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Compile Data Set for Download or QSAR

Found 8 hits with Last Name = 'platzer' and Initial = 's'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mu-type opioid receptor


(MOUSE)
BDBM50177898
PNG
(2-Fluoro-N-[4-methoxymethyl-1-(2-thiophen-2-yl-eth...)
Show SMILES COCC1(CCN(CCc2cccs2)CC1)N(C(=O)C(C)F)c1ccccc1
Show InChI InChI=1S/C22H29FN2O2S/c1-18(23)21(26)25(19-7-4-3-5-8-19)22(17-27-2)11-14-24(15-12-22)13-10-20-9-6-16-28-20/h3-9,16,18H,10-15,17H2,1-2H3
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0.100n/an/an/an/an/an/an/an/a



Technische Universit£t M£nchen

Curated by ChEMBL


Assay Description
Binding constant for Opioid receptor mu 1 in mouse


Bioorg Med Chem Lett 15: 1773-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.02.049
BindingDB Entry DOI: 10.7270/Q28916M4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50177895
PNG
(CHEMBL200456 | fluoromethyl 1-(2-phenylethyl)-4-(N...)
Show SMILES CCC(=O)N(c1ccccc1)C1(CCN(CCc2ccccc2)CC1)C(=O)OCF
Show InChI InChI=1S/C24H29FN2O3/c1-2-22(28)27(21-11-7-4-8-12-21)24(23(29)30-19-25)14-17-26(18-15-24)16-13-20-9-5-3-6-10-20/h3-12H,2,13-19H2,1H3
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0.130n/an/an/an/an/an/an/an/a



Technische Universität München

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from recombinant human mu opioid receptor


J Med Chem 48: 7720-32 (2005)


Article DOI: 10.1021/jm0507274
BindingDB Entry DOI: 10.7270/Q2G44PVB
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50177898
PNG
(2-Fluoro-N-[4-methoxymethyl-1-(2-thiophen-2-yl-eth...)
Show SMILES COCC1(CCN(CCc2cccs2)CC1)N(C(=O)C(C)F)c1ccccc1
Show InChI InChI=1S/C22H29FN2O2S/c1-18(23)21(26)25(19-7-4-3-5-8-19)22(17-27-2)11-14-24(15-12-22)13-10-20-9-6-16-28-20/h3-9,16,18H,10-15,17H2,1-2H3
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0.130n/an/an/an/an/an/an/an/a



Technische Universität München

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from recombinant human mu opioid receptor


J Med Chem 48: 7720-32 (2005)


Article DOI: 10.1021/jm0507274
BindingDB Entry DOI: 10.7270/Q2G44PVB
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50177899
PNG
(CHEMBL371710 | methyl 4-[(N-1-oxopropyl)-N-phenyla...)
Show SMILES CCC(=O)N(c1ccccc1)C1(CCN(CCCCCF)CC1)C(=O)OC
Show InChI InChI=1S/C21H31FN2O3/c1-3-19(25)24(18-10-6-4-7-11-18)21(20(26)27-2)12-16-23(17-13-21)15-9-5-8-14-22/h4,6-7,10-11H,3,5,8-9,12-17H2,1-2H3
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0.740n/an/an/an/an/an/an/an/a



Technische Universität München

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from recombinant human mu opioid receptor


J Med Chem 48: 7720-32 (2005)


Article DOI: 10.1021/jm0507274
BindingDB Entry DOI: 10.7270/Q2G44PVB
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50177897
PNG
(2-fluoroethyl 1-(2-phenylethyl)-4-(N-phenylpropana...)
Show SMILES CCC(=O)N(c1ccccc1)C1(CCN(CCc2ccccc2)CC1)C(=O)OCCF
Show InChI InChI=1S/C25H31FN2O3/c1-2-23(29)28(22-11-7-4-8-12-22)25(24(30)31-20-16-26)14-18-27(19-15-25)17-13-21-9-5-3-6-10-21/h3-12H,2,13-20H2,1H3
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1.20n/an/an/an/an/an/an/an/a



Technische Universität München

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from recombinant human mu opioid receptor


J Med Chem 48: 7720-32 (2005)


Article DOI: 10.1021/jm0507274
BindingDB Entry DOI: 10.7270/Q2G44PVB
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50177894
PNG
(2-Fluoro-N-(1-phenethyl-piperidin-4-yl)-N-phenyl-p...)
Show SMILES CC(F)C(=O)N(C1CCN(CCc2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C22H27FN2O/c1-18(23)22(26)25(20-10-6-3-7-11-20)21-13-16-24(17-14-21)15-12-19-8-4-2-5-9-19/h2-11,18,21H,12-17H2,1H3
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2.10n/an/an/an/an/an/an/an/a



Technische Universität München

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from recombinant human mu opioid receptor


J Med Chem 48: 7720-32 (2005)


Article DOI: 10.1021/jm0507274
BindingDB Entry DOI: 10.7270/Q2G44PVB
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(MOUSE)
BDBM50177894
PNG
(2-Fluoro-N-(1-phenethyl-piperidin-4-yl)-N-phenyl-p...)
Show SMILES CC(F)C(=O)N(C1CCN(CCc2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C22H27FN2O/c1-18(23)22(26)25(20-10-6-3-7-11-20)21-13-16-24(17-14-21)15-12-19-8-4-2-5-9-19/h2-11,18,21H,12-17H2,1H3
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2.10n/an/an/an/an/an/an/an/a



Technische Universit£t M£nchen

Curated by ChEMBL


Assay Description
Binding constant for Opioid receptor mu 1 in mouse


Bioorg Med Chem Lett 15: 1773-7 (2005)


Article DOI: 10.1016/j.bmcl.2005.02.049
BindingDB Entry DOI: 10.7270/Q28916M4
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50177896
PNG
(CHEMBL371268 | N[1-(5-[18F]fluoropentyl)-4-piperid...)
Show SMILES CCC(=O)N(C1CCN(CCCCCF)CC1)c1ccccc1
Show InChI InChI=1S/C19H29FN2O/c1-2-19(23)22(17-9-5-3-6-10-17)18-11-15-21(16-12-18)14-8-4-7-13-20/h3,5-6,9-10,18H,2,4,7-8,11-16H2,1H3
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13.5n/an/an/an/an/an/an/an/a



Technische Universität München

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from recombinant human mu opioid receptor


J Med Chem 48: 7720-32 (2005)


Article DOI: 10.1021/jm0507274
BindingDB Entry DOI: 10.7270/Q2G44PVB
More data for this
Ligand-Target Pair