Compile Data Set for Download or QSAR

Found 88 hits with Last Name = 'olivier' and Initial = 'ar'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402299 (CHEMBL2206064) Show SMILES CNc1nc(N)nc2nc(ccc12)-c1c(Oc2ccccc2)cccc1C(F)(F)F Show InChI InChI=1S/C21H16F3N5O/c1-26-18-13-10-11-15(27-19(13)29-20(25)28-18)17-14(21(22,23)24)8-5-9-16(17)30-12-6-3-2-4-7-12/h2-11H,1H3,(H3,25,26,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402291 (CHEMBL2206071) Show SMILES CNc1nc(N)nc2nc(c(cc12)C(O)=O)-c1ccccc1C(F)(F)F Show InChI InChI=1S/C16H12F3N5O2/c1-21-12-9-6-8(14(25)26)11(22-13(9)24-15(20)23-12)7-4-2-3-5-10(7)16(17,18)19/h2-6H,1H3,(H,25,26)(H3,20,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402302 (CHEMBL2205521) Show SMILES CNc1nc(N)nc2nc(ccc12)-c1c(F)cccc1C(F)(F)F Show InChI InChI=1S/C15H11F4N5/c1-21-12-7-5-6-10(22-13(7)24-14(20)23-12)11-8(15(17,18)19)3-2-4-9(11)16/h2-6H,1H3,(H3,20,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402292 (CHEMBL2206070) Show SMILES CCCc1cc2c(NC)nc(N)nc2nc1-c1ccccc1C(F)(F)F Show InChI InChI=1S/C18H18F3N5/c1-3-6-10-9-12-15(23-2)25-17(22)26-16(12)24-14(10)11-7-4-5-8-13(11)18(19,20)21/h4-5,7-9H,3,6H2,1-2H3,(H3,22,23,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402300 (CHEMBL2206063) Show SMILES CNc1nc(N)nc2nc(ccc12)-c1c(SC)cccc1C(F)(F)F Show InChI InChI=1S/C16H14F3N5S/c1-21-13-8-6-7-10(22-14(8)24-15(20)23-13)12-9(16(17,18)19)4-3-5-11(12)25-2/h3-7H,1-2H3,(H3,20,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402296 (CHEMBL2206067) Show SMILES CNc1nc(N)nc2nc(ccc12)-c1c(cccc1C(F)(F)F)N1CCCC1 Show InChI InChI=1S/C19H19F3N6/c1-24-16-11-7-8-13(25-17(11)27-18(23)26-16)15-12(19(20,21)22)5-4-6-14(15)28-9-2-3-10-28/h4-8H,2-3,9-10H2,1H3,(H3,23,24,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402316 (CHEMBL2206073) Show SMILES CNc1nc(N)nc2nc(ccc12)-c1ccccc1C(F)(F)F Show InChI InChI=1S/C15H12F3N5/c1-20-12-9-6-7-11(21-13(9)23-14(19)22-12)8-4-2-3-5-10(8)15(16,17)18/h2-7H,1H3,(H3,19,20,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402293 (CHEMBL2203315) Show SMILES CNc1nc(N)nc2nc(c(C)cc12)-c1ccccc1C(F)(F)F Show InChI InChI=1S/C16H14F3N5/c1-8-7-10-13(21-2)23-15(20)24-14(10)22-12(8)9-5-3-4-6-11(9)16(17,18)19/h3-7H,1-2H3,(H3,20,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402303 (CHEMBL2205520) Show SMILES CNc1nc(N)nc2nc(ccc12)-c1c(Cl)cccc1Cl Show InChI InChI=1S/C14H11Cl2N5/c1-18-12-7-5-6-10(19-13(7)21-14(17)20-12)11-8(15)3-2-4-9(11)16/h2-6H,1H3,(H3,17,18,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	510	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402308 (CHEMBL2205515) Show SMILES CNc1nc(N)nc2nc(ccc12)-c1ccccc1Br Show InChI InChI=1S/C14H12BrN5/c1-17-12-9-6-7-11(8-4-2-3-5-10(8)15)18-13(9)20-14(16)19-12/h2-7H,1H3,(H3,16,17,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402301 (CHEMBL2205522) Show SMILES CNc1nc(N)nc2nc(ccc12)-c1c(OC)cccc1C(F)(F)F Show InChI InChI=1S/C16H14F3N5O/c1-21-13-8-6-7-10(22-14(8)24-15(20)23-13)12-9(16(17,18)19)4-3-5-11(12)25-2/h3-7H,1-2H3,(H3,20,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	560	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402305 (CHEMBL2205518) Show SMILES CNc1nc(N)nc2nc(ccc12)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C14H11Cl2N5/c1-18-12-9-4-5-11(19-13(9)21-14(17)20-12)8-3-2-7(15)6-10(8)16/h2-6H,1H3,(H3,17,18,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	610	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402294 (CHEMBL2206069) Show SMILES CNc1nc(N)nc2nc(ccc12)-c1c(F)cccc1N1CCCC1 Show InChI InChI=1S/C18H19FN6/c1-21-16-11-7-8-13(22-17(11)24-18(20)23-16)15-12(19)5-4-6-14(15)25-9-2-3-10-25/h4-8H,2-3,9-10H2,1H3,(H3,20,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	620	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402295 (CHEMBL2206068) Show SMILES CNc1nc(N)nc2nc(ccc12)-c1c(Cl)cccc1N1CCCC1 Show InChI InChI=1S/C18H19ClN6/c1-21-16-11-7-8-13(22-17(11)24-18(20)23-16)15-12(19)5-4-6-14(15)25-9-2-3-10-25/h4-8H,2-3,9-10H2,1H3,(H3,20,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	820	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402304 (CHEMBL2205519) Show SMILES CNc1nc(N)nc2nc(ccc12)-c1cc(Cl)ccc1Cl Show InChI InChI=1S/C14H11Cl2N5/c1-18-12-8-3-5-11(19-13(8)21-14(17)20-12)9-6-7(15)2-4-10(9)16/h2-6H,1H3,(H3,17,18,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	960	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402290 (CHEMBL2206072) Show SMILES CNc1nc(N)nc2nc(-c3ccccc3C(F)(F)F)c(cc12)S(C)(=O)=O Show InChI InChI=1S/C16H14F3N5O2S/c1-21-13-9-7-11(27(2,25)26)12(22-14(9)24-15(20)23-13)8-5-3-4-6-10(8)16(17,18)19/h3-7H,1-2H3,(H3,20,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402298 (CHEMBL2206065) Show SMILES CNc1nc(N)nc2nc(ccc12)-c1c(cccc1C(F)(F)F)N1CCOCC1 Show InChI InChI=1S/C19H19F3N6O/c1-24-16-11-5-6-13(25-17(11)27-18(23)26-16)15-12(19(20,21)22)3-2-4-14(15)28-7-9-29-10-8-28/h2-6H,7-10H2,1H3,(H3,23,24,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.15E+3	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402307 (CHEMBL2205516) Show SMILES CNc1nc(N)nc2nc(ccc12)-c1ccccc1Cl Show InChI InChI=1S/C14H12ClN5/c1-17-12-9-6-7-11(8-4-2-3-5-10(8)15)18-13(9)20-14(16)19-12/h2-7H,1H3,(H3,16,17,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.16E+3	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402306 (CHEMBL2205517) Show SMILES CNc1nc(N)nc2nc(ccc12)-c1cccc(Cl)c1Cl Show InChI InChI=1S/C14H11Cl2N5/c1-18-12-8-5-6-10(19-13(8)21-14(17)20-12)7-3-2-4-9(15)11(7)16/h2-6H,1H3,(H3,17,18,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.18E+3	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402315 (CHEMBL2206074) Show SMILES CCNc1nc(N)nc2nc(ccc12)-c1ccccc1C(F)(F)F Show InChI InChI=1S/C16H14F3N5/c1-2-21-13-10-7-8-12(22-14(10)24-15(20)23-13)9-5-3-4-6-11(9)16(17,18)19/h3-8H,2H2,1H3,(H3,20,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.34E+3	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402297 (CHEMBL2206066) Show SMILES CNc1nc(N)nc2nc(ccc12)-c1c(cccc1C(F)(F)F)N1CCCCC1 Show InChI InChI=1S/C20H21F3N6/c1-25-17-12-8-9-14(26-18(12)28-19(24)27-17)16-13(20(21,22)23)6-5-7-15(16)29-10-3-2-4-11-29/h5-9H,2-4,10-11H2,1H3,(H3,24,25,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.35E+3	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402310 (CHEMBL2205513) Show SMILES CNc1nc(N)nc2nc(ccc12)-c1ccccc1[N+]([O-])=O Show InChI InChI=1S/C14H12N6O2/c1-16-12-9-6-7-10(17-13(9)19-14(15)18-12)8-4-2-3-5-11(8)20(21)22/h2-7H,1H3,(H3,15,16,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.37E+3	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402312 (CHEMBL2206077) Show SMILES CNc1nc(N)nc2nc(ccc12)-c1ccccc1C Show InChI InChI=1S/C15H15N5/c1-9-5-3-4-6-10(9)12-8-7-11-13(17-2)19-15(16)20-14(11)18-12/h3-8H,1-2H3,(H3,16,17,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.66E+3	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402313 (CHEMBL2206076) Show SMILES Nc1nc(NCCO)c2ccc(nc2n1)-c1ccccc1C(F)(F)F Show InChI InChI=1S/C16H14F3N5O/c17-16(18,19)11-4-2-1-3-9(11)12-6-5-10-13(21-7-8-25)23-15(20)24-14(10)22-12/h1-6,25H,7-8H2,(H3,20,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.85E+3	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402309 (CHEMBL2205514) Show SMILES CNc1nc(N)nc2nc(ccc12)-c1ccccc1C(O)=O Show InChI InChI=1S/C15H13N5O2/c1-17-12-10-6-7-11(18-13(10)20-15(16)19-12)8-4-2-3-5-9(8)14(21)22/h2-7H,1H3,(H,21,22)(H3,16,17,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.39E+3	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402314 (CHEMBL2206075) Show SMILES CCCNc1nc(N)nc2nc(ccc12)-c1ccccc1C(F)(F)F Show InChI InChI=1S/C17H16F3N5/c1-2-9-22-14-11-7-8-13(23-15(11)25-16(21)24-14)10-5-3-4-6-12(10)17(18,19)20/h3-8H,2,9H2,1H3,(H3,21,22,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.43E+3	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402311 (CHEMBL2205512) Show SMILES CNc1nc(N)nc2nc(ccc12)-c1ccccc1OC Show InChI InChI=1S/C15H15N5O/c1-17-13-10-7-8-11(18-14(10)20-15(16)19-13)9-5-3-4-6-12(9)21-2/h3-8H,1-2H3,(H3,16,17,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.79E+3	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50135663 (3-(4-Biphenyl-4-ylmethyl-piperazin-1-ylmethyl)-pyr...) Show SMILES Nc1nc(N)c2nc(CN3CCN(Cc4ccc(cc4)-c4ccccc4)CC3)nnc2n1 Show InChI InChI=1S/C23H25N9/c24-21-20-22(28-23(25)27-21)30-29-19(26-20)15-32-12-10-31(11-13-32)14-16-6-8-18(9-7-16)17-4-2-1-3-5-17/h1-9H,10-15H2,(H4,24,25,27,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of Protein-tyrosine phosphatase 1B in 300 nM DTT				Bioorg Med Chem Lett 13: 2895-8 (2003) BindingDB Entry DOI: 10.7270/Q21V5DDS
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50135663 (3-(4-Biphenyl-4-ylmethyl-piperazin-1-ylmethyl)-pyr...) Show SMILES Nc1nc(N)c2nc(CN3CCN(Cc4ccc(cc4)-c4ccccc4)CC3)nnc2n1 Show InChI InChI=1S/C23H25N9/c24-21-20-22(28-23(25)27-21)30-29-19(26-20)15-32-12-10-31(11-13-32)14-16-6-8-18(9-7-16)17-4-2-1-3-5-17/h1-9H,10-15H2,(H4,24,25,27,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of Protein-tyrosine phosphatase 1B in 300 nM DTT				Bioorg Med Chem Lett 13: 2895-8 (2003) BindingDB Entry DOI: 10.7270/Q21V5DDS
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50135667 (3-(4-Naphthalen-2-ylmethyl-piperazin-1-ylmethyl)-p...) Show SMILES Nc1nc(N)c2nc(CN3CCN(Cc4ccc5ccccc5c4)CC3)nnc2n1 Show InChI InChI=1S/C21H23N9/c22-19-18-20(26-21(23)25-19)28-27-17(24-18)13-30-9-7-29(8-10-30)12-14-5-6-15-3-1-2-4-16(15)11-14/h1-6,11H,7-10,12-13H2,(H4,22,23,25,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of Protein-tyrosine phosphatase 1B in 300 nM DTT				Bioorg Med Chem Lett 13: 2895-8 (2003) BindingDB Entry DOI: 10.7270/Q21V5DDS
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50135670 (3-(4-Naphthalen-1-ylmethyl-piperazin-1-ylmethyl)-p...) Show SMILES Nc1nc(N)c2nc(CN3CCN(Cc4cccc5ccccc45)CC3)nnc2n1 Show InChI InChI=1S/C21H23N9/c22-19-18-20(26-21(23)25-19)28-27-17(24-18)13-30-10-8-29(9-11-30)12-15-6-3-5-14-4-1-2-7-16(14)15/h1-7H,8-13H2,(H4,22,23,25,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of Protein-tyrosine phosphatase 1B in 300 nM DTT				Bioorg Med Chem Lett 13: 2895-8 (2003) BindingDB Entry DOI: 10.7270/Q21V5DDS
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50135663 (3-(4-Biphenyl-4-ylmethyl-piperazin-1-ylmethyl)-pyr...) Show SMILES Nc1nc(N)c2nc(CN3CCN(Cc4ccc(cc4)-c4ccccc4)CC3)nnc2n1 Show InChI InChI=1S/C23H25N9/c24-21-20-22(28-23(25)27-21)30-29-19(26-20)15-32-12-10-31(11-13-32)14-16-6-8-18(9-7-16)17-4-2-1-3-5-17/h1-9H,10-15H2,(H4,24,25,27,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description In vitro inhibitory concentration required against Tyrosine phosphatase SHP-2 in the presence of 300 nM DTT				Bioorg Med Chem Lett 13: 2895-8 (2003) BindingDB Entry DOI: 10.7270/Q21V5DDS
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50135668 (3-(4-Benzyl-piperazin-1-ylmethyl)-pyrimido[5,4-e][...) Show SMILES Nc1nc(N)c2nc(CN3CCN(Cc4ccccc4)CC3)nnc2n1 Show InChI InChI=1S/C17H21N9/c18-15-14-16(22-17(19)21-15)24-23-13(20-14)11-26-8-6-25(7-9-26)10-12-4-2-1-3-5-12/h1-5H,6-11H2,(H4,18,19,21,22,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	6.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of Protein-tyrosine phosphatase 1B in 300 nM DTT				Bioorg Med Chem Lett 13: 2895-8 (2003) BindingDB Entry DOI: 10.7270/Q21V5DDS
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50135668 (3-(4-Benzyl-piperazin-1-ylmethyl)-pyrimido[5,4-e][...) Show SMILES Nc1nc(N)c2nc(CN3CCN(Cc4ccccc4)CC3)nnc2n1 Show InChI InChI=1S/C17H21N9/c18-15-14-16(22-17(19)21-15)24-23-13(20-14)11-26-8-6-25(7-9-26)10-12-4-2-1-3-5-12/h1-5H,6-11H2,(H4,18,19,21,22,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	6.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of Protein-tyrosine phosphatase 1B in 300 nM DTT				Bioorg Med Chem Lett 13: 2895-8 (2003) BindingDB Entry DOI: 10.7270/Q21V5DDS
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50135668 (3-(4-Benzyl-piperazin-1-ylmethyl)-pyrimido[5,4-e][...) Show SMILES Nc1nc(N)c2nc(CN3CCN(Cc4ccccc4)CC3)nnc2n1 Show InChI InChI=1S/C17H21N9/c18-15-14-16(22-17(19)21-15)24-23-13(20-14)11-26-8-6-25(7-9-26)10-12-4-2-1-3-5-12/h1-5H,6-11H2,(H4,18,19,21,22,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description In vitro inhibitory concentration required against Tyrosine phosphatase SHP-2 in the presence of 300 nM DTT				Bioorg Med Chem Lett 13: 2895-8 (2003) BindingDB Entry DOI: 10.7270/Q21V5DDS
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (Homo sapiens (Human))	BDBM50135668 (3-(4-Benzyl-piperazin-1-ylmethyl)-pyrimido[5,4-e][...) Show SMILES Nc1nc(N)c2nc(CN3CCN(Cc4ccccc4)CC3)nnc2n1 Show InChI InChI=1S/C17H21N9/c18-15-14-16(22-17(19)21-15)24-23-13(20-14)11-26-8-6-25(7-9-26)10-12-4-2-1-3-5-12/h1-5H,6-11H2,(H4,18,19,21,22,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description In vitro inhibitory concentration required against Leukocyte antigen related receptor phosphatase (LAR) in the presence of 300 nM DTT				Bioorg Med Chem Lett 13: 2895-8 (2003) BindingDB Entry DOI: 10.7270/Q21V5DDS
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50135673 (3-Diethylaminomethyl-pyrimido[5,4-e][1,2,4]triazin...) Show SMILES CCN(CC)Cc1nnc2nc(N)nc(N)c2n1 Show InChI InChI=1S/C10H16N8/c1-3-18(4-2)5-6-13-7-8(11)14-10(12)15-9(7)17-16-6/h3-5H2,1-2H3,(H4,11,12,14,15,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description In vitro inhibitory concentration required against Tyrosine phosphatase SHP-2 in the presence of 300 nM DTT				Bioorg Med Chem Lett 13: 2895-8 (2003) BindingDB Entry DOI: 10.7270/Q21V5DDS
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase alpha (Homo sapiens (Human))	BDBM50135663 (3-(4-Biphenyl-4-ylmethyl-piperazin-1-ylmethyl)-pyr...) Show SMILES Nc1nc(N)c2nc(CN3CCN(Cc4ccc(cc4)-c4ccccc4)CC3)nnc2n1 Show InChI InChI=1S/C23H25N9/c24-21-20-22(28-23(25)27-21)30-29-19(26-20)15-32-12-10-31(11-13-32)14-16-6-8-18(9-7-16)17-4-2-1-3-5-17/h1-9H,10-15H2,(H4,24,25,27,28,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description In vitro inhibitory concentration required against Protein-tyrosine phosphatase alpha in the presence of 300 nM DTT				Bioorg Med Chem Lett 13: 2895-8 (2003) BindingDB Entry DOI: 10.7270/Q21V5DDS
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (Homo sapiens (Human))	BDBM50135663 (3-(4-Biphenyl-4-ylmethyl-piperazin-1-ylmethyl)-pyr...) Show SMILES Nc1nc(N)c2nc(CN3CCN(Cc4ccc(cc4)-c4ccccc4)CC3)nnc2n1 Show InChI InChI=1S/C23H25N9/c24-21-20-22(28-23(25)27-21)30-29-19(26-20)15-32-12-10-31(11-13-32)14-16-6-8-18(9-7-16)17-4-2-1-3-5-17/h1-9H,10-15H2,(H4,24,25,27,28,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description In vitro inhibitory concentration required against Leukocyte antigen related receptor phosphatase (LAR) in the presence of 300 nM DTT				Bioorg Med Chem Lett 13: 2895-8 (2003) BindingDB Entry DOI: 10.7270/Q21V5DDS
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50135663 (3-(4-Biphenyl-4-ylmethyl-piperazin-1-ylmethyl)-pyr...) Show SMILES Nc1nc(N)c2nc(CN3CCN(Cc4ccc(cc4)-c4ccccc4)CC3)nnc2n1 Show InChI InChI=1S/C23H25N9/c24-21-20-22(28-23(25)27-21)30-29-19(26-20)15-32-12-10-31(11-13-32)14-16-6-8-18(9-7-16)17-4-2-1-3-5-17/h1-9H,10-15H2,(H4,24,25,27,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of Protein-tyrosine phosphatase 1B in 2 mM DTT				Bioorg Med Chem Lett 13: 2895-8 (2003) BindingDB Entry DOI: 10.7270/Q21V5DDS
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50135672 (3-(4-Methyl-piperazin-1-ylmethyl)-pyrimido[5,4-e][...) Show SMILES CN1CCN(Cc2nnc3nc(N)nc(N)c3n2)CC1 Show InChI InChI=1S/C11H17N9/c1-19-2-4-20(5-3-19)6-7-14-8-9(12)15-11(13)16-10(8)18-17-7/h2-6H2,1H3,(H4,12,13,15,16,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of Protein-tyrosine phosphatase 1B in 300 nM DTT				Bioorg Med Chem Lett 13: 2895-8 (2003) BindingDB Entry DOI: 10.7270/Q21V5DDS
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50135669 (3-Piperidin-1-ylmethyl-pyrimido[5,4-e][1,2,4]triaz...) Show SMILES Nc1nc(N)c2nc(CN3CCCCC3)nnc2n1 Show InChI InChI=1S/C11H16N8/c12-9-8-10(16-11(13)15-9)18-17-7(14-8)6-19-4-2-1-3-5-19/h1-6H2,(H4,12,13,15,16,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of Protein-tyrosine phosphatase 1B in 300 nM DTT				Bioorg Med Chem Lett 13: 2895-8 (2003) BindingDB Entry DOI: 10.7270/Q21V5DDS
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50135664 (3-Morpholin-4-ylmethyl-pyrimido[5,4-e][1,2,4]triaz...) Show SMILES Nc1nc(N)c2nc(CN3CCOCC3)nnc2n1 Show InChI InChI=1S/C10H14N8O/c11-8-7-9(15-10(12)14-8)17-16-6(13-7)5-18-1-3-19-4-2-18/h1-5H2,(H4,11,12,14,15,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of Protein-tyrosine phosphatase 1B in 2 mM DTT				Bioorg Med Chem Lett 13: 2895-8 (2003) BindingDB Entry DOI: 10.7270/Q21V5DDS
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase alpha (Homo sapiens (Human))	BDBM50135668 (3-(4-Benzyl-piperazin-1-ylmethyl)-pyrimido[5,4-e][...) Show SMILES Nc1nc(N)c2nc(CN3CCN(Cc4ccccc4)CC3)nnc2n1 Show InChI InChI=1S/C17H21N9/c18-15-14-16(22-17(19)21-15)24-23-13(20-14)11-26-8-6-25(7-9-26)10-12-4-2-1-3-5-12/h1-5H,6-11H2,(H4,18,19,21,22,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description In vitro inhibitory concentration required against Protein-tyrosine phosphatase alpha in the presence of 300 nM DTT				Bioorg Med Chem Lett 13: 2895-8 (2003) BindingDB Entry DOI: 10.7270/Q21V5DDS
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase F (Homo sapiens (Human))	BDBM50135673 (3-Diethylaminomethyl-pyrimido[5,4-e][1,2,4]triazin...) Show SMILES CCN(CC)Cc1nnc2nc(N)nc(N)c2n1 Show InChI InChI=1S/C10H16N8/c1-3-18(4-2)5-6-13-7-8(11)14-10(12)15-9(7)17-16-6/h3-5H2,1-2H3,(H4,11,12,14,15,17)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description In vitro inhibitory concentration required against Leukocyte antigen related receptor phosphatase (LAR) in the presence of 300 nM DTT				Bioorg Med Chem Lett 13: 2895-8 (2003) BindingDB Entry DOI: 10.7270/Q21V5DDS
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein phosphatase alpha (Homo sapiens (Human))	BDBM50135673 (3-Diethylaminomethyl-pyrimido[5,4-e][1,2,4]triazin...) Show SMILES CCN(CC)Cc1nnc2nc(N)nc(N)c2n1 Show InChI InChI=1S/C10H16N8/c1-3-18(4-2)5-6-13-7-8(11)14-10(12)15-9(7)17-16-6/h3-5H2,1-2H3,(H4,11,12,14,15,17)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description In vitro inhibitory concentration required against Protein-tyrosine phosphatase alpha in the presence of 300 nM DTT				Bioorg Med Chem Lett 13: 2895-8 (2003) BindingDB Entry DOI: 10.7270/Q21V5DDS
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50135671 (3-Piperazin-1-ylmethyl-pyrimido[5,4-e][1,2,4]triaz...) Show SMILES Nc1nc(N)c2nc(CN3CCNCC3)nnc2n1 Show InChI InChI=1S/C10H15N9/c11-8-7-9(16-10(12)15-8)18-17-6(14-7)5-19-3-1-13-2-4-19/h13H,1-5H2,(H4,11,12,15,16,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of Protein-tyrosine phosphatase 1B in 300 nM DTT				Bioorg Med Chem Lett 13: 2895-8 (2003) BindingDB Entry DOI: 10.7270/Q21V5DDS
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50135673 (3-Diethylaminomethyl-pyrimido[5,4-e][1,2,4]triazin...) Show SMILES CCN(CC)Cc1nnc2nc(N)nc(N)c2n1 Show InChI InChI=1S/C10H16N8/c1-3-18(4-2)5-6-13-7-8(11)14-10(12)15-9(7)17-16-6/h3-5H2,1-2H3,(H4,11,12,14,15,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of Protein-tyrosine phosphatase 1B in 300 nM DTT				Bioorg Med Chem Lett 13: 2895-8 (2003) BindingDB Entry DOI: 10.7270/Q21V5DDS
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50135673 (3-Diethylaminomethyl-pyrimido[5,4-e][1,2,4]triazin...) Show SMILES CCN(CC)Cc1nnc2nc(N)nc(N)c2n1 Show InChI InChI=1S/C10H16N8/c1-3-18(4-2)5-6-13-7-8(11)14-10(12)15-9(7)17-16-6/h3-5H2,1-2H3,(H4,11,12,14,15,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of Protein-tyrosine phosphatase 1B in 300 nM DTT				Bioorg Med Chem Lett 13: 2895-8 (2003) BindingDB Entry DOI: 10.7270/Q21V5DDS
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50135667 (3-(4-Naphthalen-2-ylmethyl-piperazin-1-ylmethyl)-p...) Show SMILES Nc1nc(N)c2nc(CN3CCN(Cc4ccc5ccccc5c4)CC3)nnc2n1 Show InChI InChI=1S/C21H23N9/c22-19-18-20(26-21(23)25-19)28-27-17(24-18)13-30-9-7-29(8-10-30)12-14-5-6-15-3-1-2-4-16(15)11-14/h1-6,11H,7-10,12-13H2,(H4,22,23,25,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of Protein-tyrosine phosphatase 1B in 2 mM DTT				Bioorg Med Chem Lett 13: 2895-8 (2003) BindingDB Entry DOI: 10.7270/Q21V5DDS
					More data for this Ligand-Target Pair

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