Found 3 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
C-X-C chemokine receptor type 3
(Homo sapiens (Human)) | BDBM50361980
(CHEMBL1939555)Show SMILES C[C@@H](N(CC1CCS(=O)(=O)CC1)C(=O)Cc1ccc(OC(F)(F)F)cc1)c1nc2ccccn2c(=O)c1-c1ccc(cc1)C#N |r| Show InChI InChI=1S/C32H29F3N4O5S/c1-21(30-29(25-9-5-23(19-36)6-10-25)31(41)38-15-3-2-4-27(38)37-30)39(20-24-13-16-45(42,43)17-14-24)28(40)18-22-7-11-26(12-8-22)44-32(33,34)35/h2-12,15,21,24H,13-14,16-18,20H2,1H3/t21-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-IP-10 from CXCR3 |
Bioorg Med Chem Lett 22: 357-62 (2011)
Article DOI: 10.1016/j.bmcl.2011.10.120
BindingDB Entry DOI: 10.7270/Q2S75GS5 |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 3
(Homo sapiens (Human)) | BDBM50361980
(CHEMBL1939555)Show SMILES C[C@@H](N(CC1CCS(=O)(=O)CC1)C(=O)Cc1ccc(OC(F)(F)F)cc1)c1nc2ccccn2c(=O)c1-c1ccc(cc1)C#N |r| Show InChI InChI=1S/C32H29F3N4O5S/c1-21(30-29(25-9-5-23(19-36)6-10-25)31(41)38-15-3-2-4-27(38)37-30)39(20-24-13-16-45(42,43)17-14-24)28(40)18-22-7-11-26(12-8-22)44-32(33,34)35/h2-12,15,21,24H,13-14,16-18,20H2,1H3/t21-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-IP-10 from CXCR3 in presence of 100% human serum |
Bioorg Med Chem Lett 22: 357-62 (2011)
Article DOI: 10.1016/j.bmcl.2011.10.120
BindingDB Entry DOI: 10.7270/Q2S75GS5 |
More data for this
Ligand-Target Pair | |
C-X-C chemokine receptor type 3
(Homo sapiens (Human)) | BDBM50361980
(CHEMBL1939555)Show SMILES C[C@@H](N(CC1CCS(=O)(=O)CC1)C(=O)Cc1ccc(OC(F)(F)F)cc1)c1nc2ccccn2c(=O)c1-c1ccc(cc1)C#N |r| Show InChI InChI=1S/C32H29F3N4O5S/c1-21(30-29(25-9-5-23(19-36)6-10-25)31(41)38-15-3-2-4-27(38)37-30)39(20-24-13-16-45(42,43)17-14-24)28(40)18-22-7-11-26(12-8-22)44-32(33,34)35/h2-12,15,21,24H,13-14,16-18,20H2,1H3/t21-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at CXCR3 assessed as inhibition of ITAC-mediated cell migration in presence of 100% human serum |
Bioorg Med Chem Lett 22: 357-62 (2011)
Article DOI: 10.1016/j.bmcl.2011.10.120
BindingDB Entry DOI: 10.7270/Q2S75GS5 |
More data for this
Ligand-Target Pair | |