Compile Data Set for Download or QSAR

Found 694 hits with Last Name = 'zhou' and Initial = 'hj'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM470561 (1-(4-[(2-chloro-6-fluorophenyl)carbamoyl]-2-fluoro...) Show SMILES CCCn1c(nn(-c2cc(O[C@@H](C)C(F)(F)F)c(cc2F)C(=O)Nc2c(F)cccc2Cl)c1=O)C(O)=O |r| Show InChI InChI=1S/C22H18ClF5N4O5/c1-3-7-31-18(20(34)35)30-32(21(31)36)15-9-16(37-10(2)22(26,27)28)11(8-14(15)25)19(33)29-17-12(23)5-4-6-13(17)24/h4-6,8-10H,3,7H2,1-2H3,(H,29,33)(H,34,35)/t10-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10815215 (2020) BindingDB Entry DOI: 10.7270/Q2RJ4NJH
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM470358 (4-(3-ethyl-4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-tri...) Show SMILES CCC[C@H](C)Oc1cc(c(F)cc1C(=O)Nc1c(C)cccc1F)-n1nc(CC)n(C)c1=O |r| Show InChI InChI=1S/C24H28F2N4O3/c1-6-9-15(4)33-20-13-19(30-24(32)29(5)21(7-2)28-30)18(26)12-16(20)23(31)27-22-14(3)10-8-11-17(22)25/h8,10-13,15H,6-7,9H2,1-5H3,(H,27,31)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10815215 (2020) BindingDB Entry DOI: 10.7270/Q2RJ4NJH
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490556 (5-fluoro-N-(2-methylphenyl)-4-(3-oxo-5,6,7,8-tetra...) Show SMILES C[C@H](Oc1cc(c(F)cc1C(=O)Nc1ccccc1C)-n1nc2CCCCn2c1=O)c1ccccc1 |r| Show InChI InChI=1S/C28H27FN4O3/c1-18-10-6-7-13-23(18)30-27(34)21-16-22(29)24(33-28(35)32-15-9-8-14-26(32)31-33)17-25(21)36-19(2)20-11-4-3-5-12-20/h3-7,10-13,16-17,19H,8-9,14-15H2,1-2H3,(H,30,34)/t19-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490338 (N-(2-chloro-6-fluorophenyl)-5-fluoro-4-(3-oxo-5,6,...) Show SMILES CCC[C@H](C)Oc1cc(c(F)cc1C(=O)Nc1c(F)cccc1Cl)-n1nc2CCCCn2c1=O |r| Show InChI InChI=1S/C24H25ClF2N4O3/c1-3-7-14(2)34-20-13-19(31-24(33)30-11-5-4-10-21(30)29-31)18(27)12-15(20)23(32)28-22-16(25)8-6-9-17(22)26/h6,8-9,12-14H,3-5,7,10-11H2,1-2H3,(H,28,32)/t14-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490402 (5-fluoro-N-(2-methylphenyl)-4-(3-oxo-5,6,7,8-tetra...) Show SMILES C[C@H](Oc1cc(c(F)cc1C(=O)Nc1ccccc1C)-n1nc2CCCCn2c1=O)C(F)(F)F |r| Show InChI InChI=1S/C23H22F4N4O3/c1-13-7-3-4-8-17(13)28-21(32)15-11-16(24)18(12-19(15)34-14(2)23(25,26)27)31-22(33)30-10-6-5-9-20(30)29-31/h3-4,7-8,11-12,14H,5-6,9-10H2,1-2H3,(H,28,32)/t14-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490548 (5-fluoro-4-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3...) Show SMILES CCC[C@H](C)Oc1cc(c(F)cc1C(=O)Nc1cccc(c1)C(F)(F)F)-n1nc2ccccn2c1=O |r| Show InChI InChI=1S/C25H22F4N4O3/c1-3-7-15(2)36-21-14-20(33-24(35)32-11-5-4-10-22(32)31-33)19(26)13-18(21)23(34)30-17-9-6-8-16(12-17)25(27,28)29/h4-6,8-15H,3,7H2,1-2H3,(H,30,34)/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM470555 (1-(4-[(2,6-dichlorophenyl)carbamoyl]-2-fluoro-5-{[...) Show SMILES CCn1c(nn(-c2cc(O[C@@H](C)C(F)(F)F)c(cc2F)C(=O)Nc2c(Cl)cccc2Cl)c1=O)C(O)=O |r| Show InChI InChI=1S/C21H16Cl2F4N4O5/c1-3-30-17(19(33)34)29-31(20(30)35)14-8-15(36-9(2)21(25,26)27)10(7-13(14)24)18(32)28-16-11(22)5-4-6-12(16)23/h4-9H,3H2,1-2H3,(H,28,32)(H,33,34)/t9-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10815215 (2020) BindingDB Entry DOI: 10.7270/Q2RJ4NJH
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490357 (5-fluoro-N-[2-(methylamino)phenyl]-4-(3-oxo-5,6,7,...) Show SMILES CCC[C@H](C)Oc1cc(c(F)cc1C(=O)Nc1ccccc1NC)-n1nc2CCCCn2c1=O |r| Show InChI InChI=1S/C25H30FN5O3/c1-4-9-16(2)34-22-15-21(31-25(33)30-13-8-7-12-23(30)29-31)18(26)14-17(22)24(32)28-20-11-6-5-10-19(20)27-3/h5-6,10-11,14-16,27H,4,7-9,12-13H2,1-3H3,(H,28,32)/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM470552 (1-(4-[(2-chloro-6-fluorophenyl)carbamoyl]-2-fluoro...) Show SMILES CCn1c(nn(-c2cc(O[C@@H](C)C(F)(F)F)c(cc2F)C(=O)Nc2c(F)cccc2Cl)c1=O)C(O)=O |r| Show InChI InChI=1S/C21H16ClF5N4O5/c1-3-30-17(19(33)34)29-31(20(30)35)14-8-15(36-9(2)21(25,26)27)10(7-13(14)24)18(32)28-16-11(22)5-4-6-12(16)23/h4-9H,3H2,1-2H3,(H,28,32)(H,33,34)/t9-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10815215 (2020) BindingDB Entry DOI: 10.7270/Q2RJ4NJH
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490359 (N-(4-amino-2-methylphenyl)-5-fluoro-4-(3-oxo-5,6,7...) Show SMILES CCC[C@H](C)Oc1cc(c(F)cc1C(=O)Nc1ccc(N)cc1C)-n1nc2CCCCn2c1=O |r| Show InChI InChI=1S/C25H30FN5O3/c1-4-7-16(3)34-22-14-21(31-25(33)30-11-6-5-8-23(30)29-31)19(26)13-18(22)24(32)28-20-10-9-17(27)12-15(20)2/h9-10,12-14,16H,4-8,11,27H2,1-3H3,(H,28,32)/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM470513 (4-(3-ethyl-4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-tri...) Show SMILES CCC(CC)NC(=O)c1cc(F)c(cc1OC(C)CC=C)-n1nc(CC)n(C)c1=O Show InChI InChI=1S/C22H31FN4O3/c1-7-11-14(5)30-19-13-18(27-22(29)26(6)20(10-4)25-27)17(23)12-16(19)21(28)24-15(8-2)9-3/h7,12-15H,1,8-11H2,2-6H3,(H,24,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10815215 (2020) BindingDB Entry DOI: 10.7270/Q2RJ4NJH
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490359 (N-(4-amino-2-methylphenyl)-5-fluoro-4-(3-oxo-5,6,7...) Show SMILES CCC[C@H](C)Oc1cc(c(F)cc1C(=O)Nc1ccc(N)cc1C)-n1nc2CCCCn2c1=O |r| Show InChI InChI=1S/C25H30FN5O3/c1-4-7-16(3)34-22-14-21(31-25(33)30-11-6-5-8-23(30)29-31)19(26)13-18(22)24(32)28-20-10-9-17(27)12-15(20)2/h9-10,12-14,16H,4-8,11,27H2,1-3H3,(H,28,32)/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM470565 (1-(4-[(2-chloro-6-fluorophenyl)carbamoyl]-2-fluoro...) Show SMILES C[C@H](Oc1cc(c(F)cc1C(=O)Nc1c(F)cccc1Cl)-n1nc(C(O)=O)n(CC=C)c1=O)C(F)(F)F |r| Show InChI InChI=1S/C22H16ClF5N4O5/c1-3-7-31-18(20(34)35)30-32(21(31)36)15-9-16(37-10(2)22(26,27)28)11(8-14(15)25)19(33)29-17-12(23)5-4-6-13(17)24/h3-6,8-10H,1,7H2,2H3,(H,29,33)(H,34,35)/t10-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10815215 (2020) BindingDB Entry DOI: 10.7270/Q2RJ4NJH
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490333 (N-(2,6-difluorophenyl)-5-fluoro-4-(3-oxo-5,6,7,8-t...) Show SMILES CCC[C@H](C)Oc1cc(c(F)cc1C(=O)Nc1c(F)cccc1F)-n1nc2CCCCn2c1=O |r| Show InChI InChI=1S/C24H25F3N4O3/c1-3-7-14(2)34-20-13-19(31-24(33)30-11-5-4-10-21(30)29-31)18(27)12-15(20)23(32)28-22-16(25)8-6-9-17(22)26/h6,8-9,12-14H,3-5,7,10-11H2,1-2H3,(H,28,32)/t14-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490360 (5-fluoro-N-(2-fluoro-6-methylphenyl)-4-(3-oxo-5,6,...) Show SMILES CCC[C@H](C)Oc1cc(c(F)cc1C(=O)Nc1c(C)cccc1F)-n1nc2CCCCn2c1=O |r| Show InChI InChI=1S/C25H28F2N4O3/c1-4-8-16(3)34-21-14-20(31-25(33)30-12-6-5-11-22(30)29-31)19(27)13-17(21)24(32)28-23-15(2)9-7-10-18(23)26/h7,9-10,13-14,16H,4-6,8,11-12H2,1-3H3,(H,28,32)/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490393 (N-(2-chloro-6-methylphenyl)-5-fluoro-4-(3-oxo-5,6,...) Show SMILES CCc1cccc(Cl)c1NC(=O)c1cc(F)c(cc1O[C@@H](C)C(F)(F)F)-n1nc2CCCCn2c1=O |r| Show InChI InChI=1S/C24H23ClF4N4O3/c1-3-14-7-6-8-16(25)21(14)30-22(34)15-11-17(26)18(12-19(15)36-13(2)24(27,28)29)33-23(35)32-10-5-4-9-20(32)31-33/h6-8,11-13H,3-5,9-10H2,1-2H3,(H,30,34)/t13-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490403 (5-fluoro-N-(2-fluoro-6-methylphenyl)-4-(3-oxo-5,6,...) Show SMILES C[C@H](Oc1cc(c(F)cc1C(=O)Nc1c(C)cccc1F)-n1nc2CCCCn2c1=O)C(F)(F)F |r| Show InChI InChI=1S/C23H21F5N4O3/c1-12-6-5-7-15(24)20(12)29-21(33)14-10-16(25)17(11-18(14)35-13(2)23(26,27)28)32-22(34)31-9-4-3-8-19(31)30-32/h5-7,10-11,13H,3-4,8-9H2,1-2H3,(H,29,33)/t13-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490477 (N-(5-amino-3-methylpyridin-2-yl)-2-[(1S)-1-cyclohe...) Show SMILES C[C@H](Oc1cc(c(F)cc1C(=O)Nc1ncc(N)cc1C)-n1nc2CCCCn2c1=O)C1CCCCC1 |r| Show InChI InChI=1S/C27H33FN6O3/c1-16-12-19(29)15-30-25(16)31-26(35)20-13-21(28)22(34-27(36)33-11-7-6-10-24(33)32-34)14-23(20)37-17(2)18-8-4-3-5-9-18/h12-15,17-18H,3-11,29H2,1-2H3,(H,30,31,35)/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490481 (2-[(1S)-1-cyclohexylethoxy]-5-fluoro-N-(2-fluoroph...) Show SMILES C[C@H](Oc1cc(c(F)cc1C(=O)Nc1c(C)cccc1F)-n1nc2CCCCn2c1=O)C1CCCCC1 |r| Show InChI InChI=1S/C28H32F2N4O3/c1-17-9-8-12-21(29)26(17)31-27(35)20-15-22(30)23(34-28(36)33-14-7-6-13-25(33)32-34)16-24(20)37-18(2)19-10-4-3-5-11-19/h8-9,12,15-16,18-19H,3-7,10-11,13-14H2,1-2H3,(H,31,35)/t18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490471 (N-(3-amino-2-methylphenyl)-2-[(1S)-1-cyclohexyleth...) Show SMILES C[C@H](Oc1cc(c(F)cc1C(=O)Nc1cccc(N)c1C)-n1nc2CCCCn2c1=O)C1CCCCC1 |r| Show InChI InChI=1S/C28H34FN5O3/c1-17-22(30)11-8-12-23(17)31-27(35)20-15-21(29)24(34-28(36)33-14-7-6-13-26(33)32-34)16-25(20)37-18(2)19-9-4-3-5-10-19/h8,11-12,15-16,18-19H,3-7,9-10,13-14,30H2,1-2H3,(H,31,35)/t18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM470524 (N-(2-chloro-6-fluorophenyl)-5-fluoro-4-[3-(hydroxy...) Show SMILES C[C@H](Oc1cc(c(F)cc1C(=O)Nc1c(F)cccc1Cl)-n1nc(CO)n(CC=C)c1=O)C(F)(F)F |r| Show InChI InChI=1S/C22H18ClF5N4O4/c1-3-7-31-18(10-33)30-32(21(31)35)16-9-17(36-11(2)22(26,27)28)12(8-15(16)25)20(34)29-19-13(23)5-4-6-14(19)24/h3-6,8-9,11,33H,1,7,10H2,2H3,(H,29,34)/t11-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10815215 (2020) BindingDB Entry DOI: 10.7270/Q2RJ4NJH
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490478 (2-({2-[(1S)-1-cyclohexylethoxy]-5-fluoro-4-(3-oxo-...) Show SMILES C[C@H](Oc1cc(c(F)cc1C(=O)Nc1c(C)cccc1C(O)=O)-n1nc2CCCCn2c1=O)C1CCCCC1 |r| Show InChI InChI=1S/C29H33FN4O5/c1-17-9-8-12-20(28(36)37)26(17)31-27(35)21-15-22(30)23(34-29(38)33-14-7-6-13-25(33)32-34)16-24(21)39-18(2)19-10-4-3-5-11-19/h8-9,12,15-16,18-19H,3-7,10-11,13-14H2,1-2H3,(H,31,35)(H,36,37)/t18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490450 (2-[(1S)-1-cyclohexylethoxy]-5-fluoro-N-(2-methoxy-...) Show SMILES COc1nccc(C)c1NC(=O)c1cc(F)c(cc1O[C@@H](C)C1CCCCC1)-n1nc2CCCCn2c1=O |r| Show InChI InChI=1S/C28H34FN5O4/c1-17-12-13-30-27(37-3)25(17)31-26(35)20-15-21(29)22(34-28(36)33-14-8-7-11-24(33)32-34)16-23(20)38-18(2)19-9-5-4-6-10-19/h12-13,15-16,18-19H,4-11,14H2,1-3H3,(H,31,35)/t18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490347 (5-fluoro-N-[2-methyl-6-(trifluoromethyl)phenyl]-4-...) Show SMILES CCC[C@H](C)Oc1cc(c(F)cc1C(=O)Nc1c(C)cccc1C(F)(F)F)-n1nc2CCCCn2c1=O |r| Show InChI InChI=1S/C26H28F4N4O3/c1-4-8-16(3)37-21-14-20(34-25(36)33-12-6-5-11-22(33)32-34)19(27)13-17(21)24(35)31-23-15(2)9-7-10-18(23)26(28,29)30/h7,9-10,13-14,16H,4-6,8,11-12H2,1-3H3,(H,31,35)/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM470377 (4-(3-ethyl-4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-tri...) Show SMILES CCC[C@H](C)Oc1cc(c(F)cc1C(=O)Nc1ccccc1CC)-n1nc(CC)n(C)c1=O |r| Show InChI InChI=1S/C25H31FN4O3/c1-6-11-16(4)33-22-15-21(30-25(32)29(5)23(8-3)28-30)19(26)14-18(22)24(31)27-20-13-10-9-12-17(20)7-2/h9-10,12-16H,6-8,11H2,1-5H3,(H,27,31)/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10815215 (2020) BindingDB Entry DOI: 10.7270/Q2RJ4NJH
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM470522 (N-(2-chloro-6-fluorophenyl)-5-fluoro-4-[3-(hydroxy...) Show SMILES CCCn1c(CO)nn(-c2cc(O[C@@H](C)C(F)(F)F)c(cc2F)C(=O)Nc2c(F)cccc2Cl)c1=O |r| Show InChI InChI=1S/C22H20ClF5N4O4/c1-3-7-31-18(10-33)30-32(21(31)35)16-9-17(36-11(2)22(26,27)28)12(8-15(16)25)20(34)29-19-13(23)5-4-6-14(19)24/h4-6,8-9,11,33H,3,7,10H2,1-2H3,(H,29,34)/t11-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10815215 (2020) BindingDB Entry DOI: 10.7270/Q2RJ4NJH
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490467 (2-[(1S)-1-cyclohexylethoxy]-5-fluoro-N-(4-methylpy...) Show SMILES C[C@H](Oc1cc(c(F)cc1C(=O)Nc1nnccc1C)-n1nc2CCCCn2c1=O)C1CCCCC1 |r| Show InChI InChI=1S/C26H31FN6O3/c1-16-11-12-28-30-24(16)29-25(34)19-14-20(27)21(33-26(35)32-13-7-6-10-23(32)31-33)15-22(19)36-17(2)18-8-4-3-5-9-18/h11-12,14-15,17-18H,3-10,13H2,1-2H3,(H,29,30,34)/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490564 (N-(2-chloro-4-fluoro-6-methylphenyl)-5-fluoro-4-(3...) Show SMILES C[C@H](Oc1cc(c(F)cc1C(=O)Nc1c(C)cc(F)cc1Cl)-n1nc2COCCCn2c1=O)C(F)(F)F |r| Show InChI InChI=1S/C23H20ClF5N4O4/c1-11-6-13(25)7-15(24)20(11)30-21(34)14-8-16(26)17(9-18(14)37-12(2)23(27,28)29)33-22(35)32-4-3-5-36-10-19(32)31-33/h6-9,12H,3-5,10H2,1-2H3,(H,30,34)/t12-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM470466 (N-(2,6-dichlorophenyl)-4-[4-ethyl-3-(hydroxymethyl...) Show SMILES CCn1c(CO)nn(-c2cc(O[C@@H](C)C(F)(F)F)c(cc2F)C(=O)Nc2c(Cl)cccc2Cl)c1=O |r| Show InChI InChI=1S/C21H18Cl2F4N4O4/c1-3-30-17(9-32)29-31(20(30)34)15-8-16(35-10(2)21(25,26)27)11(7-14(15)24)19(33)28-18-12(22)5-4-6-13(18)23/h4-8,10,32H,3,9H2,1-2H3,(H,28,33)/t10-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10815215 (2020) BindingDB Entry DOI: 10.7270/Q2RJ4NJH
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM470568 (1-(4-[(2-chloro-6-fluorophenyl)carbamoyl]-2-fluoro...) Show SMILES CCn1c(nn(-c2cc(O[C@@H](C)C(F)(F)F)c(cc2F)C(=O)Nc2c(F)cccc2Cl)c1=O)C(N)=O |r| Show InChI InChI=1S/C21H17ClF5N5O4/c1-3-31-18(17(28)33)30-32(20(31)35)14-8-15(36-9(2)21(25,26)27)10(7-13(14)24)19(34)29-16-11(22)5-4-6-12(16)23/h4-9H,3H2,1-2H3,(H2,28,33)(H,29,34)/t9-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10815215 (2020) BindingDB Entry DOI: 10.7270/Q2RJ4NJH
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM470359 (N-(2,6-difluorophenyl)-4-(3-ethyl-4-methyl-5-oxo-4...) Show SMILES CCC[C@H](C)Oc1cc(c(F)cc1C(=O)Nc1c(F)cccc1F)-n1nc(CC)n(C)c1=O |r| Show InChI InChI=1S/C23H25F3N4O3/c1-5-8-13(3)33-19-12-18(30-23(32)29(4)20(6-2)28-30)17(26)11-14(19)22(31)27-21-15(24)9-7-10-16(21)25/h7,9-13H,5-6,8H2,1-4H3,(H,27,31)/t13-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10815215 (2020) BindingDB Entry DOI: 10.7270/Q2RJ4NJH
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490560 (N-(2-chloro-6-fluorophenyl)-5-fluoro-4-(3-oxo-6,7-...) Show SMILES C[C@H](Oc1cc(c(F)cc1C(=O)Nc1c(F)cccc1Cl)-n1nc2COCCCn2c1=O)C(F)(F)F |r| Show InChI InChI=1S/C22H18ClF5N4O4/c1-11(22(26,27)28)36-17-9-16(32-21(34)31-6-3-7-35-10-18(31)30-32)15(25)8-12(17)20(33)29-19-13(23)4-2-5-14(19)24/h2,4-5,8-9,11H,3,6-7,10H2,1H3,(H,29,33)/t11-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490339 (5-fluoro-N-(2-methylphenyl)-4-(3-oxo-5,6,7,8-tetra...) Show SMILES CCC[C@H](C)Oc1cc(c(F)cc1C(=O)Nc1ccccc1C)-n1nc2CCCCn2c1=O |r| Show InChI InChI=1S/C25H29FN4O3/c1-4-9-17(3)33-22-15-21(30-25(32)29-13-8-7-12-23(29)28-30)19(26)14-18(22)24(31)27-20-11-6-5-10-16(20)2/h5-6,10-11,14-15,17H,4,7-9,12-13H2,1-3H3,(H,27,31)/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490361 (N-(2,6-difluorophenyl)-5-fluoro-4-(3-oxo-5,6,7,8-t...) Show SMILES C[C@H](Oc1cc(c(F)cc1C(=O)Nc1c(F)cccc1F)-n1nc2CCCCn2c1=O)C(F)(F)F |r| Show InChI InChI=1S/C22H18F6N4O3/c1-11(22(26,27)28)35-17-10-16(32-21(34)31-8-3-2-7-18(31)30-32)15(25)9-12(17)20(33)29-19-13(23)5-4-6-14(19)24/h4-6,9-11H,2-3,7-8H2,1H3,(H,29,33)/t11-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490563 (N-(2,6-dichlorophenyl)-5-fluoro-4-(3-oxo-6,7-dihyd...) Show SMILES C[C@H](Oc1cc(c(F)cc1C(=O)Nc1c(Cl)cccc1Cl)-n1nc2COCCCn2c1=O)C(F)(F)F |r| Show InChI InChI=1S/C22H18Cl2F4N4O4/c1-11(22(26,27)28)36-17-9-16(32-21(34)31-6-3-7-35-10-18(31)30-32)15(25)8-12(17)20(33)29-19-13(23)4-2-5-14(19)24/h2,4-5,8-9,11H,3,6-7,10H2,1H3,(H,29,33)/t11-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490394 (N-(2-chloro-4-fluoro-6-methylphenyl)-5-fluoro-4-(3...) Show SMILES C[C@H](Oc1cc(c(F)cc1C(=O)Nc1c(C)cc(F)cc1Cl)-n1nc2CCCCn2c1=O)C(F)(F)F |r| Show InChI InChI=1S/C23H20ClF5N4O3/c1-11-7-13(25)8-15(24)20(11)30-21(34)14-9-16(26)17(10-18(14)36-12(2)23(27,28)29)33-22(35)32-6-4-3-5-19(32)31-33/h7-10,12H,3-6H2,1-2H3,(H,30,34)/t12-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490483 (2-[(1S)-1-cyclohexylethoxy]-N-(2,6-difluorophenyl)...) Show SMILES C[C@H](Oc1cc(c(F)cc1C(=O)Nc1c(F)cccc1F)-n1nc2CCCCn2c1=O)C1CCCCC1 |r| Show InChI InChI=1S/C27H29F3N4O3/c1-16(17-8-3-2-4-9-17)37-23-15-22(34-27(36)33-13-6-5-12-24(33)32-34)21(30)14-18(23)26(35)31-25-19(28)10-7-11-20(25)29/h7,10-11,14-17H,2-6,8-9,12-13H2,1H3,(H,31,35)/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM470472 (N-(2-chloro-6-fluorophenyl)-5-fluoro-4-[3-(hydroxy...) Show SMILES CCC[C@H](C)Oc1cc(c(F)cc1C(=O)Nc1c(F)cccc1Cl)-n1nc(CO)n(C)c1=O |r| Show InChI InChI=1S/C22H23ClF2N4O4/c1-4-6-12(2)33-18-10-17(29-22(32)28(3)19(11-30)27-29)16(25)9-13(18)21(31)26-20-14(23)7-5-8-15(20)24/h5,7-10,12,30H,4,6,11H2,1-3H3,(H,26,31)/t12-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10815215 (2020) BindingDB Entry DOI: 10.7270/Q2RJ4NJH
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490565 (N-(2-chloro-6-methylphenyl)-5-fluoro-4-(3-oxo-6,7-...) Show SMILES C[C@H](Oc1cc(c(F)cc1C(=O)Nc1c(C)cccc1Cl)-n1nc2COCCCn2c1=O)C(F)(F)F |r| Show InChI InChI=1S/C23H21ClF4N4O4/c1-12-5-3-6-15(24)20(12)29-21(33)14-9-16(25)17(10-18(14)36-13(2)23(26,27)28)32-22(34)31-7-4-8-35-11-19(31)30-32/h3,5-6,9-10,13H,4,7-8,11H2,1-2H3,(H,29,33)/t13-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490448 (2-[(1S)-1-cyclohexylethoxy]-5-fluoro-N-(6-methoxy-...) Show SMILES COc1cc(C)c(NC(=O)c2cc(F)c(cc2O[C@@H](C)C2CCCCC2)-n2nc3CCCCn3c2=O)cn1 |r| Show InChI InChI=1S/C28H34FN5O4/c1-17-13-26(37-3)30-16-22(17)31-27(35)20-14-21(29)23(34-28(36)33-12-8-7-11-25(33)32-34)15-24(20)38-18(2)19-9-5-4-6-10-19/h13-16,18-19H,4-12H2,1-3H3,(H,31,35)/t18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490622 (N-(2,6-difluoro-4-hydroxyphenyl)-5-fluoro-4-(3-oxo...) Show SMILES C[C@H](Oc1cc(c(F)cc1C(=O)Nc1c(F)cc(O)cc1F)-n1nc2CCCCn2c1=O)C(F)(F)F |r| Show InChI InChI=1S/C22H18F6N4O4/c1-10(22(26,27)28)36-17-9-16(32-21(35)31-5-3-2-4-18(31)30-32)13(23)8-12(17)20(34)29-19-14(24)6-11(33)7-15(19)25/h6-10,33H,2-5H2,1H3,(H,29,34)/t10-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM470471 (N-(2,6-dichlorophenyl)-5-fluoro-4-{3-[(1S)-1-hydro...) Show SMILES C[C@H](O)c1nn(-c2cc(O[C@@H](C)C(F)(F)F)c(cc2F)C(=O)Nc2c(Cl)cccc2Cl)c(=O)n1C |r| Show InChI InChI=1S/C21H18Cl2F4N4O4/c1-9(32)18-29-31(20(34)30(18)3)15-8-16(35-10(2)21(25,26)27)11(7-14(15)24)19(33)28-17-12(22)5-4-6-13(17)23/h4-10,32H,1-3H3,(H,28,33)/t9-,10-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10815215 (2020) BindingDB Entry DOI: 10.7270/Q2RJ4NJH
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490382 (N-(2-chloro-6-fluorophenyl)-5-fluoro-4-(3-oxo-5,6,...) Show SMILES C[C@H](Oc1cc(c(F)cc1C(=O)Nc1c(F)cccc1Cl)-n1nc2CCCCn2c1=O)C(F)(F)F |r| Show InChI InChI=1S/C22H18ClF5N4O3/c1-11(22(26,27)28)35-17-10-16(32-21(34)31-8-3-2-7-18(31)30-32)15(25)9-12(17)20(33)29-19-13(23)5-4-6-14(19)24/h4-6,9-11H,2-3,7-8H2,1H3,(H,29,33)/t11-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490555 (5-fluoro-N-(2-fluorophenyl)-4-(3-oxo[1,2,4]triazol...) Show SMILES C[C@H](Oc1cc(c(F)cc1C(=O)Nc1ccccc1F)-n1nc2ccccn2c1=O)c1ccccc1 |r| Show InChI InChI=1S/C27H20F2N4O3/c1-17(18-9-3-2-4-10-18)36-24-16-23(33-27(35)32-14-8-7-13-25(32)31-33)21(29)15-19(24)26(34)30-22-12-6-5-11-20(22)28/h2-17H,1H3,(H,30,34)/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM470516 (N-(2-chloro-6-fluorophenyl)-4-[3-(2-hydroxypropan-...) Show SMILES C[C@H](Oc1cc(ccc1C(=O)Nc1c(F)cccc1Cl)-n1nc(n(C)c1=O)C(C)(C)O)C(F)(F)F |r| Show InChI InChI=1S/C22H21ClF4N4O4/c1-11(22(25,26)27)35-16-10-12(31-20(33)30(4)19(29-31)21(2,3)34)8-9-13(16)18(32)28-17-14(23)6-5-7-15(17)24/h5-11,34H,1-4H3,(H,28,32)/t11-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10815215 (2020) BindingDB Entry DOI: 10.7270/Q2RJ4NJH
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490568 (N-(2,6-dichloro-4-fluorophenyl)-5-fluoro-4-(3-oxo-...) Show SMILES C[C@H](Oc1cc(c(F)cc1C(=O)Nc1c(Cl)cc(F)cc1Cl)-n1nc2COCCCn2c1=O)C(F)(F)F |r| Show InChI InChI=1S/C22H17Cl2F5N4O4/c1-10(22(27,28)29)37-17-8-16(33-21(35)32-3-2-4-36-9-18(32)31-33)15(26)7-12(17)20(34)30-19-13(23)5-11(25)6-14(19)24/h5-8,10H,2-4,9H2,1H3,(H,30,34)/t10-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM470454 (N-(2-chloro-6-fluorophenyl)-4-[4-ethyl-3-(hydroxym...) Show SMILES CCn1c(CO)nn(-c2cc(O[C@@H](C)C(F)(F)F)c(cc2F)C(=O)Nc2c(F)cccc2Cl)c1=O |r| Show InChI InChI=1S/C21H18ClF5N4O4/c1-3-30-17(9-32)29-31(20(30)34)15-8-16(35-10(2)21(25,26)27)11(7-14(15)24)19(33)28-18-12(22)5-4-6-13(18)23/h4-8,10,32H,3,9H2,1-2H3,(H,28,33)/t10-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	4.17	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10815215 (2020) BindingDB Entry DOI: 10.7270/Q2RJ4NJH
					More data for this Ligand-Target Pair				3D Structure (crystal)
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM470532 (N-(2-chloro-6-fluoro-4-hydroxyphenyl)-4-[4-ethyl-3...) Show SMILES CCn1c(CO)nn(-c2cc(O[C@@H](C)C(F)(F)F)c(cc2F)C(=O)Nc2c(F)cc(O)cc2Cl)c1=O |r| Show InChI InChI=1S/C21H18ClF5N4O5/c1-3-30-17(8-32)29-31(20(30)35)15-7-16(36-9(2)21(25,26)27)11(6-13(15)23)19(34)28-18-12(22)4-10(33)5-14(18)24/h4-7,9,32-33H,3,8H2,1-2H3,(H,28,34)/t9-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10815215 (2020) BindingDB Entry DOI: 10.7270/Q2RJ4NJH
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM490396 (5-fluoro-N-(4-fluoro-2,6-dimethylphenyl)-4-(3-oxo-...) Show SMILES C[C@H](Oc1cc(c(F)cc1C(=O)Nc1c(C)cc(F)cc1C)-n1nc2CCCCn2c1=O)C(F)(F)F |r| Show InChI InChI=1S/C24H23F5N4O3/c1-12-8-15(25)9-13(2)21(12)30-22(34)16-10-17(26)18(11-19(16)36-14(3)24(27,28)29)33-23(35)32-7-5-4-6-20(32)31-33/h8-11,14H,4-7H2,1-3H3,(H,30,34)/t14-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay—1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10968216 (2021) BindingDB Entry DOI: 10.7270/Q2WM1HJN
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM470465 (N-(2,6-dichlorophenyl)-5-fluoro-4-[3-(hydroxymethy...) Show SMILES C[C@H](Oc1cc(c(F)cc1C(=O)Nc1c(Cl)cccc1Cl)-n1nc(CO)n(C)c1=O)C(F)(F)F |r| Show InChI InChI=1S/C20H16Cl2F4N4O4/c1-9(20(24,25)26)34-15-7-14(30-19(33)29(2)16(8-31)28-30)13(23)6-10(15)18(32)27-17-11(21)4-3-5-12(17)22/h3-7,9,31H,8H2,1-2H3,(H,27,32)/t9-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.33	n/a	n/a	n/a	n/a	n/a	n/a
BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION US Patent					Assay Description Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...				US Patent US10815215 (2020) BindingDB Entry DOI: 10.7270/Q2RJ4NJH
					More data for this Ligand-Target Pair

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