Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Monocarboxylate transporter 4
(Homo sapiens (Human)) | BDBM356770
(US10214492, Example 134 | US11292767, Example 134)Show SMILES CC(C)Cc1ncc(o1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl Show InChI InChI=1S/C22H26ClN3O4/c1-14(2)9-20-24-11-19(30-20)18-10-16(13-29-22(3,4)21(27)28)25-26(18)12-15-7-5-6-8-17(15)23/h5-8,10-11,14H,9,12-13H2,1-4H3,(H,27,28) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2862KNG |
More data for this Ligand-Target Pair | |
Monocarboxylate transporter 4
(Homo sapiens (Human)) | BDBM356770
(US10214492, Example 134 | US11292767, Example 134)Show SMILES CC(C)Cc1ncc(o1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl Show InChI InChI=1S/C22H26ClN3O4/c1-14(2)9-20-24-11-19(30-20)18-10-16(13-29-22(3,4)21(27)28)25-26(18)12-15-7-5-6-8-17(15)23/h5-8,10-11,14H,9,12-13H2,1-4H3,(H,27,28) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Vettore, LLC
US Patent
| Assay Description MDA-MB-231 breast cancer cells may be used to measure MCT4 activity in cells with high native levels of MCT4 and low levels of MCT1 and are known to ... |
US Patent US10214492 (2019)
BindingDB Entry DOI: 10.7270/Q2Q81GC0 |
More data for this Ligand-Target Pair | |
Monocarboxylate transporter 1
(Homo sapiens (Human)) | BDBM356770
(US10214492, Example 134 | US11292767, Example 134)Show SMILES CC(C)Cc1ncc(o1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl Show InChI InChI=1S/C22H26ClN3O4/c1-14(2)9-20-24-11-19(30-20)18-10-16(13-29-22(3,4)21(27)28)25-26(18)12-15-7-5-6-8-17(15)23/h5-8,10-11,14H,9,12-13H2,1-4H3,(H,27,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 7.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2862KNG |
More data for this Ligand-Target Pair | |
Monocarboxylate transporter 1
(Homo sapiens (Human)) | BDBM356770
(US10214492, Example 134 | US11292767, Example 134)Show SMILES CC(C)Cc1ncc(o1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl Show InChI InChI=1S/C22H26ClN3O4/c1-14(2)9-20-24-11-19(30-20)18-10-16(13-29-22(3,4)21(27)28)25-26(18)12-15-7-5-6-8-17(15)23/h5-8,10-11,14H,9,12-13H2,1-4H3,(H,27,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 7.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vettore, LLC
US Patent
| Assay Description MCT1 activity may be measured using BT-20 breast cancer cells that express high native levels of MCT1, but do not express MCT4 and are known to those... |
US Patent US10214492 (2019)
BindingDB Entry DOI: 10.7270/Q2Q81GC0 |
More data for this Ligand-Target Pair | |