Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 357.4 BDBM50511263

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Acid ceramidase (Homo sapiens (Human))	BDBM50511263 (CHEMBL4448689) Show SMILES CC(=O)N1CCc2oc(=O)n(C(=O)NCCCCc3ccccc3)c2C1 Show InChI InChI=1S/C19H23N3O4/c1-14(23)21-12-10-17-16(13-21)22(19(25)26-17)18(24)20-11-6-5-9-15-7-3-2-4-8-15/h2-4,7-8H,5-6,9-13H2,1H3,(H,20,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	293	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Inhibition of human acid ceramidase expressed in HEK293 cells using Rbm14-12 as substrate preincubated for 10 mins followed by substrate addition and...				J Med Chem 63: 3634-3664 (2020) Article DOI: 10.1021/acs.jmedchem.9b02004 BindingDB Entry DOI: 10.7270/Q20C503N
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