Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Leukotriene A-4 hydrolase
(Homo sapiens (Human)) | BDBM24230
(Benzthiazole compound, 27o | [(1-{2-[4-(1,3-benzot...)Show SMILES CC(=O)OCC(=O)NC1CCN(CCc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C24H27N3O4S/c1-17(28)30-16-23(29)25-19-11-14-27(15-12-19)13-10-18-6-8-20(9-7-18)31-24-26-21-4-2-3-5-22(21)32-24/h2-9,19H,10-16H2,1H3,(H,25,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | 25 |
Johnson & Johnson Pharmaceutical
| Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,... |
J Med Chem 51: 4150-69 (2008)
Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM24230
(Benzthiazole compound, 27o | [(1-{2-[4-(1,3-benzot...)Show SMILES CC(=O)OCC(=O)NC1CCN(CCc2ccc(Oc3nc4ccccc4s3)cc2)CC1 Show InChI InChI=1S/C24H27N3O4S/c1-17(28)30-16-23(29)25-19-11-14-27(15-12-19)13-10-18-6-8-20(9-7-18)31-24-26-21-4-2-3-5-22(21)32-24/h2-9,19H,10-16H2,1H3,(H,25,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical
| Assay Description Compounds were assessed for their ability to displace [3H]astemizole using membranes from HEK-293 cells expressing the hERG K+ channel. |
J Med Chem 51: 4150-69 (2008)
Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX |
More data for this Ligand-Target Pair | |