Found 6 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM340938
(N-(4-(4-amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)Show SMILES CC(C)(C)n1nc(-c2ccc(NC(=O)C3CCCC3)cc2)c2c(N)ncnc12 Show InChI InChI=1S/C21H26N6O/c1-21(2,3)27-19-16(18(22)23-12-24-19)17(26-27)13-8-10-15(11-9-13)25-20(28)14-6-4-5-7-14/h8-12,14H,4-7H2,1-3H3,(H,25,28)(H2,22,23,24) | PDB
UniProtKB/TrEMBL
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 46.2 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center for Commercialization
US Patent
| Assay Description
Most known kinase inhibitors bind in the ATP-binding pocket of the active site19,20. These inhibitors exploit many of the same hydrophobic contacts a... |
US Patent US9765037 (2017)
BindingDB Entry DOI: 10.7270/Q2B56MVC |
More data for this
Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM340938
(N-(4-(4-amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)Show SMILES CC(C)(C)n1nc(-c2ccc(NC(=O)C3CCCC3)cc2)c2c(N)ncnc12 Show InChI InChI=1S/C21H26N6O/c1-21(2,3)27-19-16(18(22)23-12-24-19)17(26-27)13-8-10-15(11-9-13)25-20(28)14-6-4-5-7-14/h8-12,14H,4-7H2,1-3H3,(H,25,28)(H2,22,23,24) | PDB
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 46.2 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO
US Patent
| Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US10544104 (2020)
BindingDB Entry DOI: 10.7270/Q2D79DSF |
More data for this
Ligand-Target Pair | |
cGMP-dependent protein kinase
() | BDBM340938
(N-(4-(4-amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)Show SMILES CC(C)(C)n1nc(-c2ccc(NC(=O)C3CCCC3)cc2)c2c(N)ncnc12 Show InChI InChI=1S/C21H26N6O/c1-21(2,3)27-19-16(18(22)23-12-24-19)17(26-27)13-8-10-15(11-9-13)25-20(28)14-6-4-5-7-14/h8-12,14H,4-7H2,1-3H3,(H,25,28)(H2,22,23,24) | UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 46.2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K077GQ |
More data for this
Ligand-Target Pair | |
Calmodulin-domain protein kinase 1, putative
(Cryptosporidium parvum (strain Iowa II)) | BDBM340938
(N-(4-(4-amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)Show SMILES CC(C)(C)n1nc(-c2ccc(NC(=O)C3CCCC3)cc2)c2c(N)ncnc12 Show InChI InChI=1S/C21H26N6O/c1-21(2,3)27-19-16(18(22)23-12-24-19)17(26-27)13-8-10-15(11-9-13)25-20(28)14-6-4-5-7-14/h8-12,14H,4-7H2,1-3H3,(H,25,28)(H2,22,23,24) | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 417 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO
US Patent
| Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US10544104 (2020)
BindingDB Entry DOI: 10.7270/Q2D79DSF |
More data for this
Ligand-Target Pair | |
Calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands
(Cryptosporidium parvum (strain Iowa II)) | BDBM340938
(N-(4-(4-amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)Show SMILES CC(C)(C)n1nc(-c2ccc(NC(=O)C3CCCC3)cc2)c2c(N)ncnc12 Show InChI InChI=1S/C21H26N6O/c1-21(2,3)27-19-16(18(22)23-12-24-19)17(26-27)13-8-10-15(11-9-13)25-20(28)14-6-4-5-7-14/h8-12,14H,4-7H2,1-3H3,(H,25,28)(H2,22,23,24) | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 417 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K077GQ |
More data for this
Ligand-Target Pair | |
Calcium-dependent protein kinase 1
(Cryptosporidium parvum) | BDBM340938
(N-(4-(4-amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)Show SMILES CC(C)(C)n1nc(-c2ccc(NC(=O)C3CCCC3)cc2)c2c(N)ncnc12 Show InChI InChI=1S/C21H26N6O/c1-21(2,3)27-19-16(18(22)23-12-24-19)17(26-27)13-8-10-15(11-9-13)25-20(28)14-6-4-5-7-14/h8-12,14H,4-7H2,1-3H3,(H,25,28)(H2,22,23,24) | UniProtKB/TrEMBL
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 417 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center for Commercialization
US Patent
| Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha... |
US Patent US9765037 (2017)
BindingDB Entry DOI: 10.7270/Q2B56MVC |
More data for this
Ligand-Target Pair | |