Compile Data Set for Download or QSAR

Found 172 hits with Last Name = 'yamamoto' and Initial = 'f'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430058 (US10538528, Compound 2) Show SMILES CC1(C)C(=O)Nc2ncnc(N3CCC(CC3)c3nc(ccc3NCCN3CCCC3)-c3ccc(F)nc3)c12 Show InChI InChI=1S/C29H35FN8O/c1-29(2)24-26(36-28(29)39)33-18-34-27(24)38-14-9-19(10-15-38)25-22(31-11-16-37-12-3-4-13-37)7-6-21(35-25)20-5-8-23(30)32-17-20/h5-8,17-19,31H,3-4,9-16H2,1-2H3,(H,33,34,36,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430053 (US10538528, Compound 40) Show SMILES CC(C)(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1nnc(s1)C1CC1 Show InChI InChI=1S/C29H39N9OS/c1-28(2,3)33-13-12-30-19-8-9-20(26-37-36-25(40-26)18-6-7-18)34-22(19)17-10-14-38(15-11-17)24-21-23(31-16-32-24)35-27(39)29(21,4)5/h8-9,16-18,30,33H,6-7,10-15H2,1-5H3,(H,31,32,35,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430052 (US10538528, Compound 39) Show SMILES CC(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1nnc(s1)C(F)F Show InChI InChI=1S/C26H33F2N9OS/c1-14(2)29-9-10-30-16-5-6-17(23-35-36-24(39-23)20(27)28)33-19(16)15-7-11-37(12-8-15)22-18-21(31-13-32-22)34-25(38)26(18,3)4/h5-6,13-15,20,29-30H,7-12H2,1-4H3,(H,31,32,34,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430054 (US10538528, Compound 41) Show SMILES CC(C)(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1noc(n1)C(F)F Show InChI InChI=1S/C27H35F2N9O2/c1-26(2,3)33-11-10-30-16-6-7-17(21-35-24(20(28)29)40-37-21)34-19(16)15-8-12-38(13-9-15)23-18-22(31-14-32-23)36-25(39)27(18,4)5/h6-7,14-15,20,30,33H,8-13H2,1-5H3,(H,31,32,36,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430066 (US10538528, Compound 38) Show SMILES CN(C)CCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1nnc(s1)C(F)F Show InChI InChI=1S/C25H31F2N9OS/c1-25(2)17-20(32-24(25)37)29-13-30-21(17)36-10-7-14(8-11-36)18-15(28-9-12-35(3)4)5-6-16(31-18)22-33-34-23(38-22)19(26)27/h5-6,13-14,19,28H,7-12H2,1-4H3,(H,29,30,32,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430051 (US10538528, Compound 37) Show SMILES CC(C)(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1nnc(s1)C(F)F Show InChI InChI=1S/C27H35F2N9OS/c1-26(2,3)33-11-10-30-16-6-7-17(23-36-37-24(40-23)20(28)29)34-19(16)15-8-12-38(13-9-15)22-18-21(31-14-32-22)35-25(39)27(18,4)5/h6-7,14-15,20,30,33H,8-13H2,1-5H3,(H,31,32,35,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430029 (US10538528, Compound 5) Show SMILES CC(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1cnc(F)c(F)c1 Show InChI InChI=1S/C28H34F2N8O/c1-16(2)31-9-10-32-21-6-5-20(18-13-19(29)24(30)33-14-18)36-23(21)17-7-11-38(12-8-17)26-22-25(34-15-35-26)37-27(39)28(22,3)4/h5-6,13-17,31-32H,7-12H2,1-4H3,(H,34,35,37,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430064 (US10538528, Compound 12) Show SMILES CCNCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1cncc(F)c1 Show InChI InChI=1S/C27H33FN8O/c1-4-29-9-10-31-21-6-5-20(18-13-19(28)15-30-14-18)34-23(21)17-7-11-36(12-8-17)25-22-24(32-16-33-25)35-26(37)27(22,2)3/h5-6,13-17,29,31H,4,7-12H2,1-3H3,(H,32,33,35,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430030 (US10538528, Compound 11) Show SMILES CC(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1cc(Cl)nn1C Show InChI InChI=1S/C27H36ClN9O/c1-16(2)29-10-11-30-19-7-6-18(20-14-21(28)35-36(20)5)33-23(19)17-8-12-37(13-9-17)25-22-24(31-15-32-25)34-26(38)27(22,3)4/h6-7,14-17,29-30H,8-13H2,1-5H3,(H,31,32,34,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430063 (US10538528, Compound 10) Show SMILES CC(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1cc(nn1C)C(F)(F)F Show InChI InChI=1S/C28H36F3N9O/c1-16(2)32-10-11-33-19-7-6-18(20-14-21(28(29,30)31)38-39(20)5)36-23(19)17-8-12-40(13-9-17)25-22-24(34-15-35-25)37-26(41)27(22,3)4/h6-7,14-17,32-33H,8-13H2,1-5H3,(H,34,35,37,41)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430062 (US10538528, Compound 9) Show SMILES CN(C)CCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1cc(Cl)nn1C Show InChI InChI=1S/C26H34ClN9O/c1-26(2)21-23(32-25(26)37)29-15-30-24(21)36-11-8-16(9-12-36)22-18(28-10-13-34(3)4)7-6-17(31-22)19-14-20(27)33-35(19)5/h6-7,14-16,28H,8-13H2,1-5H3,(H,29,30,32,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430061 (US10538528, Compound 8) Show SMILES CC1(C)C(=O)Nc2ncnc(N3CCC(CC3)c3nc(ccc3NCCN3CCCC3)-c3cncc(F)c3)c12 Show InChI InChI=1S/C29H35FN8O/c1-29(2)24-26(36-28(29)39)33-18-34-27(24)38-12-7-19(8-13-38)25-23(32-9-14-37-10-3-4-11-37)6-5-22(35-25)20-15-21(30)17-31-16-20/h5-6,15-19,32H,3-4,7-14H2,1-2H3,(H,33,34,36,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430060 (US10538528, Compound 7) Show SMILES COc1cncc(c1)-c1ccc(NCCN2CCCC2)c(n1)C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12 Show InChI InChI=1S/C30H38N8O2/c1-30(2)25-27(36-29(30)39)33-19-34-28(25)38-13-8-20(9-14-38)26-24(32-10-15-37-11-4-5-12-37)7-6-23(35-26)21-16-22(40-3)18-31-17-21/h6-7,16-20,32H,4-5,8-15H2,1-3H3,(H,33,34,36,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430070 (US10538528, Compound 28) Show SMILES CC(C)NCCNc1cc(F)c(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1cncc(F)c1 Show InChI InChI=1S/C28H34F2N8O/c1-16(2)32-7-8-33-21-12-20(30)23(18-11-19(29)14-31-13-18)36-24(21)17-5-9-38(10-6-17)26-22-25(34-15-35-26)37-27(39)28(22,3)4/h11-17,32-33H,5-10H2,1-4H3,(H,34,35,37,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-1 (Homo sapiens (Human))	BDBM430037 (US10538528, Compound 19) Show SMILES CC1C(=O)Nc2ncnc(N3CCC(CC3)c3nc(ccc3NCCN3CCCC3)-c3cncc(F)c3)c12 Show InChI InChI=1S/C28H33FN8O/c1-18-24-26(35-28(18)38)32-17-33-27(24)37-11-6-19(7-12-37)25-23(31-8-13-36-9-2-3-10-36)5-4-22(34-25)20-14-21(29)16-30-15-20/h4-5,14-19,31H,2-3,6-13H2,1H3,(H,32,33,35,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Akt1 was prepared and assays of inhibitory activity of the compound according to the present invention against Akt1 kinase activity in vitro were con...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430056 (US10538528, Compound 43) Show SMILES CC(C)(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1nc(no1)C(F)(F)F Show InChI InChI=1S/C27H34F3N9O2/c1-25(2,3)34-11-10-31-16-6-7-17(22-37-23(38-41-22)27(28,29)30)35-19(16)15-8-12-39(13-9-15)21-18-20(32-14-33-21)36-24(40)26(18,4)5/h6-7,14-15,31,34H,8-13H2,1-5H3,(H,32,33,36,40)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430057 (US10538528, Compound 44) Show SMILES CC1(C)C(=O)Nc2ncnc(N3CCC(CC3)c3nc(ccc3NCCN3CCCC3)-c3nc(no3)C(F)(F)F)c12 Show InChI InChI=1S/C27H32F3N9O2/c1-26(2)19-21(35-25(26)40)32-15-33-22(19)39-12-7-16(8-13-39)20-17(31-9-14-38-10-3-4-11-38)5-6-18(34-20)23-36-24(37-41-23)27(28,29)30/h5-6,15-16,31H,3-4,7-14H2,1-2H3,(H,32,33,35,40)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430072 (US10538528, Compound 36) Show SMILES Cc1nnc(s1)-c1ccc(NCCN2CCCC2)c(n1)C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12 Show InChI InChI=1S/C27H35N9OS/c1-17-33-34-25(38-17)20-7-6-19(28-10-15-35-11-4-5-12-35)22(31-20)18-8-13-36(14-9-18)24-21-23(29-16-30-24)32-26(37)27(21,2)3/h6-7,16,18,28H,4-5,8-15H2,1-3H3,(H,29,30,32,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430065 (US10538528, Compound 35) Show SMILES CC1(C)C(=O)Nc2ncnc(N3CCC(CC3)c3nc(ccc3NCC3CCCN3)-c3nnc(o3)C(F)(F)F)c12 Show InChI InChI=1S/C26H30F3N9O2/c1-25(2)18-20(35-23(25)39)32-13-33-21(18)38-10-7-14(8-11-38)19-16(31-12-15-4-3-9-30-15)5-6-17(34-19)22-36-37-24(40-22)26(27,28)29/h5-6,13-15,30-31H,3-4,7-12H2,1-2H3,(H,32,33,35,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430050 (US10538528, Compound 34) Show SMILES CN(CCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1nnc(o1)C(F)(F)F)C(C)(C)C Show InChI InChI=1S/C28H36F3N9O2/c1-26(2,3)39(6)14-11-32-17-7-8-18(23-37-38-25(42-23)28(29,30)31)35-20(17)16-9-12-40(13-10-16)22-19-21(33-15-34-22)36-24(41)27(19,4)5/h7-8,15-16,32H,9-14H2,1-6H3,(H,33,34,36,41)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430047 (US10538528, Compound 32) Show SMILES CC(C)(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1nnc(o1)C(F)(F)F Show InChI InChI=1S/C27H34F3N9O2/c1-25(2,3)34-11-10-31-16-6-7-17(22-37-38-24(41-22)27(28,29)30)35-19(16)15-8-12-39(13-9-15)21-18-20(32-14-33-21)36-23(40)26(18,4)5/h6-7,14-15,31,34H,8-13H2,1-5H3,(H,32,33,36,40)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430041 (US10538528, Compound 23) Show SMILES CC1C(=O)Nc2ncnc(N3CCC(CC3)c3nc(ccc3NCCN(C)C)-c3ccsc3)c12 Show InChI InChI=1S/C25H31N7OS/c1-16-21-23(30-25(16)33)27-15-28-24(21)32-10-6-17(7-11-32)22-20(26-9-12-31(2)3)5-4-19(29-22)18-8-13-34-14-18/h4-5,8,13-17,26H,6-7,9-12H2,1-3H3,(H,27,28,30,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430031 (US10538528, Compound 13) Show SMILES CC1C(=O)Nc2ncnc(N3CCC(CC3)c3nc(ccc3NCCN3CCCC3)-c3ccnc(F)c3)c12 Show InChI InChI=1S/C28H33FN8O/c1-18-24-26(35-28(18)38)32-17-33-27(24)37-13-7-19(8-14-37)25-22(30-10-15-36-11-2-3-12-36)5-4-21(34-25)20-6-9-31-23(29)16-20/h4-6,9,16-19,30H,2-3,7-8,10-15H2,1H3,(H,32,33,35,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430059 (US10538528, Compound 6) Show SMILES CC(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1sc(C)nc1C Show InChI InChI=1S/C28H38N8OS/c1-16(2)29-11-12-30-20-7-8-21(24-17(3)33-18(4)38-24)34-23(20)19-9-13-36(14-10-19)26-22-25(31-15-32-26)35-27(37)28(22,5)6/h7-8,15-16,19,29-30H,9-14H2,1-6H3,(H,31,32,35,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430068 (US10538528, Compound 4) Show SMILES CC(C)(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1cnn(c1)C(F)F Show InChI InChI=1S/C28H37F2N9O/c1-27(2,3)34-11-10-31-20-7-6-19(18-14-35-39(15-18)26(29)30)36-22(20)17-8-12-38(13-9-17)24-21-23(32-16-33-24)37-25(40)28(21,4)5/h6-7,14-17,26,31,34H,8-13H2,1-5H3,(H,32,33,37,40)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430067 (US10538528, Compound 3) Show SMILES Cc1cc(-c2ccc(NCCN3CCCC3)c(n2)C2CCN(CC2)c2ncnc3NC(=O)C(C)(C)c23)n(C)n1 Show InChI InChI=1S/C29H39N9O/c1-19-17-23(36(4)35-19)21-7-8-22(30-11-16-37-12-5-6-13-37)25(33-21)20-9-14-38(15-10-20)27-24-26(31-18-32-27)34-28(39)29(24,2)3/h7-8,17-18,20,30H,5-6,9-16H2,1-4H3,(H,31,32,34,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430028 (US10538528, Compound 1) Show SMILES CC(C)(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1cncc(F)c1 Show InChI InChI=1S/C29H37FN8O/c1-28(2,3)35-11-10-32-22-7-6-21(19-14-20(30)16-31-15-19)36-24(22)18-8-12-38(13-9-18)26-23-25(33-17-34-26)37-27(39)29(23,4)5/h6-7,14-18,32,35H,8-13H2,1-5H3,(H,33,34,37,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430056 (US10538528, Compound 43) Show SMILES CC(C)(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1nc(no1)C(F)(F)F Show InChI InChI=1S/C27H34F3N9O2/c1-25(2,3)34-11-10-31-16-6-7-17(22-37-23(38-41-22)27(28,29)30)35-19(16)15-8-12-39(13-9-15)21-18-20(32-14-33-21)36-24(40)26(18,4)5/h6-7,14-15,31,34H,8-13H2,1-5H3,(H,32,33,36,40)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-1 (Homo sapiens (Human))	BDBM430036 (US10538528, Compound 18) Show SMILES CC1C(=O)Nc2ncnc(N3CCC(CC3)c3nc(ccc3NCCN3CCCC3)-c3ccsc3)c12 Show InChI InChI=1S/C27H33N7OS/c1-18-23-25(32-27(18)35)29-17-30-26(23)34-12-6-19(7-13-34)24-22(28-9-14-33-10-2-3-11-33)5-4-21(31-24)20-8-15-36-16-20/h4-5,8,15-19,28H,2-3,6-7,9-14H2,1H3,(H,29,30,32,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Akt1 was prepared and assays of inhibitory activity of the compound according to the present invention against Akt1 kinase activity in vitro were con...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-1 (Homo sapiens (Human))	BDBM430032 (US10538528, Compound 14) Show SMILES CC1C(=O)Nc2ncnc(N3CCC(CC3)c3nc(ccc3NCCN3CCCC3)-c3ccoc3)c12 Show InChI InChI=1S/C27H33N7O2/c1-18-23-25(32-27(18)35)29-17-30-26(23)34-12-6-19(7-13-34)24-22(28-9-14-33-10-2-3-11-33)5-4-21(31-24)20-8-15-36-16-20/h4-5,8,15-19,28H,2-3,6-7,9-14H2,1H3,(H,29,30,32,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Akt1 was prepared and assays of inhibitory activity of the compound according to the present invention against Akt1 kinase activity in vitro were con...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430051 (US10538528, Compound 37) Show SMILES CC(C)(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1nnc(s1)C(F)F Show InChI InChI=1S/C27H35F2N9OS/c1-26(2,3)33-11-10-30-16-6-7-17(23-36-37-24(40-23)20(28)29)34-19(16)15-8-12-38(13-9-15)22-18-21(31-14-32-22)35-25(39)27(18,4)5/h6-7,14-15,20,30,33H,8-13H2,1-5H3,(H,31,32,35,39)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430057 (US10538528, Compound 44) Show SMILES CC1(C)C(=O)Nc2ncnc(N3CCC(CC3)c3nc(ccc3NCCN3CCCC3)-c3nc(no3)C(F)(F)F)c12 Show InChI InChI=1S/C27H32F3N9O2/c1-26(2)19-21(35-25(26)40)32-15-33-22(19)39-12-7-16(8-13-39)20-17(31-9-14-38-10-3-4-11-38)5-6-18(34-20)23-36-24(37-41-23)27(28,29)30/h5-6,15-16,31H,3-4,7-14H2,1-2H3,(H,32,33,35,40)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430045 (US10538528, Compound 30) Show SMILES CC1(C)C(=O)Nc2ncnc(N3CCC(CC3)c3nc(ccc3NCCN3CCCC3)-c3nnc(o3)C(F)F)c12 Show InChI InChI=1S/C27H33F2N9O2/c1-27(2)19-22(34-26(27)39)31-15-32-23(19)38-12-7-16(8-13-38)20-17(30-9-14-37-10-3-4-11-37)5-6-18(33-20)24-35-36-25(40-24)21(28)29/h5-6,15-16,21,30H,3-4,7-14H2,1-2H3,(H,31,32,34,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430037 (US10538528, Compound 19) Show SMILES CC1C(=O)Nc2ncnc(N3CCC(CC3)c3nc(ccc3NCCN3CCCC3)-c3cncc(F)c3)c12 Show InChI InChI=1S/C28H33FN8O/c1-18-24-26(35-28(18)38)32-17-33-27(24)37-11-6-19(7-12-37)25-23(31-8-13-36-9-2-3-10-36)5-4-22(34-25)20-14-21(29)16-30-15-20/h4-5,14-19,31H,2-3,6-13H2,1H3,(H,32,33,35,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430049 (US10538528, Compound 33) Show SMILES CC(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1nnc(o1)C(F)(F)F Show InChI InChI=1S/C26H32F3N9O2/c1-14(2)30-9-10-31-16-5-6-17(22-36-37-24(40-22)26(27,28)29)34-19(16)15-7-11-38(12-8-15)21-18-20(32-13-33-21)35-23(39)25(18,3)4/h5-6,13-15,30-31H,7-12H2,1-4H3,(H,32,33,35,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430055 (US10538528, Compound 42) Show SMILES CC(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1noc(n1)C(F)(F)F Show InChI InChI=1S/C26H32F3N9O2/c1-14(2)30-9-10-31-16-5-6-17(20-36-24(40-37-20)26(27,28)29)34-19(16)15-7-11-38(12-8-15)22-18-21(32-13-33-22)35-23(39)25(18,3)4/h5-6,13-15,30-31H,7-12H2,1-4H3,(H,32,33,35,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430069 (US10538528, Compound 26) Show SMILES CC1C(=O)Nc2ncnc(N3CCC(=CC3)c3nc(ccc3NCCN3CCCC3)-c3cncc(F)c3)c12 |c:13| Show InChI InChI=1S/C28H31FN8O/c1-18-24-26(35-28(18)38)32-17-33-27(24)37-11-6-19(7-12-37)25-23(31-8-13-36-9-2-3-10-36)5-4-22(34-25)20-14-21(29)16-30-15-20/h4-6,14-18,31H,2-3,7-13H2,1H3,(H,32,33,35,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430042 (US10538528, Compound 24) Show SMILES CC1C(=O)Nc2ncnc(N3CCC(CC3)c3nc(ccc3NCCN3CCCC3)-c3nccs3)c12 Show InChI InChI=1S/C26H32N8OS/c1-17-21-23(32-25(17)35)29-16-30-24(21)34-12-6-18(7-13-34)22-19(27-8-14-33-10-2-3-11-33)4-5-20(31-22)26-28-9-15-36-26/h4-5,9,15-18,27H,2-3,6-8,10-14H2,1H3,(H,29,30,32,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-1 (Homo sapiens (Human))	BDBM430038 (US10538528, Compound 20) Show SMILES CC1C(=O)Nc2ncnc(N3CCC(CC3)c3nc(ccc3NCCN3CCCC3)-c3cc(nn3C)C(F)(F)F)c12 Show InChI InChI=1S/C28H34F3N9O/c1-17-23-25(36-27(17)41)33-16-34-26(23)40-12-7-18(8-13-40)24-20(32-9-14-39-10-3-4-11-39)6-5-19(35-24)21-15-22(28(29,30)31)37-38(21)2/h5-6,15-18,32H,3-4,7-14H2,1-2H3,(H,33,34,36,41)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Akt1 was prepared and assays of inhibitory activity of the compound according to the present invention against Akt1 kinase activity in vitro were con...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430038 (US10538528, Compound 20) Show SMILES CC1C(=O)Nc2ncnc(N3CCC(CC3)c3nc(ccc3NCCN3CCCC3)-c3cc(nn3C)C(F)(F)F)c12 Show InChI InChI=1S/C28H34F3N9O/c1-17-23-25(36-27(17)41)33-16-34-26(23)40-12-7-18(8-13-40)24-20(32-9-14-39-10-3-4-11-39)6-5-19(35-24)21-15-22(28(29,30)31)37-38(21)2/h5-6,15-18,32H,3-4,7-14H2,1-2H3,(H,33,34,36,41)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430053 (US10538528, Compound 40) Show SMILES CC(C)(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1nnc(s1)C1CC1 Show InChI InChI=1S/C29H39N9OS/c1-28(2,3)33-13-12-30-19-8-9-20(26-37-36-25(40-26)18-6-7-18)34-22(19)17-10-14-38(15-11-17)24-21-23(31-16-32-24)35-27(39)29(21,4)5/h8-9,16-18,30,33H,6-7,10-15H2,1-5H3,(H,31,32,35,39)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430052 (US10538528, Compound 39) Show SMILES CC(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1nnc(s1)C(F)F Show InChI InChI=1S/C26H33F2N9OS/c1-14(2)29-9-10-30-16-5-6-17(23-35-36-24(39-23)20(27)28)33-19(16)15-7-11-37(12-8-15)22-18-21(31-13-32-22)34-25(38)26(18,3)4/h5-6,13-15,20,29-30H,7-12H2,1-4H3,(H,31,32,34,38)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-1 (Homo sapiens (Human))	BDBM430035 (US10538528, Compound 17) Show SMILES CC1C(=O)Nc2ncnc(N3CCC(CC3)c3nc(ccc3NCCN3CCCC3)-c3cccnc3F)c12 Show InChI InChI=1S/C28H33FN8O/c1-18-23-26(35-28(18)38)32-17-33-27(23)37-14-8-19(9-15-37)24-22(30-11-16-36-12-2-3-13-36)7-6-21(34-24)20-5-4-10-31-25(20)29/h4-7,10,17-19,30H,2-3,8-9,11-16H2,1H3,(H,32,33,35,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Akt1 was prepared and assays of inhibitory activity of the compound according to the present invention against Akt1 kinase activity in vitro were con...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430046 (US10538528, Compound 31) Show SMILES CC(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1nnc(o1)C(F)F Show InChI InChI=1S/C26H33F2N9O2/c1-14(2)29-9-10-30-16-5-6-17(23-35-36-24(39-23)20(27)28)33-19(16)15-7-11-37(12-8-15)22-18-21(31-13-32-22)34-25(38)26(18,3)4/h5-6,13-15,20,29-30H,7-12H2,1-4H3,(H,31,32,34,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ryanodine receptor 1 [4317-4329] ()	BDBM430047 (US10538528, Compound 32) Show SMILES CC(C)(C)NCCNc1ccc(nc1C1CCN(CC1)c1ncnc2NC(=O)C(C)(C)c12)-c1nnc(o1)C(F)(F)F Show InChI InChI=1S/C27H34F3N9O2/c1-25(2,3)34-11-10-31-16-6-7-17(22-37-38-24(41-22)27(28,29)30)35-19(16)15-8-12-39(13-9-15)21-18-20(32-14-33-21)36-23(40)26(18,4)5/h6-7,14-15,31,34H,8-13H2,1-5H3,(H,32,33,36,40)	UniProtKB/SwissProt GoogleScholar AffyNet	MCE PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430039 (US10538528, Compound 21) Show SMILES COc1cncc(c1)-c1ccc(NCCN(C)C)c(n1)C1CCN(CC1)c1ncnc2NC(=O)C(C)c12 Show InChI InChI=1S/C27H34N8O2/c1-17-23-25(33-27(17)36)30-16-31-26(23)35-10-7-18(8-11-35)24-22(29-9-12-34(2)3)6-5-21(32-24)19-13-20(37-4)15-28-14-19/h5-6,13-18,29H,7-12H2,1-4H3,(H,30,31,33,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430035 (US10538528, Compound 17) Show SMILES CC1C(=O)Nc2ncnc(N3CCC(CC3)c3nc(ccc3NCCN3CCCC3)-c3cccnc3F)c12 Show InChI InChI=1S/C28H33FN8O/c1-18-23-26(35-28(18)38)32-17-33-27(23)37-14-8-19(9-15-37)24-22(30-11-16-36-12-2-3-13-36)7-6-21(34-24)20-5-4-10-31-25(20)29/h4-7,10,17-19,30H,2-3,8-9,11-16H2,1H3,(H,32,33,35,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430034 (US10538528, Compound 16) Show SMILES COc1cc(c(F)cn1)-c1ccc(NCCN2CCCC2)c(n1)C1CCN(CC1)c1ncnc2NC(=O)C(C)c12 Show InChI InChI=1S/C29H35FN8O2/c1-18-25-27(36-29(18)39)33-17-34-28(25)38-12-7-19(8-13-38)26-23(31-9-14-37-10-3-4-11-37)6-5-22(35-26)20-15-24(40-2)32-16-21(20)30/h5-6,15-19,31H,3-4,7-14H2,1-2H3,(H,33,34,36,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM430033 (US10538528, Compound 15) Show SMILES COc1cncc(c1)-c1ccc(NCCNC(C)C)c(n1)C1CCN(CC1)c1ncnc2NC(=O)C(C)c12 Show InChI InChI=1S/C28H36N8O2/c1-17(2)30-9-10-31-23-6-5-22(20-13-21(38-4)15-29-14-20)34-25(23)19-7-11-36(12-8-19)27-24-18(3)28(37)35-26(24)32-16-33-27/h5-6,13-19,30-31H,7-12H2,1-4H3,(H,32,33,35,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-1 (Homo sapiens (Human))	BDBM430041 (US10538528, Compound 23) Show SMILES CC1C(=O)Nc2ncnc(N3CCC(CC3)c3nc(ccc3NCCN(C)C)-c3ccsc3)c12 Show InChI InChI=1S/C25H31N7OS/c1-16-21-23(30-25(16)33)27-15-28-24(21)32-10-6-17(7-11-32)22-20(26-9-12-31(2)3)5-4-19(29-22)18-8-13-34-14-18/h4-5,8,13-17,26H,6-7,9-12H2,1-3H3,(H,27,28,30,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Akt1 was prepared and assays of inhibitory activity of the compound according to the present invention against Akt1 kinase activity in vitro were con...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair

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