Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cholesterol side-chain cleavage enzyme, mitochondrial (Rattus norvegicus) | BDBM50335519 ((S)-3,6-Diamino-hexanoic acid {(3S,9S,12S,15S)-3-(...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 41.4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Chemical Laboratory Curated by ChEMBL | Assay Description Antibacterial activity against gram positive bacteria Enterococcus faecalis was determined by twofold Micro-broth dilution assay | Bioorg Med Chem Lett 14: 773-7 (2004) BindingDB Entry DOI: 10.7270/Q2FJ2JZ3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol side-chain cleavage enzyme, mitochondrial (Rattus norvegicus) | BDBM50103513 (CHEBI:17076 | Chemform | Gerox | NSC-14083 | Strep...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | 2.23E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Chemical Laboratory Curated by ChEMBL | Assay Description Antibacterial activity against gram positive bacteria Enterococcus faecalis was determined by twofold Micro-broth dilution assay | Bioorg Med Chem Lett 14: 773-7 (2004) BindingDB Entry DOI: 10.7270/Q2FJ2JZ3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol side-chain cleavage enzyme, mitochondrial (Rattus norvegicus) | BDBM50221769 (CHEMBL166184) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Chemical Laboratory Curated by ChEMBL | Assay Description Antibacterial activity against gram positive bacteria Enterococcus faecalis was determined by twofold Micro-broth dilution assay | Bioorg Med Chem Lett 14: 773-7 (2004) BindingDB Entry DOI: 10.7270/Q2FJ2JZ3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol side-chain cleavage enzyme, mitochondrial (Rattus norvegicus) | BDBM50221777 (CHEMBL352932) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2.55E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Chemical Laboratory Curated by ChEMBL | Assay Description Antibacterial activity against gram positive bacteria Enterococcus faecalis was determined by twofold Micro-broth dilution assay | Bioorg Med Chem Lett 14: 773-7 (2004) BindingDB Entry DOI: 10.7270/Q2FJ2JZ3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA gyrase subunit A/B (Mycobacterium tuberculosis (strain ATCC 25618 / H3...) | BDBM21690 (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 3.77E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP) Curated by ChEMBL | Assay Description Inhibition of Mycobacterium tuberculosis DNA gyrase supercoiling activity using relaxed pBR322 as substrate after 30 mins by agarose gel electrophore... | Bioorg Med Chem 26: 4551-4559 (2018) Article DOI: 10.1016/j.bmc.2018.07.049 BindingDB Entry DOI: 10.7270/Q2XD14C3 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cholesterol side-chain cleavage enzyme, mitochondrial (Rattus norvegicus) | BDBM50221774 (CHEMBL353406) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 7.17E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Chemical Laboratory Curated by ChEMBL | Assay Description Antibacterial activity against gram positive bacteria Enterococcus faecalis was determined by twofold Micro-broth dilution assay | Bioorg Med Chem Lett 14: 773-7 (2004) BindingDB Entry DOI: 10.7270/Q2FJ2JZ3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA gyrase subunit B (Mycobacterium tuberculosis (strain ATCC 25618 / H3...) | BDBM50463548 (CHEMBL4239753) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8.57E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP) Curated by ChEMBL | Assay Description Inhibition of Mycobacterium tuberculosis DNA gyrase supercoiling activity using relaxed pBR322 as substrate after 30 mins by agarose gel electrophore... | Bioorg Med Chem 26: 4551-4559 (2018) Article DOI: 10.1016/j.bmc.2018.07.049 BindingDB Entry DOI: 10.7270/Q2XD14C3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol side-chain cleavage enzyme, mitochondrial (Rattus norvegicus) | BDBM50221746 (CHEMBL354064) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 9.95E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Chemical Laboratory Curated by ChEMBL | Assay Description Antibacterial activity against gram positive bacteria Enterococcus faecalis was determined by twofold Micro-broth dilution assay | Bioorg Med Chem Lett 14: 773-7 (2004) BindingDB Entry DOI: 10.7270/Q2FJ2JZ3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol side-chain cleavage enzyme, mitochondrial (Rattus norvegicus) | BDBM50221744 (CHEMBL349656) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.07E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
National Chemical Laboratory Curated by ChEMBL | Assay Description Antibacterial activity against gram positive bacteria Enterococcus faecalis was determined by twofold Micro-broth dilution assay | Bioorg Med Chem Lett 14: 773-7 (2004) BindingDB Entry DOI: 10.7270/Q2FJ2JZ3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol side-chain cleavage enzyme, mitochondrial (Rattus norvegicus) | BDBM50221745 (CHEMBL350726) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.10E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
National Chemical Laboratory Curated by ChEMBL | Assay Description Antibacterial activity against gram positive bacteria Enterococcus faecalis was determined by twofold Micro-broth dilution assay | Bioorg Med Chem Lett 14: 773-7 (2004) BindingDB Entry DOI: 10.7270/Q2FJ2JZ3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA gyrase subunit B (Mycobacterium tuberculosis (strain ATCC 25618 / H3...) | BDBM50463549 (CHEMBL4237298) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.94E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP) Curated by ChEMBL | Assay Description Inhibition of Mycobacterium tuberculosis DNA gyrase supercoiling activity using relaxed pBR322 as substrate after 30 mins by agarose gel electrophore... | Bioorg Med Chem 26: 4551-4559 (2018) Article DOI: 10.1016/j.bmc.2018.07.049 BindingDB Entry DOI: 10.7270/Q2XD14C3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA gyrase subunit B (Mycobacterium tuberculosis (strain ATCC 25618 / H3...) | BDBM50463550 (CHEMBL4251156) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.58E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP) Curated by ChEMBL | Assay Description Inhibition of Mycobacterium tuberculosis DNA gyrase supercoiling activity using relaxed pBR322 as substrate after 30 mins by agarose gel electrophore... | Bioorg Med Chem 26: 4551-4559 (2018) Article DOI: 10.1016/j.bmc.2018.07.049 BindingDB Entry DOI: 10.7270/Q2XD14C3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA gyrase subunit B (Mycobacterium tuberculosis (strain ATCC 25618 / H3...) | BDBM50463551 (CHEMBL4243541) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.80E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP) Curated by ChEMBL | Assay Description Inhibition of Mycobacterium tuberculosis DNA gyrase supercoiling activity using relaxed pBR322 as substrate after 30 mins by agarose gel electrophore... | Bioorg Med Chem 26: 4551-4559 (2018) Article DOI: 10.1016/j.bmc.2018.07.049 BindingDB Entry DOI: 10.7270/Q2XD14C3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol side-chain cleavage enzyme, mitochondrial (Rattus norvegicus) | BDBM50221743 (CHEMBL352152) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | >4.14E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
National Chemical Laboratory Curated by ChEMBL | Assay Description Antibacterial activity against gram positive bacteria Enterococcus faecalis was determined by twofold Micro-broth dilution assay | Bioorg Med Chem Lett 14: 773-7 (2004) BindingDB Entry DOI: 10.7270/Q2FJ2JZ3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol side-chain cleavage enzyme, mitochondrial (Rattus norvegicus) | BDBM50221775 (CHEMBL164621) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >4.61E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
National Chemical Laboratory Curated by ChEMBL | Assay Description Antibacterial activity against gram positive bacteria Enterococcus faecalis was determined by twofold Micro-broth dilution assay | Bioorg Med Chem Lett 14: 773-7 (2004) BindingDB Entry DOI: 10.7270/Q2FJ2JZ3 | |||||||||||
More data for this Ligand-Target Pair |