Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Amyloid-beta precursor protein (Homo sapiens (Human)) | BDBM195597 (US9216974, WC-5-5) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 218 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
WASHINGTON UNIVERSITY US Patent | Assay Description To determine the Ki values, fixed brain tissues prepared from 15-month-old Tg2576 mice (N=5) will be incubated for 30 min with 1 μM methoxy-X34 ... | US Patent US9216974 (2015) BindingDB Entry DOI: 10.7270/Q2WD3ZCG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amyloid-beta precursor protein (Homo sapiens (Human)) | BDBM21360 (7-ethoxy-3H-phenoxazin-3-one | 7-ethoxyresorufin |...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem Patents | US Patent | 262 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
WASHINGTON UNIVERSITY US Patent | Assay Description To determine the Ki values, fixed brain tissues prepared from 15-month-old Tg2576 mice (N=5) will be incubated for 30 min with 1 μM methoxy-X34 ... | US Patent US9216974 (2015) BindingDB Entry DOI: 10.7270/Q2WD3ZCG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amyloid-beta precursor protein (Homo sapiens (Human)) | BDBM195592 (US9216974, WC-5-42) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 347 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
WASHINGTON UNIVERSITY US Patent | Assay Description To determine the Ki values, fixed brain tissues prepared from 15-month-old Tg2576 mice (N=5) will be incubated for 30 min with 1 μM methoxy-X34 ... | US Patent US9216974 (2015) BindingDB Entry DOI: 10.7270/Q2WD3ZCG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amyloid-beta precursor protein (Homo sapiens (Human)) | BDBM195593 (US9216974, WC-5-43) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 407 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
WASHINGTON UNIVERSITY US Patent | Assay Description To determine the Ki values, fixed brain tissues prepared from 15-month-old Tg2576 mice (N=5) will be incubated for 30 min with 1 μM methoxy-X34 ... | US Patent US9216974 (2015) BindingDB Entry DOI: 10.7270/Q2WD3ZCG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amyloid-beta precursor protein (Homo sapiens (Human)) | BDBM195594 (US9216974, WC-5-45) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 421 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
WASHINGTON UNIVERSITY US Patent | Assay Description To determine the Ki values, fixed brain tissues prepared from 15-month-old Tg2576 mice (N=5) will be incubated for 30 min with 1 μM methoxy-X34 ... | US Patent US9216974 (2015) BindingDB Entry DOI: 10.7270/Q2WD3ZCG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amyloid-beta precursor protein (Homo sapiens (Human)) | BDBM195596 (US9216974, WC-5-8) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 860 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
WASHINGTON UNIVERSITY US Patent | Assay Description To determine the Ki values, fixed brain tissues prepared from 15-month-old Tg2576 mice (N=5) will be incubated for 30 min with 1 μM methoxy-X34 ... | US Patent US9216974 (2015) BindingDB Entry DOI: 10.7270/Q2WD3ZCG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amyloid-beta precursor protein (Homo sapiens (Human)) | BDBM195600 (US9216974, WC-5-1) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 4.61E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
WASHINGTON UNIVERSITY US Patent | Assay Description To determine the Ki values, fixed brain tissues prepared from 15-month-old Tg2576 mice (N=5) will be incubated for 30 min with 1 μM methoxy-X34 ... | US Patent US9216974 (2015) BindingDB Entry DOI: 10.7270/Q2WD3ZCG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amyloid-beta precursor protein (Homo sapiens (Human)) | BDBM195584 (US9216974, Methoxy-resorufin) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | 4.68E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
WASHINGTON UNIVERSITY US Patent | Assay Description To determine the Ki values, fixed brain tissues prepared from 15-month-old Tg2576 mice (N=5) will be incubated for 30 min with 1 μM methoxy-X34 ... | US Patent US9216974 (2015) BindingDB Entry DOI: 10.7270/Q2WD3ZCG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amyloid-beta precursor protein (Homo sapiens (Human)) | BDBM195589 (US9216974, WC-5-47) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
WASHINGTON UNIVERSITY US Patent | Assay Description To determine the Ki values, fixed brain tissues prepared from 15-month-old Tg2576 mice (N=5) will be incubated for 30 min with 1 μM methoxy-X34 ... | US Patent US9216974 (2015) BindingDB Entry DOI: 10.7270/Q2WD3ZCG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50586261 (CHEMBL5078689) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at human TLR8 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated TNF level preincubated for 30 mins followe... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00696 BindingDB Entry DOI: 10.7270/Q2W66QPP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50586262 (CHEMBL5091113) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at human TLR8 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated TNF level preincubated for 30 mins followe... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00696 BindingDB Entry DOI: 10.7270/Q2W66QPP | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50586259 (CHEMBL5090067) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at human TLR8 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated TNF level preincubated for 30 mins followe... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00696 BindingDB Entry DOI: 10.7270/Q2W66QPP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM50586260 (CHEMBL5079910) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at human TLR7 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated IFNalpha level preincubated for 30 mins fo... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00696 BindingDB Entry DOI: 10.7270/Q2W66QPP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50586260 (CHEMBL5079910) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at human TLR8 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated TNF level preincubated for 30 mins followe... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00696 BindingDB Entry DOI: 10.7270/Q2W66QPP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM50586259 (CHEMBL5090067) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.390 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at human TLR7 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated IFNalpha level preincubated for 30 mins fo... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00696 BindingDB Entry DOI: 10.7270/Q2W66QPP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50543142 (CHEMBL4641633) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.430 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Antagonist activity at TLR8 in human whole blood assessed as inhibition of DOTAP-ssRNA40 induced TNFalpha production preincubated for 30 mins followe... | J Med Chem 63: 8276-8295 (2020) Article DOI: 10.1021/acs.jmedchem.0c00130 BindingDB Entry DOI: 10.7270/Q2D22269 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50586262 (CHEMBL5091113) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at human TLR8 expressed in human whole blood assessed as inhibition of ssRNA stimulated TNF level preincubated for 30 mins follow... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00696 BindingDB Entry DOI: 10.7270/Q2W66QPP | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM50543142 (CHEMBL4641633) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.620 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Antagonist activity at TLR7 in human PBMC assessed as inhibition of DOTAP-ssRNA40 induced IFNalpha production preincubated for 30 mins followed by ss... | J Med Chem 63: 8276-8295 (2020) Article DOI: 10.1021/acs.jmedchem.0c00130 BindingDB Entry DOI: 10.7270/Q2D22269 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM50586256 (CHEMBL5085458) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.670 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at human TLR7 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated IFNalpha level preincubated for 30 mins fo... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00696 BindingDB Entry DOI: 10.7270/Q2W66QPP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50560358 (CHEMBL4790219) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at TLR8 in human THP-1 cells assessed as inhibition of resiquimod-induced TNFalpha production | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127366 BindingDB Entry DOI: 10.7270/Q2T43XS2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50543137 (CHEMBL4634860) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at TLR8 in human THP-1 cells assessed as inhibition of resiquimod-induced TNFalpha production | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127366 BindingDB Entry DOI: 10.7270/Q2T43XS2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM50586258 (CHEMBL5085289) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at human TLR7 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated IFNalpha level preincubated for 30 mins fo... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00696 BindingDB Entry DOI: 10.7270/Q2W66QPP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM50560358 (CHEMBL4790219) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at TLR7 in human PBMC assessed as inhibition of ssRNA40-induced IFNalpha production | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127366 BindingDB Entry DOI: 10.7270/Q2T43XS2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM50543137 (CHEMBL4634860) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at TLR7 in human PBMC assessed as inhibition of ssRNA40-induced IFNalpha production | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127366 BindingDB Entry DOI: 10.7270/Q2T43XS2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50560355 (CHEMBL4740968) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at TLR8 in human THP-1 cells assessed as inhibition of resiquimod-induced TNFalpha production | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127366 BindingDB Entry DOI: 10.7270/Q2T43XS2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM50560359 (CHEMBL4762866) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at TLR7 in human PBMC assessed as inhibition of ssRNA40-induced IFNalpha production | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127366 BindingDB Entry DOI: 10.7270/Q2T43XS2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50543163 (CHEMBL4642652) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Antagonist activity at TLR8 in human PBMC assessed as inhibition of DOTAP-ssRNA40 induced TNFalpha production preincubated for 30 mins followed by ss... | J Med Chem 63: 8276-8295 (2020) Article DOI: 10.1021/acs.jmedchem.0c00130 BindingDB Entry DOI: 10.7270/Q2D22269 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM50586253 (CHEMBL5077018) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at human TLR7 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated IFNalpha level preincubated for 30 mins fo... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00696 BindingDB Entry DOI: 10.7270/Q2W66QPP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50586256 (CHEMBL5085458) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at human TLR8 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated TNF level preincubated for 30 mins followe... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00696 BindingDB Entry DOI: 10.7270/Q2W66QPP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50586255 (CHEMBL5077828) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at human TLR8 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated TNF level preincubated for 30 mins followe... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00696 BindingDB Entry DOI: 10.7270/Q2W66QPP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50586258 (CHEMBL5085289) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at human TLR8 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated TNF level preincubated for 30 mins followe... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00696 BindingDB Entry DOI: 10.7270/Q2W66QPP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50543142 (CHEMBL4641633) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Antagonist activity at TLR8 in human PBMC assessed as inhibition of DOTAP-ssRNA40 induced TNFalpha production preincubated for 30 mins followed by ss... | J Med Chem 63: 8276-8295 (2020) Article DOI: 10.1021/acs.jmedchem.0c00130 BindingDB Entry DOI: 10.7270/Q2D22269 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50560359 (CHEMBL4762866) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at TLR8 in human THP-1 cells assessed as inhibition of resiquimod-induced TNFalpha production | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127366 BindingDB Entry DOI: 10.7270/Q2T43XS2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 7 (Mus musculus) | BDBM50586262 (CHEMBL5091113) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at mouse TLR7 expressed in human whole blood assessed as inhibition of ssRNA stimulated IFNalpha level preincubated for 30 mins f... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00696 BindingDB Entry DOI: 10.7270/Q2W66QPP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50586249 (CHEMBL5080083) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at human TLR8 expressed in Drosophila S2 by TR-FRET assay | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00696 BindingDB Entry DOI: 10.7270/Q2W66QPP | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM50543142 (CHEMBL4641633) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Antagonist activity at TLR7 in human whole blood assessed as inhibition of DOTAP-ssRNA40 induced IFNalpha production preincubated for 30 mins followe... | J Med Chem 63: 8276-8295 (2020) Article DOI: 10.1021/acs.jmedchem.0c00130 BindingDB Entry DOI: 10.7270/Q2D22269 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50543142 (CHEMBL4641633) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Antagonist activity at TLR8 in human whole blood assessed as inhibition of R848-induced TNFalpha production preincubated for 30 mins followed by R848... | J Med Chem 63: 8276-8295 (2020) Article DOI: 10.1021/acs.jmedchem.0c00130 BindingDB Entry DOI: 10.7270/Q2D22269 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50586260 (CHEMBL5079910) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at human TLR8 expressed in Drosophila S2 by TR-FRET assay | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00696 BindingDB Entry DOI: 10.7270/Q2W66QPP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50586253 (CHEMBL5077018) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at human TLR8 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated TNF level preincubated for 30 mins followe... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00696 BindingDB Entry DOI: 10.7270/Q2W66QPP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50543162 (CHEMBL4644098) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Antagonist activity at TLR8 in human PBMC assessed as inhibition of DOTAP-ssRNA40 induced TNFalpha production preincubated for 30 mins followed by ss... | J Med Chem 63: 8276-8295 (2020) Article DOI: 10.1021/acs.jmedchem.0c00130 BindingDB Entry DOI: 10.7270/Q2D22269 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM50560355 (CHEMBL4740968) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at TLR7 in human PBMC assessed as inhibition of ssRNA40-induced IFNalpha production | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127366 BindingDB Entry DOI: 10.7270/Q2T43XS2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50586262 (CHEMBL5091113) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at human TLR8 expressed in Drosophila S2 by TR-FRET assay | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00696 BindingDB Entry DOI: 10.7270/Q2W66QPP | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM50586252 (CHEMBL5086681) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at human TLR7 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated IFNalpha level preincubated for 30 mins fo... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00696 BindingDB Entry DOI: 10.7270/Q2W66QPP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50560351 (CHEMBL4748638) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at TLR8 in human THP-1 cells assessed as inhibition of resiquimod-induced TNFalpha production | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127366 BindingDB Entry DOI: 10.7270/Q2T43XS2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50586259 (CHEMBL5090067) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at human TLR8 expressed in Drosophila S2 by TR-FRET assay | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00696 BindingDB Entry DOI: 10.7270/Q2W66QPP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 7 (Mus musculus) | BDBM50543137 (CHEMBL4634860) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at TLR7 in mouse splenocytes assessed as inhibition of ssRNA40-induced IL6 production | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127366 BindingDB Entry DOI: 10.7270/Q2T43XS2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50543149 (CHEMBL4649727) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Antagonist activity at TLR8 in human PBMC assessed as inhibition of DOTAP-ssRNA40 induced TNFalpha production preincubated for 30 mins followed by ss... | J Med Chem 63: 8276-8295 (2020) Article DOI: 10.1021/acs.jmedchem.0c00130 BindingDB Entry DOI: 10.7270/Q2D22269 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50586261 (CHEMBL5078689) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at human TLR8 expressed in Drosophila S2 by TR-FRET assay | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00696 BindingDB Entry DOI: 10.7270/Q2W66QPP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM50586262 (CHEMBL5091113) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at human TLR7 expressed in human whole blood assessed as inhibition of ssRNA stimulated IFNalpha level preincubated for 30 mins f... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00696 BindingDB Entry DOI: 10.7270/Q2W66QPP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50560350 (CHEMBL4783510) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at TLR8 in human THP-1 cells assessed as inhibition of resiquimod-induced TNFalpha production | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127366 BindingDB Entry DOI: 10.7270/Q2T43XS2 | |||||||||||
More data for this Ligand-Target Pair |
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