Found 3 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Beta-secretase 1
(Homo sapiens (Human)) | BDBM214905
(US9296734, 104)Show SMILES CC#Cc1cncc(c1)-c1ccc(F)c(c1)[C@]1(CF)C[C@H](OC(N)=N1)C(F)(F)F |r,c:25| Show InChI InChI=1S/C20H16F5N3O/c1-2-3-12-6-14(10-27-9-12)13-4-5-16(22)15(7-13)19(11-21)8-17(20(23,24)25)29-18(26)28-19/h4-7,9-10,17H,8,11H2,1H3,(H2,26,28)/t17-,19+/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 318 | n/a | n/a | n/a | n/a | 4.2 | n/a |
Amgen Inc.
US Patent
| Assay Description
The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic... |
US Patent US9296734 (2016)
BindingDB Entry DOI: 10.7270/Q2DR2TB3 |
More data for this
Ligand-Target Pair | |
Beta-secretase 1
(Homo sapiens (Human)) | BDBM214905
(US9296734, 104)Show SMILES CC#Cc1cncc(c1)-c1ccc(F)c(c1)[C@]1(CF)C[C@H](OC(N)=N1)C(F)(F)F |r,c:25| Show InChI InChI=1S/C20H16F5N3O/c1-2-3-12-6-14(10-27-9-12)13-4-5-16(22)15(7-13)19(11-21)8-17(20(23,24)25)29-18(26)28-19/h4-7,9-10,17H,8,11H2,1H3,(H2,26,28)/t17-,19+/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.25E+3 | n/a | n/a | n/a | n/a | n/a | 37 |
Amgen Inc.
US Patent
| Assay Description
The cell-based assay measures inhibition or reduction of Aβ40 in conditioned medium of test compound treated cells expressing amyloid precursor ... |
US Patent US9296734 (2016)
BindingDB Entry DOI: 10.7270/Q2DR2TB3 |
More data for this
Ligand-Target Pair | |
Cathepsin D
(Homo sapiens (Human)) | BDBM214905
(US9296734, 104)Show SMILES CC#Cc1cncc(c1)-c1ccc(F)c(c1)[C@]1(CF)C[C@H](OC(N)=N1)C(F)(F)F |r,c:25| Show InChI InChI=1S/C20H16F5N3O/c1-2-3-12-6-14(10-27-9-12)13-4-5-16(22)15(7-13)19(11-21)8-17(20(23,24)25)29-18(26)28-19/h4-7,9-10,17H,8,11H2,1H3,(H2,26,28)/t17-,19+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.20E+5 | n/a | n/a | n/a | n/a | 3.5 | n/a |
Amgen Inc.
US Patent
| Assay Description
Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ... |
US Patent US9296734 (2016)
BindingDB Entry DOI: 10.7270/Q2DR2TB3 |
More data for this
Ligand-Target Pair | |