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Compile Data Set for Download or QSAR

Found 132 hits with Last Name = 'joo' and Initial = 'jh'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
NADPH oxidase 1


(Homo sapiens (Human))		BDBM50190499
PNG
(CHEMBL3827985)
Show SMILES CN(C)c1ccc(\C=C2/N(C)C(=S)N(C2=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C19H18ClN3OS/c1-21(2)15-9-7-13(8-10-15)11-17-18(24)23(19(25)22(17)3)16-6-4-5-14(20)12-16/h4-12H,1-3H3/b17-11-
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 350n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX1 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens (Human))		BDBM50190499
PNG
(CHEMBL3827985)
Show SMILES CN(C)c1ccc(\C=C2/N(C)C(=S)N(C2=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C19H18ClN3OS/c1-21(2)15-9-7-13(8-10-15)11-17-18(24)23(19(25)22(17)3)16-6-4-5-14(20)12-16/h4-12H,1-3H3/b17-11-
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 840n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens (Human))		BDBM50190343
PNG
(CHEMBL3827795)
Show SMILES CN(C)c1ccc(\C=C2/N(C)C(=S)N(C2=O)c2ccccc2)cc1
Show InChI InChI=1S/C19H19N3OS/c1-20(2)15-11-9-14(10-12-15)13-17-18(23)22(19(24)21(17)3)16-7-5-4-6-8-16/h4-13H,1-3H3/b17-13-
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 880n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 1


(Homo sapiens (Human))		BDBM50190331
PNG
(CHEMBL3828176)
Show SMILES CN(C)c1ccc(\C=C2/N(C)C(=S)N(C2=O)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C20H21N3OS/c1-14-5-9-17(10-6-14)23-19(24)18(22(4)20(23)25)13-15-7-11-16(12-8-15)21(2)3/h5-13H,1-4H3/b18-13-
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 1.02E+3n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX1 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 1


(Homo sapiens (Human))		BDBM50190390
PNG
(CHEMBL3828444)
Show SMILES Oc1cc(nn1-c1ccccn1)-c1ccccc1
Show InChI InChI=1S/C14H11N3O/c18-14-10-12(11-6-2-1-3-7-11)16-17(14)13-8-4-5-9-15-13/h1-10,18H
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 1.45E+3n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX1 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 1


(Homo sapiens (Human))		BDBM50190343
PNG
(CHEMBL3827795)
Show SMILES CN(C)c1ccc(\C=C2/N(C)C(=S)N(C2=O)c2ccccc2)cc1
Show InChI InChI=1S/C19H19N3OS/c1-20(2)15-11-9-14(10-12-15)13-17-18(23)22(19(24)21(17)3)16-7-5-4-6-8-16/h4-13H,1-3H3/b17-13-
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 1.95E+3n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX1 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens (Human))		BDBM50190331
PNG
(CHEMBL3828176)
Show SMILES CN(C)c1ccc(\C=C2/N(C)C(=S)N(C2=O)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C20H21N3OS/c1-14-5-9-17(10-6-14)23-19(24)18(22(4)20(23)25)13-15-7-11-16(12-8-15)21(2)3/h5-13H,1-4H3/b18-13-
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 2.33E+3n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens (Human))		BDBM50190497
PNG
(CHEMBL3827227)
Show SMILES CN1C(=S)N(C(=O)\C1=C\c1cccc(O)c1O)c1ccc2CCCc2c1
Show InChI InChI=1S/C20H18N2O3S/c1-21-16(11-14-6-3-7-17(23)18(14)24)19(25)22(20(21)26)15-9-8-12-4-2-5-13(12)10-15/h3,6-11,23-24H,2,4-5H2,1H3/b16-11-
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 2.36E+3n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens (Human))		BDBM50190330
PNG
(CHEMBL3828737)
Show SMILES CCc1ccc(cc1)N1C(=O)\C(=C\c2ccc(O)cc2O)N(C)C1=S
Show InChI InChI=1S/C19H18N2O3S/c1-3-12-4-7-14(8-5-12)21-18(24)16(20(2)19(21)25)10-13-6-9-15(22)11-17(13)23/h4-11,22-23H,3H2,1-2H3/b16-10-
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 2.39E+3n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens (Human))		BDBM50190328
PNG
(CHEMBL3827342)
Show SMILES CCc1ccc(cc1)N1C(=S)N(C)\C(=C/c2ccc(cc2)N(C)C)C1=O
Show InChI InChI=1S/C21H23N3OS/c1-5-15-6-12-18(13-7-15)24-20(25)19(23(4)21(24)26)14-16-8-10-17(11-9-16)22(2)3/h6-14H,5H2,1-4H3/b19-14-
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 2.63E+3n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens (Human))		BDBM50190390
PNG
(CHEMBL3828444)
Show SMILES Oc1cc(nn1-c1ccccn1)-c1ccccc1
Show InChI InChI=1S/C14H11N3O/c18-14-10-12(11-6-2-1-3-7-11)16-17(14)13-8-4-5-9-15-13/h1-10,18H
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 3.12E+3n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 1


(Homo sapiens (Human))		BDBM50190328
PNG
(CHEMBL3827342)
Show SMILES CCc1ccc(cc1)N1C(=S)N(C)\C(=C/c2ccc(cc2)N(C)C)C1=O
Show InChI InChI=1S/C21H23N3OS/c1-5-15-6-12-18(13-7-15)24-20(25)19(23(4)21(24)26)14-16-8-10-17(11-9-16)22(2)3/h6-14H,5H2,1-4H3/b19-14-
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 4.39E+3n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX1 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens (Human))		BDBM50190347
PNG
(CHEMBL3827481)
Show SMILES CN1C(=S)N(C2CCCCC2)C(=O)\C1=C\c1cccc(O)c1O
Show InChI InChI=1S/C17H20N2O3S/c1-18-13(10-11-6-5-9-14(20)15(11)21)16(22)19(17(18)23)12-7-3-2-4-8-12/h5-6,9-10,12,20-21H,2-4,7-8H2,1H3/b13-10-
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 6.35E+3n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 1


(Homo sapiens (Human))		BDBM50190498
PNG
(CHEMBL3827096)
Show SMILES CN1C(=S)N(C(=O)\C1=C\c1ccc(O)cc1O)c1ccc2CCCc2c1
Show InChI InChI=1S/C20H18N2O3S/c1-21-17(10-14-6-8-16(23)11-18(14)24)19(25)22(20(21)26)15-7-5-12-3-2-4-13(12)9-15/h5-11,23-24H,2-4H2,1H3/b17-10-
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 6.58E+3n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX1 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 1


(Homo sapiens (Human))		BDBM50190497
PNG
(CHEMBL3827227)
Show SMILES CN1C(=S)N(C(=O)\C1=C\c1cccc(O)c1O)c1ccc2CCCc2c1
Show InChI InChI=1S/C20H18N2O3S/c1-21-16(11-14-6-3-7-17(23)18(14)24)19(25)22(20(21)26)15-9-8-12-4-2-5-13(12)10-15/h3,6-11,23-24H,2,4-5H2,1H3/b16-11-
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 6.63E+3n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX1 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens (Human))		BDBM50190498
PNG
(CHEMBL3827096)
Show SMILES CN1C(=S)N(C(=O)\C1=C\c1ccc(O)cc1O)c1ccc2CCCc2c1
Show InChI InChI=1S/C20H18N2O3S/c1-21-17(10-14-6-8-16(23)11-18(14)24)19(25)22(20(21)26)15-7-5-12-3-2-4-13(12)9-15/h5-11,23-24H,2-4H2,1H3/b17-10-
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 6.83E+3n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 1


(Homo sapiens (Human))		BDBM50190347
PNG
(CHEMBL3827481)
Show SMILES CN1C(=S)N(C2CCCCC2)C(=O)\C1=C\c1cccc(O)c1O
Show InChI InChI=1S/C17H20N2O3S/c1-18-13(10-11-6-5-9-14(20)15(11)21)16(22)19(17(18)23)12-7-3-2-4-8-12/h5-6,9-10,12,20-21H,2-4,7-8H2,1H3/b13-10-
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 7.39E+3n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX1 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 1


(Homo sapiens (Human))		BDBM50190503
PNG
(CHEMBL3827569)
Show SMILES CN1C(=S)N(C(=O)\C1=C\c1cccc(O)c1O)c1cccc(Cl)c1
Show InChI InChI=1S/C17H13ClN2O3S/c1-19-13(8-10-4-2-7-14(21)15(10)22)16(23)20(17(19)24)12-6-3-5-11(18)9-12/h2-9,21-22H,1H3/b13-8-
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 7.65E+3n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX1 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 1


(Homo sapiens (Human))		BDBM50190391
PNG
(CHEMBL3826995)
Show SMILES CN(C)c1ccc(\C=C2/N(C)C(=S)N(C2=O)c2ccc3CCCc3c2)cc1
Show InChI InChI=1S/C22H23N3OS/c1-23(2)18-10-7-15(8-11-18)13-20-21(26)25(22(27)24(20)3)19-12-9-16-5-4-6-17(16)14-19/h7-14H,4-6H2,1-3H3/b20-13-
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 8.04E+3n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX1 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 1


(Homo sapiens (Human))		BDBM50190330
PNG
(CHEMBL3828737)
Show SMILES CCc1ccc(cc1)N1C(=O)\C(=C\c2ccc(O)cc2O)N(C)C1=S
Show InChI InChI=1S/C19H18N2O3S/c1-3-12-4-7-14(8-5-12)21-18(24)16(20(2)19(21)25)10-13-6-9-15(22)11-17(13)23/h4-11,22-23H,3H2,1-2H3/b16-10-
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 8.40E+3n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX1 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens (Human))		BDBM50190503
PNG
(CHEMBL3827569)
Show SMILES CN1C(=S)N(C(=O)\C1=C\c1cccc(O)c1O)c1cccc(Cl)c1
Show InChI InChI=1S/C17H13ClN2O3S/c1-19-13(8-10-4-2-7-14(21)15(10)22)16(23)20(17(19)24)12-6-3-5-11(18)9-12/h2-9,21-22H,1H3/b13-8-
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 9.31E+3n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 1


(Homo sapiens (Human))		BDBM50190346
PNG
(CHEMBL3827497)
Show SMILES CN(C)c1ccc(\C=C2/N(C)C(=S)N(C3CCCCC3)C2=O)cc1
Show InChI InChI=1S/C19H25N3OS/c1-20(2)15-11-9-14(10-12-15)13-17-18(23)22(19(24)21(17)3)16-7-5-4-6-8-16/h9-13,16H,4-8H2,1-3H3/b17-13-
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 1.23E+4n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX1 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens (Human))		BDBM50190391
PNG
(CHEMBL3826995)
Show SMILES CN(C)c1ccc(\C=C2/N(C)C(=S)N(C2=O)c2ccc3CCCc3c2)cc1
Show InChI InChI=1S/C22H23N3OS/c1-23(2)18-10-7-15(8-11-18)13-20-21(26)25(22(27)24(20)3)19-12-9-16-5-4-6-17(16)14-19/h7-14H,4-6H2,1-3H3/b20-13-
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PubMed
 1.31E+4n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens (Human))		BDBM50190344
PNG
(CHEMBL3828498)
Show SMILES CN1C(=S)N(C(=O)\C1=C\c1cccc(O)c1O)c1ccccc1
Show InChI InChI=1S/C17H14N2O3S/c1-18-13(10-11-6-5-9-14(20)15(11)21)16(22)19(17(18)23)12-7-3-2-4-8-12/h2-10,20-21H,1H3/b13-10-
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 2.40E+4n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 1


(Homo sapiens (Human))		BDBM50190348
PNG
(CHEMBL3827421)
Show SMILES CN1C(=S)N(C2CCCCC2)C(=O)\C1=C\c1ccc(O)cc1O
Show InChI InChI=1S/C17H20N2O3S/c1-18-14(9-11-7-8-13(20)10-15(11)21)16(22)19(17(18)23)12-5-3-2-4-6-12/h7-10,12,20-21H,2-6H2,1H3/b14-9-
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 2.60E+4n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX1 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens (Human))		BDBM50190329
PNG
(CHEMBL3827065)
Show SMILES CCc1ccc(cc1)N1C(=O)\C(=C\c2cccc(O)c2O)N(C)C1=S
Show InChI InChI=1S/C19H18N2O3S/c1-3-12-7-9-14(10-8-12)21-18(24)15(20(2)19(21)25)11-13-5-4-6-16(22)17(13)23/h4-11,22-23H,3H2,1-2H3/b15-11-
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 2.64E+4n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens (Human))		BDBM50190341
PNG
(CHEMBL3827688)
Show SMILES CN1C(=S)N(C(=O)\C1=C\c1cccc(O)c1O)c1ccc(C)cc1
Show InChI InChI=1S/C18H16N2O3S/c1-11-6-8-13(9-7-11)20-17(23)14(19(2)18(20)24)10-12-4-3-5-15(21)16(12)22/h3-10,21-22H,1-2H3/b14-10-
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 2.70E+4n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 1


(Homo sapiens (Human))		BDBM50190342
PNG
(CHEMBL3828713)
Show SMILES CN1C(=S)N(C(=O)\C1=C\c1ccc(O)cc1O)c1ccc(C)cc1
Show InChI InChI=1S/C18H16N2O3S/c1-11-3-6-13(7-4-11)20-17(23)15(19(2)18(20)24)9-12-5-8-14(21)10-16(12)22/h3-10,21-22H,1-2H3/b15-9-
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 2.71E+4n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX1 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens (Human))		BDBM50190345
PNG
(CHEMBL3827574)
Show SMILES CN1C(=S)N(C(=O)\C1=C\c1ccc(O)cc1O)c1ccccc1
Show InChI InChI=1S/C17H14N2O3S/c1-18-14(9-11-7-8-13(20)10-15(11)21)16(22)19(17(18)23)12-5-3-2-4-6-12/h2-10,20-21H,1H3/b14-9-
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 2.77E+4n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 1


(Homo sapiens (Human))		BDBM50190329
PNG
(CHEMBL3827065)
Show SMILES CCc1ccc(cc1)N1C(=O)\C(=C\c2cccc(O)c2O)N(C)C1=S
Show InChI InChI=1S/C19H18N2O3S/c1-3-12-7-9-14(10-8-12)21-18(24)15(20(2)19(21)25)11-13-5-4-6-16(22)17(13)23/h4-11,22-23H,3H2,1-2H3/b15-11-
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 2.79E+4n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX1 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens (Human))		BDBM50190327
PNG
(CHEMBL3828285)
Show SMILES CN1C(=S)N(C(=O)\C1=C\c1ccc(O)cc1O)c1cccc(Cl)c1
Show InChI InChI=1S/C17H13ClN2O3S/c1-19-14(7-10-5-6-13(21)9-15(10)22)16(23)20(17(19)24)12-4-2-3-11(18)8-12/h2-9,21-22H,1H3/b14-7-
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 3.38E+4n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 1


(Homo sapiens (Human))		BDBM50190345
PNG
(CHEMBL3827574)
Show SMILES CN1C(=S)N(C(=O)\C1=C\c1ccc(O)cc1O)c1ccccc1
Show InChI InChI=1S/C17H14N2O3S/c1-18-14(9-11-7-8-13(20)10-15(11)21)16(22)19(17(18)23)12-5-3-2-4-6-12/h2-10,20-21H,1H3/b14-9-
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 3.38E+4n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX1 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 1


(Homo sapiens (Human))		BDBM50190327
PNG
(CHEMBL3828285)
Show SMILES CN1C(=S)N(C(=O)\C1=C\c1ccc(O)cc1O)c1cccc(Cl)c1
Show InChI InChI=1S/C17H13ClN2O3S/c1-19-14(7-10-5-6-13(21)9-15(10)22)16(23)20(17(19)24)12-4-2-3-11(18)8-12/h2-9,21-22H,1H3/b14-7-
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 3.45E+4n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX1 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens (Human))		BDBM50190342
PNG
(CHEMBL3828713)
Show SMILES CN1C(=S)N(C(=O)\C1=C\c1ccc(O)cc1O)c1ccc(C)cc1
Show InChI InChI=1S/C18H16N2O3S/c1-11-3-6-13(7-4-11)20-17(23)15(19(2)18(20)24)9-12-5-8-14(21)10-16(12)22/h3-10,21-22H,1-2H3/b15-9-
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 3.46E+4n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens (Human))		BDBM50190346
PNG
(CHEMBL3827497)
Show SMILES CN(C)c1ccc(\C=C2/N(C)C(=S)N(C3CCCCC3)C2=O)cc1
Show InChI InChI=1S/C19H25N3OS/c1-20(2)15-11-9-14(10-12-15)13-17-18(23)22(19(24)21(17)3)16-7-5-4-6-8-16/h9-13,16H,4-8H2,1-3H3/b17-13-
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 3.56E+4n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens (Human))		BDBM50190348
PNG
(CHEMBL3827421)
Show SMILES CN1C(=S)N(C2CCCCC2)C(=O)\C1=C\c1ccc(O)cc1O
Show InChI InChI=1S/C17H20N2O3S/c1-18-14(9-11-7-8-13(20)10-15(11)21)16(22)19(17(18)23)12-5-3-2-4-6-12/h7-10,12,20-21H,2-6H2,1H3/b14-9-
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 3.76E+4n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 1


(Homo sapiens (Human))		BDBM50190344
PNG
(CHEMBL3828498)
Show SMILES CN1C(=S)N(C(=O)\C1=C\c1cccc(O)c1O)c1ccccc1
Show InChI InChI=1S/C17H14N2O3S/c1-18-13(10-11-6-5-9-14(20)15(11)21)16(22)19(17(18)23)12-7-3-2-4-8-12/h2-10,20-21H,1H3/b13-10-
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 4.97E+4n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX1 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
NADPH oxidase 1


(Homo sapiens (Human))		BDBM50190341
PNG
(CHEMBL3827688)
Show SMILES CN1C(=S)N(C(=O)\C1=C\c1cccc(O)c1O)c1ccc(C)cc1
Show InChI InChI=1S/C18H16N2O3S/c1-11-6-8-13(9-7-11)20-17(23)14(19(2)18(20)24)10-12-4-3-5-15(21)16(12)22/h3-10,21-22H,1-2H3/b14-10-
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 5.03E+4n/an/an/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of human NOX1 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay

Bioorg Med Chem 24: 4144-4151 (2016)


Article DOI: 10.1016/j.bmc.2016.06.056
BindingDB Entry DOI: 10.7270/Q2XK8HHT
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473585
PNG
(US10844062, Example 21)
Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]cnc23)ccc1F
Show InChI InChI=1S/C27H21FN8O/c1-27(2,13-29)17-6-3-5-16(11-17)26(37)36-21-12-18(8-9-20(21)28)35-24-19(7-4-10-30-24)22-23-25(33-14-31-22)34-15-32-23/h3-12,14-15H,1-2H3,(H,30,35)(H,36,37)(H,31,32,33,34)
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US Patent
n/an/a 4.10n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473613
PNG
(US10844062, Example 49)
Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1
Show InChI InChI=1S/C27H21FN8O/c1-27(2,13-29)17-6-3-5-16(11-17)26(37)35-18-8-9-20(28)21(12-18)36-24-19(7-4-10-30-24)22-23-25(33-14-31-22)34-15-32-23/h3-12,14-15H,1-2H3,(H,30,36)(H,35,37)(H,31,32,33,34)
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n/an/a 10n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473640
PNG
(US10844062, Example 76)
Show SMILES Fc1ccc(Nc2ncccc2-c2ncnc3[nH]cnc23)cc1NC(=O)Cc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H17F4N7O/c26-18-7-6-16(11-19(18)36-20(37)10-14-3-1-4-15(9-14)25(27,28)29)35-23-17(5-2-8-30-23)21-22-24(33-12-31-21)34-13-32-22/h1-9,11-13H,10H2,(H,30,35)(H,36,37)(H,31,32,33,34)
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n/an/a 11n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473594
PNG
(US10844062, Example 30)
Show SMILES Fc1ccc(Nc2ncccc2-c2ncnc3[nH]cnc23)cc1NC(=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H15F4N7O/c25-17-7-6-15(10-18(17)35-23(36)13-3-1-4-14(9-13)24(26,27)28)34-21-16(5-2-8-29-21)19-20-22(32-11-30-19)33-12-31-20/h1-12H,(H,29,34)(H,35,36)(H,30,31,32,33)
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n/an/a 11n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473190
PNG
(US10844062, Example 1)
Show SMILES Fc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C24H14F5N7O/c25-15-6-7-16(35-23(37)12-3-1-4-13(9-12)24(27,28)29)17(26)19(15)36-21-14(5-2-8-30-21)18-20-22(33-10-31-18)34-11-32-20/h1-11H,(H,30,36)(H,35,37)(H,31,32,33,34)
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n/an/a 11n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473600
PNG
(US10844062, Example 36)
Show SMILES Fc1cc(cc(c1)C(F)(F)F)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]cnc23)ccc1F
Show InChI InChI=1S/C24H14F5N7O/c25-14-7-12(6-13(8-14)24(27,28)29)23(37)36-18-9-15(3-4-17(18)26)35-21-16(2-1-5-30-21)19-20-22(33-10-31-19)34-11-32-20/h1-11H,(H,30,35)(H,36,37)(H,31,32,33,34)
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n/an/a 12n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473593
PNG
(US10844062, Example 29)
Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1cccc(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C27H21FN8O/c1-27(2,13-29)17-7-3-6-16(12-17)26(37)36-20-10-4-9-19(21(20)28)35-24-18(8-5-11-30-24)22-23-25(33-14-31-22)34-15-32-23/h3-12,14-15H,1-2H3,(H,30,35)(H,36,37)(H,31,32,33,34)
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n/an/a 12n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473573
PNG
(US10844062, Example 9)
Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C27H20F2N8O/c1-27(2,12-30)16-6-3-5-15(11-16)26(38)36-19-9-8-18(28)22(20(19)29)37-24-17(7-4-10-31-24)21-23-25(34-13-32-21)35-14-33-23/h3-11,13-14H,1-2H3,(H,31,37)(H,36,38)(H,32,33,34,35)
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n/an/a 12n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473587
PNG
(US10844062, Example 23)
Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1cccc(Nc2ncccc2-c2ncnc3[nH]cnc23)c1
Show InChI InChI=1S/C27H22N8O/c1-27(2,14-28)18-7-3-6-17(12-18)26(36)35-20-9-4-8-19(13-20)34-24-21(10-5-11-29-24)22-23-25(32-15-30-22)33-16-31-23/h3-13,15-16H,1-2H3,(H,29,34)(H,35,36)(H,30,31,32,33)
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n/an/a 14n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473648
PNG
(US10844062, Example 84)
Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]ccc23)c(F)cc1F
Show InChI InChI=1S/C28H21F2N7O/c1-28(2,14-31)17-6-3-5-16(11-17)27(38)37-23-13-22(20(29)12-21(23)30)36-26-18(7-4-9-32-26)24-19-8-10-33-25(19)35-15-34-24/h3-13,15H,1-2H3,(H,32,36)(H,37,38)(H,33,34,35)
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n/an/a 21n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473629
PNG
(US10844062, Example 65)
Show SMILES Fc1ccc(Nc2ncccc2-c2ncnc3[nH]cnc23)cc1NC(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C25H14F7N7O/c26-17-4-3-15(38-21-16(2-1-5-33-21)19-20-22(36-10-34-19)37-11-35-20)9-18(17)39-23(40)12-6-13(24(27,28)29)8-14(7-12)25(30,31)32/h1-11H,(H,33,38)(H,39,40)(H,34,35,36,37)
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n/an/a 21n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473642
PNG
(US10844062, Example 78)
Show SMILES Fc1cc(NC(=O)c2ccc(CC#N)cc2)ccc1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C25H17FN8O/c26-19-12-17(33-25(35)16-5-3-15(4-6-16)9-10-27)7-8-20(19)34-23-18(2-1-11-28-23)21-22-24(31-13-29-21)32-14-30-22/h1-8,11-14H,9H2,(H,28,34)(H,33,35)(H,29,30,31,32)
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n/an/a 28n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
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