Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Lanosterol synthase
(Rattus norvegicus) | BDBM50051375
((6S,8aS)-5,5,8a-Trimethyl-2-((E)-1,5,9-trimethyl-d...)Show SMILES [#6]-[#6](-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](\[#6])-[#6])-[#7]-1-[#6]-[#6]=[#6]2C([#6])([#6])[#6@@H](-[#8])-[#6]-[#6][C@]2([#6])[#6]-1 |t:15| Show InChI InChI=1S/C25H43NO/c1-19(2)10-8-11-20(3)12-9-13-21(4)26-17-15-22-24(5,6)23(27)14-16-25(22,7)18-26/h10,12,15,21,23,27H,8-9,11,13-14,16-18H2,1-7H3/b20-12+/t21?,23-,25+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoires Fournier SCA
Curated by ChEMBL
| Assay Description Binding affinity towards competitive inhibition against rat microsomal Oxidosqualene-lanosterol cyclase |
J Med Chem 39: 2302-12 (1996)
Article DOI: 10.1021/jm9504621 BindingDB Entry DOI: 10.7270/Q28G8JTB |
More data for this Ligand-Target Pair | |
Lanosterol synthase
(Rattus norvegicus) | BDBM50051375
((6S,8aS)-5,5,8a-Trimethyl-2-((E)-1,5,9-trimethyl-d...)Show SMILES [#6]-[#6](-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](\[#6])-[#6])-[#7]-1-[#6]-[#6]=[#6]2C([#6])([#6])[#6@@H](-[#8])-[#6]-[#6][C@]2([#6])[#6]-1 |t:15| Show InChI InChI=1S/C25H43NO/c1-19(2)10-8-11-20(3)12-9-13-21(4)26-17-15-22-24(5,6)23(27)14-16-25(22,7)18-26/h10,12,15,21,23,27H,8-9,11,13-14,16-18H2,1-7H3/b20-12+/t21?,23-,25+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoires Fournier SCA
Curated by ChEMBL
| Assay Description Binding affinity towards noncompetetive inhibition against rat microsomal Oxidosqualene-lanosterol cyclase |
J Med Chem 39: 2302-12 (1996)
Article DOI: 10.1021/jm9504621 BindingDB Entry DOI: 10.7270/Q28G8JTB |
More data for this Ligand-Target Pair | |
Lanosterol synthase
(Rattus norvegicus) | BDBM50051375
((6S,8aS)-5,5,8a-Trimethyl-2-((E)-1,5,9-trimethyl-d...)Show SMILES [#6]-[#6](-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](\[#6])-[#6])-[#7]-1-[#6]-[#6]=[#6]2C([#6])([#6])[#6@@H](-[#8])-[#6]-[#6][C@]2([#6])[#6]-1 |t:15| Show InChI InChI=1S/C25H43NO/c1-19(2)10-8-11-20(3)12-9-13-21(4)26-17-15-22-24(5,6)23(27)14-16-25(22,7)18-26/h10,12,15,21,23,27H,8-9,11,13-14,16-18H2,1-7H3/b20-12+/t21?,23-,25+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoires Fournier SCA
Curated by ChEMBL
| Assay Description Inhibitory activity against Oxidosqualene-lanosterol cyclase from Rat liver microsomes |
J Med Chem 39: 2302-12 (1996)
Article DOI: 10.1021/jm9504621 BindingDB Entry DOI: 10.7270/Q28G8JTB |
More data for this Ligand-Target Pair | |