| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 1 |
|---|
| Ligand | BDBM50135672 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_162430 (CHEMBL771833) |
|---|
| IC50 | 21000±n/a nM |
|---|
| Citation |  Guertin, KR; Setti, L; Qi, L; Dunsdon, RM; Dymock, BW; Jones, PS; Overton, H; Taylor, M; Williams, G; Sergi, JA; Wang, K; Peng, Y; Renzetti, M; Boyce, R; Falcioni, F; Garippa, R; Olivier, AR Identification of a novel class of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents with protein tyrosine phosphatase inhibitory activity. Bioorg Med Chem Lett13:2895-8 (2003) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein phosphatase non-receptor type 1 |
|---|
| Name: | Tyrosine-protein phosphatase non-receptor type 1 |
|---|
| Synonyms: | PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) |
|---|
| Type: | Protein phosphatase |
|---|
| Mol. Mass.: | 49963.76 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Human recombinant GST-fusion PTP1B (1-435). |
|---|
| Residue: | 435 |
|---|
| Sequence: | MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT
|
|
|
|---|
| BDBM50135672 |
|---|
| n/a |
|---|
| Name | BDBM50135672 |
|---|
| Synonyms: | 3-(4-Methyl-piperazin-1-ylmethyl)-pyrimido[5,4-e][1,2,4]triazine-5,7-diamine | CHEMBL99271 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C11H17N9 |
|---|
| Mol. Mass. | 275.313 |
|---|
| SMILES | CN1CCN(Cc2nnc3nc(N)nc(N)c3n2)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
