Found 5 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50315878
(2,5-bis(3-bromobenzylidene)cyclopentanone | CHEMBL...)Show SMILES Brc1cccc(\C=C2/CC\C(=C/c3cccc(Br)c3)C2=O)c1 Show InChI InChI=1S/C19H14Br2O/c20-17-5-1-3-13(11-17)9-15-7-8-16(19(15)22)10-14-4-2-6-18(21)12-14/h1-6,9-12H,7-8H2/b15-9+,16-10+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 97 | n/a | n/a | n/a | n/a | n/a | n/a |
Wenzhou Medical College
Curated by ChEMBL
| Assay Description Inhibition of human 11beta-HSD1 transfected in CHOP cells |
Bioorg Med Chem Lett 23: 4362-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.080 BindingDB Entry DOI: 10.7270/Q27D2WJM |
More data for this Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Rattus norvegicus (rat)) | BDBM50315878
(2,5-bis(3-bromobenzylidene)cyclopentanone | CHEMBL...)Show SMILES Brc1cccc(\C=C2/CC\C(=C/c3cccc(Br)c3)C2=O)c1 Show InChI InChI=1S/C19H14Br2O/c20-17-5-1-3-13(11-17)9-15-7-8-16(19(15)22)10-14-4-2-6-18(21)12-14/h1-6,9-12H,7-8H2/b15-9+,16-10+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 599 | n/a | n/a | n/a | n/a | n/a | n/a |
Wenzhou Medical College
Curated by ChEMBL
| Assay Description Inhibition of 11beta-HSD1 in rat testis microsomes using [3H]-11-DHC as substrate assessed as formation of CORT after 60 to 90 mins by radiometric an... |
Bioorg Med Chem Lett 23: 4362-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.080 BindingDB Entry DOI: 10.7270/Q27D2WJM |
More data for this Ligand-Target Pair | |
17-beta-hydroxysteroid dehydrogenase type 3
(Rattus norvegicus) | BDBM50315878
(2,5-bis(3-bromobenzylidene)cyclopentanone | CHEMBL...)Show SMILES Brc1cccc(\C=C2/CC\C(=C/c3cccc(Br)c3)C2=O)c1 Show InChI InChI=1S/C19H14Br2O/c20-17-5-1-3-13(11-17)9-15-7-8-16(19(15)22)10-14-4-2-6-18(21)12-14/h1-6,9-12H,7-8H2/b15-9+,16-10+ | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
School of Pharmacy
Curated by ChEMBL
| Assay Description Inhibition of 17beta-HSD3 in Sprague-Dawley rat testis microsomes |
Bioorg Med Chem Lett 20: 2549-51 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.089 BindingDB Entry DOI: 10.7270/Q2R211J3 |
More data for this Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Rattus norvegicus (rat)) | BDBM50315878
(2,5-bis(3-bromobenzylidene)cyclopentanone | CHEMBL...)Show SMILES Brc1cccc(\C=C2/CC\C(=C/c3cccc(Br)c3)C2=O)c1 Show InChI InChI=1S/C19H14Br2O/c20-17-5-1-3-13(11-17)9-15-7-8-16(19(15)22)10-14-4-2-6-18(21)12-14/h1-6,9-12H,7-8H2/b15-9+,16-10+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.15E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wenzhou Medical College
Curated by ChEMBL
| Assay Description Inhibition of 11beta-HSD1 in Sprague-Dawley rat leydig cells at 100 uM |
Bioorg Med Chem Lett 23: 4362-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.080 BindingDB Entry DOI: 10.7270/Q27D2WJM |
More data for this Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50315878
(2,5-bis(3-bromobenzylidene)cyclopentanone | CHEMBL...)Show SMILES Brc1cccc(\C=C2/CC\C(=C/c3cccc(Br)c3)C2=O)c1 Show InChI InChI=1S/C19H14Br2O/c20-17-5-1-3-13(11-17)9-15-7-8-16(19(15)22)10-14-4-2-6-18(21)12-14/h1-6,9-12H,7-8H2/b15-9+,16-10+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wenzhou Medical College
Curated by ChEMBL
| Assay Description Inhibition of 11beta-HSD1 in human liver microsomes using [3H]-cortisone as substrate assessed as formation of cortisol after 60 to 90 mins by radiom... |
Bioorg Med Chem Lett 23: 4362-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.080 BindingDB Entry DOI: 10.7270/Q27D2WJM |
More data for this Ligand-Target Pair | |