Found 15 hits with Last Name = 'hufner' and Initial = 'a' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50350149
(CHEMBL1814312)Show InChI InChI=1S/C21H23NO3/c1-5-7-15-11-18(21(24)19(12-15)22-14(3)23)16-9-10-20(25-4)17(13-16)8-6-2/h5-6,9-13,24H,1-2,7-8H2,3-4H3,(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a |
University of Graz
Curated by ChEMBL
| Assay Description Allosteric modulation of GABAAalpha1beta2gamma2s receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induc... |
Bioorg Med Chem 23: 6757-62 (2015)
Article DOI: 10.1016/j.bmc.2015.08.034 BindingDB Entry DOI: 10.7270/Q2WQ05KM |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50120863
(CHEMBL3616640)Show InChI InChI=1S/C20H27NO2/c1-4-7-14-11-17(20(22)18(21)12-14)15-9-10-19(23-6-3)16(13-15)8-5-2/h9-13,22H,4-8,21H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 3.32E+4 | n/a | n/a | n/a | n/a |
University of Graz
Curated by ChEMBL
| Assay Description Partial agonist activity at GABAAalpha1beta2gamma2s receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as induction of chloride c... |
Bioorg Med Chem 23: 6757-62 (2015)
Article DOI: 10.1016/j.bmc.2015.08.034 BindingDB Entry DOI: 10.7270/Q2WQ05KM |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50120858
(CHEMBL3616635)Show InChI InChI=1S/C20H23NO2/c1-4-7-14-9-10-19(23-6-3)17(11-14)16-12-15(8-5-2)20(22)18(21)13-16/h4-5,9-13,22H,1-2,6-8,21H2,3H3 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 2.15E+4 | n/a | n/a | n/a | n/a |
University of Graz
Curated by ChEMBL
| Assay Description Allosteric modulation of GABAAalpha1beta2gamma2s receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induc... |
Bioorg Med Chem 23: 6757-62 (2015)
Article DOI: 10.1016/j.bmc.2015.08.034 BindingDB Entry DOI: 10.7270/Q2WQ05KM |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50120859
(CHEMBL3616636)Show InChI InChI=1S/C19H25NO2/c1-4-6-13-8-9-18(22-3)16(10-13)15-11-14(7-5-2)19(21)17(20)12-15/h8-12,21H,4-7,20H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.58E+4 | n/a | n/a | n/a | n/a |
University of Graz
Curated by ChEMBL
| Assay Description Allosteric modulation of GABAAalpha1beta2gamma2s receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induc... |
Bioorg Med Chem 23: 6757-62 (2015)
Article DOI: 10.1016/j.bmc.2015.08.034 BindingDB Entry DOI: 10.7270/Q2WQ05KM |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50120860
(CHEMBL3616637)Show SMILES CCCc1ccc(OC)c(c1)-c1cc(CCC)c(O)c(NC(C)=O)c1 Show InChI InChI=1S/C21H27NO3/c1-5-7-15-9-10-20(25-4)18(11-15)17-12-16(8-6-2)21(24)19(13-17)22-14(3)23/h9-13,24H,5-8H2,1-4H3,(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 2.46E+4 | n/a | n/a | n/a | n/a |
University of Graz
Curated by ChEMBL
| Assay Description Allosteric modulation of GABAAalpha1beta2gamma2s receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induc... |
Bioorg Med Chem 23: 6757-62 (2015)
Article DOI: 10.1016/j.bmc.2015.08.034 BindingDB Entry DOI: 10.7270/Q2WQ05KM |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50120861
(CHEMBL3616638)Show SMILES CCCc1cc(NC(C)=O)c(O)c(c1)-c1ccc(OCC)c(CCC)c1 Show InChI InChI=1S/C22H29NO3/c1-5-8-16-12-19(22(25)20(13-16)23-15(4)24)17-10-11-21(26-7-3)18(14-17)9-6-2/h10-14,25H,5-9H2,1-4H3,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a |
University of Graz
Curated by ChEMBL
| Assay Description Allosteric modulation of GABAAalpha1beta2gamma2s receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induc... |
Bioorg Med Chem 23: 6757-62 (2015)
Article DOI: 10.1016/j.bmc.2015.08.034 BindingDB Entry DOI: 10.7270/Q2WQ05KM |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50120862
(CHEMBL3616639)Show InChI InChI=1S/C20H27NO2/c1-4-7-14-9-10-19(23-6-3)17(11-14)16-12-15(8-5-2)20(22)18(21)13-16/h9-13,22H,4-8,21H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 2.04E+4 | n/a | n/a | n/a | n/a |
University of Graz
Curated by ChEMBL
| Assay Description Allosteric modulation of GABAAalpha1beta2gamma2s receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induc... |
Bioorg Med Chem 23: 6757-62 (2015)
Article DOI: 10.1016/j.bmc.2015.08.034 BindingDB Entry DOI: 10.7270/Q2WQ05KM |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50120863
(CHEMBL3616640)Show InChI InChI=1S/C20H27NO2/c1-4-7-14-11-17(20(22)18(21)12-14)15-9-10-19(23-6-3)16(13-15)8-5-2/h9-13,22H,4-8,21H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.44E+4 | n/a | n/a | n/a | n/a |
University of Graz
Curated by ChEMBL
| Assay Description Allosteric modulation of GABAAalpha1beta2gamma2s receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induc... |
Bioorg Med Chem 23: 6757-62 (2015)
Article DOI: 10.1016/j.bmc.2015.08.034 BindingDB Entry DOI: 10.7270/Q2WQ05KM |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM24183
(4-amino-n-[2,3-3H]butyric acid | 4-aminobutanoic a...)Show InChI InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 5.10E+4 | n/a | n/a | n/a | n/a |
University of Graz
Curated by ChEMBL
| Assay Description Partial agonist activity at GABAAalpha1beta2gamma2s receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as induction of chloride c... |
Bioorg Med Chem 23: 6757-62 (2015)
Article DOI: 10.1016/j.bmc.2015.08.034 BindingDB Entry DOI: 10.7270/Q2WQ05KM |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50157304
(3',5-di-2-propenyl-1,1'-biphenyl-2,4'-diol | 3',5-...)Show InChI InChI=1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 7.62E+4 | n/a | n/a | n/a | n/a |
University of Graz
Curated by ChEMBL
| Assay Description Partial agonist activity at GABAAalpha1beta2gamma2s receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as induction of chloride c... |
Bioorg Med Chem 23: 6757-62 (2015)
Article DOI: 10.1016/j.bmc.2015.08.034 BindingDB Entry DOI: 10.7270/Q2WQ05KM |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50350149
(CHEMBL1814312)Show InChI InChI=1S/C21H23NO3/c1-5-7-15-11-18(21(24)19(12-15)22-14(3)23)16-9-10-20(25-4)17(13-16)8-6-2/h5-6,9-13,24H,1-2,7-8H2,3-4H3,(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 6.81E+4 | n/a | n/a | n/a | n/a |
University of Graz
Curated by ChEMBL
| Assay Description Partial agonist activity at GABAAalpha1beta2gamma2s receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as induction of chloride c... |
Bioorg Med Chem 23: 6757-62 (2015)
Article DOI: 10.1016/j.bmc.2015.08.034 BindingDB Entry DOI: 10.7270/Q2WQ05KM |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50120857
(CHEMBL3616634)Show InChI InChI=1S/C19H21NO2/c1-4-6-13-8-9-18(22-3)16(10-13)15-11-14(7-5-2)19(21)17(20)12-15/h4-5,8-12,21H,1-2,6-7,20H2,3H3 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.44E+5 | n/a | n/a | n/a | n/a |
University of Graz
Curated by ChEMBL
| Assay Description Partial agonist activity at GABAAalpha1beta2gamma2s receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as induction of chloride c... |
Bioorg Med Chem 23: 6757-62 (2015)
Article DOI: 10.1016/j.bmc.2015.08.034 BindingDB Entry DOI: 10.7270/Q2WQ05KM |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50120859
(CHEMBL3616636)Show InChI InChI=1S/C19H25NO2/c1-4-6-13-8-9-18(22-3)16(10-13)15-11-14(7-5-2)19(21)17(20)12-15/h8-12,21H,4-7,20H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 6.22E+4 | n/a | n/a | n/a | n/a |
University of Graz
Curated by ChEMBL
| Assay Description Partial agonist activity at GABAAalpha1beta2gamma2s receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as induction of chloride c... |
Bioorg Med Chem 23: 6757-62 (2015)
Article DOI: 10.1016/j.bmc.2015.08.034 BindingDB Entry DOI: 10.7270/Q2WQ05KM |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50120861
(CHEMBL3616638)Show SMILES CCCc1cc(NC(C)=O)c(O)c(c1)-c1ccc(OCC)c(CCC)c1 Show InChI InChI=1S/C22H29NO3/c1-5-8-16-12-19(22(25)20(13-16)23-15(4)24)17-10-11-21(26-7-3)18(14-17)9-6-2/h10-14,25H,5-9H2,1-4H3,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 6.90E+3 | n/a | n/a | n/a | n/a |
University of Graz
Curated by ChEMBL
| Assay Description Partial agonist activity at GABAAalpha1beta2gamma2s receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as induction of chloride c... |
Bioorg Med Chem 23: 6757-62 (2015)
Article DOI: 10.1016/j.bmc.2015.08.034 BindingDB Entry DOI: 10.7270/Q2WQ05KM |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50120857
(CHEMBL3616634)Show InChI InChI=1S/C19H21NO2/c1-4-6-13-8-9-18(22-3)16(10-13)15-11-14(7-5-2)19(21)17(20)12-15/h4-5,8-12,21H,1-2,6-7,20H2,3H3 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 4.76E+4 | n/a | n/a | n/a | n/a |
University of Graz
Curated by ChEMBL
| Assay Description Allosteric modulation of GABAAalpha1beta2gamma2s receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induc... |
Bioorg Med Chem 23: 6757-62 (2015)
Article DOI: 10.1016/j.bmc.2015.08.034 BindingDB Entry DOI: 10.7270/Q2WQ05KM |
More data for this Ligand-Target Pair | |