Found 861 hits with Last Name = 'wong' and Initial = 'v' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Coagulation factor XI
(Homo sapiens (Human)) | BDBM50598740
(CHEMBL5175227)Show SMILES Cn1nncc1-c1cnn(c1)[C@H](CCOC(F)F)c1ccc(c[n+]1[O-])-c1c(F)c(Cl)ccc1-n1cnnn1 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 0.120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00442 BindingDB Entry DOI: 10.7270/Q2C82FBD |
More data for this Ligand-Target Pair | |
Coagulation factor XI
(Homo sapiens (Human)) | BDBM50598738
(CHEMBL5204065)Show SMILES Cn1nncc1-c1cnn(c1)[C@H](Cc1ccc(F)cc1)c1ccc(c[n+]1[O-])-c1c(F)c(Cl)ccc1-n1cnnn1 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 0.130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00442 BindingDB Entry DOI: 10.7270/Q2C82FBD |
More data for this Ligand-Target Pair | |
Coagulation factor XI
(Homo sapiens (Human)) | BDBM50598739
(CHEMBL5188215)Show SMILES COCC[C@H](c1ccc(c[n+]1[O-])-c1c(F)c(Cl)ccc1-n1cnnn1)n1cc(cn1)-c1cnnn1C |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 0.130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00442 BindingDB Entry DOI: 10.7270/Q2C82FBD |
More data for this Ligand-Target Pair | |
Coagulation factor XI
(Homo sapiens (Human)) | BDBM50598724
(CHEMBL5170592)Show SMILES Cn1nncc1-c1cnn(c1)[C@H](CCOC(F)F)c1ccc(c[n+]1[O-])-c1c(F)c(Cl)ccc1-n1cc(Cl)nn1 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
| PDB Article PubMed
| 0.170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00442 BindingDB Entry DOI: 10.7270/Q2C82FBD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Coagulation factor XI
(Homo sapiens (Human)) | BDBM50598737
(CHEMBL5205631)Show SMILES Cn1nncc1-c1cnn(c1)[C@H](CC1CC1)c1ccc(c[n+]1[O-])-c1c(F)c(Cl)ccc1-n1cnnn1 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00442 BindingDB Entry DOI: 10.7270/Q2C82FBD |
More data for this Ligand-Target Pair | |
Coagulation factor XI
(Homo sapiens (Human)) | BDBM50598741
(CHEMBL5204894)Show SMILES Cn1nncc1-c1cnn(c1)[C@H](Cc1ccc(F)cc1)c1ccc(c[n+]1[O-])-c1c(F)c(Cl)ccc1-n1cc(Cl)nn1 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 0.220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00442 BindingDB Entry DOI: 10.7270/Q2C82FBD |
More data for this Ligand-Target Pair | |
Coagulation factor XI
(Homo sapiens (Human)) | BDBM50598725
(CHEMBL5185397)Show SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)C(CC1CC1)c1ccc(c[n+]1[O-])-c1cc(Cl)ccc1-n1cnnn1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 0.25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00442 BindingDB Entry DOI: 10.7270/Q2C82FBD |
More data for this Ligand-Target Pair | |
Coagulation factor XI
(Homo sapiens (Human)) | BDBM50598743
(CHEMBL5178223)Show SMILES Cn1nncc1-c1cnn(c1)[C@H](CCOC(F)F)c1ccc(c[n+]1[O-])-c1c(F)c(Cl)ccc1-n1cc(nn1)C(F)(F)F |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 0.260 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00442 BindingDB Entry DOI: 10.7270/Q2C82FBD |
More data for this Ligand-Target Pair | |
Coagulation factor XI
(Homo sapiens (Human)) | BDBM50598734
(CHEMBL5197480)Show SMILES Cc1ncsc1-c1cnn(c1)C(CC1CC1)c1ccc(c[n+]1[O-])-c1c(F)c(Cl)ccc1-n1cnnn1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00442 BindingDB Entry DOI: 10.7270/Q2C82FBD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Coagulation factor XI
(Homo sapiens (Human)) | BDBM50598745
(CHEMBL5198823)Show SMILES Cn1nncc1-c1cnn(c1)[C@H](Cc1ccn(n1)C(F)F)c1ccc(c[n+]1[O-])-c1c(F)c(Cl)ccc1-n1cc(nn1)C(F)(F)F |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00442 BindingDB Entry DOI: 10.7270/Q2C82FBD |
More data for this Ligand-Target Pair | |
Coagulation factor XI
(Homo sapiens (Human)) | BDBM50598736
(CHEMBL5208095)Show SMILES Cn1cncc1-c1cnn(c1)[C@H](CC1CC1)c1ccc(c[n+]1[O-])-c1c(F)c(Cl)ccc1-n1cnnn1 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00442 BindingDB Entry DOI: 10.7270/Q2C82FBD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Coagulation factor XI
(Homo sapiens (Human)) | BDBM50598744
(CHEMBL5190323)Show SMILES Cn1nncc1-c1cnn(c1)[C@H](Cn1cc(F)cn1)c1ccc(c[n+]1[O-])-c1c(F)c(Cl)ccc1-n1cc(Cl)nn1 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 0.420 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00442 BindingDB Entry DOI: 10.7270/Q2C82FBD |
More data for this Ligand-Target Pair | |
Coagulation factor XI
(Homo sapiens (Human)) | BDBM50598732
(CHEMBL5192284)Show SMILES [O-][n+]1cc(ccc1C(CC1CC1)n1cc(cn1)-c1c(F)cncc1Cl)-c1c(F)c(Cl)ccc1-n1cnnn1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00442 BindingDB Entry DOI: 10.7270/Q2C82FBD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM396607
(3-[5-Bromo-2-(5-trifluoromethyl-furan-2-ylmethoxy)...)Show InChI InChI=1S/C16H15BrF3NO2/c17-12-1-3-14(11(6-12)5-10-7-21-8-10)22-9-13-2-4-15(23-13)16(18,19)20/h1-4,6,10,21H,5,7-9H2 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis
| Assay Description Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access... |
J Med Chem 52: 3523-38 (2009)
BindingDB Entry DOI: 10.7270/Q26T0Q0F |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50011237
(CHEMBL3260334 | US9981909, Example 2)Show InChI InChI=1S/C16H15BrClNO2/c17-12-4-5-15(16(7-12)21-14-8-19-9-14)20-10-11-2-1-3-13(18)6-11/h1-7,14,19H,8-10H2 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis
| Assay Description Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access... |
J Med Chem 52: 3523-38 (2009)
BindingDB Entry DOI: 10.7270/Q26T0Q0F |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM396409
(3-[2-(Azetidin-3-yloxy)-4-chloro-phenoxymethyl]-be...)Show InChI InChI=1S/C17H15ClN2O2/c18-14-4-5-16(17(7-14)22-15-9-20-10-15)21-11-13-3-1-2-12(6-13)8-19/h1-7,15,20H,9-11H2 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis
| Assay Description Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access... |
J Med Chem 52: 3523-38 (2009)
BindingDB Entry DOI: 10.7270/Q26T0Q0F |
More data for this Ligand-Target Pair | |
Coagulation factor XI
(Homo sapiens (Human)) | BDBM50598742
(CHEMBL5182855)Show SMILES COCC[C@H](c1ccc(c[n+]1[O-])-c1c(F)c(Cl)ccc1-n1cc(Cl)nn1)n1cc(cn1)-c1cnnn1C |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00442 BindingDB Entry DOI: 10.7270/Q2C82FBD |
More data for this Ligand-Target Pair | |
Coagulation factor XI
(Homo sapiens (Human)) | BDBM50598729
(CHEMBL5195600)Show SMILES COC(=O)Nc1ccc(cc1)-c1cnn(c1)[C@H](CC1CC1)c1ccc(c[n+]1[O-])-c1c(F)c(Cl)ccc1-n1cnnn1 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00442 BindingDB Entry DOI: 10.7270/Q2C82FBD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Coagulation factor XI
(Homo sapiens (Human)) | BDBM50598727
(CHEMBL5198338)Show SMILES COC(=O)Nc1ccc(cc1)-c1cnn(c1)C(CC1CC1)c1ccc(c[n+]1[O-])-c1c(F)c(Cl)ccc1-n1cnnn1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00442 BindingDB Entry DOI: 10.7270/Q2C82FBD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Coagulation factor XI
(Homo sapiens (Human)) | BDBM50598735
(CHEMBL5193267)Show SMILES Cn1nccc1-c1cnn(c1)C(CC1CC1)c1ccc(c[n+]1[O-])-c1c(F)c(Cl)ccc1-n1cnnn1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00442 BindingDB Entry DOI: 10.7270/Q2C82FBD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50127832
(3-Methyl-2-[4-(3-piperidin-1-yl-propoxy)-phenyl]-i...)Show InChI InChI=1S/C23H28N2O/c1-19-23(18-21-8-3-6-16-25(19)21)20-9-11-22(12-10-20)26-17-7-15-24-13-4-2-5-14-24/h3,6,8-12,16,18H,2,4-5,7,13-15,17H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development L. L. C.
Curated by ChEMBL
| Assay Description Binding affinity towards human Histamine H3 receptor using [3H]-N-methyl-histamine as radioligand |
Bioorg Med Chem Lett 13: 1767-70 (2003)
BindingDB Entry DOI: 10.7270/Q21835V3 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM396570
(3-(5-Bromo-2-phenethyloxy-phenoxy)-azetidine | US9...)Show InChI InChI=1S/C17H18BrNO2/c18-14-6-7-16(17(10-14)21-15-11-19-12-15)20-9-8-13-4-2-1-3-5-13/h1-7,10,15,19H,8-9,11-12H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis
| Assay Description Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access... |
J Med Chem 52: 3523-38 (2009)
BindingDB Entry DOI: 10.7270/Q26T0Q0F |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM396384
(3-[2-(Azetidin-3-yloxy)-4-bromo-phenoxymethyl]-ben...)Show InChI InChI=1S/C17H15BrN2O2/c18-14-4-5-16(17(7-14)22-15-9-20-10-15)21-11-13-3-1-2-12(6-13)8-19/h1-7,15,20H,9-11H2 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis
| Assay Description Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access... |
J Med Chem 52: 3523-38 (2009)
BindingDB Entry DOI: 10.7270/Q26T0Q0F |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50120543
(7-Methyl-2-[4-(3-piperidin-1-yl-propoxy)-phenyl]-i...)Show InChI InChI=1S/C22H27N3O/c1-18-10-14-25-17-21(23-22(25)16-18)19-6-8-20(9-7-19)26-15-5-13-24-11-3-2-4-12-24/h6-10,14,16-17H,2-5,11-13,15H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development L. L. C.
Curated by ChEMBL
| Assay Description Binding affinity towards human Histamine H3 receptor using [3H]-N-methyl-histamine as radioligand |
Bioorg Med Chem Lett 13: 1767-70 (2003)
BindingDB Entry DOI: 10.7270/Q21835V3 |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM396633
(3-[5-Chloro-2-(naphthalen-2-yloxy)-phenoxy]-azetid...)Show InChI InChI=1S/C19H16ClNO2/c20-15-6-8-18(19(10-15)23-17-11-21-12-17)22-16-7-5-13-3-1-2-4-14(13)9-16/h1-10,17,21H,11-12H2 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis
| Assay Description Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access... |
J Med Chem 52: 3523-38 (2009)
BindingDB Entry DOI: 10.7270/Q26T0Q0F |
More data for this Ligand-Target Pair | |
Coagulation factor XI
(Homo sapiens (Human)) | BDBM50598730
(CHEMBL5204289)Show SMILES Cc1nc(N)ccc1-c1cnn(c1)C(CC1CC1)c1ccc(c[n+]1[O-])-c1c(F)c(Cl)ccc1-n1cnnn1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00442 BindingDB Entry DOI: 10.7270/Q2C82FBD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM396410
(3-[5-Chloro-2-(2-chloro-benzyloxy)-phenoxy]-azetid...)Show InChI InChI=1S/C16H15Cl2NO2/c17-12-5-6-15(16(7-12)21-13-8-19-9-13)20-10-11-3-1-2-4-14(11)18/h1-7,13,19H,8-10H2 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis
| Assay Description Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access... |
J Med Chem 52: 3523-38 (2009)
BindingDB Entry DOI: 10.7270/Q26T0Q0F |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM396468
((R)-3-[4-Chloro-2-(3-chloro-benzyloxy)-phenoxy]-1-...)Show SMILES CN1CC[C@H](C1)Oc1ccc(Cl)cc1OCc1cccc(Cl)c1 |r| Show InChI InChI=1S/C18H19Cl2NO2/c1-21-8-7-16(11-21)23-17-6-5-15(20)10-18(17)22-12-13-3-2-4-14(19)9-13/h2-6,9-10,16H,7-8,11-12H2,1H3/t16-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis
| Assay Description Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access... |
J Med Chem 52: 3523-38 (2009)
BindingDB Entry DOI: 10.7270/Q26T0Q0F |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM396607
(3-[5-Bromo-2-(5-trifluoromethyl-furan-2-ylmethoxy)...)Show InChI InChI=1S/C16H15BrF3NO2/c17-12-1-3-14(11(6-12)5-10-7-21-8-10)22-9-13-2-4-15(23-13)16(18,19)20/h1-4,6,10,21H,5,7-9H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis
| Assay Description Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access... |
J Med Chem 52: 3523-38 (2009)
BindingDB Entry DOI: 10.7270/Q26T0Q0F |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM396454
(2-[2-(Azetidin-3-yloxy)-4-chloro-phenoxymethyl]-6-...)Show InChI InChI=1S/C16H14ClF3N2O2/c17-10-4-5-13(14(6-10)24-12-7-21-8-12)23-9-11-2-1-3-15(22-11)16(18,19)20/h1-6,12,21H,7-9H2 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis
| Assay Description Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access... |
J Med Chem 52: 3523-38 (2009)
BindingDB Entry DOI: 10.7270/Q26T0Q0F |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM396604
(3-[5-Bromo-2-(3-fluoro-benzyloxy)-phenoxy]-1-tert-...)Show InChI InChI=1S/C20H23BrFNO2/c1-20(2,3)23-11-17(12-23)25-19-10-15(21)7-8-18(19)24-13-14-5-4-6-16(22)9-14/h4-10,17H,11-13H2,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis
| Assay Description Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access... |
J Med Chem 52: 3523-38 (2009)
BindingDB Entry DOI: 10.7270/Q26T0Q0F |
More data for this Ligand-Target Pair | |
Coagulation factor XI
(Homo sapiens (Human)) | BDBM50598731
(CHEMBL5198972)Show SMILES Nc1ccc(-c2cnn(c2)C(CC2CC2)c2ccc(c[n+]2[O-])-c2c(F)c(Cl)ccc2-n2cnnn2)c(F)n1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| 3.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00442 BindingDB Entry DOI: 10.7270/Q2C82FBD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM396569
(3-[5-Chloro-2-[2-(4-methoxy-phenyl)-ethoxy]-phenox...)Show InChI InChI=1S/C18H20ClNO3/c1-21-15-5-2-13(3-6-15)8-9-22-17-7-4-14(19)10-18(17)23-16-11-20-12-16/h2-7,10,16,20H,8-9,11-12H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis
| Assay Description Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access... |
J Med Chem 52: 3523-38 (2009)
BindingDB Entry DOI: 10.7270/Q26T0Q0F |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM396569
(3-[5-Chloro-2-[2-(4-methoxy-phenyl)-ethoxy]-phenox...)Show InChI InChI=1S/C18H20ClNO3/c1-21-15-5-2-13(3-6-15)8-9-22-17-7-4-14(19)10-18(17)23-16-11-20-12-16/h2-7,10,16,20H,8-9,11-12H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis
| Assay Description Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access... |
J Med Chem 52: 3523-38 (2009)
BindingDB Entry DOI: 10.7270/Q26T0Q0F |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2B
(Homo sapiens (Human)) | BDBM396570
(3-(5-Bromo-2-phenethyloxy-phenoxy)-azetidine | US9...)Show InChI InChI=1S/C17H18BrNO2/c18-14-6-7-16(17(10-14)21-15-11-19-12-15)20-9-8-13-4-2-1-3-5-13/h1-7,10,15,19H,8-9,11-12H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis
| Assay Description Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access... |
J Med Chem 52: 3523-38 (2009)
BindingDB Entry DOI: 10.7270/Q26T0Q0F |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM396550
(3-[5-Chloro-2-(5-fluoro-indan-2-yloxy)-phenoxy]-az...)Show InChI InChI=1S/C18H17ClFNO2/c19-13-2-4-17(18(8-13)23-16-9-21-10-16)22-15-6-11-1-3-14(20)5-12(11)7-15/h1-5,8,15-16,21H,6-7,9-10H2 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis
| Assay Description Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access... |
J Med Chem 52: 3523-38 (2009)
BindingDB Entry DOI: 10.7270/Q26T0Q0F |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM396388
(3-[5-Bromo-2-(3-chloro-4-methoxy-benzyloxy)-phenox...)Show InChI InChI=1S/C17H17BrClNO3/c1-21-15-4-2-11(6-14(15)19)10-22-16-5-3-12(18)7-17(16)23-13-8-20-9-13/h2-7,13,20H,8-10H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis
| Assay Description Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access... |
J Med Chem 52: 3523-38 (2009)
BindingDB Entry DOI: 10.7270/Q26T0Q0F |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM396394
(3-[5-Bromo-2-(3-fluoro-benzyloxy)-phenoxy]-1-propy...)Show InChI InChI=1S/C19H21BrFNO2/c1-2-8-22-11-17(12-22)24-19-10-15(20)6-7-18(19)23-13-14-4-3-5-16(21)9-14/h3-7,9-10,17H,2,8,11-13H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis
| Assay Description Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access... |
J Med Chem 52: 3523-38 (2009)
BindingDB Entry DOI: 10.7270/Q26T0Q0F |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM396414
(3-[5-Chloro-2-(3-trifluoromethyl-benzyloxy)-phenox...)Show InChI InChI=1S/C17H15ClF3NO2/c18-13-4-5-15(16(7-13)24-14-8-22-9-14)23-10-11-2-1-3-12(6-11)17(19,20)21/h1-7,14,22H,8-10H2 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis
| Assay Description Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access... |
J Med Chem 52: 3523-38 (2009)
BindingDB Entry DOI: 10.7270/Q26T0Q0F |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM396383
(3-[5-Bromo-2-(3-trifluoromethyl-benzyloxy)-phenoxy...)Show InChI InChI=1S/C17H15BrF3NO2/c18-13-4-5-15(16(7-13)24-14-8-22-9-14)23-10-11-2-1-3-12(6-11)17(19,20)21/h1-7,14,22H,8-10H2 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis
| Assay Description Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access... |
J Med Chem 52: 3523-38 (2009)
BindingDB Entry DOI: 10.7270/Q26T0Q0F |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM396392
(3-[5-Bromo-2-(3-fluoro-benzyloxy)-phenoxy]-azetidi...)Show InChI InChI=1S/C16H15BrFNO2/c17-12-4-5-15(16(7-12)21-14-8-19-9-14)20-10-11-2-1-3-13(18)6-11/h1-7,14,19H,8-10H2 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis
| Assay Description Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access... |
J Med Chem 52: 3523-38 (2009)
BindingDB Entry DOI: 10.7270/Q26T0Q0F |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50011239
(CHEMBL3260336 | US9981909, Example 184)Show InChI InChI=1S/C17H16ClF2NO2/c18-13-6-7-15(16(8-13)23-14-9-21-10-14)22-11-17(19,20)12-4-2-1-3-5-12/h1-8,14,21H,9-11H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis
| Assay Description Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access... |
J Med Chem 52: 3523-38 (2009)
BindingDB Entry DOI: 10.7270/Q26T0Q0F |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM396561
(3-[5-Chloro-2-(3-chloro-benzyloxy)-phenoxy]-azetid...)Show InChI InChI=1S/C17H18ClNO2/c18-14-6-7-16(17(10-14)21-15-11-19-12-15)20-9-8-13-4-2-1-3-5-13/h1-7,10,15,19H,8-9,11-12H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis
| Assay Description Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access... |
J Med Chem 52: 3523-38 (2009)
BindingDB Entry DOI: 10.7270/Q26T0Q0F |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM396568
(3-[5-Chloro-2-[2-(4-fluoro-phenyl)-ethoxy]-phenoxy...)Show InChI InChI=1S/C17H17ClFNO2/c18-13-3-6-16(17(9-13)22-15-10-20-11-15)21-8-7-12-1-4-14(19)5-2-12/h1-6,9,15,20H,7-8,10-11H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis
| Assay Description Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access... |
J Med Chem 52: 3523-38 (2009)
BindingDB Entry DOI: 10.7270/Q26T0Q0F |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM396474
((+-)-Methanesulfonic acid 3-[4-bromo-2-(1-methyl-p...)Show SMILES CN1CCC(C1)Oc1cc(Br)ccc1OCc1cccc(OS(C)(=O)=O)c1 Show InChI InChI=1S/C19H22BrNO5S/c1-21-9-8-17(12-21)25-19-11-15(20)6-7-18(19)24-13-14-4-3-5-16(10-14)26-27(2,22)23/h3-7,10-11,17H,8-9,12-13H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis
| Assay Description Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access... |
J Med Chem 52: 3523-38 (2009)
BindingDB Entry DOI: 10.7270/Q26T0Q0F |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM396476
((S)-3-[5-Chloro-2-[1-(3-trifluoromethyl-phenyl)-et...)Show SMILES C[C@@H](Oc1ccc(Cl)cc1OC1CNC1)c1cccc(c1)C(F)(F)F |r| Show InChI InChI=1S/C18H17ClF3NO2/c1-11(12-3-2-4-13(7-12)18(20,21)22)24-16-6-5-14(19)8-17(16)25-15-9-23-10-15/h2-8,11,15,23H,9-10H2,1H3/t11-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis
| Assay Description Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access... |
J Med Chem 52: 3523-38 (2009)
BindingDB Entry DOI: 10.7270/Q26T0Q0F |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50127844
(3-Ethyl-2-[4-(3-piperidin-1-yl-propoxy)-phenyl]-in...)Show InChI InChI=1S/C24H30N2O/c1-2-24-23(19-21-9-4-7-17-26(21)24)20-10-12-22(13-11-20)27-18-8-16-25-14-5-3-6-15-25/h4,7,9-13,17,19H,2-3,5-6,8,14-16,18H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development L. L. C.
Curated by ChEMBL
| Assay Description Binding affinity towards human Histamine H3 receptor using [3H]-N-methyl-histamine as radioligand |
Bioorg Med Chem Lett 13: 1767-70 (2003)
BindingDB Entry DOI: 10.7270/Q21835V3 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM396535
(3-[5-Chloro-2-(6-trifluoromethyl-indan-1-yloxy)-ph...)Show SMILES FC(F)(F)c1ccc2CCC(Oc3ccc(Cl)cc3OC3CNC3)c2c1 Show InChI InChI=1S/C19H17ClF3NO2/c20-13-4-6-17(18(8-13)25-14-9-24-10-14)26-16-5-2-11-1-3-12(7-15(11)16)19(21,22)23/h1,3-4,6-8,14,16,24H,2,5,9-10H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis
| Assay Description Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access... |
J Med Chem 52: 3523-38 (2009)
BindingDB Entry DOI: 10.7270/Q26T0Q0F |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM396390
(3-[5-Bromo-2-(2-chloro-benzyloxy)-phenoxy]-azetidi...)Show InChI InChI=1S/C16H15BrClNO2/c17-12-5-6-15(16(7-12)21-13-8-19-9-13)20-10-11-3-1-2-4-14(11)18/h1-7,13,19H,8-10H2 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis
| Assay Description Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access... |
J Med Chem 52: 3523-38 (2009)
BindingDB Entry DOI: 10.7270/Q26T0Q0F |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM396393
(3-[5-Bromo-2-(3-fluoro-benzyloxy)-phenoxy]-1-ethyl...)Show InChI InChI=1S/C18H19BrFNO2/c1-2-21-10-16(11-21)23-18-9-14(19)6-7-17(18)22-12-13-4-3-5-15(20)8-13/h3-9,16H,2,10-12H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis
| Assay Description Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI access... |
J Med Chem 52: 3523-38 (2009)
BindingDB Entry DOI: 10.7270/Q26T0Q0F |
More data for this Ligand-Target Pair | |