BindingDB PrimarySearch

Found 11 hits with Last Name = 'mcphail' and Initial = 'p'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50332241 ((S)-(1-(cyclohexylmethyl)-7-methoxy-1H-indol-3-yl)...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human CYP3A4				Bioorg Med Chem Lett 20: 7327-30 (2010) Article DOI: 10.1016/j.bmcl.2010.10.061 BindingDB Entry DOI: 10.7270/Q26T0MWV
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50332241 ((S)-(1-(cyclohexylmethyl)-7-methoxy-1H-indol-3-yl)...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human CYP2C19				Bioorg Med Chem Lett 20: 7327-30 (2010) Article DOI: 10.1016/j.bmcl.2010.10.061 BindingDB Entry DOI: 10.7270/Q26T0MWV
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM50332241 ((S)-(1-(cyclohexylmethyl)-7-methoxy-1H-indol-3-yl)...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human CYP2C9				Bioorg Med Chem Lett 20: 7327-30 (2010) Article DOI: 10.1016/j.bmcl.2010.10.061 BindingDB Entry DOI: 10.7270/Q26T0MWV
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50332241 ((S)-(1-(cyclohexylmethyl)-7-methoxy-1H-indol-3-yl)...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human CYP2D6				Bioorg Med Chem Lett 20: 7327-30 (2010) Article DOI: 10.1016/j.bmcl.2010.10.061 BindingDB Entry DOI: 10.7270/Q26T0MWV
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human))	BDBM50105786 (2-(3,4-Dihydro-1H-isoquinolin-2-yl)-propionic acid...) Show SMILES COc1cccc(OC)c1OC(=O)C(C)N1CCc2ccccc2C1 Show InChI	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a
Organon Research Curated by ChEMBL					Assay Description GABA-modulatory action compound was evaluated on Oocytes expressing recombinant human alpha-1-beta-3-gamma-2L GABA A receptor at concentrations of >=...				J Med Chem 44: 3582-91 (2001) BindingDB Entry DOI: 10.7270/Q2KW5GRD
Organon Research Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human))	BDBM50105787 ((R)-2-[Bis-(2-methoxy-ethyl)-amino]-butyric acid 2...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a
Organon Research Curated by ChEMBL					Assay Description GABA-modulatory action compound was evaluated on Oocytes expressing recombinant human alpha-1-beta-3-gamma-2L GABA A receptor at concentrations of >=...				J Med Chem 44: 3582-91 (2001) BindingDB Entry DOI: 10.7270/Q2KW5GRD
Organon Research Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human))	BDBM50105785 (2-Morpholin-4-yl-propionic acid 2,6-dimethoxy-phen...) Show SMILES COc1cccc(OC)c1OC(=O)[C@@H](C)N1CCOCC1 Show InChI	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	1.98E+5	n/a	n/a	n/a	n/a
Organon Research Curated by ChEMBL					Assay Description GABA-modulatory action compound was evaluated on Oocytes expressing recombinant human alpha-1-beta-3-gamma-2L GABA A receptor at concentrations of >=...				J Med Chem 44: 3582-91 (2001) BindingDB Entry DOI: 10.7270/Q2KW5GRD
Organon Research Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human))	BDBM50105784 (2-(3,4-Dihydro-1H-isoquinolin-2-yl)-propionic acid...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a
Organon Research Curated by ChEMBL					Assay Description GABA-modulatory action compound was evaluated on Oocytes expressing recombinant human alpha-1-beta-3-gamma-2L GABA A receptor at concentrations of >=...				J Med Chem 44: 3582-91 (2001) BindingDB Entry DOI: 10.7270/Q2KW5GRD
Organon Research Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human))	BDBM50058046 (CHEMBL526 \| propofol) Show SMILES CC(C)c1cccc(C(C)C)c1O Show InChI	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a
Organon Research Curated by ChEMBL					Assay Description GABA-mimetic action on Oocytes expressing human alpha-1-beta-3-gamma-2L GABA-A receptor subunits at >=100 uM				J Med Chem 44: 3582-91 (2001) BindingDB Entry DOI: 10.7270/Q2KW5GRD
Organon Research Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human))	BDBM50058046 (CHEMBL526 \| propofol) Show SMILES CC(C)c1cccc(C(C)C)c1O Show InChI	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a
Organon Research Curated by ChEMBL					Assay Description GABA-modulatory action compound was evaluated on Oocytes expressing recombinant human alpha-1-beta-3-gamma-2L GABA A receptor at concentrations of >=...				J Med Chem 44: 3582-91 (2001) BindingDB Entry DOI: 10.7270/Q2KW5GRD
Organon Research Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human))	BDBM50105783 (2-(3,4-Dihydro-1H-isoquinolin-2-yl)-propionic acid...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Organon Research Curated by ChEMBL					Assay Description GABA-modulatory action compound was evaluated on Oocytes expressing recombinant human alpha-1-beta-3-gamma-2L GABA A receptor at concentrations of >=...				J Med Chem 44: 3582-91 (2001) BindingDB Entry DOI: 10.7270/Q2KW5GRD
Organon Research Curated by ChEMBL					More data for this Ligand-Target Pair