(40)38-17-13-29(14-18-38)41-28-8-5-24(20-34)6-9-28/h1-10,21,27,29H,11-18,22H2,(H,36,39)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmc.2022.116951 BindingDB Entry DOI: 10.7270/Q2HX1HM7
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM328001 (N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(fluoro...) Show SMILES FC(C1CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(F)cc1 Show InChI InChI=1S/C32H33F2N5O2/c33-27-8-5-24(6-9-27)30(34)25-11-17-39(18-12-25)32(41)26-7-10-29(36-20-26)31(40)37-28-13-15-38(16-14-28)21-23-3-1-22(19-35)2-4-23/h1-10,20,25,28,30H,11-18,21H2,(H,37,40)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmc.2022.116951 BindingDB Entry DOI: 10.7270/Q2HX1HM7
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM328133 (N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(2,4- d...) Show SMILES Fc1ccc(C(=O)C2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c(F)c1 Show InChI InChI=1S/C32H31F2N5O3/c33-25-6-7-27(28(34)17-25)30(40)23-9-15-39(16-10-23)32(42)24-5-8-29(36-19-24)31(41)37-26-11-13-38(14-12-26)20-22-3-1-21(18-35)2-4-22/h1-8,17,19,23,26H,9-16,20H2,(H,37,41)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmc.2022.116951 BindingDB Entry DOI: 10.7270/Q2HX1HM7
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM327927 (N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4-fluo...) Show SMILES Fc1ccc(cc1)C(=O)C1(F)CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1 Show InChI InChI=1S/C32H31F2N5O3/c33-26-8-5-24(6-9-26)29(40)32(34)13-17-39(18-14-32)31(42)25-7-10-28(36-20-25)30(41)37-27-11-15-38(16-12-27)21-23-3-1-22(19-35)2-4-23/h1-10,20,27H,11-18,21H2,(H,37,41)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmc.2022.116951 BindingDB Entry DOI: 10.7270/Q2HX1HM7
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM328006 (N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- met...) Show SMILES COc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1 Show InChI InChI=1S/C32H35N5O4/c1-40-27-7-9-28(10-8-27)41-29-14-18-37(19-15-29)32(39)25-6-11-30(34-21-25)31(38)35-26-12-16-36(17-13-26)22-24-4-2-23(20-33)3-5-24/h2-11,21,26,29H,12-19,22H2,1H3,(H,35,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmc.2022.116951 BindingDB Entry DOI: 10.7270/Q2HX1HM7
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM328171 (N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- met...) Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1 Show InChI InChI=1S/C33H35N5O4/c1-42-29-9-6-25(7-10-29)31(39)26-12-18-38(19-13-26)33(41)30-11-8-27(21-35-30)32(40)36-28-14-16-37(17-15-28)22-24-4-2-23(20-34)3-5-24/h2-11,21,26,28H,12-19,22H2,1H3,(H,36,40)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmc.2022.116951 BindingDB Entry DOI: 10.7270/Q2HX1HM7
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM328133 (N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(2,4- d...) Show SMILES Fc1ccc(C(=O)C2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)c(F)c1 Show InChI InChI=1S/C32H31F2N5O3/c33-25-6-7-27(28(34)17-25)30(40)23-9-15-39(16-10-23)32(42)24-5-8-29(36-19-24)31(41)37-26-11-13-38(14-12-26)20-22-3-1-21(18-35)2-4-22/h1-8,17,19,23,26H,9-16,20H2,(H,37,41)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmc.2022.116951 BindingDB Entry DOI: 10.7270/Q2HX1HM7
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM328171 (N-(1-(4- cyanobenzyl)piperidin-4- yl)-6-(4-(4- met...) Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1ccc(cn1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1 Show InChI InChI=1S/C33H35N5O4/c1-42-29-9-6-25(7-10-29)31(39)26-12-18-38(19-13-26)33(41)30-11-8-27(21-35-30)32(40)36-28-14-16-37(17-15-28)22-24-4-2-23(20-34)3-5-24/h2-11,21,26,28H,12-19,22H2,1H3,(H,36,40)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmc.2022.116951 BindingDB Entry DOI: 10.7270/Q2HX1HM7
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM328006 (N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- met...) Show SMILES COc1ccc(OC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1 Show InChI InChI=1S/C32H35N5O4/c1-40-27-7-9-28(10-8-27)41-29-14-18-37(19-15-29)32(39)25-6-11-30(34-21-25)31(38)35-26-12-16-36(17-13-26)22-24-4-2-23(20-33)3-5-24/h2-11,21,26,29H,12-19,22H2,1H3,(H,35,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmc.2022.116951 BindingDB Entry DOI: 10.7270/Q2HX1HM7
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM327994 (N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4- met...) Show SMILES COc1ccc(CC2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1 Show InChI InChI=1S/C33H37N5O3/c1-41-30-9-6-24(7-10-30)20-25-12-18-38(19-13-25)33(40)28-8-11-31(35-22-28)32(39)36-29-14-16-37(17-15-29)23-27-4-2-26(21-34)3-5-27/h2-11,22,25,29H,12-20,23H2,1H3,(H,36,39)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmc.2022.116951 BindingDB Entry DOI: 10.7270/Q2HX1HM7
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM327927 (N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4-fluo...) Show SMILES Fc1ccc(cc1)C(=O)C1(F)CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1 Show InChI InChI=1S/C32H31F2N5O3/c33-26-8-5-24(6-9-26)29(40)32(34)13-17-39(18-14-32)31(42)25-7-10-28(36-20-25)30(41)37-27-11-15-38(16-12-27)21-23-3-1-22(19-35)2-4-23/h1-10,20,27H,11-18,21H2,(H,37,41)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmc.2022.116951 BindingDB Entry DOI: 10.7270/Q2HX1HM7
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327862 (N-(4-(4- cyanobenzyl)piperadin- 4-yl)-6-(4-(4- flu...) Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1 Show InChI InChI=1S/C31H33FN6O2/c32-27-8-5-25(6-9-27)22-37-15-17-38(18-16-37)31(40)29-10-7-26(20-34-29)30(39)35-28-11-13-36(14-12-28)21-24-3-1-23(19-33)2-4-24/h1-10,20,28H,11-18,21-22H2,(H,35,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<500	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327863 (N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(piperazin...) Show SMILES O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)N1CCNCC1 Show InChI InChI=1S/C24H28N6O2/c25-15-18-1-3-19(4-2-18)17-29-11-7-21(8-12-29)28-23(31)22-6-5-20(16-27-22)24(32)30-13-9-26-10-14-30/h1-6,16,21,26H,7-14,17H2,(H,28,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327864 (US10377742, Compound 3 | US9663496, Compound 3 | p...) Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N2CCN(Cc3ccc(F)cc3)CC2)cc1 Show InChI InChI=1S/C29H31F2N5O2/c30-25-6-1-22(2-7-25)20-33-11-15-35(16-12-33)28(37)24-5-10-27(32-19-24)29(38)36-17-13-34(14-18-36)21-23-3-8-26(31)9-4-23/h1-10,19H,11-18,20-21H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	750	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327865 (N-(1-(4- cyanobenzoyl)piperidin- 4-yl)-5-(4-(4- fl...) Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(CC2)C(=O)c2ccc(cc2)C#N)cc1 Show InChI InChI=1S/C31H31FN6O3/c32-26-8-3-23(4-9-26)21-36-15-17-38(18-16-36)31(41)25-7-10-28(34-20-25)29(39)35-27-11-13-37(14-12-27)30(40)24-5-1-22(19-33)2-6-24/h1-10,20,27H,11-18,21H2,(H,35,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	750	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327866 (N2-(1-(4- cyanobenzyl)piperidin-4- yl)-N5-(3- benz...) Show SMILES O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)Nc1cccc(Cc2ccccc2)c1 Show InChI InChI=1S/C33H31N5O2/c34-21-25-9-11-26(12-10-25)23-38-17-15-29(16-18-38)36-33(40)31-14-13-28(22-35-31)32(39)37-30-8-4-7-27(20-30)19-24-5-2-1-3-6-24/h1-14,20,22,29H,15-19,23H2,(H,36,40)(H,37,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	750	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327867 (N-(4-((4- cyanophenyl)sulfonyl) piperidin-4-yl)-5...) Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(CC2)S(=O)(=O)c2ccc(cc2)C#N)cc1 Show InChI InChI=1S/C30H31FN6O4S/c31-25-6-1-23(2-7-25)21-35-15-17-36(18-16-35)30(39)24-5-10-28(33-20-24)29(38)34-26-11-13-37(14-12-26)42(40,41)27-8-3-22(19-32)4-9-27/h1-10,20,26H,11-18,21H2,(H,34,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	750	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327868 (N-(1- (cyclohexanecarbonyl) piperidin-4-yl)-5-(4-...) Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(CC2)C(=O)C2CCCCC2)cc1 Show InChI InChI=1S/C30H38FN5O3/c31-25-9-6-22(7-10-25)21-34-16-18-36(19-17-34)30(39)24-8-11-27(32-20-24)28(37)33-26-12-14-35(15-13-26)29(38)23-4-2-1-3-5-23/h6-11,20,23,26H,1-5,12-19,21H2,(H,33,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<500	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327869 (N-(1-(benzoyl)piperidin- 4-yl)-5-(4-(4- fluorobenz...) Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(CC2)C(=O)c2ccccc2)cc1 Show InChI InChI=1S/C30H32FN5O3/c31-25-9-6-22(7-10-25)21-34-16-18-36(19-17-34)30(39)24-8-11-27(32-20-24)28(37)33-26-12-14-35(15-13-26)29(38)23-4-2-1-3-5-23/h1-11,20,26H,12-19,21H2,(H,33,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<500	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327870 (N-(1-(4-cyanobenzyl)- 1H-pyrazol-3-yl)-5-(4- (4- f...) Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccn(Cc3ccc(cc3)C#N)n2)cc1 Show InChI InChI=1S/C29H26FN7O2/c30-25-8-5-22(6-9-25)19-35-13-15-36(16-14-35)29(39)24-7-10-26(32-18-24)28(38)33-27-11-12-37(34-27)20-23-3-1-21(17-31)2-4-23/h1-12,18H,13-16,19-20H2,(H,33,34,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<500	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327871 (N-(4-benzylphenyl)-5- (4-(4- fluorobenzyl)piperazi...) Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Cc3ccccc3)cc2)cc1 Show InChI InChI=1S/C31H29FN4O2/c32-27-11-6-25(7-12-27)22-35-16-18-36(19-17-35)31(38)26-10-15-29(33-21-26)30(37)34-28-13-8-24(9-14-28)20-23-4-2-1-3-5-23/h1-15,21H,16-20,22H2,(H,34,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<500	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327872 (5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl-N-(4-...) Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(cc2)-c2ccccc2)cc1 Show InChI InChI=1S/C30H27FN4O2/c31-26-11-6-22(7-12-26)21-34-16-18-35(19-17-34)30(37)25-10-15-28(32-20-25)29(36)33-27-13-8-24(9-14-27)23-4-2-1-3-5-23/h1-15,20H,16-19,21H2,(H,33,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<500	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327873 (5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl-N-(3-...) Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2cccc(c2)-c2ccccc2)cc1 Show InChI InChI=1S/C30H27FN4O2/c31-26-12-9-22(10-13-26)21-34-15-17-35(18-16-34)30(37)25-11-14-28(32-20-25)29(36)33-27-8-4-7-24(19-27)23-5-2-1-3-6-23/h1-14,19-20H,15-18,21H2,(H,33,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327874 (N-(1-(cyclohexylmethyl) piperidin-4-yl)-5-(4-(4- ...) Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(CC3CCCCC3)CC2)cc1 Show InChI InChI=1S/C30H40FN5O2/c31-26-9-6-24(7-10-26)22-35-16-18-36(19-17-35)30(38)25-8-11-28(32-20-25)29(37)33-27-12-14-34(15-13-27)21-23-4-2-1-3-5-23/h6-11,20,23,27H,1-5,12-19,21-22H2,(H,33,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327875 (5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(1...) Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)NC2CCN(CC2)c2ccccc2)cc1 Show InChI InChI=1S/C29H32FN5O2/c30-24-9-6-22(7-10-24)21-33-16-18-35(19-17-33)29(37)23-8-11-27(31-20-23)28(36)32-25-12-14-34(15-13-25)26-4-2-1-3-5-26/h1-11,20,25H,12-19,21H2,(H,32,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	750	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327876 (4-((8-(5-(4-(4- fluorobenzyl)piperazine- 1-carbony...) Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N2CCC3(CCN(Cc4ccc(cc4)C#N)C3)CC2)cc1 Show InChI InChI=1S/C34H37FN6O2/c35-30-8-5-28(6-9-30)23-38-17-19-41(20-18-38)32(42)29-7-10-31(37-22-29)33(43)40-15-12-34(13-16-40)11-14-39(25-34)24-27-3-1-26(21-36)2-4-27/h1-10,22H,11-20,23-25H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327877 (5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4...) Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Oc3ccccc3)cc2)cc1 Show InChI InChI=1S/C30H27FN4O3/c31-24-9-6-22(7-10-24)21-34-16-18-35(19-17-34)30(37)23-8-15-28(32-20-23)29(36)33-25-11-13-27(14-12-25)38-26-4-2-1-3-5-26/h1-15,20H,16-19,21H2,(H,33,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<500	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327878 ((4-(4- fluorobenzyl)piperazin- 1-yl)(6-(4- (benzyl...) Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)-c2ccc(OCc3ccccc3)cc2)cc1 Show InChI InChI=1S/C30H28FN3O2/c31-27-11-6-23(7-12-27)21-33-16-18-34(19-17-33)30(35)26-10-15-29(32-20-26)25-8-13-28(14-9-25)36-22-24-4-2-1-3-5-24/h1-15,20H,16-19,21-22H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327879 (5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(1...) Show SMILES CC(N1CCC(CC1)NC(=O)c1ccc(cn1)C(=O)N1CCN(Cc2ccc(F)cc2)CC1)c1ccccc1 Show InChI InChI=1S/C31H36FN5O2/c1-23(25-5-3-2-4-6-25)36-15-13-28(14-16-36)34-30(38)29-12-9-26(21-33-29)31(39)37-19-17-35(18-20-37)22-24-7-10-27(32)11-8-24/h2-12,21,23,28H,13-20,22H2,1H3,(H,34,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<500	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327880 (5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(2...) Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccccc2-c2ccccc2)cc1 Show InChI InChI=1S/C30H27FN4O2/c31-25-13-10-22(11-14-25)21-34-16-18-35(19-17-34)30(37)24-12-15-28(32-20-24)29(36)33-27-9-5-4-8-26(27)23-6-2-1-3-7-23/h1-15,20H,16-19,21H2,(H,33,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327881 (5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4...) Show SMILES [O-][N+](=O)c1ccc(cc1)-c1ccc(NC(=O)c2ccc(cn2)C(=O)N2CCN(Cc3ccc(F)cc3)CC2)cc1 Show InChI InChI=1S/C30H26FN5O4/c31-25-8-1-21(2-9-25)20-34-15-17-35(18-16-34)30(38)24-7-14-28(32-19-24)29(37)33-26-10-3-22(4-11-26)23-5-12-27(13-6-23)36(39)40/h1-14,19H,15-18,20H2,(H,33,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327882 (5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(3...) Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2cccc(Oc3ccccc3)c2)cc1 Show InChI InChI=1S/C30H27FN4O3/c31-24-12-9-22(10-13-24)21-34-15-17-35(18-16-34)30(37)23-11-14-28(32-20-23)29(36)33-25-5-4-8-27(19-25)38-26-6-2-1-3-7-26/h1-14,19-20H,15-18,21H2,(H,33,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<500	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327883 ((6-(3- (benzyloxy)phenyl) pyridin-3-yl)(4-(4- flu...) Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)-c2cccc(OCc3ccccc3)c2)cc1 Show InChI InChI=1S/C30H28FN3O2/c31-27-12-9-23(10-13-27)21-33-15-17-34(18-16-33)30(35)26-11-14-29(32-20-26)25-7-4-8-28(19-25)36-22-24-5-2-1-3-6-24/h1-14,19-20H,15-18,21-22H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<500	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327884 (N-(1-(4-cyanobenzyl)- 1H-pyrazol-4-yl)-5-(4- (4- f...) Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2cnn(Cc3ccc(cc3)C#N)c2)cc1 Show InChI InChI=1S/C29H26FN7O2/c30-25-8-5-22(6-9-25)18-35-11-13-36(14-12-35)29(39)24-7-10-27(32-16-24)28(38)34-26-17-33-37(20-26)19-23-3-1-21(15-31)2-4-23/h1-10,16-17,20H,11-14,18-19H2,(H,34,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<500	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327885 (N-(4-(4- cyanophenyl)phenyl)-5- (4-(4- fluorobenzy...) Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(cc2)-c2ccc(cc2)C#N)cc1 Show InChI InChI=1S/C31H26FN5O2/c32-27-10-3-23(4-11-27)21-36-15-17-37(18-16-36)31(39)26-9-14-29(34-20-26)30(38)35-28-12-7-25(8-13-28)24-5-1-22(19-33)2-6-24/h1-14,20H,15-18,21H2,(H,35,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<500	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327886 (5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)-N-(4...) Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(cc2)-c2ccc(cc2)C(F)(F)F)cc1 Show InChI InChI=1S/C31H26F4N4O2/c32-26-10-1-21(2-11-26)20-38-15-17-39(18-16-38)30(41)24-7-14-28(36-19-24)29(40)37-27-12-5-23(6-13-27)22-3-8-25(9-4-22)31(33,34)35/h1-14,19H,15-18,20H2,(H,37,40)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<500	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327887 (N-(4-benzoylphenyl)-5- (4-(4- fluorobenzyl)piperaz...) Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(cc2)C(=O)c2ccccc2)cc1 Show InChI InChI=1S/C31H27FN4O3/c32-26-11-6-22(7-12-26)21-35-16-18-36(19-17-35)31(39)25-10-15-28(33-20-25)30(38)34-27-13-8-24(9-14-27)29(37)23-4-2-1-3-5-23/h1-15,20H,16-19,21H2,(H,34,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<500	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327888 (N-(4-benzyloxyphenyl)- 5-(4-(4- fluorobenzyl)piper...) Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(OCc3ccccc3)cc2)cc1 Show InChI InChI=1S/C31H29FN4O3/c32-26-9-6-23(7-10-26)21-35-16-18-36(19-17-35)31(38)25-8-15-29(33-20-25)30(37)34-27-11-13-28(14-12-27)39-22-24-4-2-1-3-5-24/h1-15,20H,16-19,21-22H2,(H,34,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	750	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327889 (N-(4-bromophenyl)-5- (4-(4- fluorobenzyl)piperazin...) Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(Br)cc2)cc1 Show InChI InChI=1S/C24H22BrFN4O2/c25-19-4-8-21(9-5-19)28-23(31)22-10-3-18(15-27-22)24(32)30-13-11-29(12-14-30)16-17-1-6-20(26)7-2-17/h1-10,15H,11-14,16H2,(H,28,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	750	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327890 (N-(4-(4- methoxyphenyl)phenyl)- 5-(4-(4- fluoroben...) Show SMILES COc1ccc(cc1)-c1ccc(NC(=O)c2ccc(cn2)C(=O)N2CCN(Cc3ccc(F)cc3)CC2)cc1 Show InChI InChI=1S/C31H29FN4O3/c1-39-28-13-6-24(7-14-28)23-4-11-27(12-5-23)34-30(37)29-15-8-25(20-33-29)31(38)36-18-16-35(17-19-36)21-22-2-9-26(32)10-3-22/h2-15,20H,16-19,21H2,1H3,(H,34,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	750	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327891 ((6-(4- benzylphenylamino) pyridin-3-yl)(4-(4- flu...) Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(Nc3ccc(Cc4ccccc4)cc3)nc2)cc1 Show InChI InChI=1S/C30H29FN4O/c31-27-11-6-25(7-12-27)22-34-16-18-35(19-17-34)30(36)26-10-15-29(32-21-26)33-28-13-8-24(9-14-28)20-23-4-2-1-3-5-23/h1-15,21H,16-20,22H2,(H,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM409010 (4-((2-(5-(4-(4-fluorobenzyl)piperazine-1- carbonyl...) Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)N2CCC3CN(Cc4ccc(cc4)C#N)CCC23)cc1 Show InChI InChI=1S/C32H35FN6O/c33-29-8-5-26(6-9-29)21-36-15-17-38(18-16-36)32(40)27-7-10-31(35-20-27)39-14-11-28-23-37(13-12-30(28)39)22-25-3-1-24(19-34)2-4-25/h1-10,20,28,30H,11-18,21-23H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<500	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327893 (N-(4-(3- cyanophenyl)phenyl)-5- (4-(4- fluorobenzy...) Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)Nc2ccc(cc2)-c2cccc(c2)C#N)cc1 Show InChI InChI=1S/C31H26FN5O2/c32-27-9-4-22(5-10-27)21-36-14-16-37(17-15-36)31(39)26-8-13-29(34-20-26)30(38)35-28-11-6-24(7-12-28)25-3-1-2-23(18-25)19-33/h1-13,18,20H,14-17,21H2,(H,35,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	750	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327894 ((6-(3- phenylphenylamino) pyridin-3-yl)(4-(4- flu...) Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(Nc3cccc(c3)-c3ccccc3)nc2)cc1 Show InChI InChI=1S/C29H27FN4O/c30-26-12-9-22(10-13-26)21-33-15-17-34(18-16-33)29(35)25-11-14-28(31-20-25)32-27-8-4-7-24(19-27)23-5-2-1-3-6-23/h1-14,19-20H,15-18,21H2,(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327895 ((4-(4- fluorobenzyl)piperazin- 1-yl)(6-(4- phenoxy...) Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(Nc3ccc(Oc4ccccc4)cc3)nc2)cc1 Show InChI InChI=1S/C29H27FN4O2/c30-24-9-6-22(7-10-24)21-33-16-18-34(19-17-33)29(35)23-8-15-28(31-20-23)32-25-11-13-27(14-12-25)36-26-4-2-1-3-5-26/h1-15,20H,16-19,21H2,(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327896 ((6-(4-(4- cyanobenzylcarbamoyl) phenyl)pyridin-3-...) Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)-c2ccc(cc2)C(=O)NCc2ccc(cc2)C#N)cc1 Show InChI InChI=1S/C32H28FN5O2/c33-29-12-5-25(6-13-29)22-37-15-17-38(18-16-37)32(40)28-11-14-30(35-21-28)26-7-9-27(10-8-26)31(39)36-20-24-3-1-23(19-34)2-4-24/h1-14,21H,15-18,20,22H2,(H,36,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	750	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327897 ((6-(4- (cyanobenzyl)piperidin- 4-ylamino)pyridin-3...) Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(NC3CCN(Cc4ccc(cc4)C#N)CC3)nc2)cc1 Show InChI InChI=1S/C30H33FN6O/c31-27-8-5-25(6-9-27)22-36-15-17-37(18-16-36)30(38)26-7-10-29(33-20-26)34-28-11-13-35(14-12-28)21-24-3-1-23(19-32)2-4-24/h1-10,20,28H,11-18,21-22H2,(H,33,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	750	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327898 ((6-(4- phenylphenylamino) pyridin-3-yl)(4-(4- flu...) Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(Nc3ccc(cc3)-c3ccccc3)nc2)cc1 Show InChI InChI=1S/C29H27FN4O/c30-26-11-6-22(7-12-26)21-33-16-18-34(19-17-33)29(35)25-10-15-28(31-20-25)32-27-13-8-24(9-14-27)23-4-2-1-3-5-23/h1-15,20H,16-19,21H2,(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327899 (N5-(1-(4-cyanobenzyl)- 1H-pyrazol-3-yl)-N2-(1- (4-...) Show SMILES O=C(NC1CCN(Cc2ccc(cc2)C#N)CC1)c1ccc(cn1)C(=O)Nc1ccn(Cc2ccc(cc2)C#N)n1 Show InChI InChI=1S/C31H28N8O2/c32-17-22-1-5-24(6-2-22)20-38-14-11-27(12-15-38)35-31(41)28-10-9-26(19-34-28)30(40)36-29-13-16-39(37-29)21-25-7-3-23(18-33)4-8-25/h1-10,13,16,19,27H,11-12,14-15,20-21H2,(H,35,41)(H,36,37,40)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	750	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair

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