Found 8 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Ubiquitin carboxyl-terminal hydrolase 30
(Homo sapiens (Human)) | BDBM489702
((R)-N-(1-((5-(N-(tert- butyl)sulfamoyl)naphthalen-...)Show SMILES CC(C)(C)NS(=O)(=O)c1cccc2c(NC(=O)[C@@H](Cc3ccccc3)NC(=O)c3ccccc3)cccc12 |r| Show InChI InChI=1S/C30H31N3O4S/c1-30(2,3)33-38(36,37)27-19-11-16-23-24(27)17-10-18-25(23)31-29(35)26(20-21-12-6-4-7-13-21)32-28(34)22-14-8-5-9-15-22/h4-19,26,33H,20H2,1-3H3,(H,31,35)(H,32,34)/t26-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| US Patent
| n/a | n/a | 248 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitobridge, Inc.
US Patent
| Assay Description The in vitro assay for USP30 evaluates the ability of a test compound to inhibit the activity of the enzyme to cleave ubiquitin from a substrate. Ubi... |
US Patent US10968172 (2021)
BindingDB Entry DOI: 10.7270/Q2P27274 |
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 30
(Homo sapiens (Human)) | BDBM489702
((R)-N-(1-((5-(N-(tert- butyl)sulfamoyl)naphthalen-...)Show SMILES CC(C)(C)NS(=O)(=O)c1cccc2c(NC(=O)[C@@H](Cc3ccccc3)NC(=O)c3ccccc3)cccc12 |r| Show InChI InChI=1S/C30H31N3O4S/c1-30(2,3)33-38(36,37)27-19-11-16-23-24(27)17-10-18-25(23)31-29(35)26(20-21-12-6-4-7-13-21)32-28(34)22-14-8-5-9-15-22/h4-19,26,33H,20H2,1-3H3,(H,31,35)(H,32,34)/t26-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
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PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of USP30 (unknown origin) using Ubiquitin-Rhodamine110-Glycine as substrate incubated for 15 mins followed by substrate addition and measu... |
Citation and Details
Article DOI: 10.1016/j.bmcl.2018.05.013 BindingDB Entry DOI: 10.7270/Q2NK3JNN |
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 30
(Homo sapiens (Human)) | BDBM489703
((S)-N-(1-((5-(N-(tert- butyl)sulfamoyl)naphthalen-...)Show SMILES CC(C)(C)NS(=O)(=O)c1cccc2c(NC(=O)[C@H](Cc3ccccc3)NC(=O)c3ccccc3)cccc12 |r| Show InChI InChI=1S/C30H31N3O4S/c1-30(2,3)33-38(36,37)27-19-11-16-23-24(27)17-10-18-25(23)31-29(35)26(20-21-12-6-4-7-13-21)32-28(34)22-14-8-5-9-15-22/h4-19,26,33H,20H2,1-3H3,(H,31,35)(H,32,34)/t26-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of USP30 (unknown origin) using Ubiquitin-Rhodamine110-Glycine as substrate incubated for 15 mins followed by substrate addition and measu... |
Citation and Details
Article DOI: 10.1016/j.bmcl.2018.05.013 BindingDB Entry DOI: 10.7270/Q2NK3JNN |
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 30
(Homo sapiens (Human)) | BDBM489703
((S)-N-(1-((5-(N-(tert- butyl)sulfamoyl)naphthalen-...)Show SMILES CC(C)(C)NS(=O)(=O)c1cccc2c(NC(=O)[C@H](Cc3ccccc3)NC(=O)c3ccccc3)cccc12 |r| Show InChI InChI=1S/C30H31N3O4S/c1-30(2,3)33-38(36,37)27-19-11-16-23-24(27)17-10-18-25(23)31-29(35)26(20-21-12-6-4-7-13-21)32-28(34)22-14-8-5-9-15-22/h4-19,26,33H,20H2,1-3H3,(H,31,35)(H,32,34)/t26-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| US Patent
| n/a | n/a | 273 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitobridge, Inc.
US Patent
| Assay Description The in vitro assay for USP30 evaluates the ability of a test compound to inhibit the activity of the enzyme to cleave ubiquitin from a substrate. Ubi... |
US Patent US10968172 (2021)
BindingDB Entry DOI: 10.7270/Q2P27274 |
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 30
(Homo sapiens (Human)) | BDBM50548233
(CHEMBL4756029)Show SMILES CC(C)(C)NS(=O)(=O)c1cccc2c(NC(=O)C(Cc3ccccc3)NC(=O)c3ccccc3)cccc12 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of USP30 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2018.05.013 BindingDB Entry DOI: 10.7270/Q2NK3JNN |
More data for this Ligand-Target Pair | |
Probable ubiquitin carboxyl-terminal hydrolase FAF-X
(Homo sapiens (Human)) | BDBM50548233
(CHEMBL4756029)Show SMILES CC(C)(C)NS(=O)(=O)c1cccc2c(NC(=O)C(Cc3ccccc3)NC(=O)c3ccccc3)cccc12 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of USP9 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2018.05.013 BindingDB Entry DOI: 10.7270/Q2NK3JNN |
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 8
(Homo sapiens (Human)) | BDBM50548233
(CHEMBL4756029)Show SMILES CC(C)(C)NS(=O)(=O)c1cccc2c(NC(=O)C(Cc3ccccc3)NC(=O)c3ccccc3)cccc12 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of USP8 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2018.05.013 BindingDB Entry DOI: 10.7270/Q2NK3JNN |
More data for this Ligand-Target Pair | |
Ubiquitin carboxyl-terminal hydrolase 1
(Homo sapiens (Human)) | BDBM50548233
(CHEMBL4756029)Show SMILES CC(C)(C)NS(=O)(=O)c1cccc2c(NC(=O)C(Cc3ccccc3)NC(=O)c3ccccc3)cccc12 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of USP1 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2018.05.013 BindingDB Entry DOI: 10.7270/Q2NK3JNN |
More data for this Ligand-Target Pair | |