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Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 454.4
BDBM96523

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Wt: 455.4
BDBM50482777

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 24 hits in this display
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Penicillin-binding protein 2x (Streptococcus pneumoniae)	BDBM50482777 (CHEBI:204928 \| Cefotaxime) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	219	n/a	n/a	n/a	n/a	n/a	n/a
Hershey Medical Center Curated by ChEMBL					Assay Description Binding affinity to penicillin-resistant Streptococcus pneumoniae 2527 PBP2X by competitive binding assay				Antimicrob Agents Chemother 54: 1670-7 (2010) Article DOI: 10.1128/AAC.00019-10 BindingDB Entry DOI: 10.7270/Q2B56NK6
Hershey Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Penicillin-binding protein 1A (Streptococcus pneumoniae serotype 4 (strain ATCC B...)	BDBM50482777 (CHEBI:204928 \| Cefotaxime) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	219	n/a	n/a	n/a	n/a	n/a	n/a
Hershey Medical Center Curated by ChEMBL					Assay Description Binding affinity to against penicillin-susceptible Streptococcus pneumoniae 1076 PBP1A by competitive binding assay				Antimicrob Agents Chemother 54: 1670-7 (2010) Article DOI: 10.1128/AAC.00019-10 BindingDB Entry DOI: 10.7270/Q2B56NK6
Hershey Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Penicillin-binding protein 1A (Streptococcus pneumoniae serotype 4 (strain ATCC B...)	BDBM50482777 (CHEBI:204928 \| Cefotaxime) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	274	n/a	n/a	n/a	n/a	n/a	n/a
Hershey Medical Center Curated by ChEMBL					Assay Description Binding affinity to penicillin-resistant Streptococcus pneumoniae 24 PBP1A by competitive binding assay				Antimicrob Agents Chemother 54: 1670-7 (2010) Article DOI: 10.1128/AAC.00019-10 BindingDB Entry DOI: 10.7270/Q2B56NK6
Hershey Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Penicillin-binding protein 1A (Streptococcus pneumoniae serotype 4 (strain ATCC B...)	BDBM50482777 (CHEBI:204928 \| Cefotaxime) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	548	n/a	n/a	n/a	n/a	n/a	n/a
Hershey Medical Center Curated by ChEMBL					Assay Description Binding affinity to penicillin-resistant Streptococcus pneumoniae 2527 PBP1A by competitive binding assay				Antimicrob Agents Chemother 54: 1670-7 (2010) Article DOI: 10.1128/AAC.00019-10 BindingDB Entry DOI: 10.7270/Q2B56NK6
Hershey Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Peptidase (Staphylococcus aureus)	BDBM50482777 (CHEBI:204928 \| Cefotaxime) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	548	n/a	n/a	n/a	n/a	n/a	n/a
Hershey Medical Center Curated by ChEMBL					Assay Description Binding affinity to against methicillin-, daptomycin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 25 PBP2a by co...				Antimicrob Agents Chemother 54: 1670-7 (2010) Article DOI: 10.1128/AAC.00019-10 BindingDB Entry DOI: 10.7270/Q2B56NK6
Hershey Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Penicillin-binding protein 2x (Streptococcus pneumoniae)	BDBM50482777 (CHEBI:204928 \| Cefotaxime) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	548	n/a	n/a	n/a	n/a	n/a	n/a
Hershey Medical Center Curated by ChEMBL					Assay Description Binding affinity to against penicillin-susceptible Streptococcus pneumoniae 1076 PBP2X by competitive binding assay				Antimicrob Agents Chemother 54: 1670-7 (2010) Article DOI: 10.1128/AAC.00019-10 BindingDB Entry DOI: 10.7270/Q2B56NK6
Hershey Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Penicillin-binding protein 1A (Streptococcus pneumoniae serotype 4 (strain ATCC B...)	BDBM50482777 (CHEBI:204928 \| Cefotaxime) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	548	n/a	n/a	n/a	n/a	n/a	n/a
Hershey Medical Center Curated by ChEMBL					Assay Description Binding affinity to penicillin-resistant Streptococcus pneumoniae 3413 PBP1A by competitive binding assay				Antimicrob Agents Chemother 54: 1670-7 (2010) Article DOI: 10.1128/AAC.00019-10 BindingDB Entry DOI: 10.7270/Q2B56NK6
Hershey Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Huntingtin (Homo sapiens (Human))	BDBM96523 (Cefotaxime sodium salt \| MLS002222330 \| SMR0013072...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	1.21E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay									PubChem Bioassay (2013) BindingDB Entry DOI: 10.7270/Q2N58K09
					More data for this Ligand-Target Pair
Penicillin-binding protein 2x (Streptococcus pneumoniae)	BDBM50482777 (CHEBI:204928 \| Cefotaxime) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	2.19E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hershey Medical Center Curated by ChEMBL					Assay Description Binding affinity to penicillin-resistant Streptococcus pneumoniae 24 PBP2X by competitive binding assay				Antimicrob Agents Chemother 54: 1670-7 (2010) Article DOI: 10.1128/AAC.00019-10 BindingDB Entry DOI: 10.7270/Q2B56NK6
Hershey Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Peptidase (Staphylococcus aureus)	BDBM50482777 (CHEBI:204928 \| Cefotaxime) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	2.19E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hershey Medical Center Curated by ChEMBL					Assay Description Binding affinity to methicillin-, vancomycin-resistant, beta-lactamase-positive Staphylococcus aureus 510 PBP2a by competitive binding assay				Antimicrob Agents Chemother 54: 1670-7 (2010) Article DOI: 10.1128/AAC.00019-10 BindingDB Entry DOI: 10.7270/Q2B56NK6
Hershey Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Peptidase (Staphylococcus aureus)	BDBM50482777 (CHEBI:204928 \| Cefotaxime) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	4.39E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hershey Medical Center Curated by ChEMBL					Assay Description Binding affinity to methicillin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 1287 PBP2a by competitive binding a...				Antimicrob Agents Chemother 54: 1670-7 (2010) Article DOI: 10.1128/AAC.00019-10 BindingDB Entry DOI: 10.7270/Q2B56NK6
Hershey Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Penicillin-binding protein 2B (Streptococcus pneumoniae serotype 4 (strain ATCC B...)	BDBM50482777 (CHEBI:204928 \| Cefotaxime) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	8.78E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hershey Medical Center Curated by ChEMBL					Assay Description Binding affinity to penicillin-resistant Streptococcus pneumoniae 2527 PBP2B by competitive binding assay				Antimicrob Agents Chemother 54: 1670-7 (2010) Article DOI: 10.1128/AAC.00019-10 BindingDB Entry DOI: 10.7270/Q2B56NK6
Hershey Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Penicillin-binding protein 2x (Streptococcus pneumoniae)	BDBM50482777 (CHEBI:204928 \| Cefotaxime) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	8.78E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hershey Medical Center Curated by ChEMBL					Assay Description Binding affinity to penicillin-resistant Streptococcus pneumoniae 3413 PBP2X by competitive binding assay				Antimicrob Agents Chemother 54: 1670-7 (2010) Article DOI: 10.1128/AAC.00019-10 BindingDB Entry DOI: 10.7270/Q2B56NK6
Hershey Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 4 (Homo sapiens (Human))	BDBM96523 (Cefotaxime sodium salt \| MLS002222330 \| SMR0013072...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...				Toxicol Sci 136: 216-41 (2013) Article DOI: 10.1093/toxsci/kft176 BindingDB Entry DOI: 10.7270/Q2JM2D2D
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Penicillin-binding protein 2B (Streptococcus pneumoniae serotype 4 (strain ATCC B...)	BDBM50482777 (CHEBI:204928 \| Cefotaxime) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	3.51E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hershey Medical Center Curated by ChEMBL					Assay Description Binding affinity to penicillin-resistant Streptococcus pneumoniae 3413 PBP2B by competitive binding assay				Antimicrob Agents Chemother 54: 1670-7 (2010) Article DOI: 10.1128/AAC.00019-10 BindingDB Entry DOI: 10.7270/Q2B56NK6
Hershey Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Penicillin-binding protein 2B (Streptococcus pneumoniae serotype 4 (strain ATCC B...)	BDBM50482777 (CHEBI:204928 \| Cefotaxime) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	3.51E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hershey Medical Center Curated by ChEMBL					Assay Description Binding affinity to penicillin-resistant Streptococcus pneumoniae 24 PBP2B by competitive binding assay				Antimicrob Agents Chemother 54: 1670-7 (2010) Article DOI: 10.1128/AAC.00019-10 BindingDB Entry DOI: 10.7270/Q2B56NK6
Hershey Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Penicillin-binding protein 2B (Streptococcus pneumoniae serotype 4 (strain ATCC B...)	BDBM50482777 (CHEBI:204928 \| Cefotaxime) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	>7.02E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hershey Medical Center Curated by ChEMBL					Assay Description Binding affinity to against penicillin-susceptible Streptococcus pneumoniae 1076 PBP2B by competitive binding assay				Antimicrob Agents Chemother 54: 1670-7 (2010) Article DOI: 10.1128/AAC.00019-10 BindingDB Entry DOI: 10.7270/Q2B56NK6
Hershey Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 2 (Homo sapiens (Human))	BDBM96523 (Cefotaxime sodium salt \| MLS002222330 \| SMR0013072...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...				Toxicol Sci 136: 216-41 (2013) Article DOI: 10.1093/toxsci/kft176 BindingDB Entry DOI: 10.7270/Q2JM2D2D
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 3 (Homo sapiens (Human))	BDBM96523 (Cefotaxime sodium salt \| MLS002222330 \| SMR0013072...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...				Toxicol Sci 136: 216-41 (2013) Article DOI: 10.1093/toxsci/kft176 BindingDB Entry DOI: 10.7270/Q2JM2D2D
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Bile salt export pump (Homo sapiens (Human))	BDBM96523 (Cefotaxime sodium salt \| MLS002222330 \| SMR0013072...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...				Toxicol Sci 136: 216-41 (2013) Article DOI: 10.1093/toxsci/kft176 BindingDB Entry DOI: 10.7270/Q2JM2D2D
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Peptidase (Staphylococcus aureus)	BDBM50482777 (CHEBI:204928 \| Cefotaxime) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	>2.81E+5	n/a	n/a	n/a	n/a	n/a	n/a
Hershey Medical Center Curated by ChEMBL					Assay Description Binding affinity to methicillin-resistant, heteroresistant vancomycin-intermediate, beta-lactamase-negative Staphylococcus aureus 873 PBP2a by compet...				Antimicrob Agents Chemother 54: 1670-7 (2010) Article DOI: 10.1128/AAC.00019-10 BindingDB Entry DOI: 10.7270/Q2B56NK6
Hershey Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Peptidase (Staphylococcus aureus)	BDBM50482777 (CHEBI:204928 \| Cefotaxime) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	>2.81E+5	n/a	n/a	n/a	n/a	n/a	n/a
Hershey Medical Center Curated by ChEMBL					Assay Description Binding affinity to methicillin-, linezolid-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 2149A PBP2a by competit...				Antimicrob Agents Chemother 54: 1670-7 (2010) Article DOI: 10.1128/AAC.00019-10 BindingDB Entry DOI: 10.7270/Q2B56NK6
Hershey Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Solute carrier family 22 member 8 (Rattus norvegicus)	BDBM50482777 (CHEBI:204928 \| Cefotaxime) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	8.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Kyorin University School of Medicine Curated by ChEMBL					Assay Description TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cells				Life Sci 70: 1861-74 (2002) Article DOI: 10.1016/s0024-3205(02)01500-x BindingDB Entry DOI: 10.7270/Q2SN0CV2
Kyorin University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Solute carrier family 22 member 6 (Rattus norvegicus)	BDBM50482777 (CHEBI:204928 \| Cefotaxime) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	>2.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Kyorin University School of Medicine Curated by ChEMBL					Assay Description TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cells				Life Sci 70: 1861-74 (2002) Article DOI: 10.1016/s0024-3205(02)01500-x BindingDB Entry DOI: 10.7270/Q2SN0CV2
Kyorin University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair