Found 272 hits with Last Name = 'kakegawa' and Initial = 'k' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Enteropeptidase
(Homo sapiens (Human)) | BDBM50595346
(CHEMBL5189108)Show SMILES NC(=N)Nc1ccc(C(=O)Oc2ccc(CC(=O)N[C@@H](CC(O)=O)C(O)=O)cc2)c(F)c1 |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.810 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00463
BindingDB Entry DOI: 10.7270/Q208699D |
More data for this
Ligand-Target Pair | |
Enteropeptidase
(Homo sapiens (Human)) | BDBM50595349
(CHEMBL5202756)Show SMILES OC(=O)C(F)(F)F.NC(=N)Nc1ccc(cc1)C(=O)Oc1cccc(c1)C(=O)N[C@@H](CC(O)=O)C(O)=O |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.820 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00463
BindingDB Entry DOI: 10.7270/Q208699D |
More data for this
Ligand-Target Pair | |
Enteropeptidase
(Homo sapiens (Human)) | BDBM50595352
(CHEMBL5175180)Show SMILES NC(=N)Nc1ccc(cc1)C(=O)Oc1cccc(c1)C1=NO[C@@](CC(O)=O)(C1)C(O)=O |r,t:21| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00463
BindingDB Entry DOI: 10.7270/Q208699D |
More data for this
Ligand-Target Pair | |
Enteropeptidase
(Homo sapiens (Human)) | BDBM50595350
(CHEMBL5182597)Show SMILES OC(=O)C(F)(F)F.NC(=N)Nc1ccc(cc1)C(=O)Oc1cccc(CC(=O)N[C@@H](CC(O)=O)C(O)=O)c1 |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00463
BindingDB Entry DOI: 10.7270/Q208699D |
More data for this
Ligand-Target Pair | |
Enteropeptidase
(Homo sapiens (Human)) | BDBM50595353
(CHEMBL5179372)Show SMILES NC(=N)Nc1ccc(cc1)C(=O)Oc1cccc(c1)C1=NO[C@](CC(O)=O)(C1)C(O)=O |r,t:21| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00463
BindingDB Entry DOI: 10.7270/Q208699D |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50149456
(CHEMBL3769702)Show SMILES Cc1c(nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cn12)C1CC1 Show InChI InChI=1S/C20H18F3N3O3/c1-12-19(13-2-3-13)25-17-9-4-14(10-26(12)17)24-18(27)11-28-15-5-7-16(8-6-15)29-20(21,22)23/h4-10,13H,2-3,11H2,1H3,(H,24,27) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis |
J Med Chem 59: 1116-39 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T |
More data for this
Ligand-Target Pair | |
Enteropeptidase
(Homo sapiens (Human)) | BDBM50595351
(CHEMBL5200092)Show SMILES OC(=O)C(F)(F)F.NC(=N)Nc1ccc(cc1)C(=O)Oc1ccc(cc1)C(=O)N[C@@H](CC(O)=O)C(O)=O |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00463
BindingDB Entry DOI: 10.7270/Q208699D |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50149457
(CHEMBL3771335)Show SMILES Cc1nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cn2c1C Show InChI InChI=1S/C18H16F3N3O3/c1-11-12(2)24-9-13(3-8-16(24)22-11)23-17(25)10-26-14-4-6-15(7-5-14)27-18(19,20)21/h3-9H,10H2,1-2H3,(H,23,25) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis |
J Med Chem 59: 1116-39 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 2
(Homo sapiens (Human)) | BDBM50355934
(CHEMBL1910404)Show SMILES CCNC(=O)Nc1sc2ccccc2c1C(=O)N1CCC(CC1)N1CCC[C@]2(CC(C)(C)OC2=O)C1 |r| Show InChI InChI=1S/C27H36N4O4S/c1-4-28-25(34)29-22-21(19-8-5-6-9-20(19)36-22)23(32)30-14-10-18(11-15-30)31-13-7-12-27(17-31)16-26(2,3)35-24(27)33/h5-6,8-9,18H,4,7,10-17H2,1-3H3,(H2,28,29,34)/t27-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human ACC2 |
Bioorg Med Chem Lett 21: 6314-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.117
BindingDB Entry DOI: 10.7270/Q2P84C9P |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Enteropeptidase
(Homo sapiens (Human)) | BDBM50595345
(CHEMBL5182234)Show SMILES NC(=N)Nc1ccc(C(=O)Oc2ccc(CC(=O)N[C@@H](CC(O)=O)C(O)=O)cc2)c(Cl)c1 |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00463
BindingDB Entry DOI: 10.7270/Q208699D |
More data for this
Ligand-Target Pair | |
Enteropeptidase
(Homo sapiens (Human)) | BDBM50595337
(CHEMBL5195621)Show SMILES Cl.NC(=N)Nc1ccc(cc1)C(=O)Oc1ccc(CC(=O)N[C@@H](CC(O)=O)C(O)=O)cc1 |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00463
BindingDB Entry DOI: 10.7270/Q208699D |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50149456
(CHEMBL3769702)Show SMILES Cc1c(nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cn12)C1CC1 Show InChI InChI=1S/C20H18F3N3O3/c1-12-19(13-2-3-13)25-17-9-4-14(10-26(12)17)24-18(27)11-28-15-5-7-16(8-6-15)29-20(21,22)23/h4-10,13H,2-3,11H2,1H3,(H,24,27) | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis |
J Med Chem 59: 1116-39 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50149444
(CHEMBL3770706)Show SMILES Cc1c(nc2ccc(cn12)-n1ccc2oc(cc2c1=O)-c1ccc(Cl)cc1)C1CC1 Show InChI InChI=1S/C24H18ClN3O2/c1-14-23(16-2-3-16)26-22-9-8-18(13-28(14)22)27-11-10-20-19(24(27)29)12-21(30-20)15-4-6-17(25)7-5-15/h4-13,16H,2-3H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis |
J Med Chem 59: 1116-39 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T |
More data for this
Ligand-Target Pair | |
Enteropeptidase
(Homo sapiens (Human)) | BDBM50595346
(CHEMBL5189108)Show SMILES NC(=N)Nc1ccc(C(=O)Oc2ccc(CC(=O)N[C@@H](CC(O)=O)C(O)=O)cc2)c(F)c1 |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00463
BindingDB Entry DOI: 10.7270/Q208699D |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50149462
(CHEMBL3771182)Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2csc(Cl)c2)cc1=O)C1CC1 Show InChI InChI=1S/C21H18ClN3O2S/c1-13-21(15-2-3-15)23-19-5-4-16(10-25(13)19)24-7-6-17(9-20(24)26)27-11-14-8-18(22)28-12-14/h4-10,12,15H,2-3,11H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis |
J Med Chem 59: 1116-39 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50149462
(CHEMBL3771182)Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2csc(Cl)c2)cc1=O)C1CC1 Show InChI InChI=1S/C21H18ClN3O2S/c1-13-21(15-2-3-15)23-19-5-4-16(10-25(13)19)24-7-6-17(9-20(24)26)27-11-14-8-18(22)28-12-14/h4-10,12,15H,2-3,11H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis |
J Med Chem 59: 1116-39 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T |
More data for this
Ligand-Target Pair | |
Enteropeptidase
(Homo sapiens (Human)) | BDBM50595348
(CHEMBL5170585)Show SMILES NC(=N)Nc1ccc(cc1)C(=O)Oc1ccc2[C@@H](CC(=O)N[C@@H](CC(O)=O)C(O)=O)COc2c1 |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00463
BindingDB Entry DOI: 10.7270/Q208699D |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50149457
(CHEMBL3771335)Show SMILES Cc1nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cn2c1C Show InChI InChI=1S/C18H16F3N3O3/c1-11-12(2)24-9-13(3-8-16(24)22-11)23-17(25)10-26-14-4-6-15(7-5-14)27-18(19,20)21/h3-9H,10H2,1-2H3,(H,23,25) | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis |
J Med Chem 59: 1116-39 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T |
More data for this
Ligand-Target Pair | |
Enteropeptidase
(Homo sapiens (Human)) | BDBM50595342
(CHEMBL5170208)Show SMILES OC(=O)C(F)(F)F.NC(=N)Nc1ccc(cc1)C(=O)Oc1ccc(CC(=O)N[C@@H](CCC(O)=O)C(O)=O)cc1 |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00463
BindingDB Entry DOI: 10.7270/Q208699D |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50163480
(CHEMBL3792707)Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2csc(Cl)c2)cc1=O)C1CC1 Show InChI InChI=1S/C21H18ClN3O2S/c1-24-18-9-15(4-5-17(18)23-21(24)14-2-3-14)25-7-6-16(10-20(25)26)27-11-13-8-19(22)28-12-13/h4-10,12,14H,2-3,11H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting |
Bioorg Med Chem 24: 2486-503 (2016)
Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50149443
(CHEMBL3771307)Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccc(Br)cc2)cc1=O)C1CC1 Show InChI InChI=1S/C23H20BrN3O2/c1-15-23(17-4-5-17)25-21-9-8-19(13-27(15)21)26-11-10-20(12-22(26)28)29-14-16-2-6-18(24)7-3-16/h2-3,6-13,17H,4-5,14H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis |
J Med Chem 59: 1116-39 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50149444
(CHEMBL3770706)Show SMILES Cc1c(nc2ccc(cn12)-n1ccc2oc(cc2c1=O)-c1ccc(Cl)cc1)C1CC1 Show InChI InChI=1S/C24H18ClN3O2/c1-14-23(16-2-3-16)26-22-9-8-18(13-28(14)22)27-11-10-20-19(24(27)29)12-21(30-20)15-4-6-17(25)7-5-15/h4-13,16H,2-3H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis |
J Med Chem 59: 1116-39 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50163476
(CHEMBL3792516)Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2ccc(Cl)s2)cc1=O)C1CC1 Show InChI InChI=1S/C21H18ClN3O2S/c1-24-18-10-14(4-6-17(18)23-21(24)13-2-3-13)25-9-8-15(11-20(25)26)27-12-16-5-7-19(22)28-16/h4-11,13H,2-3,12H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting |
Bioorg Med Chem 24: 2486-503 (2016)
Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50149443
(CHEMBL3771307)Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccc(Br)cc2)cc1=O)C1CC1 Show InChI InChI=1S/C23H20BrN3O2/c1-15-23(17-4-5-17)25-21-9-8-19(13-27(15)21)26-11-10-20(12-22(26)28)29-14-16-2-6-18(24)7-3-16/h2-3,6-13,17H,4-5,14H2,1H3 | Reactome pathway
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| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis |
J Med Chem 59: 1116-39 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 2
(Homo sapiens (Human)) | BDBM50355930
(CHEMBL1910400)Show SMILES CCNC(=O)Nc1sc2ccccc2c1C(=O)N1CCC(CC1)N1CCCC2(CC(C)(C)OC2=O)C1 Show InChI InChI=1S/C27H36N4O4S/c1-4-28-25(34)29-22-21(19-8-5-6-9-20(19)36-22)23(32)30-14-10-18(11-15-30)31-13-7-12-27(17-31)16-26(2,3)35-24(27)33/h5-6,8-9,18H,4,7,10-17H2,1-3H3,(H2,28,29,34) | PDB
MMDB
Reactome pathway
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Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human ACC2 |
Bioorg Med Chem Lett 21: 6314-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.117
BindingDB Entry DOI: 10.7270/Q2P84C9P |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Enteropeptidase
(Homo sapiens (Human)) | BDBM50595349
(CHEMBL5202756)Show SMILES OC(=O)C(F)(F)F.NC(=N)Nc1ccc(cc1)C(=O)Oc1cccc(c1)C(=O)N[C@@H](CC(O)=O)C(O)=O |r| | PDB
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TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00463
BindingDB Entry DOI: 10.7270/Q208699D |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50163481
(CHEMBL3794306)Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2ccc(s2)C(F)(F)F)cc1=O)C1CC1 Show InChI InChI=1S/C22H18F3N3O2S/c1-27-18-10-14(4-6-17(18)26-21(27)13-2-3-13)28-9-8-15(11-20(28)29)30-12-16-5-7-19(31-16)22(23,24)25/h4-11,13H,2-3,12H2,1H3 | Reactome pathway
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| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting |
Bioorg Med Chem 24: 2486-503 (2016)
Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50163480
(CHEMBL3792707)Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2csc(Cl)c2)cc1=O)C1CC1 Show InChI InChI=1S/C21H18ClN3O2S/c1-24-18-9-15(4-5-17(18)23-21(24)14-2-3-14)25-7-6-16(10-20(25)26)27-11-13-8-19(22)28-12-13/h4-10,12,14H,2-3,11H2,1H3 | Reactome pathway
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Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting |
Bioorg Med Chem 24: 2486-503 (2016)
Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1 |
More data for this
Ligand-Target Pair | |
Enteropeptidase
(Homo sapiens (Human)) | BDBM50595347
(CHEMBL5169835)Show SMILES NC(=N)Nc1ccc(cc1)C(=O)Oc1ccc2CC(CC(=O)N[C@@H](CC(O)=O)C(O)=O)Oc2c1 |r| | PDB
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TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00463
BindingDB Entry DOI: 10.7270/Q208699D |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 2
(Homo sapiens (Human)) | BDBM50355928
(CHEMBL1910398)Show SMILES CC1(C)CC2(CCCN(C2)C2CCN(CC2)C(=O)c2c(NC(N)=O)sc3ccccc23)C(=O)O1 Show InChI InChI=1S/C25H32N4O4S/c1-24(2)14-25(22(31)33-24)10-5-11-29(15-25)16-8-12-28(13-9-16)21(30)19-17-6-3-4-7-18(17)34-20(19)27-23(26)32/h3-4,6-7,16H,5,8-15H2,1-2H3,(H3,26,27,32) | PDB
MMDB
Reactome pathway
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| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human ACC2 |
Bioorg Med Chem Lett 21: 6314-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.117
BindingDB Entry DOI: 10.7270/Q2P84C9P |
More data for this
Ligand-Target Pair | |
Acetyl-CoA carboxylase 2
(Homo sapiens (Human)) | BDBM50355929
(CHEMBL1910399)Show SMILES CNC(=O)Nc1sc2ccccc2c1C(=O)N1CCC(CC1)N1CCCC2(CC(C)(C)OC2=O)C1 Show InChI InChI=1S/C26H34N4O4S/c1-25(2)15-26(23(32)34-25)11-6-12-30(16-26)17-9-13-29(14-10-17)22(31)20-18-7-4-5-8-19(18)35-21(20)28-24(33)27-3/h4-5,7-8,17H,6,9-16H2,1-3H3,(H2,27,28,33) | PDB
MMDB
Reactome pathway
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| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human ACC2 |
Bioorg Med Chem Lett 21: 6314-8 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.117
BindingDB Entry DOI: 10.7270/Q2P84C9P |
More data for this
Ligand-Target Pair | |
Ceramide glucosyltransferase
(Homo sapiens (Human)) | BDBM50585896
(CHEMBL5085509)Show SMILES CC(C)(O)c1ccc(NC(=O)c2ccnn(-c3ccccc3OCC(F)(F)F)c2=O)cc1 | NCI pathway
Reactome pathway
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| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometry |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c02078
BindingDB Entry DOI: 10.7270/Q2KW5KZB |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50149461
(CHEMBL3769762)Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2csc(c2)C(F)(F)F)cc1=O)C1CC1 Show InChI InChI=1S/C22H18F3N3O2S/c1-13-21(15-2-3-15)26-19-5-4-16(10-28(13)19)27-7-6-17(9-20(27)29)30-11-14-8-18(31-12-14)22(23,24)25/h4-10,12,15H,2-3,11H2,1H3 | Reactome pathway
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| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis |
J Med Chem 59: 1116-39 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50163481
(CHEMBL3794306)Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2ccc(s2)C(F)(F)F)cc1=O)C1CC1 Show InChI InChI=1S/C22H18F3N3O2S/c1-27-18-10-14(4-6-17(18)26-21(27)13-2-3-13)28-9-8-15(11-20(28)29)30-12-16-5-7-19(31-16)22(23,24)25/h4-11,13H,2-3,12H2,1H3 | Reactome pathway
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| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting |
Bioorg Med Chem 24: 2486-503 (2016)
Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1 |
More data for this
Ligand-Target Pair | |
Ceramide glucosyltransferase
(Homo sapiens (Human)) | BDBM50585892
(CHEMBL5092141)Show SMILES CC(C)(C#N)c1ccc(cc1)N1Cc2c(ccnc2-c2ccc(F)cc2OCC(F)(F)F)C1=O | NCI pathway
Reactome pathway
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| Article
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| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometry |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c02078
BindingDB Entry DOI: 10.7270/Q2KW5KZB |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50149461
(CHEMBL3769762)Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2csc(c2)C(F)(F)F)cc1=O)C1CC1 Show InChI InChI=1S/C22H18F3N3O2S/c1-13-21(15-2-3-15)26-19-5-4-16(10-28(13)19)27-7-6-17(9-20(27)29)30-11-14-8-18(31-12-14)22(23,24)25/h4-10,12,15H,2-3,11H2,1H3 | Reactome pathway
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| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-MCH (4 to19 residues) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis |
J Med Chem 59: 1116-39 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50163478
(CHEMBL3794345)Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2cc(Cl)cs2)cc1=O)C1CC1 Show InChI InChI=1S/C21H18ClN3O2S/c1-24-19-9-15(4-5-18(19)23-21(24)13-2-3-13)25-7-6-16(10-20(25)26)27-11-17-8-14(22)12-28-17/h4-10,12-13H,2-3,11H2,1H3 | Reactome pathway
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| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting |
Bioorg Med Chem 24: 2486-503 (2016)
Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50163467
(CHEMBL3792697)Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2cc(cs2)C(F)(F)F)cc1=O)C1CC1 Show InChI InChI=1S/C22H18F3N3O2S/c1-27-19-9-15(4-5-18(19)26-21(27)13-2-3-13)28-7-6-16(10-20(28)29)30-11-17-8-14(12-31-17)22(23,24)25/h4-10,12-13H,2-3,11H2,1H3 | Reactome pathway
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| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting |
Bioorg Med Chem 24: 2486-503 (2016)
Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50163478
(CHEMBL3794345)Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2cc(Cl)cs2)cc1=O)C1CC1 Show InChI InChI=1S/C21H18ClN3O2S/c1-24-19-9-15(4-5-18(19)23-21(24)13-2-3-13)25-7-6-16(10-20(25)26)27-11-17-8-14(22)12-28-17/h4-10,12-13H,2-3,11H2,1H3 | Reactome pathway
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| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting |
Bioorg Med Chem 24: 2486-503 (2016)
Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50163481
(CHEMBL3794306)Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2ccc(s2)C(F)(F)F)cc1=O)C1CC1 Show InChI InChI=1S/C22H18F3N3O2S/c1-27-18-10-14(4-6-17(18)26-21(27)13-2-3-13)28-9-8-15(11-20(28)29)30-12-16-5-7-19(31-16)22(23,24)25/h4-11,13H,2-3,12H2,1H3 | Reactome pathway
KEGG
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| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human MCHR1 expressed in CHO cells assessed as change in MCH(4 to 19)-stimulated Ca2+ concentration by Ca2+ mobilization assay |
Bioorg Med Chem 24: 2486-503 (2016)
Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1 |
More data for this
Ligand-Target Pair | |
Ceramide glucosyltransferase
(Homo sapiens (Human)) | BDBM50585900
(CHEMBL5083428)Show SMILES CC(C)(O)c1ccc(NC(=O)c2cccn(-c3ccccc3OCC(F)(F)F)c2=O)cc1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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antibodypedia
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| PC cid
PC sid
UniChem
| Article
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| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometry |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c02078
BindingDB Entry DOI: 10.7270/Q2KW5KZB |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50163476
(CHEMBL3792516)Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2ccc(Cl)s2)cc1=O)C1CC1 Show InChI InChI=1S/C21H18ClN3O2S/c1-24-18-10-14(4-6-17(18)23-21(24)13-2-3-13)25-9-8-15(11-20(25)26)27-12-16-5-7-19(22)28-16/h4-11,13H,2-3,12H2,1H3 | Reactome pathway
KEGG
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| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-MCH(4 to 19) from human MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting |
Bioorg Med Chem 24: 2486-503 (2016)
Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50149462
(CHEMBL3771182)Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2csc(Cl)c2)cc1=O)C1CC1 Show InChI InChI=1S/C21H18ClN3O2S/c1-13-21(15-2-3-15)23-19-5-4-16(10-25(13)19)24-7-6-17(9-20(24)26)27-11-14-8-18(22)28-12-14/h4-10,12,15H,2-3,11H2,1H3 | Reactome pathway
KEGG
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| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human MCHR1 expressed in CHO cells assessed as inhibition of MCH (4 to 19 residues)-stimulated intracellular calcium mobilizat... |
J Med Chem 59: 1116-39 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50149458
(CHEMBL3770396)Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccc(Cl)cn2)cc1=O)C1CC1 Show InChI InChI=1S/C22H19ClN4O2/c1-14-22(15-2-3-15)25-20-7-6-18(12-27(14)20)26-9-8-19(10-21(26)28)29-13-17-5-4-16(23)11-24-17/h4-12,15H,2-3,13H2,1H3 | Reactome pathway
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Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis |
J Med Chem 59: 1116-39 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50149453
(CHEMBL3770359)Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccc(Cl)cc2)cc1=O)C1CC1 Show InChI InChI=1S/C23H20ClN3O2/c1-15-23(17-4-5-17)25-21-9-8-19(13-27(15)21)26-11-10-20(12-22(26)28)29-14-16-2-6-18(24)7-3-16/h2-3,6-13,17H,4-5,14H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysis |
J Med Chem 59: 1116-39 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T |
More data for this
Ligand-Target Pair | |
Enteropeptidase
(Homo sapiens (Human)) | BDBM50595352
(CHEMBL5175180)Show SMILES NC(=N)Nc1ccc(cc1)C(=O)Oc1cccc(c1)C1=NO[C@@](CC(O)=O)(C1)C(O)=O |r,t:21| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00463
BindingDB Entry DOI: 10.7270/Q208699D |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50163490
(CHEMBL3793944)Show SMILES Cn1c(nc2ccc(cc12)-n1ccc(OCc2ccc(Cl)cc2)cc1=O)C1CC1 Show InChI InChI=1S/C23H20ClN3O2/c1-26-21-12-18(8-9-20(21)25-23(26)16-4-5-16)27-11-10-19(13-22(27)28)29-14-15-2-6-17(24)7-3-15/h2-3,6-13,16H,4-5,14H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting |
Bioorg Med Chem 24: 2486-503 (2016)
Article DOI: 10.1016/j.bmc.2016.04.011
BindingDB Entry DOI: 10.7270/Q2862JB1 |
More data for this
Ligand-Target Pair | |
Enteropeptidase
(Homo sapiens (Human)) | BDBM50595341
(CHEMBL5202535)Show SMILES OC(=O)C(F)(F)F.NC(=N)Nc1ccc(cc1)C(=O)Oc1ccc(CC(=O)N[C@@H](CC(N)=O)C(O)=O)cc1 |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00463
BindingDB Entry DOI: 10.7270/Q208699D |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50163507
(CHEMBL3794256)Show SMILES Cc1n(nc2ccc(cc12)-n1ccc(OCc2ccc(Cl)cc2)cc1=O)C1CC1 Show InChI InChI=1S/C23H20ClN3O2/c1-15-21-12-19(8-9-22(21)25-27(15)18-6-7-18)26-11-10-20(13-23(26)28)29-14-16-2-4-17(24)5-3-16/h2-5,8-13,18H,6-7,14H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]-MCH(4 to 19) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting |
Bioorg Med Chem 24: 2504-18 (2016)
Article DOI: 10.1016/j.bmc.2016.04.013
BindingDB Entry DOI: 10.7270/Q2SX6G4X |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50149453
(CHEMBL3770359)Show SMILES Cc1c(nc2ccc(cn12)-n1ccc(OCc2ccc(Cl)cc2)cc1=O)C1CC1 Show InChI InChI=1S/C23H20ClN3O2/c1-15-23(17-4-5-17)25-21-9-8-19(13-27(15)21)26-11-10-20(12-22(26)28)29-14-16-2-6-18(24)7-3-16/h2-3,6-13,17H,4-5,14H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human MCHR1 expressed in CHO cells assessed as inhibition of MCH (4 to 19 residues)-stimulated intracellular calcium mobilizat... |
J Med Chem 59: 1116-39 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01704
BindingDB Entry DOI: 10.7270/Q2V40X2T |
More data for this
Ligand-Target Pair | |
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