BindingDB PrimarySearch

Found 14 hits with Last Name = 'vollmar' and Initial = 'm'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM7401 ((2 Z,3 E)-6-Bromoindirubin-3 -oxime \| (3E)-6-bromo...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	7.5	30
University of Munich					Assay Description PDK1 protein kinase was expressed in Sf9 insect cells as human recombinant GST-fusion protein by means of the baculovirus expression systems. Protei...				Chem Biol 14: 1207-14 (2007) Article DOI: 10.1016/j.chembiol.2007.10.010 BindingDB Entry DOI: 10.7270/Q2668BN7
University of Munich					More data for this Ligand-Target Pair
Actin, alpha skeletal muscle (Oryctolagus cuniculus)	BDBM50508923 (CHEBI:49703 \| LATRUNCULIN B \| NSC-339663) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	8.47E+3	n/a	n/a	n/a	n/a	n/a	n/a
Ludwig-Maximilians-University Curated by ChEMBL					Assay Description Inhibition of rabbit skeletal muscle alpha-actin polymerization measured after 24 hrs in presence of ATP and fluorescent pyrene-labelled actin by flu...				J Nat Prod 82: 1961-1970 (2019) Article DOI: 10.1021/acs.jnatprod.9b00335 BindingDB Entry DOI: 10.7270/Q2BK1GQ5
Ludwig-Maximilians-University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
E3 ubiquitin-protein ligase XIAP (Homo sapiens (Human))	BDBM50334671 (CHEMBL1642586 \| kaempferol-3-O-alpha-L-(2'', 4''-d...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.04E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Innsbruck Curated by ChEMBL					Assay Description Displacement of fluorescent SM5F peptide from XIAP linker BIR3 domain after 3 hrs by fluorescence polarization assay				Bioorg Med Chem 19: 1002-9 (2011) Article DOI: 10.1016/j.bmc.2010.10.046 BindingDB Entry DOI: 10.7270/Q2Q240H2
University of Innsbruck Curated by ChEMBL					More data for this Ligand-Target Pair
Actin, alpha skeletal muscle (Oryctolagus cuniculus)	BDBM50508924 (CHEMBL4522174) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.52E+4	n/a	n/a	n/a	n/a	n/a	n/a
Ludwig-Maximilians-University Curated by ChEMBL					Assay Description Inhibition of rabbit skeletal muscle alpha-actin polymerization measured after 24 hrs in presence of ATP and fluorescent pyrene-labelled actin by flu...				J Nat Prod 82: 1961-1970 (2019) Article DOI: 10.1021/acs.jnatprod.9b00335 BindingDB Entry DOI: 10.7270/Q2BK1GQ5
Ludwig-Maximilians-University Curated by ChEMBL					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM81296 (5BIO) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.5	30
University of Munich					Assay Description PDK1 protein kinase was expressed in Sf9 insect cells as human recombinant GST-fusion protein by means of the baculovirus expression systems. Protei...				Chem Biol 14: 1207-14 (2007) Article DOI: 10.1016/j.chembiol.2007.10.010 BindingDB Entry DOI: 10.7270/Q2668BN7
University of Munich					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM50218894 (7-bromoindirubin-3-oxime \| 7BIO \| CHEMBL1092509) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.5	30
University of Munich					Assay Description PDK1 protein kinase was expressed in Sf9 insect cells as human recombinant GST-fusion protein by means of the baculovirus expression systems. Protei...				Chem Biol 14: 1207-14 (2007) Article DOI: 10.1016/j.chembiol.2007.10.010 BindingDB Entry DOI: 10.7270/Q2668BN7
University of Munich					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase XIAP (Homo sapiens (Human))	BDBM50213414 (CHEMBL240528 \| afzelin \| kaempferol 3-O-alpha-L-rh...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Innsbruck Curated by ChEMBL					Assay Description Displacement of fluorescent SM5F peptide from XIAP linker BIR3 domain after 3 hrs by fluorescence polarization assay				Bioorg Med Chem 19: 1002-9 (2011) Article DOI: 10.1016/j.bmc.2010.10.046 BindingDB Entry DOI: 10.7270/Q2Q240H2
University of Innsbruck Curated by ChEMBL					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase XIAP (Homo sapiens (Human))	BDBM7462 (3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-...) Show SMILES Oc1ccc(cc1)-c1oc2cc(O)cc(O)c2c(=O)c1O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Innsbruck Curated by ChEMBL					Assay Description Displacement of fluorescent SM5F peptide from XIAP linker BIR3 domain after 3 hrs by fluorescence polarization assay				Bioorg Med Chem 19: 1002-9 (2011) Article DOI: 10.1016/j.bmc.2010.10.046 BindingDB Entry DOI: 10.7270/Q2Q240H2
University of Innsbruck Curated by ChEMBL					More data for this Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human))	BDBM7393 (3-[(2Z,3E)-3-(hydroxyimino)-2,3-dihydro-1H-indol-2...) Show SMILES O=Nc1c([nH]c2ccccc12)C1C(=O)Nc2ccccc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.5	30
University of Munich					Assay Description PDK1 protein kinase was expressed in Sf9 insect cells as human recombinant GST-fusion protein by means of the baculovirus expression systems. Protei...				Chem Biol 14: 1207-14 (2007) Article DOI: 10.1016/j.chembiol.2007.10.010 BindingDB Entry DOI: 10.7270/Q2668BN7
University of Munich					More data for this Ligand-Target Pair
Histone demethylase UTY [818-1347,S1138G] (Homo sapiens (Human))	BDBM231631 (Biotin-KAPRKQLATKAARKMe3SAPATGG \| H3K27Me3 peptide) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	1.15E+5	n/a	n/a	n/a	7.5	25
University of Oxford					Assay Description Binding assays were carried out as 20-μl reactions in 384-well white ProxiPlates (Perkin-Elmer Life Sciences) as described [Hong et al., Proc. N...				J Biol Chem 289: 18302-13 (2014) Article DOI: 10.1074/jbc.M114.555052 BindingDB Entry DOI: 10.7270/Q23X85J4
University of Oxford					More data for this Ligand-Target Pair
Histone demethylase UTY [818-1347,P1214I] (Homo sapiens (Human))	BDBM231631 (Biotin-KAPRKQLATKAARKMe3SAPATGG \| H3K27Me3 peptide) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	3.50E+3	n/a	n/a	n/a	7.5	25
University of Oxford					Assay Description Binding assays were carried out as 20-μl reactions in 384-well white ProxiPlates (Perkin-Elmer Life Sciences) as described [Hong et al., Proc. N...				J Biol Chem 289: 18302-13 (2014) Article DOI: 10.1074/jbc.M114.555052 BindingDB Entry DOI: 10.7270/Q23X85J4
University of Oxford					More data for this Ligand-Target Pair
Lysine-specific demethylase 6A (Homo sapiens (Human))	BDBM231631 (Biotin-KAPRKQLATKAARKMe3SAPATGG \| H3K27Me3 peptide) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	2.00E+3	n/a	n/a	n/a	7.5	25
University of Oxford					Assay Description Binding assays were carried out as 20-μl reactions in 384-well white ProxiPlates (Perkin-Elmer Life Sciences) as described [Hong et al., Proc. N...				J Biol Chem 289: 18302-13 (2014) Article DOI: 10.1074/jbc.M114.555052 BindingDB Entry DOI: 10.7270/Q23X85J4
University of Oxford					More data for this Ligand-Target Pair
Lysine-specific demethylase 6B (Homo sapiens (Human))	BDBM231631 (Biotin-KAPRKQLATKAARKMe3SAPATGG \| H3K27Me3 peptide) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	800	n/a	n/a	n/a	7.5	25
University of Oxford					Assay Description Binding assays were carried out as 20-μl reactions in 384-well white ProxiPlates (Perkin-Elmer Life Sciences) as described [Hong et al., Proc. N...				J Biol Chem 289: 18302-13 (2014) Article DOI: 10.1074/jbc.M114.555052 BindingDB Entry DOI: 10.7270/Q23X85J4
University of Oxford					More data for this Ligand-Target Pair
Histone demethylase UTY [818-1347] (Homo sapiens (Human))	BDBM231631 (Biotin-KAPRKQLATKAARKMe3SAPATGG \| H3K27Me3 peptide) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	7.80E+4	n/a	n/a	n/a	7.5	25
University of Oxford					Assay Description Binding assays were carried out as 20-μl reactions in 384-well white ProxiPlates (Perkin-Elmer Life Sciences) as described [Hong et al., Proc. N...				J Biol Chem 289: 18302-13 (2014) Article DOI: 10.1074/jbc.M114.555052 BindingDB Entry DOI: 10.7270/Q23X85J4
University of Oxford					More data for this Ligand-Target Pair