Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM112498 (US8623883, No. 1) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 6.44 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Warner-Lambert Company LLC US Patent | Assay Description Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ... | US Patent US8623883 (2014) BindingDB Entry DOI: 10.7270/Q29885P7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM112499 (DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 6.90 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Warner-Lambert Company LLC US Patent | Assay Description Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ... | US Patent US8623883 (2014) BindingDB Entry DOI: 10.7270/Q29885P7 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM112500 (US8623883, No. 6) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 9.87 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Warner-Lambert Company LLC US Patent | Assay Description Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ... | US Patent US8623883 (2014) BindingDB Entry DOI: 10.7270/Q29885P7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM112501 (US8623883, No. 7) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 11.3 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Warner-Lambert Company LLC US Patent | Assay Description Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ... | US Patent US8623883 (2014) BindingDB Entry DOI: 10.7270/Q29885P7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM112504 (US8623883, No. 10) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 12.1 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Warner-Lambert Company LLC US Patent | Assay Description Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ... | US Patent US8623883 (2014) BindingDB Entry DOI: 10.7270/Q29885P7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human)) | BDBM112499 (DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 16.7 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Warner-Lambert Company LLC US Patent | Assay Description Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ... | US Patent US8623883 (2014) BindingDB Entry DOI: 10.7270/Q29885P7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM112503 (US8623883, No. 9) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 18.1 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Warner-Lambert Company LLC US Patent | Assay Description Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ... | US Patent US8623883 (2014) BindingDB Entry DOI: 10.7270/Q29885P7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor tyrosine-protein kinase erbB-4 (Homo sapiens (Human)) | BDBM112504 (US8623883, No. 10) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 41.3 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Warner-Lambert Company LLC US Patent | Assay Description Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ... | US Patent US8623883 (2014) BindingDB Entry DOI: 10.7270/Q29885P7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM112502 (US8623883, No. 8) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 45.3 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Warner-Lambert Company LLC US Patent | Assay Description Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ... | US Patent US8623883 (2014) BindingDB Entry DOI: 10.7270/Q29885P7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor tyrosine-protein kinase erbB-4 (Homo sapiens (Human)) | BDBM112501 (US8623883, No. 7) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 61.5 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Warner-Lambert Company LLC US Patent | Assay Description Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ... | US Patent US8623883 (2014) BindingDB Entry DOI: 10.7270/Q29885P7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor tyrosine-protein kinase erbB-4 (Homo sapiens (Human)) | BDBM112498 (US8623883, No. 1) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 77.5 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Warner-Lambert Company LLC US Patent | Assay Description Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ... | US Patent US8623883 (2014) BindingDB Entry DOI: 10.7270/Q29885P7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor tyrosine-protein kinase erbB-4 (Homo sapiens (Human)) | BDBM112499 (DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 83.7 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Warner-Lambert Company LLC US Patent | Assay Description Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ... | US Patent US8623883 (2014) BindingDB Entry DOI: 10.7270/Q29885P7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human)) | BDBM112501 (US8623883, No. 7) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 84.0 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Warner-Lambert Company LLC US Patent | Assay Description Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ... | US Patent US8623883 (2014) BindingDB Entry DOI: 10.7270/Q29885P7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human)) | BDBM112504 (US8623883, No. 10) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 86.0 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Warner-Lambert Company LLC US Patent | Assay Description Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ... | US Patent US8623883 (2014) BindingDB Entry DOI: 10.7270/Q29885P7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor tyrosine-protein kinase erbB-4 (Homo sapiens (Human)) | BDBM112503 (US8623883, No. 9) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 147 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Warner-Lambert Company LLC US Patent | Assay Description Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ... | US Patent US8623883 (2014) BindingDB Entry DOI: 10.7270/Q29885P7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor tyrosine-protein kinase erbB-4 (Homo sapiens (Human)) | BDBM112500 (US8623883, No. 6) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 154 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Warner-Lambert Company LLC US Patent | Assay Description Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ... | US Patent US8623883 (2014) BindingDB Entry DOI: 10.7270/Q29885P7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human)) | BDBM112502 (US8623883, No. 8) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 212 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Warner-Lambert Company LLC US Patent | Assay Description Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ... | US Patent US8623883 (2014) BindingDB Entry DOI: 10.7270/Q29885P7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor tyrosine-protein kinase erbB-4 (Homo sapiens (Human)) | BDBM112502 (US8623883, No. 8) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 234 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Warner-Lambert Company LLC US Patent | Assay Description Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ... | US Patent US8623883 (2014) BindingDB Entry DOI: 10.7270/Q29885P7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human)) | BDBM112500 (US8623883, No. 6) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 244 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Warner-Lambert Company LLC US Patent | Assay Description Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ... | US Patent US8623883 (2014) BindingDB Entry DOI: 10.7270/Q29885P7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human)) | BDBM112503 (US8623883, No. 9) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 247 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Warner-Lambert Company LLC US Patent | Assay Description Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ... | US Patent US8623883 (2014) BindingDB Entry DOI: 10.7270/Q29885P7 | |||||||||||
More data for this Ligand-Target Pair |