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Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 172.2
BDBM50216786

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 5 hits in this display
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Deoxyhypusine synthase (Plasmodium falciparum)	BDBM50216786 (CHEMBL229457 \| N-(7-Amino-heptyl)-guanidine \| N-gu...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institute for Medical Parasitology Curated by ChEMBL					Assay Description Inhibition of recombinant deoxyhypusine synthase in Plasmodium falciparum NF54				Bioorg Med Chem 15: 6200-7 (2007) Article DOI: 10.1016/j.bmc.2007.06.026 BindingDB Entry DOI: 10.7270/Q20Z7305
Institute for Medical Parasitology Curated by ChEMBL					More data for this Ligand-Target Pair
Deoxyhypusine synthase (Rattus norvegicus)	BDBM50216786 (CHEMBL229457 \| N-(7-Amino-heptyl)-guanidine \| N-gu...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	MMDB PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Dental Research Curated by ChEMBL					Assay Description In vitro IC50 value by measuring the inhibition of deoxyhypusine synthase.				J Med Chem 38: 3053-61 (1995) BindingDB Entry DOI: 10.7270/Q2P55MJ2
National Institute of Dental Research Curated by ChEMBL					More data for this Ligand-Target Pair
Deoxyhypusine synthase (Homo sapiens)	BDBM50216786 (CHEMBL229457 \| N-(7-Amino-heptyl)-guanidine \| N-gu...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human N-terminal His6-tagged TEV protease site linked DHPS expressed in Escherichia coli BL21 (DE3) assessed as reduction in radiolabel...				J Med Chem 63: 3215-3226 (2020) Article DOI: 10.1021/acs.jmedchem.9b01979 BindingDB Entry DOI: 10.7270/Q2K35Z1V
Takeda Pharmaceutical Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Deoxyhypusine synthase (Homo sapiens)	BDBM50216786 (CHEMBL229457 \| N-(7-Amino-heptyl)-guanidine \| N-gu...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Competitive inhibition of human N-terminal His6-tagged TEV protease site linked DHPS expressed in Escherichia coli BL21 (DE3) assessed as reduction i...				J Med Chem 63: 3215-3226 (2020) Article DOI: 10.1021/acs.jmedchem.9b01979 BindingDB Entry DOI: 10.7270/Q2K35Z1V
Takeda Pharmaceutical Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Deoxyhypusine synthase (Homo sapiens)	BDBM50216786 (CHEMBL229457 \| N-(7-Amino-heptyl)-guanidine \| N-gu...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.72E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of DHPS (unknown origin ) incubated for 30 mins by NAD/NADH-Glow assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00582 BindingDB Entry DOI: 10.7270/Q2BV7MH5
TBA					More data for this Ligand-Target Pair