Compile Data Set for Download or QSAR

Found 189 hits with Last Name = 'mcatee' and Initial = 'l'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Homo sapiens (Human))	BDBM50120543 (7-Methyl-2-[4-(3-piperidin-1-yl-propoxy)-phenyl]-i...) Show SMILES Cc1ccn2cc(nc2c1)-c1ccc(OCCCN2CCCCC2)cc1 Show InChI InChI=1S/C22H27N3O/c1-18-10-14-25-17-21(23-22(25)16-18)19-6-8-20(9-7-19)26-15-5-13-24-11-3-2-4-12-24/h6-10,14,16-17H,2-5,11-13,15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity for human histamine H3 receptor				Bioorg Med Chem Lett 12: 3309-12 (2002) BindingDB Entry DOI: 10.7270/Q2KH0MPG
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50120559 (7-Methyl-2-[2-methyl-4-(3-piperidin-1-yl-propoxy)-...) Show SMILES Cc1ccn2cc(nc2c1)-c1ccc(OCCCN2CCCCC2)cc1C Show InChI InChI=1S/C23H29N3O/c1-18-9-13-26-17-22(24-23(26)15-18)21-8-7-20(16-19(21)2)27-14-6-12-25-10-4-3-5-11-25/h7-9,13,15-17H,3-6,10-12,14H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity for human histamine H3 receptor				Bioorg Med Chem Lett 12: 3309-12 (2002) BindingDB Entry DOI: 10.7270/Q2KH0MPG
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50120537 (8-Methyl-2-[4-(3-piperidin-1-yl-propoxy)-phenyl]-i...) Show SMILES Cc1cccn2cc(nc12)-c1ccc(OCCCN2CCCCC2)cc1 Show InChI InChI=1S/C22H27N3O/c1-18-7-5-15-25-17-21(23-22(18)25)19-8-10-20(11-9-19)26-16-6-14-24-12-3-2-4-13-24/h5,7-11,15,17H,2-4,6,12-14,16H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Antagonist activity for human histamine H3 receptor was determined				Bioorg Med Chem Lett 12: 3309-12 (2002) BindingDB Entry DOI: 10.7270/Q2KH0MPG
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50120537 (8-Methyl-2-[4-(3-piperidin-1-yl-propoxy)-phenyl]-i...) Show SMILES Cc1cccn2cc(nc12)-c1ccc(OCCCN2CCCCC2)cc1 Show InChI InChI=1S/C22H27N3O/c1-18-7-5-15-25-17-21(23-22(18)25)19-8-10-20(11-9-19)26-16-6-14-24-12-3-2-4-13-24/h5,7-11,15,17H,2-4,6,12-14,16H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity for human histamine H3 receptor				Bioorg Med Chem Lett 12: 3309-12 (2002) BindingDB Entry DOI: 10.7270/Q2KH0MPG
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM50412863 (CHEMBL359632 | JNJ-10397049) Show SMILES CC1(C)OC[C@H](NC(=O)Nc2ccc(Br)cc2Br)[C@@H](O1)c1ccccc1 |r| Show InChI InChI=1S/C19H20Br2N2O3/c1-19(2)25-11-16(17(26-19)12-6-4-3-5-7-12)23-18(24)22-15-9-8-13(20)10-14(15)21/h3-10,16-17H,11H2,1-2H3,(H2,22,23,24)/t16-,17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity towards human orexin receptor type 2 was determined using [125I]-Orexin A as radio ligand				Bioorg Med Chem Lett 14: 4225-9 (2004) Article DOI: 10.1016/j.bmcl.2004.06.032 BindingDB Entry DOI: 10.7270/Q2K64MV4
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50120544 (7-Methyl-2-[4-(3-pyrrolidin-1-yl-propoxy)-phenyl]-...) Show SMILES Cc1ccn2cc(nc2c1)-c1ccc(OCCCN2CCCC2)cc1 Show InChI InChI=1S/C21H25N3O/c1-17-9-13-24-16-20(22-21(24)15-17)18-5-7-19(8-6-18)25-14-4-12-23-10-2-3-11-23/h5-9,13,15-16H,2-4,10-12,14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity for human histamine H3 receptor				Bioorg Med Chem Lett 12: 3309-12 (2002) BindingDB Entry DOI: 10.7270/Q2KH0MPG
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50120562 (2-[4-(3-Azepan-1-yl-propoxy)-phenyl]-7-methyl-imid...) Show SMILES Cc1ccn2cc(nc2c1)-c1ccc(OCCCN2CCCCCC2)cc1 Show InChI InChI=1S/C23H29N3O/c1-19-11-15-26-18-22(24-23(26)17-19)20-7-9-21(10-8-20)27-16-6-14-25-12-4-2-3-5-13-25/h7-11,15,17-18H,2-6,12-14,16H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity for human histamine H3 receptor				Bioorg Med Chem Lett 12: 3309-12 (2002) BindingDB Entry DOI: 10.7270/Q2KH0MPG
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50120542 (2-[4-(3-Piperidin-1-yl-propoxy)-phenyl]-imidazo[1,...) Show SMILES C(COc1ccc(cc1)-c1cn2ccccc2n1)CN1CCCCC1 Show InChI InChI=1S/C21H25N3O/c1-3-12-23(13-4-1)14-6-16-25-19-10-8-18(9-11-19)20-17-24-15-5-2-7-21(24)22-20/h2,5,7-11,15,17H,1,3-4,6,12-14,16H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity for human histamine H3 receptor				Bioorg Med Chem Lett 12: 3309-12 (2002) BindingDB Entry DOI: 10.7270/Q2KH0MPG
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM50412861 (CHEMBL185088) Show SMILES CC1(C)OC[C@H](NC(=O)Nc2ccc(Br)cc2Cl)[C@@H](O1)c1ccccc1 |r| Show InChI InChI=1S/C19H20BrClN2O3/c1-19(2)25-11-16(17(26-19)12-6-4-3-5-7-12)23-18(24)22-15-9-8-13(20)10-14(15)21/h3-10,16-17H,11H2,1-2H3,(H2,22,23,24)/t16-,17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity towards human orexin receptor type 2 was determined using [125I]-Orexin A as radio ligand				Bioorg Med Chem Lett 14: 4225-9 (2004) Article DOI: 10.1016/j.bmcl.2004.06.032 BindingDB Entry DOI: 10.7270/Q2K64MV4
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50120561 (7-Methyl-2-[4-(4-piperidin-1-yl-but-1-ynyl)-phenyl...) Show SMILES Cc1ccn2cc(nc2c1)-c1ccc(cc1)C#CCCN1CCCCC1 Show InChI InChI=1S/C23H25N3/c1-19-12-16-26-18-22(24-23(26)17-19)21-10-8-20(9-11-21)7-3-6-15-25-13-4-2-5-14-25/h8-12,16-18H,2,4-6,13-15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity for human histamine H3 receptor				Bioorg Med Chem Lett 12: 3309-12 (2002) BindingDB Entry DOI: 10.7270/Q2KH0MPG
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50120551 (2-[2-Fluoro-4-(3-piperidin-1-yl-propoxy)-phenyl]-7...) Show SMILES Cc1ccn2cc(nc2c1)-c1ccc(OCCCN2CCCCC2)cc1F Show InChI InChI=1S/C22H26FN3O/c1-17-8-12-26-16-21(24-22(26)14-17)19-7-6-18(15-20(19)23)27-13-5-11-25-9-3-2-4-10-25/h6-8,12,14-16H,2-5,9-11,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity for human histamine H3 receptor				Bioorg Med Chem Lett 12: 3309-12 (2002) BindingDB Entry DOI: 10.7270/Q2KH0MPG
					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50120543 (7-Methyl-2-[4-(3-piperidin-1-yl-propoxy)-phenyl]-i...) Show SMILES Cc1ccn2cc(nc2c1)-c1ccc(OCCCN2CCCCC2)cc1 Show InChI InChI=1S/C22H27N3O/c1-18-10-14-25-17-21(23-22(25)16-18)19-6-8-20(9-7-19)26-15-5-13-24-11-3-2-4-12-24/h6-10,14,16-17H,2-5,11-13,15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Compound was tested for its binding affinity for rat histamine H3 receptor				Bioorg Med Chem Lett 12: 3309-12 (2002) BindingDB Entry DOI: 10.7270/Q2KH0MPG
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50120549 (CHEMBL70944 | Dimethyl-{3-[4-(8-methyl-imidazo[1,2...) Show SMILES CN(C)CCCOc1ccc(cc1)-c1cn2cccc(C)c2n1 Show InChI InChI=1S/C19H23N3O/c1-15-6-4-12-22-14-18(20-19(15)22)16-7-9-17(10-8-16)23-13-5-11-21(2)3/h4,6-10,12,14H,5,11,13H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity for human histamine H3 receptor				Bioorg Med Chem Lett 12: 3309-12 (2002) BindingDB Entry DOI: 10.7270/Q2KH0MPG
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50120539 (CHEMBL113236 | [4-(8-Methyl-imidazo[1,2-a]pyridin-...) Show SMILES Cc1cccn2cc(nc12)-c1ccc(NCCCN2CCCCC2)cc1 Show InChI InChI=1S/C22H28N4/c1-18-7-5-16-26-17-21(24-22(18)26)19-8-10-20(11-9-19)23-12-6-15-25-13-3-2-4-14-25/h5,7-11,16-17,23H,2-4,6,12-15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity for human histamine H3 receptor				Bioorg Med Chem Lett 12: 3309-12 (2002) BindingDB Entry DOI: 10.7270/Q2KH0MPG
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50120565 (7-Methyl-2-[4-(4-piperidin-1-yl-butyl)-phenyl]-imi...) Show SMILES Cc1ccn2cc(nc2c1)-c1ccc(CCCCN2CCCCC2)cc1 Show InChI InChI=1S/C23H29N3/c1-19-12-16-26-18-22(24-23(26)17-19)21-10-8-20(9-11-21)7-3-6-15-25-13-4-2-5-14-25/h8-12,16-18H,2-7,13-15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	17	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity for human histamine H3 receptor				Bioorg Med Chem Lett 12: 3309-12 (2002) BindingDB Entry DOI: 10.7270/Q2KH0MPG
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM50412862 (CHEMBL185136) Show SMILES CC1(C)OC[C@H](NC(=O)Nc2ccc(Cl)cc2Cl)[C@@H](O1)c1ccccc1 |r| Show InChI InChI=1S/C19H20Cl2N2O3/c1-19(2)25-11-16(17(26-19)12-6-4-3-5-7-12)23-18(24)22-15-9-8-13(20)10-14(15)21/h3-10,16-17H,11H2,1-2H3,(H2,22,23,24)/t16-,17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity towards human orexin receptor type 2 was determined using [125I]-Orexin A as radio ligand				Bioorg Med Chem Lett 14: 4225-9 (2004) Article DOI: 10.1016/j.bmcl.2004.06.032 BindingDB Entry DOI: 10.7270/Q2K64MV4
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50120556 (7-Methyl-2-[4-((E)-4-piperidin-1-yl-but-1-enyl)-ph...) Show SMILES Cc1ccn2cc(nc2c1)-c1ccc(\C=C\CCN2CCCCC2)cc1 Show InChI InChI=1S/C23H27N3/c1-19-12-16-26-18-22(24-23(26)17-19)21-10-8-20(9-11-21)7-3-6-15-25-13-4-2-5-14-25/h3,7-12,16-18H,2,4-6,13-15H2,1H3/b7-3+	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	22	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity for human histamine H3 receptor				Bioorg Med Chem Lett 12: 3309-12 (2002) BindingDB Entry DOI: 10.7270/Q2KH0MPG
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM50474855 (CHEMBL364814) Show SMILES CC1(C)OC[C@H](NC(=O)Nc2ccccc2-c2ccccc2Cl)[C@@H](O1)c1ccccc1 Show InChI InChI=1S/C25H25ClN2O3/c1-25(2)30-16-22(23(31-25)17-10-4-3-5-11-17)28-24(29)27-21-15-9-7-13-19(21)18-12-6-8-14-20(18)26/h3-15,22-23H,16H2,1-2H3,(H2,27,28,29)/t22-,23-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity towards human orexin receptor type 2 was determined using [125I]-Orexin A as radio ligand				Bioorg Med Chem Lett 14: 4225-9 (2004) Article DOI: 10.1016/j.bmcl.2004.06.032 BindingDB Entry DOI: 10.7270/Q2K64MV4
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50120547 (2-[3-Methyl-4-(3-piperidin-1-yl-propoxy)-phenyl]-i...) Show SMILES Cc1cc(ccc1OCCCN1CCCCC1)-c1cn2ccccc2n1 Show InChI InChI=1S/C22H27N3O/c1-18-16-19(20-17-25-14-6-3-8-22(25)23-20)9-10-21(18)26-15-7-13-24-11-4-2-5-12-24/h3,6,8-10,14,16-17H,2,4-5,7,11-13,15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	28	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity for human histamine H3 receptor				Bioorg Med Chem Lett 12: 3309-12 (2002) BindingDB Entry DOI: 10.7270/Q2KH0MPG
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM50412860 (CHEMBL185093) Show SMILES Cc1cc(Br)ccc1NC(=O)N[C@H]1COC(C)(C)O[C@H]1c1ccccc1 |r| Show InChI InChI=1S/C20H23BrN2O3/c1-13-11-15(21)9-10-16(13)22-19(24)23-17-12-25-20(2,3)26-18(17)14-7-5-4-6-8-14/h4-11,17-18H,12H2,1-3H3,(H2,22,23,24)/t17-,18-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity towards human orexin receptor type 2 was determined using [125I]-Orexin A as radio ligand				Bioorg Med Chem Lett 14: 4225-9 (2004) Article DOI: 10.1016/j.bmcl.2004.06.032 BindingDB Entry DOI: 10.7270/Q2K64MV4
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50120569 (CHEMBL306911 | {3-[4-(8-Methyl-imidazo[1,2-a]pyrid...) Show SMILES CCCN(CCC)CCCOc1ccc(cc1)-c1cn2cccc(C)c2n1 Show InChI InChI=1S/C23H31N3O/c1-4-13-25(14-5-2)15-7-17-27-21-11-9-20(10-12-21)22-18-26-16-6-8-19(3)23(26)24-22/h6,8-12,16,18H,4-5,7,13-15,17H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	43	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity for human histamine H3 receptor				Bioorg Med Chem Lett 12: 3309-12 (2002) BindingDB Entry DOI: 10.7270/Q2KH0MPG
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM50474849 (CHEMBL185424) Show SMILES CC1(C)OC[C@H](NC(=O)Nc2ccccc2-c2cccs2)[C@@H](O1)c1ccccc1 Show InChI InChI=1S/C23H24N2O3S/c1-23(2)27-15-19(21(28-23)16-9-4-3-5-10-16)25-22(26)24-18-12-7-6-11-17(18)20-13-8-14-29-20/h3-14,19,21H,15H2,1-2H3,(H2,24,25,26)/t19-,21-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity towards human orexin receptor type 2 was determined using [125I]-Orexin A as radio ligand				Bioorg Med Chem Lett 14: 4225-9 (2004) Article DOI: 10.1016/j.bmcl.2004.06.032 BindingDB Entry DOI: 10.7270/Q2K64MV4
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM50412857 (CHEMBL361716) Show SMILES CC1(C)OC[C@H](NC(=O)Nc2cc(Cl)ccc2Cl)[C@@H](O1)c1ccccc1 |r| Show InChI InChI=1S/C19H20Cl2N2O3/c1-19(2)25-11-16(17(26-19)12-6-4-3-5-7-12)23-18(24)22-15-10-13(20)8-9-14(15)21/h3-10,16-17H,11H2,1-2H3,(H2,22,23,24)/t16-,17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	63	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity towards human orexin receptor type 2 was determined using [125I]-Orexin A as radio ligand				Bioorg Med Chem Lett 14: 4225-9 (2004) Article DOI: 10.1016/j.bmcl.2004.06.032 BindingDB Entry DOI: 10.7270/Q2K64MV4
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM50412859 (CHEMBL182473) Show SMILES Cc1ccc(Cl)c(NC(=O)N[C@H]2COC(C)(C)O[C@H]2c2ccccc2)c1 |r| Show InChI InChI=1S/C20H23ClN2O3/c1-13-9-10-15(21)16(11-13)22-19(24)23-17-12-25-20(2,3)26-18(17)14-7-5-4-6-8-14/h4-11,17-18H,12H2,1-3H3,(H2,22,23,24)/t17-,18-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	63	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity towards human orexin receptor type 2 was determined using [125I]-Orexin A as radio ligand				Bioorg Med Chem Lett 14: 4225-9 (2004) Article DOI: 10.1016/j.bmcl.2004.06.032 BindingDB Entry DOI: 10.7270/Q2K64MV4
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50120566 (2-[3-Methoxy-4-(3-piperidin-1-yl-propoxy)-phenyl]-...) Show SMILES COc1cc(ccc1OCCCN1CCCCC1)-c1cn2ccc(C)cc2n1 Show InChI InChI=1S/C23H29N3O2/c1-18-9-13-26-17-20(24-23(26)15-18)19-7-8-21(22(16-19)27-2)28-14-6-12-25-10-4-3-5-11-25/h7-9,13,15-17H,3-6,10-12,14H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	69	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity for human histamine H3 receptor				Bioorg Med Chem Lett 12: 3309-12 (2002) BindingDB Entry DOI: 10.7270/Q2KH0MPG
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM50474846 (CHEMBL185131) Show SMILES CC1(C)OC[C@H](NC(=O)Nc2ccccc2-c2cccc(Cl)c2)[C@@H](O1)c1ccccc1 Show InChI InChI=1S/C25H25ClN2O3/c1-25(2)30-16-22(23(31-25)17-9-4-3-5-10-17)28-24(29)27-21-14-7-6-13-20(21)18-11-8-12-19(26)15-18/h3-15,22-23H,16H2,1-2H3,(H2,27,28,29)/t22-,23-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	79	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity towards human orexin receptor type 2 was determined using [125I]-Orexin A as radio ligand				Bioorg Med Chem Lett 14: 4225-9 (2004) Article DOI: 10.1016/j.bmcl.2004.06.032 BindingDB Entry DOI: 10.7270/Q2K64MV4
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM50412855 (CHEMBL185382) Show SMILES CC1(C)OC[C@H](NC(=O)Nc2ccccc2I)[C@@H](O1)c1ccccc1 |r| Show InChI InChI=1S/C19H21IN2O3/c1-19(2)24-12-16(17(25-19)13-8-4-3-5-9-13)22-18(23)21-15-11-7-6-10-14(15)20/h3-11,16-17H,12H2,1-2H3,(H2,21,22,23)/t16-,17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	79	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity towards human orexin receptor type 2 was determined using [125I]-Orexin A as radio ligand				Bioorg Med Chem Lett 14: 4225-9 (2004) Article DOI: 10.1016/j.bmcl.2004.06.032 BindingDB Entry DOI: 10.7270/Q2K64MV4
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM50412854 (CHEMBL185435) Show SMILES CC1(C)OC[C@H](NC(=O)Nc2ccccc2Cl)[C@@H](O1)c1ccccc1 |r| Show InChI InChI=1S/C19H21ClN2O3/c1-19(2)24-12-16(17(25-19)13-8-4-3-5-9-13)22-18(23)21-15-11-7-6-10-14(15)20/h3-11,16-17H,12H2,1-2H3,(H2,21,22,23)/t16-,17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	79	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity towards human orexin receptor type 2 was determined using [125I]-Orexin A as radio ligand				Bioorg Med Chem Lett 14: 4225-9 (2004) Article DOI: 10.1016/j.bmcl.2004.06.032 BindingDB Entry DOI: 10.7270/Q2K64MV4
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM50474848 (CHEMBL184596) Show SMILES CC1(C)OC[C@H](NC(=O)Nc2ccccc2-c2ccsc2)[C@@H](O1)c1ccccc1 Show InChI InChI=1S/C23H24N2O3S/c1-23(2)27-14-20(21(28-23)16-8-4-3-5-9-16)25-22(26)24-19-11-7-6-10-18(19)17-12-13-29-15-17/h3-13,15,20-21H,14H2,1-2H3,(H2,24,25,26)/t20-,21-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	79	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity towards human orexin receptor type 2 was determined using [125I]-Orexin A as radio ligand				Bioorg Med Chem Lett 14: 4225-9 (2004) Article DOI: 10.1016/j.bmcl.2004.06.032 BindingDB Entry DOI: 10.7270/Q2K64MV4
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50120570 (8-Methyl-2-[4-(3-morpholin-4-yl-propoxy)-phenyl]-i...) Show SMILES Cc1cccn2cc(nc12)-c1ccc(OCCCN2CCOCC2)cc1 Show InChI InChI=1S/C21H25N3O2/c1-17-4-2-10-24-16-20(22-21(17)24)18-5-7-19(8-6-18)26-13-3-9-23-11-14-25-15-12-23/h2,4-8,10,16H,3,9,11-15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity for human histamine H3 receptor				Bioorg Med Chem Lett 12: 3309-12 (2002) BindingDB Entry DOI: 10.7270/Q2KH0MPG
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM50474847 (CHEMBL183421) Show SMILES CC1(C)OC[C@H](NC(=O)Nc2ccccc2-c2ccccc2)[C@@H](O1)c1ccccc1 Show InChI InChI=1S/C25H26N2O3/c1-25(2)29-17-22(23(30-25)19-13-7-4-8-14-19)27-24(28)26-21-16-10-9-15-20(21)18-11-5-3-6-12-18/h3-16,22-23H,17H2,1-2H3,(H2,26,27,28)/t22-,23-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity towards human orexin receptor type 2 was determined using [125I]-Orexin A as radio ligand				Bioorg Med Chem Lett 14: 4225-9 (2004) Article DOI: 10.1016/j.bmcl.2004.06.032 BindingDB Entry DOI: 10.7270/Q2K64MV4
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM50412849 (CHEMBL363743) Show SMILES CC1(C)OC[C@H](NC(=O)Nc2ccccc2Br)[C@@H](O1)c1ccccc1 |r| Show InChI InChI=1S/C19H21BrN2O3/c1-19(2)24-12-16(17(25-19)13-8-4-3-5-9-13)22-18(23)21-15-11-7-6-10-14(15)20/h3-11,16-17H,12H2,1-2H3,(H2,21,22,23)/t16-,17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity towards human orexin receptor type 2 was determined using [125I]-Orexin A as radio ligand				Bioorg Med Chem Lett 14: 4225-9 (2004) Article DOI: 10.1016/j.bmcl.2004.06.032 BindingDB Entry DOI: 10.7270/Q2K64MV4
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM50412851 (CHEMBL363951) Show SMILES CC1(C)OC[C@H](NC(=O)Nc2ccccc2C(F)(F)F)[C@@H](O1)c1ccccc1 |r| Show InChI InChI=1S/C20H21F3N2O3/c1-19(2)27-12-16(17(28-19)13-8-4-3-5-9-13)25-18(26)24-15-11-7-6-10-14(15)20(21,22)23/h3-11,16-17H,12H2,1-2H3,(H2,24,25,26)/t16-,17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity towards human orexin receptor type 2 was determined using [125I]-Orexin A as radio ligand				Bioorg Med Chem Lett 14: 4225-9 (2004) Article DOI: 10.1016/j.bmcl.2004.06.032 BindingDB Entry DOI: 10.7270/Q2K64MV4
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM50474855 (CHEMBL364814) Show SMILES CC1(C)OC[C@H](NC(=O)Nc2ccccc2-c2ccccc2Cl)[C@@H](O1)c1ccccc1 Show InChI InChI=1S/C25H25ClN2O3/c1-25(2)30-16-22(23(31-25)17-10-4-3-5-11-17)28-24(29)27-21-15-9-7-13-19(21)18-12-6-8-14-20(18)26/h3-15,22-23H,16H2,1-2H3,(H2,27,28,29)/t22-,23-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	126	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity towards human orexin receptor type 1 was determined using [125I]-Orexin A as radio ligand				Bioorg Med Chem Lett 14: 4225-9 (2004) Article DOI: 10.1016/j.bmcl.2004.06.032 BindingDB Entry DOI: 10.7270/Q2K64MV4
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM50412858 (CHEMBL183576) Show SMILES Cc1ccc(NC(=O)N[C@H]2COC(C)(C)O[C@H]2c2ccccc2)c(C)c1 |r| Show InChI InChI=1S/C21H26N2O3/c1-14-10-11-17(15(2)12-14)22-20(24)23-18-13-25-21(3,4)26-19(18)16-8-6-5-7-9-16/h5-12,18-19H,13H2,1-4H3,(H2,22,23,24)/t18-,19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	126	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity towards human orexin receptor type 2 was determined using [125I]-Orexin A as radio ligand				Bioorg Med Chem Lett 14: 4225-9 (2004) Article DOI: 10.1016/j.bmcl.2004.06.032 BindingDB Entry DOI: 10.7270/Q2K64MV4
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM50474844 (CHEMBL183734) Show SMILES CC1(C)OC[C@H](\N=C(/S)Nc2ccc(Cl)cc2Cl)[C@@H](O1)c1ccccc1 Show InChI InChI=1S/C19H20Cl2N2O2S/c1-19(2)24-11-16(17(25-19)12-6-4-3-5-7-12)23-18(26)22-15-9-8-13(20)10-14(15)21/h3-10,16-17H,11H2,1-2H3,(H2,22,23,26)/t16-,17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity towards human orexin receptor type 2 was determined using [125I]-Orexin A as radio ligand				Bioorg Med Chem Lett 14: 4225-9 (2004) Article DOI: 10.1016/j.bmcl.2004.06.032 BindingDB Entry DOI: 10.7270/Q2K64MV4
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM50474850 (CHEMBL185324) Show SMILES CC1(C)OC[C@H](NC(=O)c2ccc(Cl)cc2Cl)[C@@H](O1)c1ccccc1 Show InChI InChI=1S/C19H19Cl2NO3/c1-19(2)24-11-16(17(25-19)12-6-4-3-5-7-12)22-18(23)14-9-8-13(20)10-15(14)21/h3-10,16-17H,11H2,1-2H3,(H,22,23)/t16-,17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity towards human orexin receptor type 2 was determined using [125I]-Orexin A as radio ligand				Bioorg Med Chem Lett 14: 4225-9 (2004) Article DOI: 10.1016/j.bmcl.2004.06.032 BindingDB Entry DOI: 10.7270/Q2K64MV4
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM50412864 (CHEMBL184936) Show SMILES CC1(C)OC[C@H](NC(=O)Nc2ccc(Br)cc2)[C@@H](O1)c1ccccc1 |r| Show InChI InChI=1S/C19H21BrN2O3/c1-19(2)24-12-16(17(25-19)13-6-4-3-5-7-13)22-18(23)21-15-10-8-14(20)9-11-15/h3-11,16-17H,12H2,1-2H3,(H2,21,22,23)/t16-,17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	251	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity towards human orexin receptor type 2 was determined using [125I]-Orexin A as radio ligand				Bioorg Med Chem Lett 14: 4225-9 (2004) Article DOI: 10.1016/j.bmcl.2004.06.032 BindingDB Entry DOI: 10.7270/Q2K64MV4
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50120567 (CHEMBL114231 | N-[4-(8-Methyl-imidazo[1,2-a]pyridi...) Show SMILES Cc1cccn2cc(nc12)-c1ccc(NC(=O)CCN2CCCCC2)cc1 Show InChI InChI=1S/C22H26N4O/c1-17-6-5-14-26-16-20(24-22(17)26)18-7-9-19(10-8-18)23-21(27)11-15-25-12-3-2-4-13-25/h5-10,14,16H,2-4,11-13,15H2,1H3,(H,23,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity for human histamine H3 receptor				Bioorg Med Chem Lett 12: 3309-12 (2002) BindingDB Entry DOI: 10.7270/Q2KH0MPG
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM50474845 (CHEMBL182269) Show SMILES CC1(C)OC[C@H](NC(=O)Nc2ccccc2-c2cccnc2)[C@@H](O1)c1ccccc1 Show InChI InChI=1S/C24H25N3O3/c1-24(2)29-16-21(22(30-24)17-9-4-3-5-10-17)27-23(28)26-20-13-7-6-12-19(20)18-11-8-14-25-15-18/h3-15,21-22H,16H2,1-2H3,(H2,26,27,28)/t21-,22-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	316	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity towards human orexin receptor type 2 was determined using [125I]-Orexin A as radio ligand				Bioorg Med Chem Lett 14: 4225-9 (2004) Article DOI: 10.1016/j.bmcl.2004.06.032 BindingDB Entry DOI: 10.7270/Q2K64MV4
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM50474854 (CHEMBL184303) Show SMILES CC1(C)OC[C@H](\N=C(/S)Nc2ccccc2Br)[C@@H](O1)c1ccccc1 Show InChI InChI=1S/C19H21BrN2O2S/c1-19(2)23-12-16(17(24-19)13-8-4-3-5-9-13)22-18(25)21-15-11-7-6-10-14(15)20/h3-11,16-17H,12H2,1-2H3,(H2,21,22,25)/t16-,17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	398	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity towards human orexin receptor type 2 was determined using [125I]-Orexin A as radio ligand				Bioorg Med Chem Lett 14: 4225-9 (2004) Article DOI: 10.1016/j.bmcl.2004.06.032 BindingDB Entry DOI: 10.7270/Q2K64MV4
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM50412853 (CHEMBL361748) Show SMILES CC1(C)OC[C@H](NC(=O)Nc2ccccc2F)[C@@H](O1)c1ccccc1 |r| Show InChI InChI=1S/C19H21FN2O3/c1-19(2)24-12-16(17(25-19)13-8-4-3-5-9-13)22-18(23)21-15-11-7-6-10-14(15)20/h3-11,16-17H,12H2,1-2H3,(H2,21,22,23)/t16-,17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	398	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity towards human orexin receptor type 2 was determined using [125I]-Orexin A as radio ligand				Bioorg Med Chem Lett 14: 4225-9 (2004) Article DOI: 10.1016/j.bmcl.2004.06.032 BindingDB Entry DOI: 10.7270/Q2K64MV4
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50120550 (3-Piperidin-1-yl-propane-1-sulfonic acid [4-(8-met...) Show SMILES Cc1cccn2cc(nc12)-c1ccc(NS(=O)(=O)CCCN2CCCCC2)cc1 Show InChI InChI=1S/C22H28N4O2S/c1-18-7-5-15-26-17-21(23-22(18)26)19-8-10-20(11-9-19)24-29(27,28)16-6-14-25-12-3-2-4-13-25/h5,7-11,15,17,24H,2-4,6,12-14,16H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity for human histamine H3 receptor				Bioorg Med Chem Lett 12: 3309-12 (2002) BindingDB Entry DOI: 10.7270/Q2KH0MPG
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM50412866 (CHEMBL360377) Show SMILES CC1(C)OC[C@H](NC(=O)Nc2ccccc2)[C@@H](O1)c1ccccc1 |r| Show InChI InChI=1S/C19H22N2O3/c1-19(2)23-13-16(17(24-19)14-9-5-3-6-10-14)21-18(22)20-15-11-7-4-8-12-15/h3-12,16-17H,13H2,1-2H3,(H2,20,21,22)/t16-,17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	501	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity towards human orexin receptor type 2 was determined using [125I]-Orexin A as radio ligand				Bioorg Med Chem Lett 14: 4225-9 (2004) Article DOI: 10.1016/j.bmcl.2004.06.032 BindingDB Entry DOI: 10.7270/Q2K64MV4
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM50474846 (CHEMBL185131) Show SMILES CC1(C)OC[C@H](NC(=O)Nc2ccccc2-c2cccc(Cl)c2)[C@@H](O1)c1ccccc1 Show InChI InChI=1S/C25H25ClN2O3/c1-25(2)30-16-22(23(31-25)17-9-4-3-5-10-17)28-24(29)27-21-14-7-6-13-20(21)18-11-8-12-19(26)15-18/h3-15,22-23H,16H2,1-2H3,(H2,27,28,29)/t22-,23-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	501	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity towards human orexin receptor type 1 was determined using [125I]-Orexin A as radio ligand				Bioorg Med Chem Lett 14: 4225-9 (2004) Article DOI: 10.1016/j.bmcl.2004.06.032 BindingDB Entry DOI: 10.7270/Q2K64MV4
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM50474847 (CHEMBL183421) Show SMILES CC1(C)OC[C@H](NC(=O)Nc2ccccc2-c2ccccc2)[C@@H](O1)c1ccccc1 Show InChI InChI=1S/C25H26N2O3/c1-25(2)29-17-22(23(30-25)19-13-7-4-8-14-19)27-24(28)26-21-16-10-9-15-20(21)18-11-5-3-6-12-18/h3-16,22-23H,17H2,1-2H3,(H2,26,27,28)/t22-,23-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	501	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity towards human orexin receptor type 1 was determined using [125I]-Orexin A as radio ligand				Bioorg Med Chem Lett 14: 4225-9 (2004) Article DOI: 10.1016/j.bmcl.2004.06.032 BindingDB Entry DOI: 10.7270/Q2K64MV4
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50120538 (CHEMBL445619 | Dibutyl-{3-[4-(3,8-dimethyl-imidazo...) Show SMILES CCCCN(CCCC)CCCOc1ccc(cc1)-c1nc2c(C)cccn2c1C Show InChI InChI=1S/C26H37N3O/c1-5-7-16-28(17-8-6-2)18-10-20-30-24-14-12-23(13-15-24)25-22(4)29-19-9-11-21(3)26(29)27-25/h9,11-15,19H,5-8,10,16-18,20H2,1-4H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	870	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity for human histamine H3 receptor				Bioorg Med Chem Lett 12: 3309-12 (2002) BindingDB Entry DOI: 10.7270/Q2KH0MPG
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50120560 (2-[4-(3-Imidazol-1-yl-propoxy)-phenyl]-8-methyl-im...) Show SMILES Cc1cccn2cc(nc12)-c1ccc(OCCCn2ccnc2)cc1 Show InChI InChI=1S/C20H20N4O/c1-16-4-2-11-24-14-19(22-20(16)24)17-5-7-18(8-6-17)25-13-3-10-23-12-9-21-15-23/h2,4-9,11-12,14-15H,3,10,13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity for human histamine H3 receptor				Bioorg Med Chem Lett 12: 3309-12 (2002) BindingDB Entry DOI: 10.7270/Q2KH0MPG
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM50412865 (CHEMBL185080) Show SMILES CC1(C)OC[C@H](NC(=O)Nc2cccc(Br)c2)[C@@H](O1)c1ccccc1 |r| Show InChI InChI=1S/C19H21BrN2O3/c1-19(2)24-12-16(17(25-19)13-7-4-3-5-8-13)22-18(23)21-15-10-6-9-14(20)11-15/h3-11,16-17H,12H2,1-2H3,(H2,21,22,23)/t16-,17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity towards human orexin receptor type 2 was determined using [125I]-Orexin A as radio ligand				Bioorg Med Chem Lett 14: 4225-9 (2004) Article DOI: 10.1016/j.bmcl.2004.06.032 BindingDB Entry DOI: 10.7270/Q2K64MV4
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM50474849 (CHEMBL185424) Show SMILES CC1(C)OC[C@H](NC(=O)Nc2ccccc2-c2cccs2)[C@@H](O1)c1ccccc1 Show InChI InChI=1S/C23H24N2O3S/c1-23(2)27-15-19(21(28-23)16-9-4-3-5-10-16)25-22(26)24-18-12-7-6-11-17(18)20-13-8-14-29-20/h3-14,19,21H,15H2,1-2H3,(H2,24,25,26)/t19-,21-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Binding affinity towards human orexin receptor type 1 was determined using [125I]-Orexin A as radio ligand				Bioorg Med Chem Lett 14: 4225-9 (2004) Article DOI: 10.1016/j.bmcl.2004.06.032 BindingDB Entry DOI: 10.7270/Q2K64MV4
					More data for this Ligand-Target Pair

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