| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4D |
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| Ligand | BDBM50548526 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2022524 (CHEMBL4676337) |
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| IC50 | 3.9±n/a nM |
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| Citation |  Larsen, J; Lambert, M; Pettersson, H; Vifian, T; Larsen, M; Ollerstam, A; Hegardt, P; Eskilsson, C; Laursen, S; Soehoel, A; Skak-Nielsen, T; Hansen, LM; Knudsen, NØ; Eirefelt, S; Sørensen, MD; Stilou, TG; Nielsen, SF Discovery and Early Clinical Development of Isobutyl 1-[8-Methoxy-5-(1-oxo-3 J Med Chem63:14502-14521 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP-specific 3',5'-cyclic phosphodiesterase 4D |
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| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4D |
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| Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE3 | PDE43 | PDE4D | PDE4D_HUMAN | Phosphodiesterase 4D |
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| Type: | Protein |
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| Mol. Mass.: | 91092.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q08499 |
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| Residue: | 809 |
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| Sequence: | MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPP
PPPSPQPQPQCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCRA
MDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQA
NFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNF
AALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSV
SEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRP
MSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPL
TVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLST
PALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGF
KLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVL
LLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMC
DKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAP
DDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPL
DEQVEEEAVGEEEESQPEACVIDDRSPDT
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| BDBM50548526 |
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| n/a |
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| Name | BDBM50548526 |
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| Synonyms: | CHEMBL4750576 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H27N3O5 |
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| Mol. Mass. | 461.5097 |
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| SMILES | COc1ccc(-c2ccc3C(=O)OCc3c2)n2nc(nc12)C1(CC1)C(=O)OC1CCCCCC1 |
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| Structure | 
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