Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = '11-beta-hydroxysteroid dehydrogenase 1' and Ligand = 'BDBM50315878'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50315878 (2,5-bis(3-bromobenzylidene)cyclopentanone | CHEMBL...) Show SMILES Brc1cccc(\C=C2/CC\C(=C/c3cccc(Br)c3)C2=O)c1 Show InChI InChI=1S/C19H14Br2O/c20-17-5-1-3-13(11-17)9-15-7-8-16(19(15)22)10-14-4-2-6-18(21)12-14/h1-6,9-12H,7-8H2/b15-9+,16-10+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	97	n/a	n/a	n/a	n/a	n/a	n/a
Wenzhou Medical College Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 transfected in CHOP cells				Bioorg Med Chem Lett 23: 4362-6 (2013) Article DOI: 10.1016/j.bmcl.2013.05.080 BindingDB Entry DOI: 10.7270/Q27D2WJM
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Rattus norvegicus (rat))	BDBM50315878 (2,5-bis(3-bromobenzylidene)cyclopentanone | CHEMBL...) Show SMILES Brc1cccc(\C=C2/CC\C(=C/c3cccc(Br)c3)C2=O)c1 Show InChI InChI=1S/C19H14Br2O/c20-17-5-1-3-13(11-17)9-15-7-8-16(19(15)22)10-14-4-2-6-18(21)12-14/h1-6,9-12H,7-8H2/b15-9+,16-10+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	599	n/a	n/a	n/a	n/a	n/a	n/a
Wenzhou Medical College Curated by ChEMBL					Assay Description Inhibition of 11beta-HSD1 in rat testis microsomes using [3H]-11-DHC as substrate assessed as formation of CORT after 60 to 90 mins by radiometric an...				Bioorg Med Chem Lett 23: 4362-6 (2013) Article DOI: 10.1016/j.bmcl.2013.05.080 BindingDB Entry DOI: 10.7270/Q27D2WJM
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Rattus norvegicus (rat))	BDBM50315878 (2,5-bis(3-bromobenzylidene)cyclopentanone | CHEMBL...) Show SMILES Brc1cccc(\C=C2/CC\C(=C/c3cccc(Br)c3)C2=O)c1 Show InChI InChI=1S/C19H14Br2O/c20-17-5-1-3-13(11-17)9-15-7-8-16(19(15)22)10-14-4-2-6-18(21)12-14/h1-6,9-12H,7-8H2/b15-9+,16-10+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.15E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wenzhou Medical College Curated by ChEMBL					Assay Description Inhibition of 11beta-HSD1 in Sprague-Dawley rat leydig cells at 100 uM				Bioorg Med Chem Lett 23: 4362-6 (2013) Article DOI: 10.1016/j.bmcl.2013.05.080 BindingDB Entry DOI: 10.7270/Q27D2WJM
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50315878 (2,5-bis(3-bromobenzylidene)cyclopentanone | CHEMBL...) Show SMILES Brc1cccc(\C=C2/CC\C(=C/c3cccc(Br)c3)C2=O)c1 Show InChI InChI=1S/C19H14Br2O/c20-17-5-1-3-13(11-17)9-15-7-8-16(19(15)22)10-14-4-2-6-18(21)12-14/h1-6,9-12H,7-8H2/b15-9+,16-10+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.51E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wenzhou Medical College Curated by ChEMBL					Assay Description Inhibition of 11beta-HSD1 in human liver microsomes using [3H]-cortisone as substrate assessed as formation of cortisol after 60 to 90 mins by radiom...				Bioorg Med Chem Lett 23: 4362-6 (2013) Article DOI: 10.1016/j.bmcl.2013.05.080 BindingDB Entry DOI: 10.7270/Q27D2WJM
					More data for this Ligand-Target Pair