Found 179 hits with Last Name = 'van poelje' and Initial = 'pd' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Thyroid hormone receptor alpha
(Homo sapiens (Human)) | BDBM18860
((2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-di...)Show SMILES N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O |r| Show InChI InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank PDB Article PubMed
| 0.220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Displacement of [125I]T3 from recombinant thyroid hormone receptor alpha (unknown origin) expressed in sf9 cells by scintillation proximity assay |
Proc Natl Acad Sci U S A 104: 15490-5 (2007)
Article DOI: 10.1073/pnas.0702759104 BindingDB Entry DOI: 10.7270/Q2JW8DPH |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Thyroid hormone receptor beta
(Homo sapiens (Human)) | BDBM18869
(2-{3,5-dichloro-4-[4-hydroxy-3-(propan-2-yl)phenox...)Show InChI InChI=1S/C17H16Cl2O4/c1-9(2)12-8-11(3-4-15(12)20)23-17-13(18)5-10(6-14(17)19)7-16(21)22/h3-6,8-9,20H,7H2,1-2H3,(H,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| MMDB PDB Article PubMed
| 0.370 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Displacement of [125I]T3 from recombinant thyroid hormone receptor beta (unknown origin) expressed in sf9 cells by scintillation proximity assay |
Proc Natl Acad Sci U S A 104: 15490-5 (2007)
Article DOI: 10.1073/pnas.0702759104 BindingDB Entry DOI: 10.7270/Q2JW8DPH |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Thyroid hormone receptor beta
(Homo sapiens (Human)) | BDBM18860
((2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-di...)Show SMILES N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O |r| Show InChI InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank PDB Article PubMed
| 0.550 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Displacement of [125I]T3 from recombinant thyroid hormone receptor beta (unknown origin) expressed in sf9 cells by scintillation proximity assay |
Proc Natl Acad Sci U S A 104: 15490-5 (2007)
Article DOI: 10.1073/pnas.0702759104 BindingDB Entry DOI: 10.7270/Q2JW8DPH |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Thyroid hormone receptor beta
(Homo sapiens (Human)) | BDBM50242403
((3,5-dimethyl-4-(4-hydroxy-3-isopropylbenzyl)pheno...)Show InChI InChI=1S/C19H25O5P/c1-12(2)17-9-15(5-6-19(17)20)10-18-13(3)7-16(8-14(18)4)24-11-25(21,22)23/h5-9,12,20H,10-11H2,1-4H3,(H2,21,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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| Article PubMed
| 2.17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Displacement of [125I]T3 from recombinant thyroid hormone receptor beta (unknown origin) expressed in sf9 cells by scintillation proximity assay |
Proc Natl Acad Sci U S A 104: 15490-5 (2007)
Article DOI: 10.1073/pnas.0702759104 BindingDB Entry DOI: 10.7270/Q2JW8DPH |
More data for this Ligand-Target Pair | |
Thyroid hormone receptor alpha
(Homo sapiens (Human)) | BDBM18869
(2-{3,5-dichloro-4-[4-hydroxy-3-(propan-2-yl)phenox...)Show InChI InChI=1S/C17H16Cl2O4/c1-9(2)12-8-11(3-4-15(12)20)23-17-13(18)5-10(6-14(17)19)7-16(21)22/h3-6,8-9,20H,7H2,1-2H3,(H,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| PDB Article PubMed
| 7.18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Displacement of [125I]T3 from recombinant thyroid hormone receptor alpha (unknown origin) expressed in sf9 cells by scintillation proximity assay |
Proc Natl Acad Sci U S A 104: 15490-5 (2007)
Article DOI: 10.1073/pnas.0702759104 BindingDB Entry DOI: 10.7270/Q2JW8DPH |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Thyroid hormone receptor alpha
(Homo sapiens (Human)) | BDBM50242403
((3,5-dimethyl-4-(4-hydroxy-3-isopropylbenzyl)pheno...)Show InChI InChI=1S/C19H25O5P/c1-12(2)17-9-15(5-6-19(17)20)10-18-13(3)7-16(8-14(18)4)24-11-25(21,22)23/h5-9,12,20H,10-11H2,1-4H3,(H2,21,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
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Similars
| Article PubMed
| 35.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Displacement of [125I]T3 from recombinant thyroid hormone receptor alpha (unknown origin) expressed in sf9 cells by scintillation proximity assay |
Proc Natl Acad Sci U S A 104: 15490-5 (2007)
Article DOI: 10.1073/pnas.0702759104 BindingDB Entry DOI: 10.7270/Q2JW8DPH |
More data for this Ligand-Target Pair | |
Thyroid hormone receptor alpha
(Homo sapiens (Human)) | BDBM50242404
((4S)-4-(3-chlorophenyl)-2-[(3,5-dimethyl-4-(4-hydr...)Show SMILES CC(C)c1cc(Cc2c(C)cc(OCP3(=O)OCC[C@H](O3)c3cccc(Cl)c3)cc2C)ccc1O |r| Show InChI InChI=1S/C28H32ClO5P/c1-18(2)25-14-21(8-9-27(25)30)15-26-19(3)12-24(13-20(26)4)32-17-35(31)33-11-10-28(34-35)22-6-5-7-23(29)16-22/h5-9,12-14,16,18,28,30H,10-11,15,17H2,1-4H3/t28-,35?/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.25E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Displacement of [125I]T3 from recombinant thyroid hormone receptor alpha (unknown origin) expressed in sf9 cells by scintillation proximity assay |
Proc Natl Acad Sci U S A 104: 15490-5 (2007)
Article DOI: 10.1073/pnas.0702759104 BindingDB Entry DOI: 10.7270/Q2JW8DPH |
More data for this Ligand-Target Pair | |
Thyroid hormone receptor beta
(Homo sapiens (Human)) | BDBM50242404
((4S)-4-(3-chlorophenyl)-2-[(3,5-dimethyl-4-(4-hydr...)Show SMILES CC(C)c1cc(Cc2c(C)cc(OCP3(=O)OCC[C@H](O3)c3cccc(Cl)c3)cc2C)ccc1O |r| Show InChI InChI=1S/C28H32ClO5P/c1-18(2)25-14-21(8-9-27(25)30)15-26-19(3)12-24(13-20(26)4)32-17-35(31)33-11-10-28(34-35)22-6-5-7-23(29)16-22/h5-9,12-14,16,18,28,30H,10-11,15,17H2,1-4H3/t28-,35?/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.46E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Displacement of [125I]T3 from recombinant thyroid hormone receptor beta (unknown origin) expressed in sf9 cells by scintillation proximity assay |
Proc Natl Acad Sci U S A 104: 15490-5 (2007)
Article DOI: 10.1073/pnas.0702759104 BindingDB Entry DOI: 10.7270/Q2JW8DPH |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50293594
(5-(2-amino-5-isobutylthiazol-4-yl)furan-2-ylphosph...)Show InChI InChI=1S/C11H15N2O4PS/c1-6(2)5-8-10(13-11(12)19-8)7-3-4-9(17-7)18(14,15)16/h3-4,6H,5H2,1-2H3,(H2,12,13)(H2,14,15,16) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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Similars
| PDB Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303854
(5-(4-amino-7-ethyl-5-fluoro-1-isobutyl-1H-benzo[d]...)Show SMILES CCc1cc(F)c(N)c2nc(-c3ccc(o3)P(O)(O)=O)n(CC(C)C)c12 Show InChI InChI=1S/C17H21FN3O4P/c1-4-10-7-11(18)14(19)15-16(10)21(8-9(2)3)17(20-15)12-5-6-13(25-12)26(22,23)24/h5-7,9H,4,8,19H2,1-3H3,(H2,22,23,24) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303879
(4-Amino-5-fluoro-7-[3-(N,N-dimethylamino)propyl]-1...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(CCCN(C)C)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C20H28FN4O4P/c1-12(2)11-25-19-13(6-5-9-24(3)4)10-14(21)17(22)18(19)23-20(25)15-7-8-16(29-15)30(26,27)28/h7-8,10,12H,5-6,9,11,22H2,1-4H3,(H2,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303863
(4-Amino-5-fluoro-1-cyclopropylmethyl-2-[5-(2-phosp...)Show SMILES Nc1c(F)ccc2n(CC3CC3)c(nc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H15FN3O4P/c16-9-3-4-10-14(13(9)17)18-15(19(10)7-8-1-2-8)11-5-6-12(23-11)24(20,21)22/h3-6,8H,1-2,7,17H2,(H2,20,21,22) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303871
(4-Amino-7-cyclopropyl-5-fluoro-1-isobutyl-2-[5-(2-...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(C3CC3)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C18H21FN3O4P/c1-9(2)8-22-17-11(10-3-4-10)7-12(19)15(20)16(17)21-18(22)13-5-6-14(26-13)27(23,24)25/h5-7,9-10H,3-4,8,20H2,1-2H3,(H2,23,24,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303880
(4-Amino-5-fluoro-7-(4-chlorobutyl)-1-isobutyl-2-[5...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(CCCCCl)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C19H24ClFN3O4P/c1-11(2)10-24-18-12(5-3-4-8-20)9-13(21)16(22)17(18)23-19(24)14-6-7-15(28-14)29(25,26)27/h6-7,9,11H,3-5,8,10,22H2,1-2H3,(H2,25,26,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303878
(4-Amino-7-(3-hydroxypropyl)-5-fluoro-1-isobutyl-2-...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(CCCO)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C18H23FN3O5P/c1-10(2)9-22-17-11(4-3-7-23)8-12(19)15(20)16(17)21-18(22)13-5-6-14(27-13)28(24,25)26/h5-6,8,10,23H,3-4,7,9,20H2,1-2H3,(H2,24,25,26) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303872
(4-Amino-7-phenyl-5-fluoro-1-isobutyl-2-[5-(2-phosp...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(-c3ccccc3)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C21H21FN3O4P/c1-12(2)11-25-20-14(13-6-4-3-5-7-13)10-15(22)18(23)19(20)24-21(25)16-8-9-17(29-16)30(26,27)28/h3-10,12H,11,23H2,1-2H3,(H2,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303874
(4-Amino-7-(p-chlorophenyl)-5-fluoro-1-isobutyl-2-[...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(-c3ccc(Cl)cc3)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C21H20ClFN3O4P/c1-11(2)10-26-20-14(12-3-5-13(22)6-4-12)9-15(23)18(24)19(20)25-21(26)16-7-8-17(30-16)31(27,28)29/h3-9,11H,10,24H2,1-2H3,(H2,27,28,29) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303866
(4-Amino-5-fluoro-7-chloro-1-isobutyl-2-[5-(2-phosp...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(Cl)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H16ClFN3O4P/c1-7(2)6-20-14-8(16)5-9(17)12(18)13(14)19-15(20)10-3-4-11(24-10)25(21,22)23/h3-5,7H,6,18H2,1-2H3,(H2,21,22,23) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303875
(4-Amino-5-fluoro-7-(n-propyl)-1-isobutyl-2-[5-(2-p...)Show SMILES CCCc1cc(F)c(N)c2nc(-c3ccc(o3)P(O)(O)=O)n(CC(C)C)c12 Show InChI InChI=1S/C18H23FN3O4P/c1-4-5-11-8-12(19)15(20)16-17(11)22(9-10(2)3)18(21-16)13-6-7-14(26-13)27(23,24)25/h6-8,10H,4-5,9,20H2,1-3H3,(H2,23,24,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303877
(4-Amino-7-(4-methylpentyl)-5-fluoro-1-isobutyl-2-[...)Show SMILES CC(C)CCCc1cc(F)c(N)c2nc(-c3ccc(o3)P(O)(O)=O)n(CC(C)C)c12 Show InChI InChI=1S/C21H29FN3O4P/c1-12(2)6-5-7-14-10-15(22)18(23)19-20(14)25(11-13(3)4)21(24-19)16-8-9-17(29-16)30(26,27)28/h8-10,12-13H,5-7,11,23H2,1-4H3,(H2,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303860
(4-Amino-5-fluoro-1-isobutyl-2-[5-(2-phosphono)fura...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)ccc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H17FN3O4P/c1-8(2)7-19-10-4-3-9(16)13(17)14(10)18-15(19)11-5-6-12(23-11)24(20,21)22/h3-6,8H,7,17H2,1-2H3,(H2,20,21,22) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303867
(4-Amino-5-fluoro-7-bromo-1-isobutyl-2-[5-(2-phosph...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(Br)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H16BrFN3O4P/c1-7(2)6-20-14-8(16)5-9(17)12(18)13(14)19-15(20)10-3-4-11(24-10)25(21,22)23/h3-5,7H,6,18H2,1-2H3,(H2,21,22,23) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303861
(4-Amino-5-fluoro-1-(2-ethylbutyl)-2-[5-(2-phosphon...)Show SMILES CCC(CC)Cn1c(nc2c(N)c(F)ccc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C17H21FN3O4P/c1-3-10(4-2)9-21-12-6-5-11(18)15(19)16(12)20-17(21)13-7-8-14(25-13)26(22,23)24/h5-8,10H,3-4,9,19H2,1-2H3,(H2,22,23,24) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303873
(4-Amino-7-(p-fluorophenyl)-5-fluoro-1-isobutyl-2-[...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(-c3ccc(F)cc3)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C21H20F2N3O4P/c1-11(2)10-26-20-14(12-3-5-13(22)6-4-12)9-15(23)18(24)19(20)25-21(26)16-7-8-17(30-16)31(27,28)29/h3-9,11H,10,24H2,1-2H3,(H2,27,28,29) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303856
(4-Amino-5-chloro-1-isobutyl-2-[2-(5-phosphono)fura...)Show SMILES CC(C)Cn1c(nc2c(N)c(Cl)ccc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H17ClN3O4P/c1-8(2)7-19-10-4-3-9(16)13(17)14(10)18-15(19)11-5-6-12(23-11)24(20,21)22/h3-6,8H,7,17H2,1-2H3,(H2,20,21,22) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303876
(4-Amino-7-(3,3-dimethyl-n-butyl)-5-fluoro-1-isobut...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(CCC(C)(C)C)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C21H29FN3O4P/c1-12(2)11-25-19-13(8-9-21(3,4)5)10-14(22)17(23)18(19)24-20(25)15-6-7-16(29-15)30(26,27)28/h6-7,10,12H,8-9,11,23H2,1-5H3,(H2,26,27,28) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303868
(4-Amino-5-fluoro-6-chloro-1-isobutyl-2-[5-(2-phosp...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)c(Cl)cc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H16ClFN3O4P/c1-7(2)6-20-9-5-8(16)12(17)13(18)14(9)19-15(20)10-3-4-11(24-10)25(21,22)23/h3-5,7H,6,18H2,1-2H3,(H2,21,22,23) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 225 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303870
(4-Amino-7-vinyl-5-fluoro-1-isobutyl-2-[5-(2-phosph...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(C=C)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C17H19FN3O4P/c1-4-10-7-11(18)14(19)15-16(10)21(8-9(2)3)17(20-15)12-5-6-13(25-12)26(22,23)24/h4-7,9H,1,8,19H2,2-3H3,(H2,22,23,24) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303871
(4-Amino-7-cyclopropyl-5-fluoro-1-isobutyl-2-[5-(2-...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(C3CC3)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C18H21FN3O4P/c1-9(2)8-22-17-11(10-3-4-10)7-12(19)15(20)16(17)21-18(22)13-5-6-14(26-13)27(23,24)25/h5-7,9-10H,3-4,8,20H2,1-2H3,(H2,23,24,25) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303879
(4-Amino-5-fluoro-7-[3-(N,N-dimethylamino)propyl]-1...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(CCCN(C)C)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C20H28FN4O4P/c1-12(2)11-25-19-13(6-5-9-24(3)4)10-14(21)17(22)18(19)23-20(25)15-7-8-16(29-15)30(26,27)28/h7-8,10,12H,5-6,9,11,22H2,1-4H3,(H2,26,27,28) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303859
(4-Amino-7-bromo-1-isobutyl-2-[2-(5-phosphono)furan...)Show SMILES CC(C)Cn1c(nc2c(N)ccc(Br)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H17BrN3O4P/c1-8(2)7-19-14-9(16)3-4-10(17)13(14)18-15(19)11-5-6-12(23-11)24(20,21)22/h3-6,8H,7,17H2,1-2H3,(H2,20,21,22) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303858
(4-Amino-5-bromo-1-isobutyl-2-[2-(5-phosphono)furan...)Show SMILES CC(C)Cn1c(nc2c(N)c(Br)ccc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H17BrN3O4P/c1-8(2)7-19-10-4-3-9(16)13(17)14(10)18-15(19)11-5-6-12(23-11)24(20,21)22/h3-6,8H,7,17H2,1-2H3,(H2,20,21,22) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303878
(4-Amino-7-(3-hydroxypropyl)-5-fluoro-1-isobutyl-2-...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(CCCO)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C18H23FN3O5P/c1-10(2)9-22-17-11(4-3-7-23)8-12(19)15(20)16(17)21-18(22)13-5-6-14(27-13)28(24,25)26/h5-6,8,10,23H,3-4,7,9,20H2,1-2H3,(H2,24,25,26) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303865
(4-Amino-5,7-dichloro-1-isobutyl-2-[5-(2-phosphono)...)Show SMILES CC(C)Cn1c(nc2c(N)c(Cl)cc(Cl)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H16Cl2N3O4P/c1-7(2)6-20-14-9(17)5-8(16)12(18)13(14)19-15(20)10-3-4-11(24-10)25(21,22)23/h3-5,7H,6,18H2,1-2H3,(H2,21,22,23) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303880
(4-Amino-5-fluoro-7-(4-chlorobutyl)-1-isobutyl-2-[5...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(CCCCCl)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C19H24ClFN3O4P/c1-11(2)10-24-18-12(5-3-4-8-20)9-13(21)16(22)17(18)23-19(24)14-6-7-15(28-14)29(25,26)27/h6-7,9,11H,3-5,8,10,22H2,1-2H3,(H2,25,26,27) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303855
(5-(4-amino-5-hydroxy-1-isobutyl-1H-benzo[d]imidazo...)Show SMILES CC(C)Cn1c(nc2c(N)c(O)ccc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H18N3O5P/c1-8(2)7-18-9-3-4-10(19)13(16)14(9)17-15(18)11-5-6-12(23-11)24(20,21)22/h3-6,8,19H,7,16H2,1-2H3,(H2,20,21,22) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303854
(5-(4-amino-7-ethyl-5-fluoro-1-isobutyl-1H-benzo[d]...)Show SMILES CCc1cc(F)c(N)c2nc(-c3ccc(o3)P(O)(O)=O)n(CC(C)C)c12 Show InChI InChI=1S/C17H21FN3O4P/c1-4-10-7-11(18)14(19)15-16(10)21(8-9(2)3)17(20-15)12-5-6-13(25-12)26(22,23)24/h5-7,9H,4,8,19H2,1-3H3,(H2,22,23,24) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303875
(4-Amino-5-fluoro-7-(n-propyl)-1-isobutyl-2-[5-(2-p...)Show SMILES CCCc1cc(F)c(N)c2nc(-c3ccc(o3)P(O)(O)=O)n(CC(C)C)c12 Show InChI InChI=1S/C18H23FN3O4P/c1-4-5-11-8-12(19)15(20)16-17(11)22(9-10(2)3)18(21-16)13-6-7-14(26-13)27(23,24)25/h6-8,10H,4-5,9,20H2,1-3H3,(H2,23,24,25) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 650 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303892
(4-Amino-5-methoxy-1-isobutyl-2-[5-(2-phosphono)fur...)Show SMILES COc1ccc2n(CC(C)C)c(nc2c1N)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C16H20N3O5P/c1-9(2)8-19-10-4-5-11(23-3)14(17)15(10)18-16(19)12-6-7-13(24-12)25(20,21)22/h4-7,9H,8,17H2,1-3H3,(H2,20,21,22) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50277609
(CHEMBL507312 | [5-(6-Amino-9-isobutyl-2-methylsulf...)Show SMILES CSc1nc(N)c2nc(-c3ccc(o3)P(O)(O)=O)n(CC(C)C)c2n1 Show InChI InChI=1S/C14H18N5O4PS/c1-7(2)6-19-12(8-4-5-9(23-8)24(20,21)22)16-10-11(15)17-14(25-3)18-13(10)19/h4-5,7H,6H2,1-3H3,(H2,15,17,18)(H2,20,21,22) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase expressed in Escherichia coli by spectrophotometry |
J Med Chem 52: 2880-98 (2009)
Article DOI: 10.1021/jm900078f BindingDB Entry DOI: 10.7270/Q2V40V20 |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303885
(4-Amino-1-cyclopropylmethyl-2-[2-(5-phosphono)fura...)Show SMILES Nc1cccc2n(CC3CC3)c(nc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H16N3O4P/c16-10-2-1-3-11-14(10)17-15(18(11)8-9-4-5-9)12-6-7-13(22-12)23(19,20)21/h1-3,6-7,9H,4-5,8,16H2,(H2,19,20,21) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50277565
(5-(6-amino-9-neopentyl-9H-purin-8-yl)furan-2-ylpho...)Show SMILES CC(C)(C)Cn1c(nc2c(N)ncnc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C14H18N5O4P/c1-14(2,3)6-19-12(8-4-5-9(23-8)24(20,21)22)18-10-11(15)16-7-17-13(10)19/h4-5,7H,6H2,1-3H3,(H2,15,16,17)(H2,20,21,22) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50277565
(5-(6-amino-9-neopentyl-9H-purin-8-yl)furan-2-ylpho...)Show SMILES CC(C)(C)Cn1c(nc2c(N)ncnc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C14H18N5O4P/c1-14(2,3)6-19-12(8-4-5-9(23-8)24(20,21)22)18-10-11(15)16-7-17-13(10)19/h4-5,7H,6H2,1-3H3,(H2,15,16,17)(H2,20,21,22) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase expressed in Escherichia coli by spectrophotometry |
J Med Chem 52: 2880-98 (2009)
Article DOI: 10.1021/jm900078f BindingDB Entry DOI: 10.7270/Q2V40V20 |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303886
(4-Amino-1-cyclobutylmethyl-2-[2-(5-phosphono)furan...)Show SMILES Nc1cccc2n(CC3CCC3)c(nc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C16H18N3O4P/c17-11-5-2-6-12-15(11)18-16(19(12)9-10-3-1-4-10)13-7-8-14(23-13)24(20,21)22/h2,5-8,10H,1,3-4,9,17H2,(H2,20,21,22) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303862
(4-Amino-5-fluoro-1-(3-pentyl)-2-[5-(2-phosphono)fu...)Show SMILES CCC(CC)n1c(nc2c(N)c(F)ccc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C16H19FN3O4P/c1-3-9(4-2)20-11-6-5-10(17)14(18)15(11)19-16(20)12-7-8-13(24-12)25(21,22)23/h5-9H,3-4,18H2,1-2H3,(H2,21,22,23) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 850 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303861
(4-Amino-5-fluoro-1-(2-ethylbutyl)-2-[5-(2-phosphon...)Show SMILES CCC(CC)Cn1c(nc2c(N)c(F)ccc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C17H21FN3O4P/c1-3-10(4-2)9-21-12-6-5-11(18)15(19)16(12)20-17(21)13-7-8-14(25-13)26(22,23)24/h5-8,10H,3-4,9,19H2,1-2H3,(H2,22,23,24) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 850 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303872
(4-Amino-7-phenyl-5-fluoro-1-isobutyl-2-[5-(2-phosp...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(-c3ccccc3)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C21H21FN3O4P/c1-12(2)11-25-20-14(13-6-4-3-5-7-13)10-15(22)18(23)19(20)24-21(25)16-8-9-17(29-16)30(26,27)28/h3-10,12H,11,23H2,1-2H3,(H2,26,27,28) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50303857
(4-Amino-7-chloro-1-isobutyl-2-[2-(5-phosphono)fura...)Show SMILES CC(C)Cn1c(nc2c(N)ccc(Cl)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C15H17ClN3O4P/c1-8(2)7-19-14-9(16)3-4-10(17)13(14)18-15(19)11-5-6-12(23-11)24(20,21)22/h3-6,8H,7,17H2,1-2H3,(H2,20,21,22) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Rattus norvegicus) | BDBM50303870
(4-Amino-7-vinyl-5-fluoro-1-isobutyl-2-[5-(2-phosph...)Show SMILES CC(C)Cn1c(nc2c(N)c(F)cc(C=C)c12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C17H19FN3O4P/c1-4-10-7-11(18)14(19)15-16(10)21(8-9(2)3)17(20-15)12-5-6-13(25-12)26(22,23)24/h4-7,9H,1,8,19H2,2-3H3,(H2,22,23,24) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of rat liver FBPase 1 |
J Med Chem 53: 441-51 (2010)
Article DOI: 10.1021/jm901420x BindingDB Entry DOI: 10.7270/Q2N58MFJ |
More data for this Ligand-Target Pair | |
Fructose-1,6-bisphosphatase 1
(Homo sapiens (Human)) | BDBM50277613
(CHEMBL484332 | {5-[6-Amino-9-(3-chloro-2,2-dimethy...)Show SMILES CC(C)(CCl)Cn1c(nc2c(N)ncnc12)-c1ccc(o1)P(O)(O)=O Show InChI InChI=1S/C14H17ClN5O4P/c1-14(2,5-15)6-20-12(8-3-4-9(24-8)25(21,22)23)19-10-11(16)17-7-18-13(10)20/h3-4,7H,5-6H2,1-2H3,(H2,16,17,18)(H2,21,22,23) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver FBPase expressed in Escherichia coli by spectrophotometry |
J Med Chem 52: 2880-98 (2009)
Article DOI: 10.1021/jm900078f BindingDB Entry DOI: 10.7270/Q2V40V20 |
More data for this Ligand-Target Pair | |