| Reaction Details |
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 | Report a problem with these data |
| Target | NADPH oxidase 1 |
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| Ligand | BDBM50190342 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1589207 (CHEMBL3829980) |
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| Ki | 27100±n/a nM |
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| Citation |  Bae, YS; Choi, S; Park, JJ; Joo, JH; Cui, M; Cho, H; Lee, WJ; Lee, SH Synthesis and biological evaluation of 3-substituted 5-benzylidene-1-methyl-2-thiohydantoins as potent NADPH oxidase (NOX) inhibitors. Bioorg Med Chem24:4144-4151 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NADPH oxidase 1 |
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| Name: | NADPH oxidase 1 |
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| Synonyms: | MOX-1 | MOX1 | Mitogenic oxidase 1 | NADH/NADPH mitogenic oxidase subunit P65-MOX | NOH-1 | NOH1 | NOX-1 | NOX1 | NOX1_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 64890.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_792877 |
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| Residue: | 564 |
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| Sequence: | MGNWVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKADKYYYTRKILGSTLACARASALCL
NFNSTLILLPVCRNLLSFLRGTCSFCSRTLRKQLDHNLTFHKLVAYMICLHTAIHIIAHL
FNFDCYSRSRQATDGSLASILSSLSHDEKKGGSWLNPIQSRNTTVEYVTFTSIAGLTGVI
MTIALILMVTSATEFIRRSYFEVFWYTHHLFIFYILGLGIHGIGGIVRGQTEESMNESHP
RKCAESFEMWDDRDSHCRRPKFEGHPPESWKWILAPVILYICERILRFYRSQQKVVITKV
VMHPSKVLELQMNKRGFSMEVGQYIFVNCPSISLLEWHPFTLTSAPEEDFFSIHIRAAGD
WTENLIRAFEQQYSPIPRIEVDGPFGTASEDVFQYEVAVLVGAGIGVTPFASILKSIWYK
FQCADHNLKTKKIYFYWICRETGAFSWFNNLLTSLEQEMEELGKVGFLNYRLFLTGWDSN
IVGHAALNFDKATDIVTGLKQKTSFGRPMWDNEFSTIATSHPKSVVGVFLCGPRTLAKSL
RKCCHRYSSLDPRKVQFYFNKENF
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| BDBM50190342 |
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| n/a |
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| Name | BDBM50190342 |
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| Synonyms: | CHEMBL3828713 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H16N2O3S |
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| Mol. Mass. | 340.396 |
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| SMILES | CN1C(=S)N(C(=O)\C1=C\c1ccc(O)cc1O)c1ccc(C)cc1 |
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| Structure | 
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