Found 576 hits with Last Name = 'nielsen' and Initial = 'sf' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM14774
(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)Show SMILES FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1c(Cl)cncc1Cl Show InChI InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PDE4 (unknown origin) |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00797
BindingDB Entry DOI: 10.7270/Q2T43XPQ |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50088456
(1-(6-Chloro-5-methoxy-pyridin-3-yl)-[1,4]diazepane...)Show InChI InChI=1S/C11H16ClN3O/c1-16-10-7-9(8-14-11(10)12)15-5-2-3-13-4-6-15/h7-8,13H,2-6H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.680 | n/a | n/a | n/a | n/a | n/a | n/a |
NeuroSearch A/S
Curated by ChEMBL
| Assay Description
In vitro binding affinity for Nicotinic acetylcholine receptor alpha4-beta2 (alpha4 beta-2 subtype of nAChRs) in rat cerebral cortical membrane using... |
J Med Chem 43: 2217-26 (2000)
BindingDB Entry DOI: 10.7270/Q2NC62DS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50548547
(CHEMBL4784121)Show SMILES COc1ccc(-c2ccc3C(=O)OCc3c2)n2nc(nc12)C1(CC1)C(=O)NCC(C)C | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.680 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PDE4D in human PBMC assessed as reduction in lipopolysaccharide-induced TNFalpha production pre-incubated for 30 mins before LPS stimul... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00797
BindingDB Entry DOI: 10.7270/Q2T43XPQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50548547
(CHEMBL4784121)Show SMILES COc1ccc(-c2ccc3C(=O)OCc3c2)n2nc(nc12)C1(CC1)C(=O)NCC(C)C | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human PDE4D catalytic domain using cAMP and FAM-conjugated cAMP by IMAP FRET progressive binding assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00797
BindingDB Entry DOI: 10.7270/Q2T43XPQ |
More data for this
Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50088453
(1-(6-Bromo-5-ethoxy-pyridin-3-yl)-[1,4]diazepane |...)Show InChI InChI=1S/C12H18BrN3O/c1-2-17-11-8-10(9-15-12(11)13)16-6-3-4-14-5-7-16/h8-9,14H,2-7H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.870 | n/a | n/a | n/a | n/a | n/a | n/a |
NeuroSearch A/S
Curated by ChEMBL
| Assay Description
In vitro binding affinity for Nicotinic acetylcholine receptor alpha4-beta2 (alpha4 beta-2 subtype of nAChRs) in rat cerebral cortical membrane using... |
J Med Chem 43: 2217-26 (2000)
BindingDB Entry DOI: 10.7270/Q2NC62DS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50048422
(CHEMBL3315084)Show SMILES COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c(OCC(=O)Nc2ccccc2)c1OC Show InChI InChI=1S/C23H20Cl2N2O5/c1-30-20-9-8-15(19(28)10-16-17(24)11-26-12-18(16)25)22(23(20)31-2)32-13-21(29)27-14-6-4-3-5-7-14/h3-9,11-12H,10,13H2,1-2H3,(H,27,29) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
LEO Pharma A/S
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4D after 1 hr by SPA in presence of radioactively labeled cAMP |
J Med Chem 57: 5893-903 (2014)
Article DOI: 10.1021/jm500378a
BindingDB Entry DOI: 10.7270/Q2CV4KC4 |
More data for this
Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50088454
(1-(6-Bromo-pyridin-3-yl)-[1,4]diazepane | 1-(6-bro...)Show InChI InChI=1S/C10H14BrN3/c11-10-3-2-9(8-13-10)14-6-1-4-12-5-7-14/h2-3,8,12H,1,4-7H2 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| Purchase
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
NeuroSearch A/S
Curated by ChEMBL
| Assay Description
In vitro binding affinity for Nicotinic acetylcholine receptor alpha4-beta2 (alpha4 beta-2 subtype of nAChRs) in rat cerebral cortical membrane using... |
J Med Chem 43: 2217-26 (2000)
BindingDB Entry DOI: 10.7270/Q2NC62DS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50548531
(CHEMBL4747201)Show SMILES COc1ccc(-c2ccc3C(=O)OCc3c2)n2nc(nc12)C1(CC1)C(=O)OCC(C)C | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human PDE4B catalytic domain using cAMP and FAM-conjugated cAMP by IMAP FRET progressive binding assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00797
BindingDB Entry DOI: 10.7270/Q2T43XPQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM50548531
(CHEMBL4747201)Show SMILES COc1ccc(-c2ccc3C(=O)OCc3c2)n2nc(nc12)C1(CC1)C(=O)OCC(C)C | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human PDE4A catalytic domain using cAMP and FAM-conjugated cAMP by IMAP FRET progressive binding assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00797
BindingDB Entry DOI: 10.7270/Q2T43XPQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM130923
(US8829190, 101)Show SMILES COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)n2nc(nc12)C1CC1 Show InChI InChI=1S/C17H14Cl2N4O2/c1-25-15-5-4-13(23-17(15)21-16(22-23)9-2-3-9)14(24)6-10-11(18)7-20-8-12(10)19/h4-5,7-9H,2-3,6H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PDE4 (unknown origin) |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00797
BindingDB Entry DOI: 10.7270/Q2T43XPQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM47184
(US8980905, 110 | US9637499, Compound 110)Show SMILES FC(F)Oc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2OC3(CCSCC3)Oc12 Show InChI InChI=1S/C18H14Cl2F2N2O4S/c19-10-7-23-8-11(20)13(10)24-16(25)9-1-2-12(26-17(21)22)15-14(9)27-18(28-15)3-5-29-6-4-18/h1-2,7-8,17H,3-6H2,(H,23,24,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
LEO PHARMA A/S
US Patent
| Assay Description
Human recombinant PDE4 (Genbank accession no NM_006203) was incubated for 1 hour, with the test compound at concentrations up to 10 μM, with cAM... |
US Patent US9637499 (2017)
BindingDB Entry DOI: 10.7270/Q20R9RHF |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50548527
(CHEMBL4740828)Show SMILES COc1ccc(-c2ccc3C(=O)OCc3c2)n2nc(nc12)C1(CC1)C(=O)OC1CCCCC1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human PDE4D catalytic domain using cAMP and FAM-conjugated cAMP by IMAP FRET progressive binding assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00797
BindingDB Entry DOI: 10.7270/Q2T43XPQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM47184
(US8980905, 110 | US9637499, Compound 110)Show SMILES FC(F)Oc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2OC3(CCSCC3)Oc12 Show InChI InChI=1S/C18H14Cl2F2N2O4S/c19-10-7-23-8-11(20)13(10)24-16(25)9-1-2-12(26-17(21)22)15-14(9)27-18(28-15)3-5-29-6-4-18/h1-2,7-8,17H,3-6H2,(H,23,24,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Leo Pharma A/S
US Patent
| Assay Description
Human recombinant PDE4 (Genbank accession no NM006203) was incubated for 1 hour, with the test compound at concentrations up to 10 μM, with cAMP... |
US Patent US8980905 (2015)
BindingDB Entry DOI: 10.7270/Q20V8BH4 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50548555
(CHEMBL4779112)Show SMILES COc1ccc(-c2cccc(c2)C#N)n2nc(nc12)C1(CC1)C(=O)NCC(C)C | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human PDE4D catalytic domain using cAMP and FAM-conjugated cAMP by IMAP FRET progressive binding assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00797
BindingDB Entry DOI: 10.7270/Q2T43XPQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50548528
(CHEMBL4740242)Show SMILES COc1ccc(-c2ccc3C(=O)OCc3c2)n2nc(nc12)C1(CC1)C(=O)OC1CCCC1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human PDE4D catalytic domain using cAMP and FAM-conjugated cAMP by IMAP FRET progressive binding assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00797
BindingDB Entry DOI: 10.7270/Q2T43XPQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50548526
(CHEMBL4750576)Show SMILES COc1ccc(-c2ccc3C(=O)OCc3c2)n2nc(nc12)C1(CC1)C(=O)OC1CCCCCC1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human PDE4D catalytic domain using cAMP and FAM-conjugated cAMP by IMAP FRET progressive binding assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00797
BindingDB Entry DOI: 10.7270/Q2T43XPQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50048446
(CHEMBL3315088)Show SMILES CCCNC(=O)COc1c(ccc(OC)c1OC)C(=O)Cc1c(Cl)cncc1Cl Show InChI InChI=1S/C20H22Cl2N2O5/c1-4-7-24-18(26)11-29-19-12(5-6-17(27-2)20(19)28-3)16(25)8-13-14(21)9-23-10-15(13)22/h5-6,9-10H,4,7-8,11H2,1-3H3,(H,24,26) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PDE4 (unknown origin) |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00797
BindingDB Entry DOI: 10.7270/Q2T43XPQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50548527
(CHEMBL4740828)Show SMILES COc1ccc(-c2ccc3C(=O)OCc3c2)n2nc(nc12)C1(CC1)C(=O)OC1CCCCC1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PDE4D in human PBMC assessed as reduction in lipopolysaccharide-induced TNFalpha production pre-incubated for 30 mins before LPS stimul... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00797
BindingDB Entry DOI: 10.7270/Q2T43XPQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Homo sapiens (Human)) | BDBM50548531
(CHEMBL4747201)Show SMILES COc1ccc(-c2ccc3C(=O)OCc3c2)n2nc(nc12)C1(CC1)C(=O)OCC(C)C | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human PDE4C catalytic domain using cAMP and FAM-conjugated cAMP by IMAP FRET progressive binding assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00797
BindingDB Entry DOI: 10.7270/Q2T43XPQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50048421
(CHEMBL3315083)Show SMILES COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c(OCC(=O)NCc2ccccc2)c1OC Show InChI InChI=1S/C24H22Cl2N2O5/c1-31-21-9-8-16(20(29)10-17-18(25)12-27-13-19(17)26)23(24(21)32-2)33-14-22(30)28-11-15-6-4-3-5-7-15/h3-9,12-13H,10-11,14H2,1-2H3,(H,28,30) | PDB
KEGG
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B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
LEO Pharma A/S
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4D after 1 hr by SPA in presence of radioactively labeled cAMP |
J Med Chem 57: 5893-903 (2014)
Article DOI: 10.1021/jm500378a
BindingDB Entry DOI: 10.7270/Q2CV4KC4 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50548528
(CHEMBL4740242)Show SMILES COc1ccc(-c2ccc3C(=O)OCc3c2)n2nc(nc12)C1(CC1)C(=O)OC1CCCC1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PDE4D in human PBMC assessed as reduction in lipopolysaccharide-induced TNFalpha production pre-incubated for 30 mins before LPS stimul... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00797
BindingDB Entry DOI: 10.7270/Q2T43XPQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50548555
(CHEMBL4779112)Show SMILES COc1ccc(-c2cccc(c2)C#N)n2nc(nc12)C1(CC1)C(=O)NCC(C)C | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PDE4D in human PBMC assessed as reduction in lipopolysaccharide-induced TNFalpha production pre-incubated for 30 mins before LPS stimul... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00797
BindingDB Entry DOI: 10.7270/Q2T43XPQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50548531
(CHEMBL4747201)Show SMILES COc1ccc(-c2ccc3C(=O)OCc3c2)n2nc(nc12)C1(CC1)C(=O)OCC(C)C | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human PDE4D catalytic domain using cAMP and FAM-conjugated cAMP by IMAP FRET progressive binding assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00797
BindingDB Entry DOI: 10.7270/Q2T43XPQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50548526
(CHEMBL4750576)Show SMILES COc1ccc(-c2ccc3C(=O)OCc3c2)n2nc(nc12)C1(CC1)C(=O)OC1CCCCCC1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
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| PC cid
PC sid
UniChem
| Article
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| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PDE4D in human PBMC assessed as reduction in lipopolysaccharide-induced TNFalpha production pre-incubated for 30 mins before LPS stimul... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00797
BindingDB Entry DOI: 10.7270/Q2T43XPQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM150197
(US8980905, 104 | US9637499, Compound 104)Show SMILES [O-][n+]1cc(Cl)c(CC(=O)c2ccc(OC(F)F)c3OCC4(CCOCC4)COc23)c(Cl)c1 Show InChI InChI=1S/C21H19Cl2F2NO6/c22-14-8-26(28)9-15(23)13(14)7-16(27)12-1-2-17(32-20(24)25)19-18(12)30-10-21(11-31-19)3-5-29-6-4-21/h1-2,8-9,20H,3-7,10-11H2 | PDB
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| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Leo Pharma A/S
US Patent
| Assay Description
Human recombinant PDE4 (Genbank accession no NM006203) was incubated for 1 hour, with the test compound at concentrations up to 10 μM, with cAMP... |
US Patent US8980905 (2015)
BindingDB Entry DOI: 10.7270/Q20V8BH4 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM150197
(US8980905, 104 | US9637499, Compound 104)Show SMILES [O-][n+]1cc(Cl)c(CC(=O)c2ccc(OC(F)F)c3OCC4(CCOCC4)COc23)c(Cl)c1 Show InChI InChI=1S/C21H19Cl2F2NO6/c22-14-8-26(28)9-15(23)13(14)7-16(27)12-1-2-17(32-20(24)25)19-18(12)30-10-21(11-31-19)3-5-29-6-4-21/h1-2,8-9,20H,3-7,10-11H2 | PDB
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Similars
| US Patent
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
LEO PHARMA A/S
US Patent
| Assay Description
Human recombinant PDE4 (Genbank accession no NM_006203) was incubated for 1 hour, with the test compound at concentrations up to 10 μM, with cAM... |
US Patent US9637499 (2017)
BindingDB Entry DOI: 10.7270/Q20R9RHF |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50548533
(CHEMBL4739987)Show SMILES CC[C@@H](C)OC(=O)C1(CC1)c1nc2c(OC)ccc(-c3ccc4C(=O)OCc4c3)n2n1 |r| | PDB
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| Article
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| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human PDE4D catalytic domain using cAMP and FAM-conjugated cAMP by IMAP FRET progressive binding assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00797
BindingDB Entry DOI: 10.7270/Q2T43XPQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50548533
(CHEMBL4739987)Show SMILES CC[C@@H](C)OC(=O)C1(CC1)c1nc2c(OC)ccc(-c3ccc4C(=O)OCc4c3)n2n1 |r| | PDB
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TBA
| Assay Description
Inhibition of PDE4D in human PBMC assessed as reduction in lipopolysaccharide-induced TNFalpha production pre-incubated for 30 mins before LPS stimul... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00797
BindingDB Entry DOI: 10.7270/Q2T43XPQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50048447
(CHEMBL3315089)Show SMILES COc1ccc(C(=O)Cc2c(Cl)c[n+]([O-])cc2Cl)c(OCC(=O)NCc2ccccc2)c1OC Show InChI InChI=1S/C24H22Cl2N2O6/c1-32-21-9-8-16(20(29)10-17-18(25)12-28(31)13-19(17)26)23(24(21)33-2)34-14-22(30)27-11-15-6-4-3-5-7-15/h3-9,12-13H,10-11,14H2,1-2H3,(H,27,30) | PDB
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LEO Pharma A/S
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4D after 1 hr by SPA in presence of radioactively labeled cAMP |
J Med Chem 57: 5893-903 (2014)
Article DOI: 10.1021/jm500378a
BindingDB Entry DOI: 10.7270/Q2CV4KC4 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM150199
(US8980905, 106 | US9637499, Compound 106)Show SMILES [O-][n+]1cc(Cl)c(CC(=O)c2ccc(OC(F)F)c3OC4(CCOCC4)Oc23)c(Cl)c1 Show InChI InChI=1S/C19H15Cl2F2NO6/c20-12-8-24(26)9-13(21)11(12)7-14(25)10-1-2-15(28-18(22)23)17-16(10)29-19(30-17)3-5-27-6-4-19/h1-2,8-9,18H,3-7H2 | PDB
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| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
LEO PHARMA A/S
US Patent
| Assay Description
Human recombinant PDE4 (Genbank accession no NM_006203) was incubated for 1 hour, with the test compound at concentrations up to 10 μM, with cAM... |
US Patent US9637499 (2017)
BindingDB Entry DOI: 10.7270/Q20R9RHF |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM150199
(US8980905, 106 | US9637499, Compound 106)Show SMILES [O-][n+]1cc(Cl)c(CC(=O)c2ccc(OC(F)F)c3OC4(CCOCC4)Oc23)c(Cl)c1 Show InChI InChI=1S/C19H15Cl2F2NO6/c20-12-8-24(26)9-13(21)11(12)7-14(25)10-1-2-15(28-18(22)23)17-16(10)29-19(30-17)3-5-27-6-4-19/h1-2,8-9,18H,3-7H2 | PDB
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Leo Pharma A/S
US Patent
| Assay Description
Human recombinant PDE4 (Genbank accession no NM006203) was incubated for 1 hour, with the test compound at concentrations up to 10 μM, with cAMP... |
US Patent US8980905 (2015)
BindingDB Entry DOI: 10.7270/Q20V8BH4 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50048446
(CHEMBL3315088)Show SMILES CCCNC(=O)COc1c(ccc(OC)c1OC)C(=O)Cc1c(Cl)cncc1Cl Show InChI InChI=1S/C20H22Cl2N2O5/c1-4-7-24-18(26)11-29-19-12(5-6-17(27-2)20(19)28-3)16(25)8-13-14(21)9-23-10-15(13)22/h5-6,9-10H,4,7-8,11H2,1-3H3,(H,24,26) | PDB
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| Article
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| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
LEO Pharma A/S
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4D after 1 hr by SPA in presence of radioactively labeled cAMP |
J Med Chem 57: 5893-903 (2014)
Article DOI: 10.1021/jm500378a
BindingDB Entry DOI: 10.7270/Q2CV4KC4 |
More data for this
Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Rattus norvegicus (Rat)) | BDBM50088450
(1-(5-(vinyloxy)pyridin-3-yl)-1,4-diazepane | 1-(5-...)Show InChI InChI=1S/C12H17N3O/c1-2-16-12-8-11(9-14-10-12)15-6-3-4-13-5-7-15/h2,8-10,13H,1,3-7H2 | PDB
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| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
NeuroSearch A/S
Curated by ChEMBL
| Assay Description
In vitro binding affinity for Nicotinic acetylcholine receptor alpha4-beta2 (alpha4 beta-2 subtype of nAChRs) in rat cerebral cortical membrane using... |
J Med Chem 43: 2217-26 (2000)
BindingDB Entry DOI: 10.7270/Q2NC62DS |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50548543
(CHEMBL4741065)Show SMILES COc1ccc(-c2cccc(c2)C#N)n2nc(nc12)C1(COC(=O)C(C)C)CC1 | PDB
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| n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human PDE4D catalytic domain using cAMP and FAM-conjugated cAMP by IMAP FRET progressive binding assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00797
BindingDB Entry DOI: 10.7270/Q2T43XPQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50548532
(CHEMBL4764289)Show SMILES CC[C@H](C)OC(=O)C1(CC1)c1nc2c(OC)ccc(-c3ccc4C(=O)OCc4c3)n2n1 |r| | PDB
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| n/a | n/a | 5.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human PDE4D catalytic domain using cAMP and FAM-conjugated cAMP by IMAP FRET progressive binding assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00797
BindingDB Entry DOI: 10.7270/Q2T43XPQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50548531
(CHEMBL4747201)Show SMILES COc1ccc(-c2ccc3C(=O)OCc3c2)n2nc(nc12)C1(CC1)C(=O)OCC(C)C | PDB
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| Article
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| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PDE4D in human PBMC assessed as reduction in lipopolysaccharide-induced TNFalpha production pre-incubated for 30 mins before LPS stimul... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00797
BindingDB Entry DOI: 10.7270/Q2T43XPQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM150194
(US8980905, 101 | US9637499, Compound 101)Show SMILES FC(F)Oc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c2OCC3(COC3)COc12 Show InChI InChI=1S/C19H15Cl2F2NO5/c20-12-4-24-5-13(21)11(12)3-14(25)10-1-2-15(29-18(22)23)17-16(10)27-8-19(9-28-17)6-26-7-19/h1-2,4-5,18H,3,6-9H2 | PDB
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| US Patent
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Leo Pharma A/S
US Patent
| Assay Description
Human recombinant PDE4 (Genbank accession no NM006203) was incubated for 1 hour, with the test compound at concentrations up to 10 μM, with cAMP... |
US Patent US8980905 (2015)
BindingDB Entry DOI: 10.7270/Q20V8BH4 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50548534
(CHEMBL4761069)Show SMILES COc1ccc(-c2ccc3C(=O)OCc3c2)n2nc(nc12)C1(CC1)C(=O)OC(C)(C)C | PDB
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TBA
| Assay Description
Inhibition of PDE4D in human PBMC assessed as reduction in lipopolysaccharide-induced TNFalpha production pre-incubated for 30 mins before LPS stimul... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00797
BindingDB Entry DOI: 10.7270/Q2T43XPQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM150194
(US8980905, 101 | US9637499, Compound 101)Show SMILES FC(F)Oc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c2OCC3(COC3)COc12 Show InChI InChI=1S/C19H15Cl2F2NO5/c20-12-4-24-5-13(21)11(12)3-14(25)10-1-2-15(29-18(22)23)17-16(10)27-8-19(9-28-17)6-26-7-19/h1-2,4-5,18H,3,6-9H2 | PDB
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| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
LEO PHARMA A/S
US Patent
| Assay Description
Human recombinant PDE4 (Genbank accession no NM_006203) was incubated for 1 hour, with the test compound at concentrations up to 10 μM, with cAM... |
US Patent US9637499 (2017)
BindingDB Entry DOI: 10.7270/Q20R9RHF |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM150196
(US8980905, 103 | US9637499, Compound 103)Show SMILES FC(F)Oc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c2OCC3(CCOCC3)COc12 Show InChI InChI=1S/C21H19Cl2F2NO5/c22-14-8-26-9-15(23)13(14)7-16(27)12-1-2-17(31-20(24)25)19-18(12)29-10-21(11-30-19)3-5-28-6-4-21/h1-2,8-9,20H,3-7,10-11H2 | PDB
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| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Leo Pharma A/S
US Patent
| Assay Description
Human recombinant PDE4 (Genbank accession no NM006203) was incubated for 1 hour, with the test compound at concentrations up to 10 μM, with cAMP... |
US Patent US8980905 (2015)
BindingDB Entry DOI: 10.7270/Q20V8BH4 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM150196
(US8980905, 103 | US9637499, Compound 103)Show SMILES FC(F)Oc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c2OCC3(CCOCC3)COc12 Show InChI InChI=1S/C21H19Cl2F2NO5/c22-14-8-26-9-15(23)13(14)7-16(27)12-1-2-17(31-20(24)25)19-18(12)29-10-21(11-30-19)3-5-28-6-4-21/h1-2,8-9,20H,3-7,10-11H2 | PDB
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| PC cid
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UniChem
Similars
| US Patent
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
LEO PHARMA A/S
US Patent
| Assay Description
Human recombinant PDE4 (Genbank accession no NM_006203) was incubated for 1 hour, with the test compound at concentrations up to 10 μM, with cAM... |
US Patent US9637499 (2017)
BindingDB Entry DOI: 10.7270/Q20R9RHF |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50548532
(CHEMBL4764289)Show SMILES CC[C@H](C)OC(=O)C1(CC1)c1nc2c(OC)ccc(-c3ccc4C(=O)OCc4c3)n2n1 |r| | PDB
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| Article
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| n/a | n/a | 6.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PDE4D in human PBMC assessed as reduction in lipopolysaccharide-induced TNFalpha production pre-incubated for 30 mins before LPS stimul... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00797
BindingDB Entry DOI: 10.7270/Q2T43XPQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM150198
(US8980905, 105 | US9637499, Compound 105)Show SMILES FC(F)Oc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c2OC3(CCOCC3)Oc12 Show InChI InChI=1S/C19H15Cl2F2NO5/c20-12-8-24-9-13(21)11(12)7-14(25)10-1-2-15(27-18(22)23)17-16(10)28-19(29-17)3-5-26-6-4-19/h1-2,8-9,18H,3-7H2 | PDB
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Similars
| US Patent
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Leo Pharma A/S
US Patent
| Assay Description
Human recombinant PDE4 (Genbank accession no NM006203) was incubated for 1 hour, with the test compound at concentrations up to 10 μM, with cAMP... |
US Patent US8980905 (2015)
BindingDB Entry DOI: 10.7270/Q20V8BH4 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50548511
(CHEMBL4744621)Show SMILES COc1ccc(-c2ccc(cc2)C(O)=O)n2nc(nc12)C1(CC1)C(=O)NCC(C)C | PDB
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| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human PDE4D catalytic domain using cAMP and FAM-conjugated cAMP by IMAP FRET progressive binding assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00797
BindingDB Entry DOI: 10.7270/Q2T43XPQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM150198
(US8980905, 105 | US9637499, Compound 105)Show SMILES FC(F)Oc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c2OC3(CCOCC3)Oc12 Show InChI InChI=1S/C19H15Cl2F2NO5/c20-12-8-24-9-13(21)11(12)7-14(25)10-1-2-15(27-18(22)23)17-16(10)28-19(29-17)3-5-26-6-4-19/h1-2,8-9,18H,3-7H2 | PDB
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UniChem
Similars
| US Patent
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
LEO PHARMA A/S
US Patent
| Assay Description
Human recombinant PDE4 (Genbank accession no NM_006203) was incubated for 1 hour, with the test compound at concentrations up to 10 μM, with cAM... |
US Patent US9637499 (2017)
BindingDB Entry DOI: 10.7270/Q20R9RHF |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50548553
(CHEMBL4795054)Show SMILES COC(=O)c1cccc(c1)-c1ccc(OC)c2nc(nn12)C1(CC1)C(=O)NCC(C)C | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human PDE4D catalytic domain using cAMP and FAM-conjugated cAMP by IMAP FRET progressive binding assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00797
BindingDB Entry DOI: 10.7270/Q2T43XPQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50548566
(CHEMBL4796321) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human PDE4D catalytic domain using cAMP and FAM-conjugated cAMP by IMAP FRET progressive binding assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00797
BindingDB Entry DOI: 10.7270/Q2T43XPQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50548534
(CHEMBL4761069)Show SMILES COc1ccc(-c2ccc3C(=O)OCc3c2)n2nc(nc12)C1(CC1)C(=O)OC(C)(C)C | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human PDE4D catalytic domain using cAMP and FAM-conjugated cAMP by IMAP FRET progressive binding assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00797
BindingDB Entry DOI: 10.7270/Q2T43XPQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50548529
(CHEMBL4745874)Show SMILES COc1ccc(-c2ccc3C(=O)OCc3c2)n2nc(nc12)C1(CC1)C(=O)OC1CCC1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human PDE4D catalytic domain using cAMP and FAM-conjugated cAMP by IMAP FRET progressive binding assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00797
BindingDB Entry DOI: 10.7270/Q2T43XPQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50048476
(CHEMBL3315079)Show SMILES COc1ccc(C(=O)Cc2c(Cl)cncc2Cl)c(OCCc2ccc(O)cc2)c1OC Show InChI InChI=1S/C23H21Cl2NO5/c1-29-21-8-7-16(20(28)11-17-18(24)12-26-13-19(17)25)22(23(21)30-2)31-10-9-14-3-5-15(27)6-4-14/h3-8,12-13,27H,9-11H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
LEO Pharma A/S
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant PDE4D after 1 hr by SPA in presence of radioactively labeled cAMP |
J Med Chem 57: 5893-903 (2014)
Article DOI: 10.1021/jm500378a
BindingDB Entry DOI: 10.7270/Q2CV4KC4 |
More data for this
Ligand-Target Pair | |
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