Found 22 hits with Last Name = 'meguro' and Initial = 'h' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM141316
(US8653304, 3)Show SMILES COc1c(CO)cc(cc1NC(=O)N[C@@H]1Cc2c(cccc2F)[C@@H]1O)C(C)(C)C |r| Show InChI InChI=1S/C22H27FN2O4/c1-22(2,3)13-8-12(11-26)20(29-4)18(9-13)25-21(28)24-17-10-15-14(19(17)27)6-5-7-16(15)23/h5-9,17,19,26-27H,10-11H2,1-4H3,(H2,24,25,28)/t17-,19+/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | 25 |
Toray Industries, Inc.
US Patent
| Assay Description
Using human p38 MAPK alpha , the p38 MAPK inhibitory activity of Compound (I) was studied by a method partially modified from the method described in... |
US Patent US8653304 (2014)
BindingDB Entry DOI: 10.7270/Q29022HQ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50387580
(CHEMBL2058051)Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)NCc1cc(F)cc(F)c1Oc1ccnc(n1)N1CCOCC1)C(C)(C)C Show InChI InChI=1S/C30H33F2N7O3/c1-19-5-7-22(8-6-19)39-25(17-24(37-39)30(2,3)4)35-29(40)34-18-20-15-21(31)16-23(32)27(20)42-26-9-10-33-28(36-26)38-11-13-41-14-12-38/h5-10,15-17H,11-14,18H2,1-4H3,(H2,34,35,40) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant P38alpha-mediated ATF2 phosphorylation after 1 hr |
Bioorg Med Chem Lett 22: 5118-22 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.095
BindingDB Entry DOI: 10.7270/Q2H41SH8 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50387576
(CHEMBL2058047)Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)NCc1cc(F)ccc1Oc1ccnc(n1)N1CCOCC1)C(C)(C)C Show InChI InChI=1S/C30H34FN7O3/c1-20-5-8-23(9-6-20)38-26(18-25(36-38)30(2,3)4)34-29(39)33-19-21-17-22(31)7-10-24(21)41-27-11-12-32-28(35-27)37-13-15-40-16-14-37/h5-12,17-18H,13-16,19H2,1-4H3,(H2,33,34,39) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant P38alpha-mediated ATF2 phosphorylation after 1 hr |
Bioorg Med Chem Lett 22: 5118-22 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.095
BindingDB Entry DOI: 10.7270/Q2H41SH8 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50387577
(CHEMBL2058048)Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)NCc1cc(Cl)ccc1Oc1ccnc(n1)N1CCOCC1)C(C)(C)C Show InChI InChI=1S/C30H34ClN7O3/c1-20-5-8-23(9-6-20)38-26(18-25(36-38)30(2,3)4)34-29(39)33-19-21-17-22(31)7-10-24(21)41-27-11-12-32-28(35-27)37-13-15-40-16-14-37/h5-12,17-18H,13-16,19H2,1-4H3,(H2,33,34,39) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant P38alpha-mediated ATF2 phosphorylation after 1 hr |
Bioorg Med Chem Lett 22: 5118-22 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.095
BindingDB Entry DOI: 10.7270/Q2H41SH8 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM13533
(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
MMDB
PDB
Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant P38alpha-mediated ATF2 phosphorylation after 1 hr |
Bioorg Med Chem Lett 22: 5118-22 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.095
BindingDB Entry DOI: 10.7270/Q2H41SH8 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50387581
(CHEMBL2058052)Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)NCc1cc(F)cc(Cl)c1Oc1ccnc(n1)N1CCOCC1)C(C)(C)C Show InChI InChI=1S/C30H33ClFN7O3/c1-19-5-7-22(8-6-19)39-25(17-24(37-39)30(2,3)4)35-29(40)34-18-20-15-21(32)16-23(31)27(20)42-26-9-10-33-28(36-26)38-11-13-41-14-12-38/h5-10,15-17H,11-14,18H2,1-4H3,(H2,34,35,40) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant P38alpha-mediated ATF2 phosphorylation after 1 hr |
Bioorg Med Chem Lett 22: 5118-22 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.095
BindingDB Entry DOI: 10.7270/Q2H41SH8 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50387574
(CHEMBL2058044)Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)NCc1ccccc1Oc1ccnc(n1)N1CCOCC1)C(C)(C)C Show InChI InChI=1S/C30H35N7O3/c1-21-9-11-23(12-10-21)37-26(19-25(35-37)30(2,3)4)33-29(38)32-20-22-7-5-6-8-24(22)40-27-13-14-31-28(34-27)36-15-17-39-18-16-36/h5-14,19H,15-18,20H2,1-4H3,(H2,32,33,38) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant P38alpha-mediated ATF2 phosphorylation after 1 hr |
Bioorg Med Chem Lett 22: 5118-22 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.095
BindingDB Entry DOI: 10.7270/Q2H41SH8 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50387578
(CHEMBL2058049)Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)NCc1cc(C)ccc1Oc1ccnc(n1)N1CCOCC1)C(C)(C)C Show InChI InChI=1S/C31H37N7O3/c1-21-6-9-24(10-7-21)38-27(19-26(36-38)31(3,4)5)34-30(39)33-20-23-18-22(2)8-11-25(23)41-28-12-13-32-29(35-28)37-14-16-40-17-15-37/h6-13,18-19H,14-17,20H2,1-5H3,(H2,33,34,39) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant P38alpha-mediated ATF2 phosphorylation after 1 hr |
Bioorg Med Chem Lett 22: 5118-22 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.095
BindingDB Entry DOI: 10.7270/Q2H41SH8 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50387575
(CHEMBL2058045)Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)NCc1ccccc1Oc1ccnc(n1)N1CCCCC1)C(C)(C)C Show InChI InChI=1S/C31H37N7O2/c1-22-12-14-24(15-13-22)38-27(20-26(36-38)31(2,3)4)34-30(39)33-21-23-10-6-7-11-25(23)40-28-16-17-32-29(35-28)37-18-8-5-9-19-37/h6-7,10-17,20H,5,8-9,18-19,21H2,1-4H3,(H2,33,34,39) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant P38alpha-mediated ATF2 phosphorylation after 1 hr |
Bioorg Med Chem Lett 22: 5118-22 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.095
BindingDB Entry DOI: 10.7270/Q2H41SH8 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM141323
(US8653304, 108b)Show SMILES COc1c(NC(=O)N[C@@H]2Cc3ccccc3[C@@H]2O)cc(cc1[C@@H](O)C(F)(F)F)C1(C)CCOCC1 |r| Show InChI InChI=1S/C25H29F3N2O5/c1-24(7-9-35-10-8-24)15-12-17(22(32)25(26,27)28)21(34-2)19(13-15)30-23(33)29-18-11-14-5-3-4-6-16(14)20(18)31/h3-6,12-13,18,20,22,31-32H,7-11H2,1-2H3,(H2,29,30,33)/t18-,20+,22-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | 25 |
Toray Industries, Inc.
US Patent
| Assay Description
Using human p38 MAPK alpha , the p38 MAPK inhibitory activity of Compound (I) was studied by a method partially modified from the method described in... |
US Patent US8653304 (2014)
BindingDB Entry DOI: 10.7270/Q29022HQ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50387572
(CHEMBL2058053)Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)NCc1cc(F)cc(C)c1Oc1ccnc(n1)N1CCOCC1)C(C)(C)C Show InChI InChI=1S/C31H36FN7O3/c1-20-6-8-24(9-7-20)39-26(18-25(37-39)31(3,4)5)35-30(40)34-19-22-17-23(32)16-21(2)28(22)42-27-10-11-33-29(36-27)38-12-14-41-15-13-38/h6-11,16-18H,12-15,19H2,1-5H3,(H2,34,35,40) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant P38alpha-mediated ATF2 phosphorylation after 1 hr |
Bioorg Med Chem Lett 22: 5118-22 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.095
BindingDB Entry DOI: 10.7270/Q2H41SH8 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM141317
(US8653304, 46b | US8653304, 47b)Show SMILES COc1c(NC(=O)N[C@@H]2Cc3ccccc3[C@@H]2O)cc(cc1[C@@H](O)C(F)(F)F)C(C)(C)C |r| Show InChI InChI=1S/C23H27F3N2O4/c1-22(2,3)13-10-15(20(30)23(24,25)26)19(32-4)17(11-13)28-21(31)27-16-9-12-7-5-6-8-14(12)18(16)29/h5-8,10-11,16,18,20,29-30H,9H2,1-4H3,(H2,27,28,31)/t16-,18+,20-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | 25 |
Toray Industries, Inc.
US Patent
| Assay Description
Using human p38 MAPK alpha , the p38 MAPK inhibitory activity of Compound (I) was studied by a method partially modified from the method described in... |
US Patent US8653304 (2014)
BindingDB Entry DOI: 10.7270/Q29022HQ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM141321
(US8653304, 84b)Show SMILES COc1c(NC(=O)N[C@@H]2Cc3c(cccc3F)[C@@H]2O)cc(cc1[C@@H](O)C(F)(F)F)N1CCOCC1 |r| Show InChI InChI=1S/C23H25F4N3O5/c1-34-20-15(21(32)23(25,26)27)9-12(30-5-7-35-8-6-30)10-18(20)29-22(33)28-17-11-14-13(19(17)31)3-2-4-16(14)24/h2-4,9-10,17,19,21,31-32H,5-8,11H2,1H3,(H2,28,29,33)/t17-,19+,21-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | 25 |
Toray Industries, Inc.
US Patent
| Assay Description
Using human p38 MAPK alpha , the p38 MAPK inhibitory activity of Compound (I) was studied by a method partially modified from the method described in... |
US Patent US8653304 (2014)
BindingDB Entry DOI: 10.7270/Q29022HQ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM141317
(US8653304, 46b | US8653304, 47b)Show SMILES COc1c(NC(=O)N[C@@H]2Cc3ccccc3[C@@H]2O)cc(cc1[C@@H](O)C(F)(F)F)C(C)(C)C |r| Show InChI InChI=1S/C23H27F3N2O4/c1-22(2,3)13-10-15(20(30)23(24,25)26)19(32-4)17(11-13)28-21(31)27-16-9-12-7-5-6-8-14(12)18(16)29/h5-8,10-11,16,18,20,29-30H,9H2,1-4H3,(H2,27,28,31)/t16-,18+,20-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | 25 |
Toray Industries, Inc.
US Patent
| Assay Description
Using human p38 MAPK alpha , the p38 MAPK inhibitory activity of Compound (I) was studied by a method partially modified from the method described in... |
US Patent US8653304 (2014)
BindingDB Entry DOI: 10.7270/Q29022HQ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50387571
(CHEMBL2058046)Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)NCc1ccccc1Oc1ccnc(Cl)n1)C(C)(C)C Show InChI InChI=1S/C26H27ClN6O2/c1-17-9-11-19(12-10-17)33-22(15-21(32-33)26(2,3)4)30-25(34)29-16-18-7-5-6-8-20(18)35-23-13-14-28-24(27)31-23/h5-15H,16H2,1-4H3,(H2,29,30,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant P38alpha-mediated ATF2 phosphorylation after 1 hr |
Bioorg Med Chem Lett 22: 5118-22 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.095
BindingDB Entry DOI: 10.7270/Q2H41SH8 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM141320
(US8653304, 52b)Show SMILES COc1cccc2[C@H](O)[C@@H](Cc12)NC(=O)Nc1cc(cc([C@H](O)C(F)(F)F)c1OC)C(C)(C)C |r| Show InChI InChI=1S/C24H29F3N2O5/c1-23(2,3)12-9-15(21(31)24(25,26)27)20(34-5)17(10-12)29-22(32)28-16-11-14-13(19(16)30)7-6-8-18(14)33-4/h6-10,16,19,21,30-31H,11H2,1-5H3,(H2,28,29,32)/t16-,19+,21+/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | 25 |
Toray Industries, Inc.
US Patent
| Assay Description
Using human p38 MAPK alpha , the p38 MAPK inhibitory activity of Compound (I) was studied by a method partially modified from the method described in... |
US Patent US8653304 (2014)
BindingDB Entry DOI: 10.7270/Q29022HQ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM141324
(US8653304, 123b)Show SMILES CCC(C)(C)c1cc(NC(=O)N[C@@H]2Cc3ccccc3[C@@H]2O)c(OC)c(c1)[C@@H](O)C(F)(F)F |r| Show InChI InChI=1S/C24H29F3N2O4/c1-5-23(2,3)14-11-16(21(31)24(25,26)27)20(33-4)18(12-14)29-22(32)28-17-10-13-8-6-7-9-15(13)19(17)30/h6-9,11-12,17,19,21,30-31H,5,10H2,1-4H3,(H2,28,29,32)/t17-,19+,21-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | 25 |
Toray Industries, Inc.
US Patent
| Assay Description
Using human p38 MAPK alpha , the p38 MAPK inhibitory activity of Compound (I) was studied by a method partially modified from the method described in... |
US Patent US8653304 (2014)
BindingDB Entry DOI: 10.7270/Q29022HQ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM141319
(US8653304, 50b)Show SMILES COc1c(NC(=O)N[C@@H]2Cc3c(cccc3F)[C@@H]2O)cc(cc1[C@@H](O)C(F)(F)F)C(C)(C)C |r| Show InChI InChI=1S/C23H26F4N2O4/c1-22(2,3)11-8-14(20(31)23(25,26)27)19(33-4)17(9-11)29-21(32)28-16-10-13-12(18(16)30)6-5-7-15(13)24/h5-9,16,18,20,30-31H,10H2,1-4H3,(H2,28,29,32)/t16-,18+,20-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | 25 |
Toray Industries, Inc.
US Patent
| Assay Description
Using human p38 MAPK alpha , the p38 MAPK inhibitory activity of Compound (I) was studied by a method partially modified from the method described in... |
US Patent US8653304 (2014)
BindingDB Entry DOI: 10.7270/Q29022HQ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50387579
(CHEMBL2058050)Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)NCc1cc(ccc1Oc1ccnc(n1)N1CCOCC1)C(F)(F)F)C(C)(C)C Show InChI InChI=1S/C31H34F3N7O3/c1-20-5-8-23(9-6-20)41-26(18-25(39-41)30(2,3)4)37-29(42)36-19-21-17-22(31(32,33)34)7-10-24(21)44-27-11-12-35-28(38-27)40-13-15-43-16-14-40/h5-12,17-18H,13-16,19H2,1-4H3,(H2,36,37,42) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant P38alpha-mediated ATF2 phosphorylation after 1 hr |
Bioorg Med Chem Lett 22: 5118-22 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.095
BindingDB Entry DOI: 10.7270/Q2H41SH8 |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM141322
(US8653304, 92b)Show SMILES COc1c(NC(=O)N[C@@H]2Cc3ccccc3[C@@H]2O)cc(cc1[C@@H](O)C(F)(F)F)N1CCCC1 |r| Show InChI InChI=1S/C23H26F3N3O4/c1-33-20-16(21(31)23(24,25)26)11-14(29-8-4-5-9-29)12-18(20)28-22(32)27-17-10-13-6-2-3-7-15(13)19(17)30/h2-3,6-7,11-12,17,19,21,30-31H,4-5,8-10H2,1H3,(H2,27,28,32)/t17-,19+,21-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | 25 |
Toray Industries, Inc.
US Patent
| Assay Description
Using human p38 MAPK alpha , the p38 MAPK inhibitory activity of Compound (I) was studied by a method partially modified from the method described in... |
US Patent US8653304 (2014)
BindingDB Entry DOI: 10.7270/Q29022HQ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM141325
(US8653304, Comparative Compound 1)Show SMILES COc1c(NC(=O)NC2Cc3ccccc3C2)cc(cc1C(O)C(F)(F)F)C(C)(C)C Show InChI InChI=1S/C23H27F3N2O3/c1-22(2,3)15-11-17(20(29)23(24,25)26)19(31-4)18(12-15)28-21(30)27-16-9-13-7-5-6-8-14(13)10-16/h5-8,11-12,16,20,29H,9-10H2,1-4H3,(H2,27,28,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 117 | n/a | n/a | n/a | n/a | n/a | 25 |
Toray Industries, Inc.
US Patent
| Assay Description
Using human p38 MAPK alpha , the p38 MAPK inhibitory activity of Compound (I) was studied by a method partially modified from the method described in... |
US Patent US8653304 (2014)
BindingDB Entry DOI: 10.7270/Q29022HQ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50387573
(CHEMBL2058043)Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)NCc1ccccc1O)C(C)(C)C Show InChI InChI=1S/C22H26N4O2/c1-15-9-11-17(12-10-15)26-20(13-19(25-26)22(2,3)4)24-21(28)23-14-16-7-5-6-8-18(16)27/h5-13,27H,14H2,1-4H3,(H2,23,24,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant P38alpha-mediated ATF2 phosphorylation after 1 hr |
Bioorg Med Chem Lett 22: 5118-22 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.095
BindingDB Entry DOI: 10.7270/Q2H41SH8 |
More data for this
Ligand-Target Pair | |
Search and Browse
