Found 6 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM340939
(N-(4-(4-amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)Show SMILES CC(C)(C)n1nc(-c2ccc(NC(=O)C3CCCCC3)cc2)c2c(N)ncnc12 Show InChI InChI=1S/C22H28N6O/c1-22(2,3)28-20-17(19(23)24-13-25-20)18(27-28)14-9-11-16(12-10-14)26-21(29)15-7-5-4-6-8-15/h9-13,15H,4-8H2,1-3H3,(H,26,29)(H2,23,24,25) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 143 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center for Commercialization
US Patent
| Assay Description Most known kinase inhibitors bind in the ATP-binding pocket of the active site19,20. These inhibitors exploit many of the same hydrophobic contacts a... |
US Patent US9765037 (2017)
BindingDB Entry DOI: 10.7270/Q2B56MVC |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM340939
(N-(4-(4-amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)Show SMILES CC(C)(C)n1nc(-c2ccc(NC(=O)C3CCCCC3)cc2)c2c(N)ncnc12 Show InChI InChI=1S/C22H28N6O/c1-22(2,3)28-20-17(19(23)24-13-25-20)18(27-28)14-9-11-16(12-10-14)26-21(29)15-7-5-4-6-8-15/h9-13,15H,4-8H2,1-3H3,(H,26,29)(H2,23,24,25) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 143 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US10544104 (2020)
BindingDB Entry DOI: 10.7270/Q2D79DSF |
More data for this Ligand-Target Pair | |
cGMP-dependent protein kinase
() | BDBM340939
(N-(4-(4-amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)Show SMILES CC(C)(C)n1nc(-c2ccc(NC(=O)C3CCCCC3)cc2)c2c(N)ncnc12 Show InChI InChI=1S/C22H28N6O/c1-22(2,3)28-20-17(19(23)24-13-25-20)18(27-28)14-9-11-16(12-10-14)26-21(29)15-7-5-4-6-8-15/h9-13,15H,4-8H2,1-3H3,(H,26,29)(H2,23,24,25) | UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 143 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K077GQ |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1, putative
(Cryptosporidium parvum (strain Iowa II)) | BDBM340939
(N-(4-(4-amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)Show SMILES CC(C)(C)n1nc(-c2ccc(NC(=O)C3CCCCC3)cc2)c2c(N)ncnc12 Show InChI InChI=1S/C22H28N6O/c1-22(2,3)28-20-17(19(23)24-13-25-20)18(27-28)14-9-11-16(12-10-14)26-21(29)15-7-5-4-6-8-15/h9-13,15H,4-8H2,1-3H3,(H,26,29)(H2,23,24,25) | PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 928 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US10544104 (2020)
BindingDB Entry DOI: 10.7270/Q2D79DSF |
More data for this Ligand-Target Pair | |
Calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands
(Cryptosporidium parvum (strain Iowa II)) | BDBM340939
(N-(4-(4-amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)Show SMILES CC(C)(C)n1nc(-c2ccc(NC(=O)C3CCCCC3)cc2)c2c(N)ncnc12 Show InChI InChI=1S/C22H28N6O/c1-22(2,3)28-20-17(19(23)24-13-25-20)18(27-28)14-9-11-16(12-10-14)26-21(29)15-7-5-4-6-8-15/h9-13,15H,4-8H2,1-3H3,(H,26,29)(H2,23,24,25) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 928 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K077GQ |
More data for this Ligand-Target Pair | |
Calcium-dependent protein kinase 1
(Cryptosporidium parvum) | BDBM340939
(N-(4-(4-amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)Show SMILES CC(C)(C)n1nc(-c2ccc(NC(=O)C3CCCCC3)cc2)c2c(N)ncnc12 Show InChI InChI=1S/C22H28N6O/c1-22(2,3)28-20-17(19(23)24-13-25-20)18(27-28)14-9-11-16(12-10-14)26-21(29)15-7-5-4-6-8-15/h9-13,15H,4-8H2,1-3H3,(H,26,29)(H2,23,24,25) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 928 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center for Commercialization
US Patent
| Assay Description Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha... |
US Patent US9765037 (2017)
BindingDB Entry DOI: 10.7270/Q2B56MVC |
More data for this Ligand-Target Pair | |