Found 11 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM50389691
(CHEMBL2070057 | US10544104, Compound 43 | US112479...)Show SMILES CC(C)COc1ccc2cc(ccc2c1)-c1nn(C(C)C)c2ncnc(N)c12 Show InChI InChI=1S/C22H25N5O/c1-13(2)11-28-18-8-7-15-9-17(6-5-16(15)10-18)20-19-21(23)24-12-25-22(19)27(26-20)14(3)4/h5-10,12-14H,11H2,1-4H3,(H2,23,24,25) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US10544104 (2020)
BindingDB Entry DOI: 10.7270/Q2D79DSF |
More data for this Ligand-Target Pair | |
cGMP-dependent protein kinase
() | BDBM50389691
(CHEMBL2070057 | US10544104, Compound 43 | US112479...)Show SMILES CC(C)COc1ccc2cc(ccc2c1)-c1nn(C(C)C)c2ncnc(N)c12 Show InChI InChI=1S/C22H25N5O/c1-13(2)11-28-18-8-7-15-9-17(6-5-16(15)10-18)20-19-21(23)24-12-25-22(19)27(26-20)14(3)4/h5-10,12-14H,11H2,1-4H3,(H2,23,24,25) | UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K077GQ |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM50389691
(CHEMBL2070057 | US10544104, Compound 43 | US112479...)Show SMILES CC(C)COc1ccc2cc(ccc2c1)-c1nn(C(C)C)c2ncnc(N)c12 Show InChI InChI=1S/C22H25N5O/c1-13(2)11-28-18-8-7-15-9-17(6-5-16(15)10-18)20-19-21(23)24-12-25-22(19)27(26-20)14(3)4/h5-10,12-14H,11H2,1-4H3,(H2,23,24,25) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center for Commercialization
US Patent
| Assay Description Most known kinase inhibitors bind in the ATP-binding pocket of the active site19,20. These inhibitors exploit many of the same hydrophobic contacts a... |
US Patent US9765037 (2017)
BindingDB Entry DOI: 10.7270/Q2B56MVC |
More data for this Ligand-Target Pair | |
Calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands
(Cryptosporidium parvum (strain Iowa II)) | BDBM50389691
(CHEMBL2070057 | US10544104, Compound 43 | US112479...)Show SMILES CC(C)COc1ccc2cc(ccc2c1)-c1nn(C(C)C)c2ncnc(N)c12 Show InChI InChI=1S/C22H25N5O/c1-13(2)11-28-18-8-7-15-9-17(6-5-16(15)10-18)20-19-21(23)24-12-25-22(19)27(26-20)14(3)4/h5-10,12-14H,11H2,1-4H3,(H2,23,24,25) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 244 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K077GQ |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1, putative
(Cryptosporidium parvum (strain Iowa II)) | BDBM50389691
(CHEMBL2070057 | US10544104, Compound 43 | US112479...)Show SMILES CC(C)COc1ccc2cc(ccc2c1)-c1nn(C(C)C)c2ncnc(N)c12 Show InChI InChI=1S/C22H25N5O/c1-13(2)11-28-18-8-7-15-9-17(6-5-16(15)10-18)20-19-21(23)24-12-25-22(19)27(26-20)14(3)4/h5-10,12-14H,11H2,1-4H3,(H2,23,24,25) | PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 244 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US10544104 (2020)
BindingDB Entry DOI: 10.7270/Q2D79DSF |
More data for this Ligand-Target Pair | |
Calcium-dependent protein kinase 1
(Cryptosporidium parvum) | BDBM50389691
(CHEMBL2070057 | US10544104, Compound 43 | US112479...)Show SMILES CC(C)COc1ccc2cc(ccc2c1)-c1nn(C(C)C)c2ncnc(N)c12 Show InChI InChI=1S/C22H25N5O/c1-13(2)11-28-18-8-7-15-9-17(6-5-16(15)10-18)20-19-21(23)24-12-25-22(19)27(26-20)14(3)4/h5-10,12-14H,11H2,1-4H3,(H2,23,24,25) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 244 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center for Commercialization
US Patent
| Assay Description Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha... |
US Patent US9765037 (2017)
BindingDB Entry DOI: 10.7270/Q2B56MVC |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50389691
(CHEMBL2070057 | US10544104, Compound 43 | US112479...)Show SMILES CC(C)COc1ccc2cc(ccc2c1)-c1nn(C(C)C)c2ncnc(N)c12 Show InChI InChI=1S/C22H25N5O/c1-13(2)11-28-18-8-7-15-9-17(6-5-16(15)10-18)20-19-21(23)24-12-25-22(19)27(26-20)14(3)4/h5-10,12-14H,11H2,1-4H3,(H2,23,24,25) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington
Curated by ChEMBL
| Assay Description Inhibition of human SRC using Ac-EIYGEFKKK-OH as substrate after 60 mins by phosphorimaging method |
J Med Chem 55: 2416-26 (2012)
Article DOI: 10.1021/jm201713h BindingDB Entry DOI: 10.7270/Q2P2706V |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50389691
(CHEMBL2070057 | US10544104, Compound 43 | US112479...)Show SMILES CC(C)COc1ccc2cc(ccc2c1)-c1nn(C(C)C)c2ncnc(N)c12 Show InChI InChI=1S/C22H25N5O/c1-13(2)11-28-18-8-7-15-9-17(6-5-16(15)10-18)20-19-21(23)24-12-25-22(19)27(26-20)14(3)4/h5-10,12-14H,11H2,1-4H3,(H2,23,24,25) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 263 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center for Commercialization
US Patent
| Assay Description Inhibition of human tyrosine kinases. |
US Patent US9765037 (2017)
BindingDB Entry DOI: 10.7270/Q2B56MVC |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50389691
(CHEMBL2070057 | US10544104, Compound 43 | US112479...)Show SMILES CC(C)COc1ccc2cc(ccc2c1)-c1nn(C(C)C)c2ncnc(N)c12 Show InChI InChI=1S/C22H25N5O/c1-13(2)11-28-18-8-7-15-9-17(6-5-16(15)10-18)20-19-21(23)24-12-25-22(19)27(26-20)14(3)4/h5-10,12-14H,11H2,1-4H3,(H2,23,24,25) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 263 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US10544104 (2020)
BindingDB Entry DOI: 10.7270/Q2D79DSF |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase ABL1
(Homo sapiens (Human)) | BDBM50389691
(CHEMBL2070057 | US10544104, Compound 43 | US112479...)Show SMILES CC(C)COc1ccc2cc(ccc2c1)-c1nn(C(C)C)c2ncnc(N)c12 Show InChI InChI=1S/C22H25N5O/c1-13(2)11-28-18-8-7-15-9-17(6-5-16(15)10-18)20-19-21(23)24-12-25-22(19)27(26-20)14(3)4/h5-10,12-14H,11H2,1-4H3,(H2,23,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 1.15E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center for Commercialization
US Patent
| Assay Description Inhibition of human tyrosine kinases. |
US Patent US9765037 (2017)
BindingDB Entry DOI: 10.7270/Q2B56MVC |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase ABL1
(Homo sapiens (Human)) | BDBM50389691
(CHEMBL2070057 | US10544104, Compound 43 | US112479...)Show SMILES CC(C)COc1ccc2cc(ccc2c1)-c1nn(C(C)C)c2ncnc(N)c12 Show InChI InChI=1S/C22H25N5O/c1-13(2)11-28-18-8-7-15-9-17(6-5-16(15)10-18)20-19-21(23)24-12-25-22(19)27(26-20)14(3)4/h5-10,12-14H,11H2,1-4H3,(H2,23,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 1.15E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US10544104 (2020)
BindingDB Entry DOI: 10.7270/Q2D79DSF |
More data for this Ligand-Target Pair | |