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Compile Data Set for Download or QSAR

Found 19 hits with Last Name = 'shaimi' and Initial = 'm'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Presenilin-1


(Homo sapiens (Human))
BDBM50480056
PNG
(CHEMBL468083)
Show SMILES [H][C@]12CC[C@]([H])(Cc3cc(ccc3C1)-c1cn(cn1)-c1ccc(F)cc1)[C@@]21CN(CC(F)(F)F)S(=O)(=O)N1 |r|
Show InChI InChI=1S/C25H24F4N4O2S/c26-21-5-7-22(8-6-21)32-12-23(30-15-32)17-2-1-16-10-19-3-4-20(11-18(16)9-17)24(19)13-33(14-25(27,28)29)36(34,35)31-24/h1-2,5-9,12,15,19-20,31H,3-4,10-11,13-14H2/t19-,20+,24+/m0/s1
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n/an/a 0.0300n/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assay


J Med Chem 52: 3441-4 (2009)


Article DOI: 10.1021/jm900056p
BindingDB Entry DOI: 10.7270/Q2B85BZ2
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50480051
PNG
(CHEMBL512282)
Show SMILES [H][C@]12CC[C@]([H])(Cc3cc(ccc3C1)-c1cc(-c3ccc(F)cc3F)n(C)n1)[C@@]21CN(CC(F)(F)F)S(=O)(=O)N1 |r|
Show InChI InChI=1S/C26H25F5N4O2S/c1-34-24(21-7-6-20(27)11-22(21)28)12-23(32-34)16-3-2-15-9-18-4-5-19(10-17(15)8-16)25(18)13-35(14-26(29,30)31)38(36,37)33-25/h2-3,6-8,11-12,18-19,33H,4-5,9-10,13-14H2,1H3/t18-,19+,25+/m0/s1
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Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assay


J Med Chem 52: 3441-4 (2009)


Article DOI: 10.1021/jm900056p
BindingDB Entry DOI: 10.7270/Q2B85BZ2
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50480052
PNG
(CHEMBL467457)
Show SMILES [H][C@]12CC[C@]([H])(Cc3cc(ccc3C1)-c1cc(-c3ccc(F)c(F)c3)n(C)n1)[C@@]21CN(CC(F)(F)F)S(=O)(=O)N1 |r|
Show InChI InChI=1S/C26H25F5N4O2S/c1-34-24(17-4-7-21(27)22(28)11-17)12-23(32-34)16-3-2-15-9-19-5-6-20(10-18(15)8-16)25(19)13-35(14-26(29,30)31)38(36,37)33-25/h2-4,7-8,11-12,19-20,33H,5-6,9-10,13-14H2,1H3/t19-,20+,25+/m0/s1
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Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assay


J Med Chem 52: 3441-4 (2009)


Article DOI: 10.1021/jm900056p
BindingDB Entry DOI: 10.7270/Q2B85BZ2
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50480058
PNG
(CHEMBL495009)
Show SMILES [H][C@]12CC[C@]([H])(Cc3cc(ccc3C1)-c1cn(cn1)-c1ccc(F)cc1F)[C@@]21CN(CC(F)(F)F)S(=O)(=O)N1 |r|
Show InChI InChI=1S/C25H23F5N4O2S/c26-20-5-6-23(21(27)10-20)33-11-22(31-14-33)16-2-1-15-8-18-3-4-19(9-17(15)7-16)24(18)12-34(13-25(28,29)30)37(35,36)32-24/h1-2,5-7,10-11,14,18-19,32H,3-4,8-9,12-13H2/t18-,19+,24+/m0/s1
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Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assay


J Med Chem 52: 3441-4 (2009)


Article DOI: 10.1021/jm900056p
BindingDB Entry DOI: 10.7270/Q2B85BZ2
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50480057
PNG
(CHEMBL523832)
Show SMILES [H][C@]12CC[C@]([H])(Cc3cc(ccc3C1)-c1cc(-c3ccc(F)cc3)n(C)n1)[C@@]21CN(CC(F)(F)F)S(=O)(=O)N1 |r|
Show InChI InChI=1S/C26H26F4N4O2S/c1-33-24(16-4-8-22(27)9-5-16)13-23(31-33)18-3-2-17-11-20-6-7-21(12-19(17)10-18)25(20)14-34(15-26(28,29)30)37(35,36)32-25/h2-5,8-10,13,20-21,32H,6-7,11-12,14-15H2,1H3/t20-,21+,25+/m0/s1
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Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assay


J Med Chem 52: 3441-4 (2009)


Article DOI: 10.1021/jm900056p
BindingDB Entry DOI: 10.7270/Q2B85BZ2
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50480062
PNG
(CHEMBL511572)
Show SMILES [H][C@]12CC[C@]([H])(Cc3cc(ccc3C1)-c1cc(-c3ccc(Cl)cc3)n(C)n1)[C@@]21CN(CC(F)(F)F)S(=O)(=O)N1 |r|
Show InChI InChI=1S/C26H26ClF3N4O2S/c1-33-24(16-4-8-22(27)9-5-16)13-23(31-33)18-3-2-17-11-20-6-7-21(12-19(17)10-18)25(20)14-34(15-26(28,29)30)37(35,36)32-25/h2-5,8-10,13,20-21,32H,6-7,11-12,14-15H2,1H3/t20-,21+,25+/m0/s1
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n/an/a 0.0700n/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assay


J Med Chem 52: 3441-4 (2009)


Article DOI: 10.1021/jm900056p
BindingDB Entry DOI: 10.7270/Q2B85BZ2
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50480065
PNG
(CHEMBL495185)
Show SMILES [H][C@]12CC[C@]([H])(Cc3cc(ccc3C1)-c1cn(cn1)-c1ccc(Cl)cc1)[C@@]21CN(CC(F)(F)F)S(=O)(=O)N1 |r|
Show InChI InChI=1S/C25H24ClF3N4O2S/c26-21-5-7-22(8-6-21)32-12-23(30-15-32)17-2-1-16-10-19-3-4-20(11-18(16)9-17)24(19)13-33(14-25(27,28)29)36(34,35)31-24/h1-2,5-9,12,15,19-20,31H,3-4,10-11,13-14H2/t19-,20+,24+/m0/s1
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Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assay


J Med Chem 52: 3441-4 (2009)


Article DOI: 10.1021/jm900056p
BindingDB Entry DOI: 10.7270/Q2B85BZ2
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50480059
PNG
(CHEMBL523883)
Show SMILES [H][C@]12CC[C@]([H])(Cc3cc(ccc3C1)-c1cn(cn1)-c1ccc(F)c(F)c1)[C@@]21CN(CC(F)(F)F)S(=O)(=O)N1 |r|
Show InChI InChI=1S/C25H23F5N4O2S/c26-21-6-5-20(10-22(21)27)33-11-23(31-14-33)16-2-1-15-8-18-3-4-19(9-17(15)7-16)24(18)12-34(13-25(28,29)30)37(35,36)32-24/h1-2,5-7,10-11,14,18-19,32H,3-4,8-9,12-13H2/t18-,19+,24+/m0/s1
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n/an/a 0.120n/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assay


J Med Chem 52: 3441-4 (2009)


Article DOI: 10.1021/jm900056p
BindingDB Entry DOI: 10.7270/Q2B85BZ2
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50480063
PNG
(CHEMBL511928)
Show SMILES [H][C@]12CC[C@]([H])(Cc3cc(ccc3C1)-c1ncn(n1)-c1ccc(F)cc1)[C@@]21CN(CC(F)(F)F)S(=O)(=O)N1 |r|
Show InChI InChI=1S/C24H23F4N5O2S/c25-20-5-7-21(8-6-20)33-14-29-22(30-33)16-2-1-15-10-18-3-4-19(11-17(15)9-16)23(18)12-32(13-24(26,27)28)36(34,35)31-23/h1-2,5-9,14,18-19,31H,3-4,10-13H2/t18-,19+,23+/m0/s1
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n/an/a 0.150n/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assay


J Med Chem 52: 3441-4 (2009)


Article DOI: 10.1021/jm900056p
BindingDB Entry DOI: 10.7270/Q2B85BZ2
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50480066
PNG
(CHEMBL494588)
Show SMILES [H][C@]12CC[C@]([H])(Cc3cc(ccc3C1)-c1cn(cn1)-c1ccccc1F)[C@@]21CN(CC(F)(F)F)S(=O)(=O)N1 |r|
Show InChI InChI=1S/C25H24F4N4O2S/c26-21-3-1-2-4-23(21)32-12-22(30-15-32)17-6-5-16-10-19-7-8-20(11-18(16)9-17)24(19)13-33(14-25(27,28)29)36(34,35)31-24/h1-6,9,12,15,19-20,31H,7-8,10-11,13-14H2/t19-,20+,24+/m0/s1
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n/an/a 0.170n/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assay


J Med Chem 52: 3441-4 (2009)


Article DOI: 10.1021/jm900056p
BindingDB Entry DOI: 10.7270/Q2B85BZ2
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50480050
PNG
(CHEMBL511375)
Show SMILES Cn1nc(cc1-c1ccccc1F)-c1ccc2CC3CCC(Cc2c1)C31CN(CC(F)(F)F)S(=O)(=O)N1
Show InChI InChI=1S/C26H26F4N4O2S/c1-33-24(21-4-2-3-5-22(21)27)13-23(31-33)17-7-6-16-11-19-8-9-20(12-18(16)10-17)25(19)14-34(15-26(28,29)30)37(35,36)32-25/h2-7,10,13,19-20,32H,8-9,11-12,14-15H2,1H3
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n/an/a 0.210n/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assay


J Med Chem 52: 3441-4 (2009)


Article DOI: 10.1021/jm900056p
BindingDB Entry DOI: 10.7270/Q2B85BZ2
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50171224
PNG
(CHEMBL196215 | Cyclic sulfamide)
Show SMILES FC(F)(F)CN1C[C@@]2(NS1(=O)=O)[C@H]1CC[C@@H]2Cc2cc(\C=C\CN3CCC(CC3)C(F)(F)F)ccc2C1 |r|
Show InChI InChI=1S/C25H31F6N3O2S/c26-24(27,28)16-34-15-23(32-37(34,35)36)21-5-6-22(23)14-19-12-17(3-4-18(19)13-21)2-1-9-33-10-7-20(8-11-33)25(29,30)31/h1-4,12,20-22,32H,5-11,13-16H2/b2-1+/t21-,22+,23+/m0/s1
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n/an/a 0.240n/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assay


J Med Chem 52: 3441-4 (2009)


Article DOI: 10.1021/jm900056p
BindingDB Entry DOI: 10.7270/Q2B85BZ2
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50480054
PNG
(CHEMBL506323)
Show SMILES [H][C@]12CC[C@]([H])(Cc3cc(ccc3C1)-c1ncc(s1)N1CCC(CC1)C(F)(F)F)[C@@]21CN(CC(F)(F)F)S(=O)(=O)N1 |r|
Show InChI InChI=1S/C25H28F6N4O2S2/c26-24(27,28)14-35-13-23(33-39(35,36)37)19-3-4-20(23)11-17-9-16(2-1-15(17)10-19)22-32-12-21(38-22)34-7-5-18(6-8-34)25(29,30)31/h1-2,9,12,18-20,33H,3-8,10-11,13-14H2/t19-,20+,23+/m0/s1
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Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assay


J Med Chem 52: 3441-4 (2009)


Article DOI: 10.1021/jm900056p
BindingDB Entry DOI: 10.7270/Q2B85BZ2
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50480053
PNG
(CHEMBL466421)
Show SMILES [H][C@]12CC[C@]([H])(Cc3cc(ccc3C1)-c1cc(-c3ccc(Cl)c(Cl)c3)n(C)n1)[C@@]21CN(CC(F)(F)F)S(=O)(=O)N1 |r|
Show InChI InChI=1S/C26H25Cl2F3N4O2S/c1-34-24(17-4-7-21(27)22(28)11-17)12-23(32-34)16-3-2-15-9-19-5-6-20(10-18(15)8-16)25(19)13-35(14-26(29,30)31)38(36,37)33-25/h2-4,7-8,11-12,19-20,33H,5-6,9-10,13-14H2,1H3/t19-,20+,25+/m0/s1
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Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assay


J Med Chem 52: 3441-4 (2009)


Article DOI: 10.1021/jm900056p
BindingDB Entry DOI: 10.7270/Q2B85BZ2
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50480060
PNG
(CHEMBL466256)
Show SMILES [H][C@]12CC[C@]([H])(Cc3cc(ccc3C1)-c1cn(cn1)-c1ccc(Cl)c(Cl)c1)[C@@]21CN(CC(F)(F)F)S(=O)(=O)N1 |r|
Show InChI InChI=1S/C25H23Cl2F3N4O2S/c26-21-6-5-20(10-22(21)27)33-11-23(31-14-33)16-2-1-15-8-18-3-4-19(9-17(15)7-16)24(18)12-34(13-25(28,29)30)37(35,36)32-24/h1-2,5-7,10-11,14,18-19,32H,3-4,8-9,12-13H2/t18-,19+,24+/m0/s1
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n/an/a 0.420n/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assay


J Med Chem 52: 3441-4 (2009)


Article DOI: 10.1021/jm900056p
BindingDB Entry DOI: 10.7270/Q2B85BZ2
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50480055
PNG
(CHEMBL513674)
Show SMILES [H][C@]12CC[C@]([H])(Cc3cc(ccc3C1)-c1ncc(s1)-c1ccc(F)cc1)[C@@]21CN(CC(F)(F)F)S(=O)(=O)N1 |r|
Show InChI InChI=1S/C25H23F4N3O2S2/c26-21-7-3-15(4-8-21)22-12-30-23(35-22)17-2-1-16-10-19-5-6-20(11-18(16)9-17)24(19)13-32(14-25(27,28)29)36(33,34)31-24/h1-4,7-9,12,19-20,31H,5-6,10-11,13-14H2/t19-,20+,24+/m0/s1
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Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assay


J Med Chem 52: 3441-4 (2009)


Article DOI: 10.1021/jm900056p
BindingDB Entry DOI: 10.7270/Q2B85BZ2
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50480061
PNG
(CHEMBL512596)
Show SMILES [H][C@]12CC[C@]([H])(Cc3cc(ccc3C1)-c1cc(-c3cccc(F)c3)n(C)n1)[C@@]21CN(CC(F)(F)F)S(=O)(=O)N1 |r|
Show InChI InChI=1S/C26H26F4N4O2S/c1-33-24(18-3-2-4-22(27)12-18)13-23(31-33)17-6-5-16-10-20-7-8-21(11-19(16)9-17)25(20)14-34(15-26(28,29)30)37(35,36)32-25/h2-6,9,12-13,20-21,32H,7-8,10-11,14-15H2,1H3/t20-,21+,25+/m0/s1
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n/an/a 0.460n/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assay


J Med Chem 52: 3441-4 (2009)


Article DOI: 10.1021/jm900056p
BindingDB Entry DOI: 10.7270/Q2B85BZ2
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50480064
PNG
(CHEMBL494769)
Show SMILES [H][C@]12CC[C@]([H])(Cc3cc(ccc3C1)-c1cn(cn1)-c1cccc(F)c1)[C@@]21CN(CC(F)(F)F)S(=O)(=O)N1 |r|
Show InChI InChI=1S/C25H24F4N4O2S/c26-21-2-1-3-22(11-21)32-12-23(30-15-32)17-5-4-16-9-19-6-7-20(10-18(16)8-17)24(19)13-33(14-25(27,28)29)36(34,35)31-24/h1-5,8,11-12,15,19-20,31H,6-7,9-10,13-14H2/t19-,20+,24+/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.820n/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assay


J Med Chem 52: 3441-4 (2009)


Article DOI: 10.1021/jm900056p
BindingDB Entry DOI: 10.7270/Q2B85BZ2
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50480067
PNG
(CHEMBL492394)
Show SMILES Cn1nc(cc1-c1ccc2CC3CCC(Cc2c1)C31CN(CC(F)(F)F)S(=O)(=O)N1)-c1ccc(F)cc1
Show InChI InChI=1S/C26H26F4N4O2S/c1-33-24(13-23(31-33)16-4-8-22(27)9-5-16)18-3-2-17-11-20-6-7-21(12-19(17)10-18)25(20)14-34(15-26(28,29)30)37(35,36)32-25/h2-5,8-10,13,20-21,32H,6-7,11-12,14-15H2,1H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.70n/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assay


J Med Chem 52: 3441-4 (2009)


Article DOI: 10.1021/jm900056p
BindingDB Entry DOI: 10.7270/Q2B85BZ2
More data for this
Ligand-Target Pair