Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Programmed cell death 1 ligand 1
(Homo sapiens (Human)) | BDBM482313
(US10919852, Compound TABLE 1.12 | US11708326, Comp...)Show SMILES C[C@@H](O)[C@H](NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2cccc(OCCCN3CCC[C@@H](O)C3)c2C)cc1OCc1cncc(c1)C#N)C(O)=O |r| Show InChI InChI=1S/C42H47ClN4O7/c1-26-32(8-4-11-37(26)52-16-6-15-47-14-5-7-31(49)24-47)33-9-3-10-35-34(33)12-13-38(35)54-40-19-39(53-25-29-17-28(20-44)21-45-22-29)30(18-36(40)43)23-46-41(27(2)48)42(50)51/h3-4,8-11,17-19,21-22,27,31,38,41,46,48-49H,5-7,12-16,23-25H2,1-2H3,(H,50,51)/t27-,31-,38+,41+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q22N56DJ |
More data for this Ligand-Target Pair | |
Programmed cell death protein 1
(Homo sapiens) | BDBM482313
(US10919852, Compound TABLE 1.12 | US11708326, Comp...)Show SMILES C[C@@H](O)[C@H](NCc1cc(Cl)c(O[C@H]2CCc3c2cccc3-c2cccc(OCCCN3CCC[C@@H](O)C3)c2C)cc1OCc1cncc(c1)C#N)C(O)=O |r| Show InChI InChI=1S/C42H47ClN4O7/c1-26-32(8-4-11-37(26)52-16-6-15-47-14-5-7-31(49)24-47)33-9-3-10-35-34(33)12-13-38(35)54-40-19-39(53-25-29-17-28(20-44)21-45-22-29)30(18-36(40)43)23-46-41(27(2)48)42(50)51/h3-4,8-11,17-19,21-22,27,31,38,41,46,48-49H,5-7,12-16,23-25H2,1-2H3,(H,50,51)/t27-,31-,38+,41+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
ChemoCentryx, Inc.
US Patent
| Assay Description 96 Well plates were coated with 1 g/mL of human PD-L1 (obtained from R&D) in PBS overnight at 4° C. The wells were then blocked with 2% BSA in PBS (W... |
US Patent US10919852 (2021)
BindingDB Entry DOI: 10.7270/Q2RF5Z3R |
More data for this Ligand-Target Pair | |