Compile Data Set for Download or QSAR

Found 536 hits with Last Name = 'voegtli' and Initial = 'wc'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50496954 (CHEMBL3236470) Show SMILES CCCS(=O)(=O)Nc1ccc(Cl)c(Oc2ccc3ncn(C)c(=O)c3c2)c1C#N Show InChI InChI=1S/C19H17ClN4O4S/c1-3-8-29(26,27)23-17-7-5-15(20)18(14(17)10-21)28-12-4-6-16-13(9-12)19(25)24(2)11-22-16/h4-7,9,11,23H,3,8H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. Curated by ChEMBL					Assay Description Inhibition of full-length B-Raf V600E mutant (unknown origin)				Bioorg Med Chem Lett 24: 1923-7 (2014) Article DOI: 10.1016/j.bmcl.2014.03.007 BindingDB Entry DOI: 10.7270/Q2Q24368
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50496943 (CHEMBL3236471) Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(Oc2ccc3ncn(C)c(=O)c3c2)c1C#N Show InChI InChI=1S/C19H17FN4O4S/c1-3-8-29(26,27)23-17-7-5-15(20)18(14(17)10-21)28-12-4-6-16-13(9-12)19(25)24(2)11-22-16/h4-7,9,11,23H,3,8H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. Curated by ChEMBL					Assay Description Inhibition of full-length B-Raf V600E mutant (unknown origin)				Bioorg Med Chem Lett 24: 1923-7 (2014) Article DOI: 10.1016/j.bmcl.2014.03.007 BindingDB Entry DOI: 10.7270/Q2Q24368
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50484212 (CHEMBL1822264) Show SMILES COc1n[nH]c2ncc(NC(=O)c3c(F)ccc(NS(=O)(=O)c4cccs4)c3F)cc12 Show InChI InChI=1S/C18H13F2N5O4S2/c1-29-18-10-7-9(8-21-16(10)23-24-18)22-17(26)14-11(19)4-5-12(15(14)20)25-31(27,28)13-3-2-6-30-13/h2-8,25H,1H3,(H,22,26)(H,21,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
ArrayBioPharma Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant				Bioorg Med Chem Lett 21: 5533-7 (2011) Article DOI: 10.1016/j.bmcl.2011.06.097 BindingDB Entry DOI: 10.7270/Q28K7CX8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50496941 (CHEMBL3236463) Show SMILES CCCS(=O)(=O)Nc1ccc(Cl)c(Nc2ccc3ncn(C)c(=O)c3c2)c1C#N Show InChI InChI=1S/C19H18ClN5O3S/c1-3-8-29(27,28)24-17-7-5-15(20)18(14(17)10-21)23-12-4-6-16-13(9-12)19(26)25(2)11-22-16/h4-7,9,11,23-24H,3,8H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. Curated by ChEMBL					Assay Description Inhibition of full-length B-Raf V600E mutant (unknown origin)				Bioorg Med Chem Lett 24: 1923-7 (2014) Article DOI: 10.1016/j.bmcl.2014.03.007 BindingDB Entry DOI: 10.7270/Q2Q24368
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50496948 (CHEMBL3236472) Show SMILES CCCS(=O)(=O)Nc1cccc(Oc2ccc3ncn(C)c(=O)c3c2)c1C#N Show InChI InChI=1S/C19H18N4O4S/c1-3-9-28(25,26)22-17-5-4-6-18(15(17)11-20)27-13-7-8-16-14(10-13)19(24)23(2)12-21-16/h4-8,10,12,22H,3,9H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. Curated by ChEMBL					Assay Description Inhibition of full-length B-Raf V600E mutant (unknown origin)				Bioorg Med Chem Lett 24: 1923-7 (2014) Article DOI: 10.1016/j.bmcl.2014.03.007 BindingDB Entry DOI: 10.7270/Q2Q24368
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50496946 (CHEMBL3236464) Show SMILES CCCS(=O)(=O)Nc1cccc(Nc2ccc3ncn(C)c(=O)c3c2)c1C#N Show InChI InChI=1S/C19H19N5O3S/c1-3-9-28(26,27)23-18-6-4-5-17(15(18)11-20)22-13-7-8-16-14(10-13)19(25)24(2)12-21-16/h4-8,10,12,22-23H,3,9H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. Curated by ChEMBL					Assay Description Inhibition of full-length B-Raf V600E mutant (unknown origin)				Bioorg Med Chem Lett 24: 1923-7 (2014) Article DOI: 10.1016/j.bmcl.2014.03.007 BindingDB Entry DOI: 10.7270/Q2Q24368
					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50485033 (CHEMBL2023502) Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(c1F)-c1cc2cnc(Nc3cnn(C)c3)nc2n(C)c1=O |(13.75,-37.45,;12.42,-36.67,;11.08,-37.45,;9.76,-36.68,;8.98,-35.34,;10.52,-35.34,;8.42,-37.46,;7.09,-36.69,;7.08,-35.14,;5.74,-34.38,;4.42,-35.14,;3.08,-34.38,;4.42,-36.69,;5.75,-37.46,;5.75,-39,;3.08,-37.46,;1.76,-36.68,;.43,-37.45,;-.9,-36.67,;-2.23,-37.44,;-2.23,-38.98,;-3.57,-39.75,;-4.82,-38.87,;-4.86,-37.33,;-6.33,-36.88,;-7.21,-38.15,;-8.75,-38.18,;-6.28,-39.37,;-.91,-39.74,;.42,-38.98,;1.76,-39.75,;1.76,-41.29,;3.09,-38.99,;4.42,-39.75,)| Show InChI InChI=1S/C21H21F2N7O3S/c1-4-7-34(32,33)28-16-6-5-15(22)17(18(16)23)14-8-12-9-24-21(26-13-10-25-29(2)11-13)27-19(12)30(3)20(14)31/h5-6,8-11,28H,4,7H2,1-3H3,(H,24,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. Curated by ChEMBL					Assay Description Inhibition of full-length B-Raf V600E mutant assessed as reduction in incorporation of radiolabeled phosphate from [gamma-33P]ATP into FSBA-modified ...				Bioorg Med Chem Lett 22: 3387-91 (2012) Article DOI: 10.1016/j.bmcl.2012.04.015 BindingDB Entry DOI: 10.7270/Q24J0HZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50485015 (CHEMBL2023500) Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(c1F)-c1cc2cnc(Nc3ccccc3)nc2n(C)c1=O |(14.17,-24.55,;12.84,-23.77,;11.5,-24.55,;10.18,-23.78,;9.4,-22.44,;10.94,-22.44,;8.85,-24.56,;7.52,-23.79,;7.51,-22.24,;6.17,-21.48,;4.84,-22.24,;3.51,-21.48,;4.84,-23.79,;6.18,-24.56,;6.18,-26.1,;3.51,-24.56,;2.18,-23.78,;.85,-24.55,;-.47,-23.77,;-1.8,-24.54,;-1.8,-26.08,;-3.13,-26.85,;-4.47,-26.08,;-4.46,-24.54,;-5.79,-23.77,;-7.13,-24.54,;-7.13,-26.09,;-5.79,-26.85,;-.48,-26.84,;.84,-26.08,;2.18,-26.85,;2.18,-28.39,;3.51,-26.09,;4.85,-26.85,)| Show InChI InChI=1S/C23H21F2N5O3S/c1-3-11-34(32,33)29-18-10-9-17(24)19(20(18)25)16-12-14-13-26-23(27-15-7-5-4-6-8-15)28-21(14)30(2)22(16)31/h4-10,12-13,29H,3,11H2,1-2H3,(H,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. Curated by ChEMBL					Assay Description Inhibition of full-length B-Raf V600E mutant assessed as reduction in incorporation of radiolabeled phosphate from [gamma-33P]ATP into FSBA-modified ...				Bioorg Med Chem Lett 22: 3387-91 (2012) Article DOI: 10.1016/j.bmcl.2012.04.015 BindingDB Entry DOI: 10.7270/Q24J0HZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50484243 (CHEMBL1822262) Show SMILES COc1n[nH]c2ncc(NC(=O)c3c(F)ccc(NS(=O)(=O)c4cccnc4)c3F)cc12 Show InChI InChI=1S/C19H14F2N6O4S/c1-31-19-12-7-10(8-23-17(12)25-26-19)24-18(28)15-13(20)4-5-14(16(15)21)27-32(29,30)11-3-2-6-22-9-11/h2-9,27H,1H3,(H,24,28)(H,23,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
ArrayBioPharma Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant				Bioorg Med Chem Lett 21: 5533-7 (2011) Article DOI: 10.1016/j.bmcl.2011.06.097 BindingDB Entry DOI: 10.7270/Q28K7CX8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50485028 (CHEMBL2023501) Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(c1F)-c1cc2cnc(Nc3cccnc3)nc2n(C)c1=O |(39.5,-24.7,;38.16,-23.92,;36.83,-24.7,;35.5,-23.93,;34.72,-22.59,;36.26,-22.59,;34.17,-24.71,;32.84,-23.94,;32.83,-22.39,;31.49,-21.63,;30.16,-22.39,;28.83,-21.63,;30.16,-23.94,;31.5,-24.71,;31.5,-26.25,;28.83,-24.71,;27.5,-23.93,;26.17,-24.7,;24.84,-23.92,;23.52,-24.69,;23.52,-26.23,;22.18,-27,;20.85,-26.23,;19.53,-27,;18.19,-26.24,;18.19,-24.7,;19.52,-23.92,;20.86,-24.69,;24.84,-26.99,;26.16,-26.23,;27.5,-27,;27.5,-28.54,;28.83,-26.24,;30.17,-27,)| Show InChI InChI=1S/C22H20F2N6O3S/c1-3-9-34(32,33)29-17-7-6-16(23)18(19(17)24)15-10-13-11-26-22(27-14-5-4-8-25-12-14)28-20(13)30(2)21(15)31/h4-8,10-12,29H,3,9H2,1-2H3,(H,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. Curated by ChEMBL					Assay Description Inhibition of full-length B-Raf V600E mutant assessed as reduction in incorporation of radiolabeled phosphate from [gamma-33P]ATP into FSBA-modified ...				Bioorg Med Chem Lett 22: 3387-91 (2012) Article DOI: 10.1016/j.bmcl.2012.04.015 BindingDB Entry DOI: 10.7270/Q24J0HZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50430022 (CHEMBL2144069) Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(C)(C)C#N)cc1Nc1ccc2ncn(C)c(=O)c2c1 Show InChI InChI=1S/C27H25N5O2/c1-17-8-9-21(31-25(33)18-6-5-7-19(12-18)27(2,3)15-28)14-24(17)30-20-10-11-23-22(13-20)26(34)32(4)16-29-23/h5-14,16,30H,1-4H3,(H,31,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. Curated by ChEMBL					Assay Description Inhibition of full-length B-Raf V600E mutant (unknown origin)				Bioorg Med Chem Lett 24: 1923-7 (2014) Article DOI: 10.1016/j.bmcl.2014.03.007 BindingDB Entry DOI: 10.7270/Q2Q24368
					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50484215 (CHEMBL1822258) Show SMILES COc1n[nH]c2ncc(NC(=O)c3c(F)ccc(NS(=O)(=O)c4cccc(F)c4)c3F)cc12 Show InChI InChI=1S/C20H14F3N5O4S/c1-32-20-13-8-11(9-24-18(13)26-27-20)25-19(29)16-14(22)5-6-15(17(16)23)28-33(30,31)12-4-2-3-10(21)7-12/h2-9,28H,1H3,(H,25,29)(H,24,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
ArrayBioPharma Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant				Bioorg Med Chem Lett 21: 5533-7 (2011) Article DOI: 10.1016/j.bmcl.2011.06.097 BindingDB Entry DOI: 10.7270/Q28K7CX8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50484211 (CHEMBL1822265) Show SMILES COc1n[nH]c2ncc(NC(=O)c3c(F)ccc(NS(=O)(=O)c4ccco4)c3F)cc12 Show InChI InChI=1S/C18H13F2N5O5S/c1-29-18-10-7-9(8-21-16(10)23-24-18)22-17(26)14-11(19)4-5-12(15(14)20)25-31(27,28)13-3-2-6-30-13/h2-8,25H,1H3,(H,22,26)(H,21,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
ArrayBioPharma Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant				Bioorg Med Chem Lett 21: 5533-7 (2011) Article DOI: 10.1016/j.bmcl.2011.06.097 BindingDB Entry DOI: 10.7270/Q28K7CX8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50485674 (CHEMBL2153639) Show SMILES O=C(Nc1ccccc1)Nc1cccc(c1)C(=O)Nc1cnc2[nH]ncc2c1 Show InChI InChI=1S/C20H16N6O2/c27-19(23-17-10-14-11-22-26-18(14)21-12-17)13-5-4-8-16(9-13)25-20(28)24-15-6-2-1-3-7-15/h1-12H,(H,23,27)(H,21,22,26)(H2,24,25,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant				Bioorg Med Chem Lett 22: 6237-41 (2012) Article DOI: 10.1016/j.bmcl.2012.08.007 BindingDB Entry DOI: 10.7270/Q2PR7ZVV
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50493611 (CHEMBL2436807) Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2cccc(Br)c2)c1F Show InChI InChI=1S/C22H18BrF2N5O3S/c1-2-8-34(32,33)30-16-7-6-15(24)18(19(16)25)22(31)27-14-10-17-21(26-11-14)29-20(28-17)12-4-3-5-13(23)9-12/h3-7,9-11,30H,2,8H2,1H3,(H,27,31)(H,26,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.760	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant (unknown origin)				Bioorg Med Chem Lett 23: 5896-9 (2013) Article DOI: 10.1016/j.bmcl.2013.08.086 BindingDB Entry DOI: 10.7270/Q29889X1
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50485677 (CHEMBL2153514) Show SMILES COc1n[nH]c2ncc(NC(=O)c3cccc(NC(=O)c4cccc(c4)C(C)(C)C#N)c3)cc12 Show InChI InChI=1S/C25H22N6O3/c1-25(2,14-26)17-8-4-6-15(10-17)22(32)28-18-9-5-7-16(11-18)23(33)29-19-12-20-21(27-13-19)30-31-24(20)34-3/h4-13H,1-3H3,(H,28,32)(H,29,33)(H,27,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant				Bioorg Med Chem Lett 22: 6237-41 (2012) Article DOI: 10.1016/j.bmcl.2012.08.007 BindingDB Entry DOI: 10.7270/Q2PR7ZVV
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50493601 (CHEMBL2436919) Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2ccccc2)c1F Show InChI InChI=1S/C23H20F2N4O3S/c1-2-10-33(31,32)29-18-9-8-17(24)20(21(18)25)23(30)27-16-11-15-12-19(28-22(15)26-13-16)14-6-4-3-5-7-14/h3-9,11-13,29H,2,10H2,1H3,(H,26,28)(H,27,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant (unknown origin)				Bioorg Med Chem Lett 23: 5896-9 (2013) Article DOI: 10.1016/j.bmcl.2013.08.086 BindingDB Entry DOI: 10.7270/Q29889X1
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50485685 (CHEMBL2153513) Show SMILES COc1n[nH]c2ncc(NC(=O)c3cc(NC(=O)c4cccc(c4)C(C)(C)C#N)ccc3F)cc12 Show InChI InChI=1S/C25H21FN6O3/c1-25(2,13-27)15-6-4-5-14(9-15)22(33)29-16-7-8-20(26)18(10-16)23(34)30-17-11-19-21(28-12-17)31-32-24(19)35-3/h4-12H,1-3H3,(H,29,33)(H,30,34)(H,28,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant				Bioorg Med Chem Lett 22: 6237-41 (2012) Article DOI: 10.1016/j.bmcl.2012.08.007 BindingDB Entry DOI: 10.7270/Q2PR7ZVV
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50485033 (CHEMBL2023502) Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(c1F)-c1cc2cnc(Nc3cnn(C)c3)nc2n(C)c1=O |(13.75,-37.45,;12.42,-36.67,;11.08,-37.45,;9.76,-36.68,;8.98,-35.34,;10.52,-35.34,;8.42,-37.46,;7.09,-36.69,;7.08,-35.14,;5.74,-34.38,;4.42,-35.14,;3.08,-34.38,;4.42,-36.69,;5.75,-37.46,;5.75,-39,;3.08,-37.46,;1.76,-36.68,;.43,-37.45,;-.9,-36.67,;-2.23,-37.44,;-2.23,-38.98,;-3.57,-39.75,;-4.82,-38.87,;-4.86,-37.33,;-6.33,-36.88,;-7.21,-38.15,;-8.75,-38.18,;-6.28,-39.37,;-.91,-39.74,;.42,-38.98,;1.76,-39.75,;1.76,-41.29,;3.09,-38.99,;4.42,-39.75,)| Show InChI InChI=1S/C21H21F2N7O3S/c1-4-7-34(32,33)28-16-6-5-15(22)17(18(16)23)14-8-12-9-24-21(26-13-10-25-29(2)11-13)27-19(12)30(3)20(14)31/h5-6,8-11,28H,4,7H2,1-3H3,(H,24,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. Curated by ChEMBL					Assay Description Inhibition of full-length B-Raf V600E mutant in human MALME-3M cells assessed as reduction in basal ERK1/2 phosphorylation incubated for 1 hr				Bioorg Med Chem Lett 22: 3387-91 (2012) Article DOI: 10.1016/j.bmcl.2012.04.015 BindingDB Entry DOI: 10.7270/Q24J0HZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50484266 (CHEMBL1822259) Show SMILES COc1n[nH]c2ncc(NC(=O)c3c(F)ccc(NS(=O)(=O)c4cc(F)ccc4F)c3F)cc12 Show InChI InChI=1S/C20H13F4N5O4S/c1-33-20-11-7-10(8-25-18(11)27-28-20)26-19(30)16-13(23)4-5-14(17(16)24)29-34(31,32)15-6-9(21)2-3-12(15)22/h2-8,29H,1H3,(H,26,30)(H,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
ArrayBioPharma Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant				Bioorg Med Chem Lett 21: 5533-7 (2011) Article DOI: 10.1016/j.bmcl.2011.06.097 BindingDB Entry DOI: 10.7270/Q28K7CX8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50493632 (CHEMBL2436796) Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2cccc(c2)C(F)(F)F)c1F Show InChI InChI=1S/C23H18F5N5O3S/c1-2-8-37(35,36)33-16-7-6-15(24)18(19(16)25)22(34)30-14-10-17-21(29-11-14)32-20(31-17)12-4-3-5-13(9-12)23(26,27)28/h3-7,9-11,33H,2,8H2,1H3,(H,30,34)(H,29,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant (unknown origin)				Bioorg Med Chem Lett 23: 5896-9 (2013) Article DOI: 10.1016/j.bmcl.2013.08.086 BindingDB Entry DOI: 10.7270/Q29889X1
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50493623 (CHEMBL2436806) Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2cccc(Cl)c2)c1F Show InChI InChI=1S/C22H18ClF2N5O3S/c1-2-8-34(32,33)30-16-7-6-15(24)18(19(16)25)22(31)27-14-10-17-21(26-11-14)29-20(28-17)12-4-3-5-13(23)9-12/h3-7,9-11,30H,2,8H2,1H3,(H,27,31)(H,26,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant (unknown origin)				Bioorg Med Chem Lett 23: 5896-9 (2013) Article DOI: 10.1016/j.bmcl.2013.08.086 BindingDB Entry DOI: 10.7270/Q29889X1
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50493608 (CHEMBL2436789) Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2ccc(OC)cc2)c1F Show InChI InChI=1S/C23H21F2N5O4S/c1-3-10-35(32,33)30-17-9-8-16(24)19(20(17)25)23(31)27-14-11-18-22(26-12-14)29-21(28-18)13-4-6-15(34-2)7-5-13/h4-9,11-12,30H,3,10H2,1-2H3,(H,27,31)(H,26,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant (unknown origin)				Bioorg Med Chem Lett 23: 5896-9 (2013) Article DOI: 10.1016/j.bmcl.2013.08.086 BindingDB Entry DOI: 10.7270/Q29889X1
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50493630 (CHEMBL2436921) Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2ccc(F)cc2)c1F Show InChI InChI=1S/C23H19F3N4O3S/c1-2-9-34(32,33)30-18-8-7-17(25)20(21(18)26)23(31)28-16-10-14-11-19(29-22(14)27-12-16)13-3-5-15(24)6-4-13/h3-8,10-12,30H,2,9H2,1H3,(H,27,29)(H,28,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant (unknown origin)				Bioorg Med Chem Lett 23: 5896-9 (2013) Article DOI: 10.1016/j.bmcl.2013.08.086 BindingDB Entry DOI: 10.7270/Q29889X1
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50493606 (CHEMBL2436795) Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2cccc(OC)c2)c1F Show InChI InChI=1S/C23H21F2N5O4S/c1-3-9-35(32,33)30-17-8-7-16(24)19(20(17)25)23(31)27-14-11-18-22(26-12-14)29-21(28-18)13-5-4-6-15(10-13)34-2/h4-8,10-12,30H,3,9H2,1-2H3,(H,27,31)(H,26,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant (unknown origin)				Bioorg Med Chem Lett 23: 5896-9 (2013) Article DOI: 10.1016/j.bmcl.2013.08.086 BindingDB Entry DOI: 10.7270/Q29889X1
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50485679 (CHEMBL2153635) Show SMILES COc1n[nH]c2ncc(NC(=O)c3cc(NC(=O)c4cccc(c4)C(C)(C)C#N)ccc3Cl)cc12 Show InChI InChI=1S/C25H21ClN6O3/c1-25(2,13-27)15-6-4-5-14(9-15)22(33)29-16-7-8-20(26)18(10-16)23(34)30-17-11-19-21(28-12-17)31-32-24(19)35-3/h4-12H,1-3H3,(H,29,33)(H,30,34)(H,28,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant				Bioorg Med Chem Lett 22: 6237-41 (2012) Article DOI: 10.1016/j.bmcl.2012.08.007 BindingDB Entry DOI: 10.7270/Q2PR7ZVV
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50493616 (CHEMBL2436790) Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2ccc(C)cc2)c1F Show InChI InChI=1S/C23H21F2N5O3S/c1-3-10-34(32,33)30-17-9-8-16(24)19(20(17)25)23(31)27-15-11-18-22(26-12-15)29-21(28-18)14-6-4-13(2)5-7-14/h4-9,11-12,30H,3,10H2,1-2H3,(H,27,31)(H,26,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant (unknown origin)				Bioorg Med Chem Lett 23: 5896-9 (2013) Article DOI: 10.1016/j.bmcl.2013.08.086 BindingDB Entry DOI: 10.7270/Q29889X1
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50485686 (CHEMBL2153634) Show SMILES COc1n[nH]c2ncc(NC(=O)c3cc(NC(=O)c4ccc(Cl)c(c4)C(F)(F)F)ccc3F)cc12 Show InChI InChI=1S/C22H14ClF4N5O3/c1-35-21-14-8-12(9-28-18(14)31-32-21)30-20(34)13-7-11(3-5-17(13)24)29-19(33)10-2-4-16(23)15(6-10)22(25,26)27/h2-9H,1H3,(H,29,33)(H,30,34)(H,28,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant				Bioorg Med Chem Lett 22: 6237-41 (2012) Article DOI: 10.1016/j.bmcl.2012.08.007 BindingDB Entry DOI: 10.7270/Q2PR7ZVV
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50484202 (CHEMBL1822089) Show SMILES COc1n[nH]c2ncc(NC(=O)c3c(F)ccc(NS(=O)(=O)CCCF)c3F)cc12 Show InChI InChI=1S/C17H16F3N5O4S/c1-29-17-10-7-9(8-21-15(10)23-24-17)22-16(26)13-11(19)3-4-12(14(13)20)25-30(27,28)6-2-5-18/h3-4,7-8,25H,2,5-6H2,1H3,(H,22,26)(H,21,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
ArrayBioPharma Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant				Bioorg Med Chem Lett 21: 5533-7 (2011) Article DOI: 10.1016/j.bmcl.2011.06.097 BindingDB Entry DOI: 10.7270/Q28K7CX8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50484249 (CHEMBL1822069) Show SMILES CCCS(=O)(=O)Nc1ccc(Cl)c(C(=O)Nc2cnc3[nH]nc(OC)c3c2)c1Cl Show InChI InChI=1S/C17H17Cl2N5O4S/c1-3-6-29(26,27)24-12-5-4-11(18)13(14(12)19)16(25)21-9-7-10-15(20-8-9)22-23-17(10)28-2/h4-5,7-8,24H,3,6H2,1-2H3,(H,21,25)(H,20,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
ArrayBioPharma Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant				Bioorg Med Chem Lett 21: 5533-7 (2011) Article DOI: 10.1016/j.bmcl.2011.06.097 BindingDB Entry DOI: 10.7270/Q28K7CX8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50493628 (CHEMBL2436791) Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2ccc(cc2)C(F)(F)F)c1F Show InChI InChI=1S/C23H18F5N5O3S/c1-2-9-37(35,36)33-16-8-7-15(24)18(19(16)25)22(34)30-14-10-17-21(29-11-14)32-20(31-17)12-3-5-13(6-4-12)23(26,27)28/h3-8,10-11,33H,2,9H2,1H3,(H,30,34)(H,29,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant (unknown origin)				Bioorg Med Chem Lett 23: 5896-9 (2013) Article DOI: 10.1016/j.bmcl.2013.08.086 BindingDB Entry DOI: 10.7270/Q29889X1
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50493615 (CHEMBL2436794) Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2ccc(cc2)S(C)(=O)=O)c1F Show InChI InChI=1S/C23H21F2N5O5S2/c1-3-10-37(34,35)30-17-9-8-16(24)19(20(17)25)23(31)27-14-11-18-22(26-12-14)29-21(28-18)13-4-6-15(7-5-13)36(2,32)33/h4-9,11-12,30H,3,10H2,1-2H3,(H,27,31)(H,26,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant (unknown origin)				Bioorg Med Chem Lett 23: 5896-9 (2013) Article DOI: 10.1016/j.bmcl.2013.08.086 BindingDB Entry DOI: 10.7270/Q29889X1
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50493609 (CHEMBL2436803) Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2ccc(Cl)c(Cl)c2)c1F Show InChI InChI=1S/C22H17Cl2F2N5O3S/c1-2-7-35(33,34)31-16-6-5-15(25)18(19(16)26)22(32)28-12-9-17-21(27-10-12)30-20(29-17)11-3-4-13(23)14(24)8-11/h3-6,8-10,31H,2,7H2,1H3,(H,28,32)(H,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant (unknown origin)				Bioorg Med Chem Lett 23: 5896-9 (2013) Article DOI: 10.1016/j.bmcl.2013.08.086 BindingDB Entry DOI: 10.7270/Q29889X1
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50484216 (CHEMBL1822256) Show SMILES COc1n[nH]c2ncc(NC(=O)c3c(F)ccc(NS(=O)(=O)c4ccccc4)c3F)cc12 Show InChI InChI=1S/C20H15F2N5O4S/c1-31-20-13-9-11(10-23-18(13)25-26-20)24-19(28)16-14(21)7-8-15(17(16)22)27-32(29,30)12-5-3-2-4-6-12/h2-10,27H,1H3,(H,24,28)(H,23,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
ArrayBioPharma Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant				Bioorg Med Chem Lett 21: 5533-7 (2011) Article DOI: 10.1016/j.bmcl.2011.06.097 BindingDB Entry DOI: 10.7270/Q28K7CX8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50493602 (CHEMBL2436813) Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2ccccc2)c1F Show InChI InChI=1S/C22H19F2N5O3S/c1-2-10-33(31,32)29-16-9-8-15(23)18(19(16)24)22(30)26-14-11-17-21(25-12-14)28-20(27-17)13-6-4-3-5-7-13/h3-9,11-12,29H,2,10H2,1H3,(H,26,30)(H,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant (unknown origin)				Bioorg Med Chem Lett 23: 5896-9 (2013) Article DOI: 10.1016/j.bmcl.2013.08.086 BindingDB Entry DOI: 10.7270/Q29889X1
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50484231 (CHEMBL1822068) Show SMILES CCCS(=O)(=O)Nc1ccc(Cl)c(C(=O)Nc2cnc3[nH]nc(OC)c3c2)c1F Show InChI InChI=1S/C17H17ClFN5O4S/c1-3-6-29(26,27)24-12-5-4-11(18)13(14(12)19)16(25)21-9-7-10-15(20-8-9)22-23-17(10)28-2/h4-5,7-8,24H,3,6H2,1-2H3,(H,21,25)(H,20,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
ArrayBioPharma Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant				Bioorg Med Chem Lett 21: 5533-7 (2011) Article DOI: 10.1016/j.bmcl.2011.06.097 BindingDB Entry DOI: 10.7270/Q28K7CX8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50484231 (CHEMBL1822068) Show SMILES CCCS(=O)(=O)Nc1ccc(Cl)c(C(=O)Nc2cnc3[nH]nc(OC)c3c2)c1F Show InChI InChI=1S/C17H17ClFN5O4S/c1-3-6-29(26,27)24-12-5-4-11(18)13(14(12)19)16(25)21-9-7-10-15(20-8-9)22-23-17(10)28-2/h4-5,7-8,24H,3,6H2,1-2H3,(H,21,25)(H,20,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Curated by ChEMBL					Assay Description Inhibition of full length human B-Raf V600E mutant expressed in baculovirus infected insect cells assessed as [gamma-33P]incorporation into MEK after...				ACS Med Chem Lett 2: 342-7 (2011) Article DOI: 10.1021/ml200025q BindingDB Entry DOI: 10.7270/Q2H134VM
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50484242 (CHEMBL1822257) Show SMILES COc1n[nH]c2ncc(NC(=O)c3c(F)ccc(NS(=O)(=O)c4ccccc4F)c3F)cc12 Show InChI InChI=1S/C20H14F3N5O4S/c1-32-20-11-8-10(9-24-18(11)26-27-20)25-19(29)16-13(22)6-7-14(17(16)23)28-33(30,31)15-5-3-2-4-12(15)21/h2-9,28H,1H3,(H,25,29)(H,24,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
ArrayBioPharma Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant				Bioorg Med Chem Lett 21: 5533-7 (2011) Article DOI: 10.1016/j.bmcl.2011.06.097 BindingDB Entry DOI: 10.7270/Q28K7CX8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50484222 (CHEMBL1822242) Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]nc(I)c3c2)c1F Show InChI InChI=1S/C16H14F2IN5O3S/c1-2-5-28(26,27)24-11-4-3-10(17)12(13(11)18)16(25)21-8-6-9-14(19)22-23-15(9)20-7-8/h3-4,6-7,24H,2,5H2,1H3,(H,21,25)(H,20,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
ArrayBioPharma Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant				Bioorg Med Chem Lett 21: 5533-7 (2011) Article DOI: 10.1016/j.bmcl.2011.06.097 BindingDB Entry DOI: 10.7270/Q28K7CX8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50485683 (CHEMBL2153636) Show SMILES COc1n[nH]c2ncc(NC(=O)c3cc(NC(=O)c4cccc(c4)C(C)(C)C#N)ccc3C)cc12 Show InChI InChI=1S/C26H24N6O3/c1-15-8-9-18(29-23(33)16-6-5-7-17(10-16)26(2,3)14-27)11-20(15)24(34)30-19-12-21-22(28-13-19)31-32-25(21)35-4/h5-13H,1-4H3,(H,29,33)(H,30,34)(H,28,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant				Bioorg Med Chem Lett 22: 6237-41 (2012) Article DOI: 10.1016/j.bmcl.2012.08.007 BindingDB Entry DOI: 10.7270/Q2PR7ZVV
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50496940 (CHEMBL3236459) Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(Nc2ccc3ncn(-c4cnn(C)c4)c(=O)c3c2)c1Cl Show InChI InChI=1S/C21H20ClFN6O3S/c1-3-8-33(31,32)27-18-7-5-16(23)20(19(18)22)26-13-4-6-17-15(9-13)21(30)29(12-24-17)14-10-25-28(2)11-14/h4-7,9-12,26-27H,3,8H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. Curated by ChEMBL					Assay Description Inhibition of full-length B-Raf V600E mutant (unknown origin)				Bioorg Med Chem Lett 24: 1923-7 (2014) Article DOI: 10.1016/j.bmcl.2014.03.007 BindingDB Entry DOI: 10.7270/Q2Q24368
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50496939 (CHEMBL3236198) Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(Nc2ccc3ncn(C)c(=O)c3c2)c1Cl Show InChI InChI=1S/C18H18ClFN4O3S/c1-3-8-28(26,27)23-15-7-5-13(20)17(16(15)19)22-11-4-6-14-12(9-11)18(25)24(2)10-21-14/h4-7,9-10,22-23H,3,8H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. Curated by ChEMBL					Assay Description Inhibition of full-length B-Raf V600E mutant (unknown origin)				Bioorg Med Chem Lett 24: 1923-7 (2014) Article DOI: 10.1016/j.bmcl.2014.03.007 BindingDB Entry DOI: 10.7270/Q2Q24368
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50493626 (CHEMBL2436804) Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2ccc(Br)cc2)c1F Show InChI InChI=1S/C22H18BrF2N5O3S/c1-2-9-34(32,33)30-16-8-7-15(24)18(19(16)25)22(31)27-14-10-17-21(26-11-14)29-20(28-17)12-3-5-13(23)6-4-12/h3-8,10-11,30H,2,9H2,1H3,(H,27,31)(H,26,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant (unknown origin)				Bioorg Med Chem Lett 23: 5896-9 (2013) Article DOI: 10.1016/j.bmcl.2013.08.086 BindingDB Entry DOI: 10.7270/Q29889X1
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50493627 (CHEMBL2436808) Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2ccc(Cl)cc2)c1F Show InChI InChI=1S/C22H18ClF2N5O3S/c1-2-9-34(32,33)30-16-8-7-15(24)18(19(16)25)22(31)27-14-10-17-21(26-11-14)29-20(28-17)12-3-5-13(23)6-4-12/h3-8,10-11,30H,2,9H2,1H3,(H,27,31)(H,26,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant (unknown origin)				Bioorg Med Chem Lett 23: 5896-9 (2013) Article DOI: 10.1016/j.bmcl.2013.08.086 BindingDB Entry DOI: 10.7270/Q29889X1
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50484220 (CHEMBL1822247) Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]cc(I)c3c2)c1F Show InChI InChI=1S/C17H15F2IN4O3S/c1-2-5-28(26,27)24-13-4-3-11(18)14(15(13)19)17(25)23-9-6-10-12(20)8-22-16(10)21-7-9/h3-4,6-8,24H,2,5H2,1H3,(H,21,22)(H,23,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
ArrayBioPharma Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant				Bioorg Med Chem Lett 21: 5533-7 (2011) Article DOI: 10.1016/j.bmcl.2011.06.097 BindingDB Entry DOI: 10.7270/Q28K7CX8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50484233 (CHEMBL1822074) Show SMILES CCCS(=O)(=O)Nc1cc(F)c(F)c(C(=O)Nc2cnc3[nH]nc(OC)c3c2)c1F Show InChI InChI=1S/C17H16F3N5O4S/c1-3-4-30(27,28)25-11-6-10(18)13(19)12(14(11)20)16(26)22-8-5-9-15(21-7-8)23-24-17(9)29-2/h5-7,25H,3-4H2,1-2H3,(H,22,26)(H,21,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
ArrayBioPharma Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant				Bioorg Med Chem Lett 21: 5533-7 (2011) Article DOI: 10.1016/j.bmcl.2011.06.097 BindingDB Entry DOI: 10.7270/Q28K7CX8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50485675 (CHEMBL2153510) Show SMILES COc1n[nH]c2ncc(NC(=O)c3c(F)ccc(NC(=O)c4cccc(c4)C(C)(C)C#N)c3F)cc12 Show InChI InChI=1S/C25H20F2N6O3/c1-25(2,12-28)14-6-4-5-13(9-14)22(34)31-18-8-7-17(26)19(20(18)27)23(35)30-15-10-16-21(29-11-15)32-33-24(16)36-3/h4-11H,1-3H3,(H,30,35)(H,31,34)(H,29,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant				Bioorg Med Chem Lett 22: 6237-41 (2012) Article DOI: 10.1016/j.bmcl.2012.08.007 BindingDB Entry DOI: 10.7270/Q2PR7ZVV
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50484218 (CHEMBL1822251) Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]nc(OCC)c3c2)c1F Show InChI InChI=1S/C18H19F2N5O4S/c1-3-7-30(27,28)25-13-6-5-12(19)14(15(13)20)17(26)22-10-8-11-16(21-9-10)23-24-18(11)29-4-2/h5-6,8-9,25H,3-4,7H2,1-2H3,(H,22,26)(H,21,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
ArrayBioPharma Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant				Bioorg Med Chem Lett 21: 5533-7 (2011) Article DOI: 10.1016/j.bmcl.2011.06.097 BindingDB Entry DOI: 10.7270/Q28K7CX8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50493612 (CHEMBL2436809) Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2ccc(Cl)cc2)c1F Show InChI InChI=1S/C23H19ClF2N4O3S/c1-2-9-34(32,33)30-18-8-7-17(25)20(21(18)26)23(31)28-16-10-14-11-19(29-22(14)27-12-16)13-3-5-15(24)6-4-13/h3-8,10-12,30H,2,9H2,1H3,(H,27,29)(H,28,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant (unknown origin)				Bioorg Med Chem Lett 23: 5896-9 (2013) Article DOI: 10.1016/j.bmcl.2013.08.086 BindingDB Entry DOI: 10.7270/Q29889X1
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50493620 (CHEMBL2436792) Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2ccc(OC(F)(F)F)cc2)c1F Show InChI InChI=1S/C23H18F5N5O4S/c1-2-9-38(35,36)33-16-8-7-15(24)18(19(16)25)22(34)30-13-10-17-21(29-11-13)32-20(31-17)12-3-5-14(6-4-12)37-23(26,27)28/h3-8,10-11,33H,2,9H2,1H3,(H,30,34)(H,29,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. Curated by ChEMBL					Assay Description Inhibition of full length B-Raf V600E mutant (unknown origin)				Bioorg Med Chem Lett 23: 5896-9 (2013) Article DOI: 10.1016/j.bmcl.2013.08.086 BindingDB Entry DOI: 10.7270/Q29889X1
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 536 total )  |  Next  |  Last  >>

Jump to: