| Reaction Details |
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 | Report a problem with these data |
| Target | Presenilin-1 |
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| Ligand | BDBM50480051 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_523678 (CHEMBL997193) |
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| IC50 | 0.060000±n/a nM |
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| Citation |  Keown, LE; Collins, I; Cooper, LC; Harrison, T; Madin, A; Mistry, J; Reilly, M; Shaimi, M; Welch, CJ; Clarke, EE; Lewis, HD; Wrigley, JD; Best, JD; Murray, F; Shearman, MS Novel orally bioavailable gamma-secretase inhibitors with excellent in vivo activity. J Med Chem52:3441-4 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Presenilin-1 |
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| Name: | Presenilin-1 |
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| Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 |
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| Type: | n/a |
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| Mol. Mass.: | 52657.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49768 |
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| Residue: | 467 |
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| Sequence: | MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
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| BDBM50480051 |
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| n/a |
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| Name | BDBM50480051 |
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| Synonyms: | CHEMBL512282 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H25F5N4O2S |
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| Mol. Mass. | 552.559 |
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| SMILES | [H][C@]12CC[C@]([H])(Cc3cc(ccc3C1)-c1cc(-c3ccc(F)cc3F)n(C)n1)[C@@]21CN(CC(F)(F)F)S(=O)(=O)N1 |r| |
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| Structure | 
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