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Compile Data Set for Download or QSAR

Found 171 hits with Last Name = 'ikenogami' and Initial = 't'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Extracellular calcium-sensing receptor


(Homo sapiens (Human))		BDBM50337114
PNG
(2'-((1R)-1-{(2R)-3-[2-Methyl-1-(naphthalen-2-yl)pr...)
Show SMILES C[C@@H](OC[C@H](O)CNC(C)(C)Cc1ccc2ccccc2c1)c1ccccc1-c1ccc(cc1)C(O)=O |r|
Show InChI InChI=1S/C32H35NO4/c1-22(29-10-6-7-11-30(29)25-14-16-26(17-15-25)31(35)36)37-21-28(34)20-33-32(2,3)19-23-12-13-24-8-4-5-9-27(24)18-23/h4-18,22,28,33-34H,19-21H2,1-3H3,(H,35,36)/t22-,28-/m1/s1
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n/an/a 4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at human CaSR expressed in rat PC12h cells by reporter gene assay

ACS Med Chem Lett 2: 238-242 (2011)


Article DOI: 10.1021/ml100268k
BindingDB Entry DOI: 10.7270/Q21R6QT7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50532190
PNG
(CHEMBL4452717)
Show SMILES COc1cc(ccc1OCc1ccc(cc1)C1CC1)C1CN(C1)C(=O)c1cc(OCCN2CCN(C)CC2)ccn1
Show InChI InChI=1S/C33H40N4O4/c1-35-13-15-36(16-14-35)17-18-40-29-11-12-34-30(20-29)33(38)37-21-28(22-37)27-9-10-31(32(19-27)39-2)41-23-24-3-5-25(6-4-24)26-7-8-26/h3-6,9-12,19-20,26,28H,7-8,13-18,21-23H2,1-2H3
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n/an/a 4.40n/an/an/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Extracellular calcium-sensing receptor


(Homo sapiens (Human))		BDBM50337116
PNG
(2'-((1R)-1-{(2R)-3-[2-methyl-1-(naphthalen-2-yl)pr...)
Show SMILES C[C@@H](OC[C@H](O)CNC(C)(C)Cc1ccc2ccccc2c1)c1ccccc1-c1ccc(C(O)=O)c(C)c1 |r|
Show InChI InChI=1S/C33H37NO4/c1-22-17-27(15-16-29(22)32(36)37)31-12-8-7-11-30(31)23(2)38-21-28(35)20-34-33(3,4)19-24-13-14-25-9-5-6-10-26(25)18-24/h5-18,23,28,34-35H,19-21H2,1-4H3,(H,36,37)/t23-,28-/m1/s1
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TBA

Curated by ChEMBL


Assay Description
Antagonist activity at human CaSR expressed in rat PC12h cells by reporter gene assay

ACS Med Chem Lett 2: 238-242 (2011)


Article DOI: 10.1021/ml100268k
BindingDB Entry DOI: 10.7270/Q21R6QT7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50532193
PNG
(CHEMBL4539279)
Show SMILES CCc1ccc(COc2ccc(cc2OC)C2CN(C2)C(=O)c2cc(OCCN3C[C@@H](O)[C@H](O)C3)ccn2)cc1 |r|
Show InChI InChI=1S/C31H37N3O6/c1-3-21-4-6-22(7-5-21)20-40-29-9-8-23(14-30(29)38-2)24-16-34(17-24)31(37)26-15-25(10-11-32-26)39-13-12-33-18-27(35)28(36)19-33/h4-11,14-15,24,27-28,35-36H,3,12-13,16-20H2,1-2H3/t27-,28-/m1/s1
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n/an/a 8.90n/an/an/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50503530
PNG
(CHEMBL4437645)
Show SMILES CCc1ccc(COc2ccc(cc2OC)C2CN(C2)C(=O)c2cc(OCCO)ccn2)cc1
Show InChI InChI=1S/C27H30N2O5/c1-3-19-4-6-20(7-5-19)18-34-25-9-8-21(14-26(25)32-2)22-16-29(17-22)27(31)24-15-23(10-11-28-24)33-13-12-30/h4-11,14-15,22,30H,3,12-13,16-18H2,1-2H3
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Central Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...

Bioorg Med Chem Lett 29: 115-118 (2019)


Article DOI: 10.1016/j.bmcl.2018.10.051
BindingDB Entry DOI: 10.7270/Q2RN3C4G
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50503530
PNG
(CHEMBL4437645)
Show SMILES CCc1ccc(COc2ccc(cc2OC)C2CN(C2)C(=O)c2cc(OCCO)ccn2)cc1
Show InChI InChI=1S/C27H30N2O5/c1-3-19-4-6-20(7-5-19)18-34-25-9-8-21(14-26(25)32-2)22-16-29(17-22)27(31)24-15-23(10-11-28-24)33-13-12-30/h4-11,14-15,22,30H,3,12-13,16-18H2,1-2H3
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Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50532178
PNG
(CHEMBL4460662)
Show SMILES CCc1ccc(COc2ccc(cc2OC)C2CN(C2)C(=O)c2cc(OCCN3C[C@H](O)[C@H](O)C3)ccn2)cc1 |r|
Show InChI InChI=1S/C31H37N3O6/c1-3-21-4-6-22(7-5-21)20-40-29-9-8-23(14-30(29)38-2)24-16-34(17-24)31(37)26-15-25(10-11-32-26)39-13-12-33-18-27(35)28(36)19-33/h4-11,14-15,24,27-28,35-36H,3,12-13,16-20H2,1-2H3/t27-,28+
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Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50532197
PNG
(CHEMBL4522278)
Show SMILES COc1cc(ccc1OCc1ccc(cc1)C1CC1)C1CN(C1)C(=O)c1cc(COCC(CO)CO)ccn1
Show InChI InChI=1S/C31H36N2O6/c1-37-30-13-26(8-9-29(30)39-20-21-2-4-24(5-3-21)25-6-7-25)27-14-33(15-27)31(36)28-12-22(10-11-32-28)18-38-19-23(16-34)17-35/h2-5,8-13,23,25,27,34-35H,6-7,14-20H2,1H3
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Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Extracellular calcium-sensing receptor


(Homo sapiens (Human))		BDBM50337113
PNG
((RS)-2'-(1-{(2R)-3-[2-Methyl-1-(naphthalen-2-yl)pr...)
Show SMILES CC(OC[C@H](O)CNC(C)(C)Cc1ccc2ccccc2c1)c1ccccc1-c1ccc(cc1)C(O)=O |r|
Show InChI InChI=1S/C32H35NO4/c1-22(29-10-6-7-11-30(29)25-14-16-26(17-15-25)31(35)36)37-21-28(34)20-33-32(2,3)19-23-12-13-24-8-4-5-9-27(24)18-23/h4-18,22,28,33-34H,19-21H2,1-3H3,(H,35,36)/t22?,28-/m1/s1
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TBA

Curated by ChEMBL


Assay Description
Antagonist activity at human CaSR expressed in rat PC12h cells by reporter gene assay

ACS Med Chem Lett 2: 238-242 (2011)


Article DOI: 10.1021/ml100268k
BindingDB Entry DOI: 10.7270/Q21R6QT7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50532180
PNG
(CHEMBL4473704)
Show SMILES COc1cc(ccc1OCc1ccc(cc1)C1CC1)C1CN(C1)C(=O)c1cc(OCCN2CCOCC2)ccn1
Show InChI InChI=1S/C32H37N3O5/c1-37-31-18-26(8-9-30(31)40-22-23-2-4-24(5-3-23)25-6-7-25)27-20-35(21-27)32(36)29-19-28(10-11-33-29)39-17-14-34-12-15-38-16-13-34/h2-5,8-11,18-19,25,27H,6-7,12-17,20-22H2,1H3
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Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50532194
PNG
(CHEMBL4575001)
Show SMILES COc1cc(ccc1OCc1ccc(cc1)C1CC1)C1CN(C1)C(=O)c1cc(OCCO)ccn1
Show InChI InChI=1S/C28H30N2O5/c1-33-27-14-22(8-9-26(27)35-18-19-2-4-20(5-3-19)21-6-7-21)23-16-30(17-23)28(32)25-15-24(10-11-29-25)34-13-12-31/h2-5,8-11,14-15,21,23,31H,6-7,12-13,16-18H2,1H3
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Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Extracellular calcium-sensing receptor


(Homo sapiens (Human))		BDBM50337103
PNG
(2'-((1R)-1-{(2R)-3-[1-(4-Chloro-3-fluorophenyl)-2-...)
Show SMILES C[C@@H](OC[C@H](O)CNC(C)(C)Cc1ccc(Cl)c(F)c1)c1ccccc1-c1ccc(C(O)=O)c(C)c1 |r|
Show InChI InChI=1S/C29H33ClFNO4/c1-18-13-21(10-11-23(18)28(34)35)25-8-6-5-7-24(25)19(2)36-17-22(33)16-32-29(3,4)15-20-9-12-26(30)27(31)14-20/h5-14,19,22,32-33H,15-17H2,1-4H3,(H,34,35)/t19-,22-/m1/s1
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TBA

Curated by ChEMBL


Assay Description
Antagonist activity at human CaSR expressed in rat PC12h cells by reporter gene assay

ACS Med Chem Lett 2: 238-242 (2011)


Article DOI: 10.1021/ml100268k
BindingDB Entry DOI: 10.7270/Q21R6QT7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50532183
PNG
(CHEMBL4543929)
Show SMILES COc1ccc(COc2ccc(cc2OC)C2CN(C2)C(=O)c2cc(OCCO)ccn2)cc1
Show InChI InChI=1S/C26H28N2O6/c1-31-21-6-3-18(4-7-21)17-34-24-8-5-19(13-25(24)32-2)20-15-28(16-20)26(30)23-14-22(9-10-27-23)33-12-11-29/h3-10,13-14,20,29H,11-12,15-17H2,1-2H3
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Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50532195
PNG
(CHEMBL4555993)
Show SMILES COc1cc(ccc1OCc1ccc(cc1)C1CC1)C1CN(C1)C(=O)c1cc(COC[C@H](O)CO)ccn1 |r|
Show InChI InChI=1S/C30H34N2O6/c1-36-29-13-24(8-9-28(29)38-18-20-2-4-22(5-3-20)23-6-7-23)25-14-32(15-25)30(35)27-12-21(10-11-31-27)17-37-19-26(34)16-33/h2-5,8-13,23,25-26,33-34H,6-7,14-19H2,1H3/t26-/m1/s1
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Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50532188
PNG
(CHEMBL4570496)
Show SMILES CCc1ccc(COc2ccc(cc2OC)C2CN(C2)C(=O)c2cc(OCCN3CCOCC3)ccn2)cc1
Show InChI InChI=1S/C31H37N3O5/c1-3-23-4-6-24(7-5-23)22-39-29-9-8-25(18-30(29)36-2)26-20-34(21-26)31(35)28-19-27(10-11-32-28)38-17-14-33-12-15-37-16-13-33/h4-11,18-19,26H,3,12-17,20-22H2,1-2H3
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Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50532181
PNG
(CHEMBL4474690)
Show SMILES COc1cc(ccc1OCc1ccc(cc1)C1CC1)C1CN(C1)C(=O)c1cc(COC[C@@H](O)CO)ccn1 |r|
Show InChI InChI=1S/C30H34N2O6/c1-36-29-13-24(8-9-28(29)38-18-20-2-4-22(5-3-20)23-6-7-23)25-14-32(15-25)30(35)27-12-21(10-11-31-27)17-37-19-26(34)16-33/h2-5,8-13,23,25-26,33-34H,6-7,14-19H2,1H3/t26-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50532186
PNG
(CHEMBL4526056)
Show SMILES COc1cc(ccc1OCc1ccc(cc1)C1CC1)C1CN(C1)C(=O)c1cc(OC[C@H](O)CO)ccn1 |r|
Show InChI InChI=1S/C29H32N2O6/c1-35-28-12-22(8-9-27(28)37-17-19-2-4-20(5-3-19)21-6-7-21)23-14-31(15-23)29(34)26-13-25(10-11-30-26)36-18-24(33)16-32/h2-5,8-13,21,23-24,32-33H,6-7,14-18H2,1H3/t24-/m1/s1
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Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50532185
PNG
(CHEMBL4467199)
Show SMILES COc1cc(ccc1OCc1ccc(cc1)C1CC1)C1CN(C1)C(=O)c1cc(OC[C@@H](O)CO)ccn1 |r|
Show InChI InChI=1S/C29H32N2O6/c1-35-28-12-22(8-9-27(28)37-17-19-2-4-20(5-3-19)21-6-7-21)23-14-31(15-23)29(34)26-13-25(10-11-30-26)36-18-24(33)16-32/h2-5,8-13,21,23-24,32-33H,6-7,14-18H2,1H3/t24-/m0/s1
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Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM50532197
PNG
(CHEMBL4522278)
Show SMILES COc1cc(ccc1OCc1ccc(cc1)C1CC1)C1CN(C1)C(=O)c1cc(COCC(CO)CO)ccn1
Show InChI InChI=1S/C31H36N2O6/c1-37-30-13-26(8-9-29(30)39-20-21-2-4-24(5-3-21)25-6-7-25)27-14-33(15-27)31(36)28-12-22(10-11-32-28)18-38-19-23(16-34)17-35/h2-5,8-13,23,25,27,34-35H,6-7,14-20H2,1H3
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n/an/a 15n/an/an/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of CSF1R in CSF1-induced DBA/1J mouse BMMC assessed as reduction in LPS-induced IL6 production preincubated for overnight followed by LPS-...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50532187
PNG
(CHEMBL4574414)
Show SMILES CCc1ccc(COc2ccc(cc2OC)C2CN(C2)C(=O)c2cc(OCCN3CCNC(=O)C3)ccn2)cc1
Show InChI InChI=1S/C31H36N4O5/c1-3-22-4-6-23(7-5-22)21-40-28-9-8-24(16-29(28)38-2)25-18-35(19-25)31(37)27-17-26(10-11-32-27)39-15-14-34-13-12-33-30(36)20-34/h4-11,16-17,25H,3,12-15,18-21H2,1-2H3,(H,33,36)
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n/an/a 15n/an/an/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50532189
PNG
(CHEMBL4547269)
Show SMILES COc1ccc(COc2ccc(cc2OC)C2CN(C2)C(=O)c2cc(OCCN3CCN(C)CC3)ccn2)cc1
Show InChI InChI=1S/C31H38N4O5/c1-33-12-14-34(15-13-33)16-17-39-27-10-11-32-28(19-27)31(36)35-20-25(21-35)24-6-9-29(30(18-24)38-3)40-22-23-4-7-26(37-2)8-5-23/h4-11,18-19,25H,12-17,20-22H2,1-3H3
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n/an/a 17n/an/an/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50532184
PNG
(CHEMBL4526802)
Show SMILES CCc1ccc(COc2ccc(cc2OC)C2CN(C2)C(=O)c2cc(COCC(CO)(CO)CO)ccn2)cc1
Show InChI InChI=1S/C31H38N2O7/c1-3-22-4-6-23(7-5-22)17-40-28-9-8-25(13-29(28)38-2)26-14-33(15-26)30(37)27-12-24(10-11-32-27)16-39-21-31(18-34,19-35)20-36/h4-13,26,34-36H,3,14-21H2,1-2H3
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n/an/a 17n/an/an/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50532179
PNG
(CHEMBL4455662)
Show SMILES CCc1ccc(COc2ccc(cc2OC)C2CN(C2)C(=O)c2cc(COC[C@@H](O)CO)ccn2)cc1 |r|
Show InChI InChI=1S/C29H34N2O6/c1-3-20-4-6-21(7-5-20)18-37-27-9-8-23(13-28(27)35-2)24-14-31(15-24)29(34)26-12-22(10-11-30-26)17-36-19-25(33)16-32/h4-13,24-25,32-33H,3,14-19H2,1-2H3/t25-/m0/s1
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n/an/a 18n/an/an/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Extracellular calcium-sensing receptor


(Homo sapiens (Human))		BDBM50337105
PNG
((R)-1-((R)-cyclopropyl(2-(hydroxymethyl)phenyl)met...)
Show SMILES CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)CO[C@H](C1CC1)c1ccccc1CO |r|
Show InChI InChI=1S/C28H35NO3/c1-28(2,16-20-11-12-21-7-3-4-8-23(21)15-20)29-17-25(31)19-32-27(22-13-14-22)26-10-6-5-9-24(26)18-30/h3-12,15,22,25,27,29-31H,13-14,16-19H2,1-2H3/t25-,27-/m1/s1
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n/an/a 18n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at human CaSR expressed in rat PC12h cells by reporter gene assay

ACS Med Chem Lett 2: 238-242 (2011)


Article DOI: 10.1021/ml100268k
BindingDB Entry DOI: 10.7270/Q21R6QT7
More data for this
Ligand-Target Pair
Extracellular calcium-sensing receptor


(Homo sapiens (Human))		BDBM50337112
PNG
((RS)-3'-(1-{(2R)-3-[2-Methyl-1-(naphthalen-2-yl)pr...)
Show SMILES CC(OC[C@H](O)CNC(C)(C)Cc1ccc2ccccc2c1)c1cccc(c1)-c1ccc(cc1)C(O)=O |r|
Show InChI InChI=1S/C32H35NO4/c1-22(27-9-6-10-29(18-27)25-13-15-26(16-14-25)31(35)36)37-21-30(34)20-33-32(2,3)19-23-11-12-24-7-4-5-8-28(24)17-23/h4-18,22,30,33-34H,19-21H2,1-3H3,(H,35,36)/t22?,30-/m1/s1
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n/an/a 18n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at human CaSR expressed in rat PC12h cells by reporter gene assay

ACS Med Chem Lett 2: 238-242 (2011)


Article DOI: 10.1021/ml100268k
BindingDB Entry DOI: 10.7270/Q21R6QT7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM50532181
PNG
(CHEMBL4474690)
Show SMILES COc1cc(ccc1OCc1ccc(cc1)C1CC1)C1CN(C1)C(=O)c1cc(COC[C@@H](O)CO)ccn1 |r|
Show InChI InChI=1S/C30H34N2O6/c1-36-29-13-24(8-9-28(29)38-18-20-2-4-22(5-3-20)23-6-7-23)25-14-32(15-25)30(35)27-12-21(10-11-31-27)17-37-19-26(34)16-33/h2-5,8-13,23,25-26,33-34H,6-7,14-19H2,1H3/t26-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of CSF1R in CSF1-induced DBA/1J mouse BMMC assessed as reduction in LPS-induced IL6 production preincubated for overnight followed by LPS-...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50532192
PNG
(CHEMBL4451717)
Show SMILES COc1cc(ccc1OCc1ccc(cc1)C1CC1)C1CN(C1)C(=O)c1cc(COCC(CO)(CO)CO)ccn1
Show InChI InChI=1S/C32H38N2O7/c1-39-30-13-26(8-9-29(30)41-17-22-2-4-24(5-3-22)25-6-7-25)27-14-34(15-27)31(38)28-12-23(10-11-33-28)16-40-21-32(18-35,19-36)20-37/h2-5,8-13,25,27,35-37H,6-7,14-21H2,1H3
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n/an/a 20n/an/an/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM50532195
PNG
(CHEMBL4555993)
Show SMILES COc1cc(ccc1OCc1ccc(cc1)C1CC1)C1CN(C1)C(=O)c1cc(COC[C@H](O)CO)ccn1 |r|
Show InChI InChI=1S/C30H34N2O6/c1-36-29-13-24(8-9-28(29)38-18-20-2-4-22(5-3-20)23-6-7-23)25-14-32(15-25)30(35)27-12-21(10-11-31-27)17-37-19-26(34)16-33/h2-5,8-13,23,25-26,33-34H,6-7,14-19H2,1H3/t26-/m1/s1
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n/an/a 21n/an/an/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of CSF1R in CSF1-induced DBA/1J mouse BMMC assessed as reduction in LPS-induced IL6 production preincubated for overnight followed by LPS-...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Extracellular calcium-sensing receptor


(Homo sapiens (Human))		BDBM50320009
PNG
((R)-1-((R)-cyclopropyl(o-tolyl)methoxy)-3-(2-methy...)
Show SMILES Cc1ccccc1[C@H](OC[C@H](O)CNC(C)(C)Cc1ccc2ccccc2c1)C1CC1 |r|
Show InChI InChI=1S/C28H35NO2/c1-20-8-4-7-11-26(20)27(23-14-15-23)31-19-25(30)18-29-28(2,3)17-21-12-13-22-9-5-6-10-24(22)16-21/h4-13,16,23,25,27,29-30H,14-15,17-19H2,1-3H3/t25-,27-/m1/s1
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n/an/a 23n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at human CaSR expressed in rat PC12h cells by reporter gene assay

ACS Med Chem Lett 2: 238-242 (2011)


Article DOI: 10.1021/ml100268k
BindingDB Entry DOI: 10.7270/Q21R6QT7
More data for this
Ligand-Target Pair
Extracellular calcium-sensing receptor


(Homo sapiens (Human))		BDBM50337115
PNG
(2'-((1R)-1-{(2R)-3-[1-(4-Chloro-3-fluorophenyl)-2-...)
Show SMILES C[C@@H](OC[C@H](O)CNC(C)(C)Cc1ccc(Cl)c(F)c1)c1ccccc1-c1ccc(cc1)C(O)=O |r|
Show InChI InChI=1S/C28H31ClFNO4/c1-18(23-6-4-5-7-24(23)20-9-11-21(12-10-20)27(33)34)35-17-22(32)16-31-28(2,3)15-19-8-13-25(29)26(30)14-19/h4-14,18,22,31-32H,15-17H2,1-3H3,(H,33,34)/t18-,22-/m1/s1
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n/an/a 23n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at human CaSR expressed in rat PC12h cells by reporter gene assay

ACS Med Chem Lett 2: 238-242 (2011)


Article DOI: 10.1021/ml100268k
BindingDB Entry DOI: 10.7270/Q21R6QT7
More data for this
Ligand-Target Pair
Extracellular calcium-sensing receptor


(Homo sapiens (Human))		BDBM50337104
PNG
(3-[2-((1R)-1-{(2R)-2-Hydroxy-3-[2-methyl-1-(naphth...)
Show SMILES C[C@@H](OC[C@H](O)CNC(C)(C)Cc1ccc2ccccc2c1)c1ccccc1CCC(O)=O |r|
Show InChI InChI=1S/C28H35NO4/c1-20(26-11-7-6-9-23(26)14-15-27(31)32)33-19-25(30)18-29-28(2,3)17-21-12-13-22-8-4-5-10-24(22)16-21/h4-13,16,20,25,29-30H,14-15,17-19H2,1-3H3,(H,31,32)/t20-,25-/m1/s1
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n/an/a 24n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at human CaSR expressed in rat PC12h cells by reporter gene assay

ACS Med Chem Lett 2: 238-242 (2011)


Article DOI: 10.1021/ml100268k
BindingDB Entry DOI: 10.7270/Q21R6QT7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50503517
PNG
(CHEMBL4522333)
Show SMILES CCc1ccc(COc2ccc(cc2OC)C2CN(C2)C(=O)c2ccc(OCCO)cn2)cc1
Show InChI InChI=1S/C27H30N2O5/c1-3-19-4-6-20(7-5-19)18-34-25-11-8-21(14-26(25)32-2)22-16-29(17-22)27(31)24-10-9-23(15-28-24)33-13-12-30/h4-11,14-15,22,30H,3,12-13,16-18H2,1-2H3
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n/an/a 25n/an/an/an/an/an/a



Central Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...

Bioorg Med Chem Lett 29: 115-118 (2019)


Article DOI: 10.1016/j.bmcl.2018.10.051
BindingDB Entry DOI: 10.7270/Q2RN3C4G
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM50532192
PNG
(CHEMBL4451717)
Show SMILES COc1cc(ccc1OCc1ccc(cc1)C1CC1)C1CN(C1)C(=O)c1cc(COCC(CO)(CO)CO)ccn1
Show InChI InChI=1S/C32H38N2O7/c1-39-30-13-26(8-9-29(30)41-17-22-2-4-24(5-3-22)25-6-7-25)27-14-34(15-27)31(38)28-12-23(10-11-33-28)16-40-21-32(18-35,19-36)20-37/h2-5,8-13,25,27,35-37H,6-7,14-21H2,1H3
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n/an/a 28n/an/an/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of CSF1R in CSF1-induced DBA/1J mouse BMMC assessed as reduction in LPS-induced IL6 production preincubated for overnight followed by LPS-...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50532191
PNG
(CHEMBL4543802)
Show SMILES COc1cc(ccc1OCc1ccc(cc1)C1CC1)C1CN(C1)C(=O)c1cc(OCCCC(O)=O)ccn1
Show InChI InChI=1S/C30H32N2O6/c1-36-28-15-23(10-11-27(28)38-19-20-4-6-21(7-5-20)22-8-9-22)24-17-32(18-24)30(35)26-16-25(12-13-31-26)37-14-2-3-29(33)34/h4-7,10-13,15-16,22,24H,2-3,8-9,14,17-19H2,1H3,(H,33,34)
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n/an/a 29n/an/an/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM50532193
PNG
(CHEMBL4539279)
Show SMILES CCc1ccc(COc2ccc(cc2OC)C2CN(C2)C(=O)c2cc(OCCN3C[C@@H](O)[C@H](O)C3)ccn2)cc1 |r|
Show InChI InChI=1S/C31H37N3O6/c1-3-21-4-6-22(7-5-21)20-40-29-9-8-23(14-30(29)38-2)24-16-34(17-24)31(37)26-15-25(10-11-32-26)39-13-12-33-18-27(35)28(36)19-33/h4-11,14-15,24,27-28,35-36H,3,12-13,16-20H2,1-2H3/t27-,28-/m1/s1
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Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of CSF1R in CSF1-induced DBA/1J mouse BMMC assessed as reduction in LPS-induced IL6 production preincubated for overnight followed by LPS-...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM50532180
PNG
(CHEMBL4473704)
Show SMILES COc1cc(ccc1OCc1ccc(cc1)C1CC1)C1CN(C1)C(=O)c1cc(OCCN2CCOCC2)ccn1
Show InChI InChI=1S/C32H37N3O5/c1-37-31-18-26(8-9-30(31)40-22-23-2-4-24(5-3-23)25-6-7-25)27-20-35(21-27)32(36)29-19-28(10-11-33-29)39-17-14-34-12-15-38-16-13-34/h2-5,8-11,18-19,25,27H,6-7,12-17,20-22H2,1H3
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n/an/a 30n/an/an/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of CSF1R in CSF1-induced DBA/1J mouse BMMC assessed as reduction in LPS-induced IL6 production preincubated for overnight followed by LPS-...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM50532194
PNG
(CHEMBL4575001)
Show SMILES COc1cc(ccc1OCc1ccc(cc1)C1CC1)C1CN(C1)C(=O)c1cc(OCCO)ccn1
Show InChI InChI=1S/C28H30N2O5/c1-33-27-14-22(8-9-26(27)35-18-19-2-4-20(5-3-19)21-6-7-21)23-16-30(17-23)28(32)25-15-24(10-11-29-25)34-13-12-31/h2-5,8-11,14-15,21,23,31H,6-7,12-13,16-18H2,1H3
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Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of CSF1R in CSF1-induced DBA/1J mouse BMMC assessed as reduction in LPS-induced IL6 production preincubated for overnight followed by LPS-...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM50532184
PNG
(CHEMBL4526802)
Show SMILES CCc1ccc(COc2ccc(cc2OC)C2CN(C2)C(=O)c2cc(COCC(CO)(CO)CO)ccn2)cc1
Show InChI InChI=1S/C31H38N2O7/c1-3-22-4-6-23(7-5-22)17-40-28-9-8-25(13-29(28)38-2)26-14-33(15-26)30(37)27-12-24(10-11-32-27)16-39-21-31(18-34,19-35)20-36/h4-13,26,34-36H,3,14-21H2,1-2H3
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Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of CSF1R in CSF1-induced DBA/1J mouse BMMC assessed as reduction in LPS-induced IL6 production preincubated for overnight followed by LPS-...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM50532189
PNG
(CHEMBL4547269)
Show SMILES COc1ccc(COc2ccc(cc2OC)C2CN(C2)C(=O)c2cc(OCCN3CCN(C)CC3)ccn2)cc1
Show InChI InChI=1S/C31H38N4O5/c1-33-12-14-34(15-13-33)16-17-39-27-10-11-32-28(19-27)31(36)35-20-25(21-35)24-6-9-29(30(18-24)38-3)40-22-23-4-7-26(37-2)8-5-23/h4-11,18-19,25H,12-17,20-22H2,1-3H3
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Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of CSF1R in CSF1-induced DBA/1J mouse BMMC assessed as reduction in LPS-induced IL6 production preincubated for overnight followed by LPS-...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM50532196
PNG
(CHEMBL4586087)
Show SMILES CCc1ccc(COc2ccc(cc2OC)C2CN(C2)C(=O)c2cc(OCCN3CCN(C)CC3)ccn2)cc1
Show InChI InChI=1S/C32H40N4O4/c1-4-24-5-7-25(8-6-24)23-40-30-10-9-26(19-31(30)38-3)27-21-36(22-27)32(37)29-20-28(11-12-33-29)39-18-17-35-15-13-34(2)14-16-35/h5-12,19-20,27H,4,13-18,21-23H2,1-3H3
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Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of CSF1R in CSF1-induced DBA/1J mouse BMMC assessed as reduction in LPS-induced IL6 production preincubated for overnight followed by LPS-...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM50532178
PNG
(CHEMBL4460662)
Show SMILES CCc1ccc(COc2ccc(cc2OC)C2CN(C2)C(=O)c2cc(OCCN3C[C@H](O)[C@H](O)C3)ccn2)cc1 |r|
Show InChI InChI=1S/C31H37N3O6/c1-3-21-4-6-22(7-5-21)20-40-29-9-8-23(14-30(29)38-2)24-16-34(17-24)31(37)26-15-25(10-11-32-26)39-13-12-33-18-27(35)28(36)19-33/h4-11,14-15,24,27-28,35-36H,3,12-13,16-20H2,1-2H3/t27-,28+
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Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of CSF1R in CSF1-induced DBA/1J mouse BMMC assessed as reduction in LPS-induced IL6 production preincubated for overnight followed by LPS-...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50503520
PNG
(CHEMBL4532484)
Show SMILES CCc1ccc(COc2ccc(cc2OC)C2CN(C2)C(=O)c2cc(C)ccn2)cc1
Show InChI InChI=1S/C26H28N2O3/c1-4-19-5-7-20(8-6-19)17-31-24-10-9-21(14-25(24)30-3)22-15-28(16-22)26(29)23-13-18(2)11-12-27-23/h5-14,22H,4,15-17H2,1-3H3
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n/an/a 41n/an/an/an/an/an/a



Central Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...

Bioorg Med Chem Lett 29: 115-118 (2019)


Article DOI: 10.1016/j.bmcl.2018.10.051
BindingDB Entry DOI: 10.7270/Q2RN3C4G
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM50532186
PNG
(CHEMBL4526056)
Show SMILES COc1cc(ccc1OCc1ccc(cc1)C1CC1)C1CN(C1)C(=O)c1cc(OC[C@H](O)CO)ccn1 |r|
Show InChI InChI=1S/C29H32N2O6/c1-35-28-12-22(8-9-27(28)37-17-19-2-4-20(5-3-19)21-6-7-21)23-14-31(15-23)29(34)26-13-25(10-11-30-26)36-18-24(33)16-32/h2-5,8-13,21,23-24,32-33H,6-7,14-18H2,1H3/t24-/m1/s1
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Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of CSF1R in CSF1-induced DBA/1J mouse BMMC assessed as reduction in LPS-induced IL6 production preincubated for overnight followed by LPS-...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM50532183
PNG
(CHEMBL4543929)
Show SMILES COc1ccc(COc2ccc(cc2OC)C2CN(C2)C(=O)c2cc(OCCO)ccn2)cc1
Show InChI InChI=1S/C26H28N2O6/c1-31-21-6-3-18(4-7-21)17-34-24-8-5-19(13-25(24)32-2)20-15-28(16-20)26(30)23-14-22(9-10-27-23)33-12-11-29/h3-10,13-14,20,29H,11-12,15-17H2,1-2H3
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Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of CSF1R in CSF1-induced DBA/1J mouse BMMC assessed as reduction in LPS-induced IL6 production preincubated for overnight followed by LPS-...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM50532179
PNG
(CHEMBL4455662)
Show SMILES CCc1ccc(COc2ccc(cc2OC)C2CN(C2)C(=O)c2cc(COC[C@@H](O)CO)ccn2)cc1 |r|
Show InChI InChI=1S/C29H34N2O6/c1-3-20-4-6-21(7-5-20)18-37-27-9-8-23(13-28(27)35-2)24-14-31(15-24)29(34)26-12-22(10-11-30-26)17-36-19-25(33)16-32/h4-13,24-25,32-33H,3,14-19H2,1-2H3/t25-/m0/s1
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Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of CSF1R in CSF1-induced DBA/1J mouse BMMC assessed as reduction in LPS-induced IL6 production preincubated for overnight followed by LPS-...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50532196
PNG
(CHEMBL4586087)
Show SMILES CCc1ccc(COc2ccc(cc2OC)C2CN(C2)C(=O)c2cc(OCCN3CCN(C)CC3)ccn2)cc1
Show InChI InChI=1S/C32H40N4O4/c1-4-24-5-7-25(8-6-24)23-40-30-10-9-26(19-31(30)38-3)27-21-36(22-27)32(37)29-20-28(11-12-33-29)39-18-17-35-15-13-34(2)14-16-35/h5-12,19-20,27H,4,13-18,21-23H2,1-3H3
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n/an/a 53n/an/an/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM50532187
PNG
(CHEMBL4574414)
Show SMILES CCc1ccc(COc2ccc(cc2OC)C2CN(C2)C(=O)c2cc(OCCN3CCNC(=O)C3)ccn2)cc1
Show InChI InChI=1S/C31H36N4O5/c1-3-22-4-6-23(7-5-22)21-40-28-9-8-24(16-29(28)38-2)25-18-35(19-25)31(37)27-17-26(10-11-32-27)39-15-14-34-13-12-33-30(36)20-34/h4-11,16-17,25H,3,12-15,18-21H2,1-2H3,(H,33,36)
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Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of CSF1R in CSF1-induced DBA/1J mouse BMMC assessed as reduction in LPS-induced IL6 production preincubated for overnight followed by LPS-...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Mus musculus (Mouse))		BDBM50532190
PNG
(CHEMBL4452717)
Show SMILES COc1cc(ccc1OCc1ccc(cc1)C1CC1)C1CN(C1)C(=O)c1cc(OCCN2CCN(C)CC2)ccn1
Show InChI InChI=1S/C33H40N4O4/c1-35-13-15-36(16-14-35)17-18-40-29-11-12-34-30(20-29)33(38)37-21-28(22-37)27-9-10-31(32(19-27)39-2)41-23-24-3-5-25(6-4-24)26-7-8-26/h3-6,9-12,19-20,26,28H,7-8,13-18,21-23H2,1-2H3
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Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of CSF1R in CSF1-induced DBA/1J mouse BMMC assessed as reduction in LPS-induced IL6 production preincubated for overnight followed by LPS-...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50503525
PNG
(CHEMBL4467529)
Show SMILES CCc1ccc(COc2ccc(cc2OC)C2CN(C2)C(=O)c2ccccn2)cc1
Show InChI InChI=1S/C25H26N2O3/c1-3-18-7-9-19(10-8-18)17-30-23-12-11-20(14-24(23)29-2)21-15-27(16-21)25(28)22-6-4-5-13-26-22/h4-14,21H,3,15-17H2,1-2H3
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Central Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...

Bioorg Med Chem Lett 29: 115-118 (2019)


Article DOI: 10.1016/j.bmcl.2018.10.051
BindingDB Entry DOI: 10.7270/Q2RN3C4G
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50532182
PNG
(CHEMBL4472513)
Show SMILES COc1cc(ccc1OCc1ccc(cc1)C1CC1)C1CN(C1)C(=O)c1cc(OCCCC(C)(C)C(O)=O)ccn1
Show InChI InChI=1S/C33H38N2O6/c1-33(2,32(37)38)14-4-16-40-27-13-15-34-28(18-27)31(36)35-19-26(20-35)25-11-12-29(30(17-25)39-3)41-21-22-5-7-23(8-6-22)24-9-10-24/h5-8,11-13,15,17-18,24,26H,4,9-10,14,16,19-21H2,1-3H3,(H,37,38)
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n/an/a 64n/an/an/an/an/an/a



Japan Tobacco Inc.

Curated by ChEMBL


Assay Description
Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...

Bioorg Med Chem Lett 29: 873-877 (2019)


Article DOI: 10.1016/j.bmcl.2019.02.006
BindingDB Entry DOI: 10.7270/Q22F7RXK
More data for this
Ligand-Target Pair
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