| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Ubiquitin carboxyl-terminal hydrolase 30 |
|---|
| Ligand | BDBM489703 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2020815 (CHEMBL4674628) |
|---|
| IC50 | 270±n/a nM |
|---|
| Citation |  Kluge, AF; Lagu, BR; Maiti, P; Jaleel, M; Webb, M; Malhotra, J; Mallat, A; Srinivas, PA; Thompson, JE Novel highly selective inhibitors of ubiquitin specific protease 30 (USP30) accelerate mitophagy. Bioorg Med Chem Lett28:2655-2659 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Ubiquitin carboxyl-terminal hydrolase 30 |
|---|
| Name: | Ubiquitin carboxyl-terminal hydrolase 30 |
|---|
| Synonyms: | Deubiquitinating enzyme 30 | UBP30_HUMAN | USP30 | Ub-specific protease 30 | Ubiquitin carboxyl-terminal hydrolase 30 (USP30) | Ubiquitin thioesterase 30 | Ubiquitin-specific-processing protease 30 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 58522.90 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q70CQ3 |
|---|
| Residue: | 517 |
|---|
| Sequence: | MLSSRAEAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERK
KRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTL
LHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQ
PRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQ
SPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEK
VEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLG
HKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQIFMNGACSPSLLPTLSAPMP
FPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDT
VRKASLQEVLSSSAYLLFYERVLSRMQHQSQECKSEE
|
|
|
|---|
| BDBM489703 |
|---|
| n/a |
|---|
| Name | BDBM489703 |
|---|
| Synonyms: | (S)-N-(1-((5-(N-(tert- butyl)sulfamoyl)naphthalen-1- yl)amino)-1-oxo-3-phenylpropan- 2-yl)benzamide | US10968172, ID # 4b |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H31N3O4S |
|---|
| Mol. Mass. | 529.65 |
|---|
| SMILES | CC(C)(C)NS(=O)(=O)c1cccc2c(NC(=O)[C@H](Cc3ccccc3)NC(=O)c3ccccc3)cccc12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
